Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70

Figure 1 Effect of sham operation (SO), IP, resveratrol (RES) or rofecoxib (ROF) applied alone or in combination on serum lipase activity (A), IL-1® (B), poly-C ribonuclease (C), pancreatic DNA synthesis (D), and pancreatic blood flow (E) in rats with or without cerulein-induced pancreatitis. ^aP<0.05 vs shamoperated rats treated with cerulein alone, ^bP<0.001 vs sham-operated salinetreated control (SO), ^cP<0.05 vs rats exposed to IP and treated with cerulein.

Figure 2 Representative Western blot analysis of b-actin protein (A) and HSP 70 (B), and the ratio of HSP 70 over b-actin protein (C) in pancreatic tissue of sham-operated control rats (lane 1), rats exposed to IP (lane 2), sham-operated rats with cerulein-induced pancreatitis (CIP, lane 3), and rats with IP applied prior to cerulein-induced pancreatitis (IP+CIP, lane 4). ^bP<0.001 vs sham-operated rats treated with cerulein alone (CIP), ^aP<0.05 vs sham-operated saline-treated control, ^dP<0.001 vs rats exposed to IP without induction of acute pancreatitis (CIP).