Chronic Epstein-Barr virus-related hepatitis in immunocompetent patients

Figure 1 Significant differences detected between patients and control group by immunophenotyping. Patients were characterized by a decreased absolute number of naive CCCR7⁺CD45RA⁺CD4⁺ (A) and CD8⁺ (C) T cells, increased absolute number of memory CD45RA^-CD4⁺ (B) and CD8⁺ (D)T cells, increased absolute number of effector CD28^-CD27^-CD8⁺ T cells (E), as well as by increased percentage of IFNγ⁺CD69⁺CD8⁺ T cells after stimulation with EBV peptide GLCTMVL (F) and with PHA (G). Box-and-whiskers indicate the 25-75 percentile and min-max values for each group. Mean values are designated on all plots by a horizontal line. Man-Witney. P values are indicated for each comparison.

Figure 2 Liver biopsy, showing lymphocyte infiltrate within the lobule and some hepatocyte injury, with mild steatosis displayed in some cells.