Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats

Figure 1 Effect of treatment on liver collagen content by biochemical method. ^bP < 0.01, ^dP < 0.001 vs sham; ^fP < 0.001 vs control.

Figure 2 Effects of vitamin E, C and combination treatment on hepatic fibrosis as determined by computerized image analysis. ^aP < 0.05 vs control.

Figure 3 A: Necroinflammation disperses the lobular parenchyma from the portal areas (HE x 100); B: Prominent bile duct proliferation; C, D: Severe portal fibrosis with porto-portal bridging by sirius red collagen stain (x 100).

Figure 4 Effects of vitamin E, C and combination treatment on serum hyaluronate levels. ^bP < 0.001 vs control.