Effect of indomethacin on electrical field stimulation-induced contractions of isolated transverse and longitudinal rat gastric fundus strips

Figure 1 Cumulative concentration-response curves for the effect of indomethacin on EFS-induced contractions of transverse (◆) and longitudinal (■) rat gastric fundus strips. Each point represents the mean ± SE of responses observed in eight strips. Relaxations are expressed as percentages of the amplitude of contractions induced in the same strip by EFS before drug treatment. The responses of transverse and longitudinal strips of rat gastric fundus for each concentration of indomethacin were compared. ^aP < 0.05 vs EFS-induced contractions of transverse.

Figure 2 Effect of diazoxide (10^-4 mol/L) on cumulative concentration-response curves for relaxant effect of indomethacin on EFS-induced contractions of transverse (A) and longitudinal (B) strips of rat gastric fundus. Each point represents the mean ± SE of responses observed in eight strips. Relaxations or early contractions are expressed as percentages of the amplitude of contractions induced in the same strip by EFS before drug treatment. A: Responses of transverse strips of rat gastric fundus pretreated with diazoxide (◇) after administration of each concentration of indomethacin compared to saline-treated (◆) strips; B: responses of longitudinal strips of rat gastric fundus pretreated with diazoxide (□) after administration of each concentration of indomethacin compared to saline-treated (■) strips. ^aP < 0.05 vs saline-treated strips.

Figure 3 Effect of glybenclamide (4 × 10^-6 mol/L) on cumulative concentration-response curves for relaxant effect of indomethacin on EFS-induced contractions of transverse (A) and longitudinal (B) strips of rat gastric fundus. Each point represents the mean ± SE of responses observed in eight strips. Relaxations or early contractions are expressed as percentages of the amplitude of contractions induced in the same strip by EFS before drug treatment. A: Responses of transverse strips of rat gastric fundus pretreated with glybenclamide (◇) after administration of each concentration of indomethacin compared to saline-treated (◆) strips; B: responses of longitudinal strips of rat gastric fundus pretreated with glybenclamide (□) after administration of each concentration of indomethacin compared to saline-treated (■) strips. ^aP < 0.05 vs saline-treated strips.