A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance

Figure 1 Increased resistin secretion (A) and insulin-inhibited resistin secretion (B) during 3T3-L1 preadipocyte differentiation. ^aP < 0.05.

Figure 2 Up-regulation (A) and down-regulation (B) of resistin mRNA level by insulin during 3T3-L1 preadipocyte differentiation.

Figure 3 Cellular insulin resistance induced by resistin after treatment of serum-starved H4IIE hepatocytes with 50 ng/mL resistin (A) and 100 nmol/L resistin (B). ^aP < 0.05 vs negative control, ^cP < 0.05 vs positive control.

Figure 4 Correlation of serum resistin with rat insulin sensitivity index (A) and insulin levels (B).