Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 21, 2006; 12(35): 5599-5605
Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5599
Figure 1
Figure 1 H pylori binds to CD74 on gastric epithelial cells and induces NF-κB activation and IL-8 production.
Figure 2
Figure 2 CagA is injected into the cell by a type IV secretion system where it is phosphorylated and induces ERK1/2 phosphorylation and increased cell proliferation. CagA also induces disruption of the tight junctions between adjacent cells.
Figure 3
Figure 3 H pylori induces chronic inflammation leading to either ulceration or malignant outgrowths.