Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2006; 12(37): 5932-5940
Published online Oct 7, 2006. doi: 10.3748/wjg.v12.i37.5932
Figure 1
Figure 1 Microsatellite unstable CRCs are normally located proximal to the splenic flexure and reveal non-polypoid pattern. MSI can be demonstrated by fluorescence in-situ hybridization (FISH) or molecular techniques. Histopathologically, these tumors show solid growth, mucinous differentiation, prominent lymphocytic infiltrate, and no dirty necrosis[10].
Figure 2
Figure 2 Molecular pathways contributing to the phenotype of microsatellite stable (MSS) CRC. MMR protein expression results in enhanced RAS signaling through ERK pathway (increased proliferation) and down-regulation of PI3P phosphatase, caspase 9 (apoptosis blockade), as well as TNF (decreased inflammation).