Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells

Figure 1 Expression of survivin mRNA in different groups of SGC-7901 cells. A: Survivin mRNA expression in RT-PCR assay; B: Survivin mRNA expression in SGC-7901. 1: treated with survivin siRNA; 2: treated with non-silencing siRNA; 3: untreated. Data are expressed as mean ± SD of three experiments, survivin siRNA group vs non-silencing siRNA group, ^bP < 0.01 ; survivin siRNA group vs untreated group, ^bP < 0.01.

Figure 2 Western blot assay of survivin protein expression in SGC-7901 cells. A: Survivin protein expression in Western blot assay; B: Survivin protein expression in SGC-7901.1: untreated; 2: non-silencing siRNA; 3: survivin siRNA. Data are expressed as mean ± SD of three experiments, survivin siRNA group vs non-silencing siRNA group, ^bP < 0.01; survivin siRNA group vs untreated group, ^bP < 0.01.

Figure 3 Effects on cell viability after non-silencing siRNA and survivin siRNA treatment. 1: untreated; 2: non-silencing siRNA; 3: survivin siRNA. Data are expressed as mean ± SD, survivin siRNA group vs non-silencing siRNA group, ^bP < 0.01; survivin siRNA group vs untreated group, ^bP < 0.01.