Clear cell adenocarcinoma of the colon: A case report and review of literature

Figure 1 The 7-mm diameter “berrylike” polyp on the sigmoid colon.

Figure 2 A: Polypectomy specimen containing adenoma and partial clear cell carcinoma. The cut margin was showed on the bottom side; B: There was no transition between the areas of the usual adenoma on right top of the figure and the clear cell adenocarcinoma on left bottom of the figure; C: The cut margin was showed normal colonic mucosa, indicating that this polypectomy was curative treatment. Each bar indicates 200 &mgr;m.

Figure 3 HE staining shows clear cell carcinoma with clear cytoplasm in a normal colonic adenoma (Two top figures). PAS staining shows purple staining on the adenoma on right of the figure, and mild purple staining on the clear cell carcinoma on left of the figure. Alcian blue staining shows granular mucin on the adenoma on right of the figure, and there are no staining on the clear cell carcinoma on left of the figure. Each bar indicates 200 &mgr;m.

Figure 4 Ki67 is about 70% positive, p53 is positive, CK7 is negative, CK20 is positive, and CD10 is weakly positive on immunochemical staining. Each bar indicates 200 &mgr;m.