Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480

Figure 1 Effect of aspirin on proliferation of SW480 cells.

Figure 2 Effect of aspirin on morphological change in normal SW480 cells (A), after treatment with aspirin at the concentration of 2. 5 mmol/L (B), 5.0 mmol/L (C), and 10.0 mmol/L (D) for 72 h, respectively.

Figure 3 Effect of aspirin on the expression of Bcl-2 in normal SW480 cells (A, C) and Bax after treatment with aspirin at the concentration of 5 mmol/L (B, D).

Figure 4 Effect of aspirin on the expression of Bcl-2 and Bax in SW480 cells. The expression of Bcl-2 protein was down-regulated while that of Bax protein was up-regulated in a dose-depend manner. ^aP < 0.05, ^bP < 0.01 vs control group.