Relationship between T-lymphocyte cytokine levels and sero-response to hepatitis B vaccines

Figure 1 Comparison of anti-HBs levels from vaccine non-responders (NS), hyporesponders (Hypo) and high-responders (High) after booster HBV vaccination. ^aP < 0.05; ^bP = 0.001.

Figure 2 Cytokine secreted by PBMC’s from high-responders, hypo-responders and non-responder adults after in vitro stimulation with HBsAg. A: Comparison of Th1 cytokines (IFN-γ, IL-2, TNF-α, and IL-12) between the three groups of vaccine responders; B: Comparison of Th2 cytokines (IL-10 and IL-4) between the three groups of vaccine responders. ^aP < 0.05.

Figure 3 Correlation between anti-HBs titers and cytokine levels secreted after in vitro stimulation of PBMC with HBsAg from high-responder, hypo-responder and non-responder adults. A: Correlation of anti-HBs antibody response and the Th1 cytokine (IFN-γ, IL-2, IL-12 and TNF-α) response to HBsAg; B: Correlation of anti-HBs antibody response and the Th2 cytokine (IL-10 and IL-4) response to HBsAg.