Basic Research
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2006; 12(27): 4345-4351
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4345
Figure 1
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Figure 1 Histological appearance of rat liver tissue. Masson X 270. A: Intact control; B: Control, zinc sulfate; The liver showing vacuolated hepatocytes (→) in the centrilobuler area with mild dilation of sinusoids (►) and hyperemia (*); C: Absolute ethanol; D: Zinc pre-treatment.
Figure 2
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Figure 2 Immunreactive metallothionein-producing cells (►) in rat liver. Streptavidin-Biotin-Peroxidase x 270. A: Intact control; B: Control, zinc sulfate; The reduced metallothionein expression (►); C: Ethanol; Note the increase of immunoreactivity of metallothionein-producing cells, D: Ethanol + zinc sulfate; E: Intact control, PCNA-positive hepatocytes (►); F: Control, zinc sulfate; G: Ethanol; The increase in immunoreactivity of PCNA-positive cells, H: Ethanol + zinc sulfate.
Figure 3
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Figure 3 A: Metallothionein, aP = 0. 018 vs Ethanol; B: PCNA labeling indeces, bP = 0.007 vs Ethanol.
Figure 4
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Figure 4 Ultrastructure of the hepatocytes of the rat. TEM X5000. A: Control; B: Ethanol; C: Zinc sulfate + ethanol. An increase in smooth endoplasmic reticulum (SER), lipid vacuoles (L) and degeneration in mitochondria (M) of the hepatocyte of a rat given ethanol. These ultrastructural changes were improved by zinc pre-treatment.