Mutations in carboxy-terminal part of E2 including PKR/eIF2α phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: Their correlation with response to interferon monotherapy and viral load

Figure 1 Amino acid sequences of C-terminal part of E2 protein with 0-2 substitutions (A) and 3-6 substitutions (B) in 45 and 40 HCV 1b-infected patients treated by IFN therapy respectively.

Figure 2 Amino acid sequences of C-terminal part of E2 before and after IFN therapy in 16 non-responders.

Figure 3 Amino acid sequences of ISDR in 82 HCV-infected patients.

Figure 4 Correlation between the number of amino acid substitutions in ISDR and C-terminal part of E2 protein.