Gilbert’s syndrome: High frequency of the (TA)7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene

Figure 1 Distributions of un-conjugated serum bilirubin values among Gilbert’s syndrome patients classified by the genotype of the common TA insertion in the TATA box of the UGT1A1 promoter.

Figure 2 Folded DNA structures of the UGT1A1 promoter region with one copy of the CAT trinucleotide (shaded region) (A) and two copies of the CAT trinucleotide (CAT insertion allele, shaded region) (B).

Figure 3 Transcriptional activities of the (TA) ₆TAA, (TA)₇ TAA and CAT alleles as assessed by a luciferase reporter assay.