Veno occlusive disease: Update on clinical management

Figure 1 Liver biopsy in a patient with diagnosis of VOD 5 mo post liver transplantation. There is centrilobular liver cell loss, sinusoidal ectasia, haemorrhage, and a stenotic hepatic outflow venule (in the centre of the picture). The appearance is of venous outflow obstruction. MSB stain.

Figure 2 Flow chart in diagnosis and management of veno-occlusive disease. VOD: veno occlusive disease; SCT, stem cell transplantation; OLT: ortothopic liver transplantation; HVPG: hepatic venous pressure gradient; HV hepatic vein; IVC: inferior vena cava; KT: kidney transplantation; MOF: multi organ failure; TIPS: transjugular intrahepatic portosystemic shunt.