Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats

Figure 1 Morphological change in HH group (A) and NC group (B). (×20 000). A: The liver of rats anesthetized with 14% O₂/86% N₂/1.2MAC Halothane had extensive centrilobular necrosis and denaturation; B: There was a increase in serum glutamic pyruvic transminase accompanying the morphologic damage, but no marked change was found in liver morphology inhaled with 21% O₂/79% N₂.

Figure 2 Hepatic Ca²⁺ cytochemical changes in HH group (A) and NC group(B). A: The liver of rats anesthetized with 14% O₂/86% N₂/1.2MAC. Halothane had a large amount of calcium deposition as shown in cytoplasm and mitochondria; B: The liver of rats inhaled with 21% O₂/79% N₂, calcium precipitation was mainly located in nucleus, in mitochondria and cytoplasm as fine particles.