Predictive value of Ki67 and p53 in locally advanced rectal cancer: Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy

Figure 1 Rectal adenocarcinomas with different tumor regression grade (TRG) after preoperative chemoradiotherapy: dominant tumor with obvious fibrosis in a non-responder, TRG1 (A); dominant fibrosis with very few tumor cell groups in a responder, TRG3 (B).

Figure 2 Ki67 expression in post-therapeutical resection specimens. High proliferative index with more than 90% positive nuclei (magnification × 10; insert: × 40) (A), and low proliferative index with less than 40% positive nuclei (magnification × 20) (B).

Figure 3 P53 expression in post-therapeutical resection specimens. Overexpression of p53 with more than 75% (A) and about 25% positive nuclei (B) (magnification × 10; inserts × 20).