Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families

Figure 1 Missense germline mutation of exon 6 of MSH6 gene in the proband of H14 HNPCC kindreds. Arrow indicates the mutation site, The single basyl substitution was transversed from A to T (A>T) at the codon 1163, the codon from GAA to GTA, causing the amiod acid changes from glutamine to valine, the change was identified as a new SNP. A and B represent the forward sequence and reverse, respectively.

Figure 2 Missense germline mutation of exon 4. 6 of MSH6 gene in the proband of H40 HNPCC kindreds. Arrow indicates the mutation site, The single basyl substitution was transvered from T to C (T>C) at the codon 666, the codon from TCT to CCT, causing the amiod acid changes from serine to proline. A and B represent the forward and reverse sequence, respectively.