Immunogenetic phenotypes in inflammatory bowel disease

Figure 1 The frequency of disease behavior. The test for trend demonstrated a positive linear trend in the frequency of patients with IP and/or S disease as the number of positive immune responses toward I2, OmpC, ASCA and CBir1 increased (P = 0.002). The odds ratios (OR) reflect the odds of having internal penetrating and/or stricturing disease when positive for any 1, combination of 2, 3 or all 4 immune responses, as compared to those patients negative for all immune responses (baseline group).

Figure 2 Association of the summed level of antibody responses towards multiple microbial antigens and disease phenotypes. Quartile sums used to reflect lowest (3) to highest titer level (12) for ASCA, anti-I2 and anti-OmpC.

Figure 3 Kaplan Meier survival analysis. Comparison of time to progression from non-complicating to complicating disease behaviors between patients positive for 1 immune response to ASCA, I2 and OmpC (n = 97) (—) and those negative for all 3 (n = 70) (----).

Figure 4 Frequency of anti-OmpC in unaffected relatives from CD only families, mixed families, UC only families, and healthy controls.