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Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Mar 21, 2008; 14(11): 1670-1681
Published online Mar 21, 2008. doi: 10.3748/wjg.14.1670
Figure 1
Figure 1 Schematic illustration of the RNAi pathway showing the essential steps, with nuclear or cytoplasmic location, involved in micro RNA processing. Exogenous activators of the pathway, which may be synthetic siRNA or expressed mimics of miR precursors, are shown.
Figure 2
Figure 2 RNAi targets that may be silenced to counter HCC. In addition to HBV and HCV genes, cellular sequences that are involved in hepatocyte transformation may be silenced to inhibit growth of malignant liver cells. Growth of HCC is also dependent on angiogenesis and inhibition of this process is expected to limit tumor growth.