A case of advanced intrahepatic cholangiocarcinoma successfully treated with chemosensitivity test-guided systemic chemotherapy

Figure 1 Computed tomography (CT) of the tumor on first admission. CT shows a low-density lesion with rim enhancement in segment VIII of the liver (black arrows) (A) and enlarged lymph node in the para-aorta (white arrow) (B).

Figure 2 Hematoxylin-eosin staining. Cuboidal cancer cells with chromatin-rich nuclei had proliferated invasively, forming indistinct glandular structures.

Figure 3 Reduction in tumors in the liver and lymph node following chemotherapy.

Figure 4 Decreased pleural metastases following chemotherapy.

Figure 5 Cell viability evaluated by measuring the intracellular ATP level using bioluminescence. The T/C (treated/control) ratio, or the ratio of ATP quantity of a tumor sample treated with anticancer drugs to that of the control, was used as the index of chemosensitivity.