A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats

Figure 1 Effect of post-AA administration on gastric mucosal total AA (A), reduced AA (B), and oxidized AA (C) concentrations in C48/80-treated rats. mean±SD (n = 5 for C48/80-untreated groups; n = 10 for C48/80-treated groups). ^aP<0.05 vs corresponding control rats without C48/80 treatment; ^cP<0.05 vs rats treated with C48/80 alone.

Figure 2 Effect of post-AA administration on serum total AA (A), reduced AA (B), and oxidized AA (C) concentrations in C48/80-treated rats. Mean±SD (n = 5 for C48/80-untreated groups; n = 10 for C48/80-treated groups). ^aP<0.05 vs corresponding control rats without C48/80 treatment; ^cP<0.05 vs rats treated with C48/80 alone.

Figure 3 Effect of post-AA administration on gastric mucosal vitamin E (A), NPSH (B), and adherent mucus (C) concentrations in C48/80-treated rats. mean±SD (n = 5 for C48/80-untreated groups; n = 10 for C48/80-treated groups). ^aP<0.05 vs corresponding control rats without C48/80 treatment; ^cP<0.05 vs rats treated with C48/80 alone.

Figure 4 Effect of post-AA administration on gastric mucosal TBARS concentration (A) and MPO activity (B) in C48/80-treated rats. mean±SD (n = 5 for C48/80-untreated groups; n = 10 for C48/80-treated groups). ^aP<0.05 vs corresponding control rats without C48/80 treatment; ^cP<0.05 vs rats treated with C48/80 alone.

Figure 5 Effect of post-AA administration on NOx concentrations in the gastric mucosal tissue (A) and serum (B) of C48/80-treated rats. mean±SD (n = 5 for C48/80-untreated groups; n = 10 for C48/80-treated groups). ^aP<0.05 vs corresponding control rats without C48/80 treatment; ^cP<0.05 vs rats treated with C48/80 alone.

Figure 6 Effect of post-AA administration on gastric mucosal blood flow in C48/80-treated rats. Mean±SD (n = 5 for C48/80-untreated groups; n = 10 for C48/80-treated groups). ^aP<0.05 vs corresponding control rats without C48/80 treatment.