Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

Figure 1 Method of DSS colitis model and administration of PDTC.

Figure 2 The effect of PDTC on clinical indices (DAI). ^aP < 0.05, ^bP < 0.01, vs control group.

Figure 3 Comparison of length of colon in different groups.

Figure 4 The effect of PDTC on length of colon. ^aP < 0.05, P = NS, vs control group. NS: not significant.

Figure 5 Histological findings of distal colon in mouse. A: normal; B: control; C: PDTC-treated groupI (low dose); D: PDTC-treated group II (high dose).

Figure 6 The effect of PDTC on histological disease score. P = NS vs control group. NS: not significant.

Figure 7 The effect of PDTC on NF-κ concentration. ^aP < 0.05, ^bP < 0.01, vs control group.

Figure 8 A: The effect of PDTC on IL-1β cytokine concentration. ^aP < 0.05, P = NS, vs control group. NS: not significant; B: The effect of PDTC on TNF-α cytokine concentration. ^aP < 0.05 vs control group.