Basic Research
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2005; 11(47): 7430-7435
Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7430
Figure 1
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Figure 1 Microscopic appearance of gastric mucosa showing the effect of DA-9601 and rebamipide on sodium taurocholate (TCA)-induced erosive and atrophic gastritis in rats (×100). Rats were administered with 5 mmol/L TCA for
Figure 2
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Figure 2 Inhibitory effects of DA-9601 and rebamipide on the length of mucosal lesion of TCA-induced erosive and atrophic gastritis in rats. DA-9601 (0.065% and 0.0.216%) and rebamipide (1.08%) were mixed with rodent chow and then administered to the rats. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 3
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Figure 3 Effects of DA-9601 and rebamipide on the mucosal thickness of TCA-induced erosive and atrophic gastritis in rats. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 4
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Figure 4 Effects of DA-9601 and rebamipide on the number of parietal cells in TCA-induced erosive and atrophic gastritis in rats. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 5
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Figure 5 Effects of DA-9601 and rebamipide on the infiltration of inflammatory cells induced by TCA. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 6
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Figure 6 Effects of DA-9601 and rebamipide on the proliferation of collagenous fiber induced by TCA in rats. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 7
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Figure 7 Effects of DA-9601 and rebamipide on malondialdehyde (MDA) induced by TCA in rat gastric mucosa. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 8
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Figure 8 Effects of DA-9601 and rebamipide on PGE2 induced by TCA in rat gastric mucosa. N: normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.
Figure 9
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Figure 9 Effects of DA-9601 and rebamipide on glutathione (GSH) induced by TCA in rat gastric mucosa. N: Normal; C: control; DL: 0.065% DA-9601; DH: 0.216% DA-9601; R: 1.08% rebamipide. Data are expressed as mean±SE. aP<0.05 vs controls.