Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma

Figure 1 Different immunohistochemical (IHC) staining patterns for β-catenin in colorectal carcinomas. A: In normal colonic epithelium, β-catenin is predominantly expressed in the cell membrane; B: A medium-powered view of a colonic adenocarcinoma showing membranous and cytoplasmic expression of β-catenin; C: This case shows intense nuclear expression of β-catenin.

Figure 2 Disease-specific survival predicted by the nuclear index (NI) of colorectal tumors. The stippled line: nuclear expression positive. The continuous line: nuclear expression negative. The Kaplan-Meier, log rank test; P = 0.046. One patient died of another cause and was excluded from analyses.

Figure 3 Disease-free survival predicted by the nuclear index (NI) of colorectal tumors. The stippled line: nuclear expression positive. The continuous line: nuclear expression negative. The Kaplan-Meier, log rank test; P = 0.041.