H pylori and host interactions that influence pathogenesis

Figure 1 H pylori binds to CD74 on gastric epithelial cells and induces NF-κB activation and IL-8 production.

Figure 2 CagA is injected into the cell by a type IV secretion system where it is phosphorylated and induces ERK1/2 phosphorylation and increased cell proliferation. CagA also induces disruption of the tight junctions between adjacent cells.

Figure 3 H pylori induces chronic inflammation leading to either ulceration or malignant outgrowths.