Effects of Changtai granules, a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats

Figure 1 Photos of distal colons from normal (A), control (B), DX (C), and CTG at dose of 2. 9, 5.7, and 11.4 g crude drug/kg (D-F) groups. At model control PIC, histological inflammatory features including mucosal hemorrhage, submucosal edema and inflammatory infiltration in the lamina propria and submucosa were observed. At CTG PIC, there was no remarkable inflammatory feature. At DX PIC, ulcer was recovered, but inflammatory feature was still remarkable.

Figure 2 Histological findings in UC. A: Normal group, the mucosa is normal (HE, ×200); B: control group, gross ulcers, epithelial necrosis at mucosal surface and inflammatory cell infiltration (HE, ×200); C: DX group, gross ulcers and proliferous granuloma, inflammatory cell infiltration (HE, ×200); D: CTG group at dose of 2.9 g crude drug/kg, small mucosal ulcers and crypto abscess formation (HE, ×200); E: CTG group at dose of 5.7 g crude drug/kg, inflammatory cell infiltration (HE, ×200); F: CTG group at dose of 11.4 g crude drug/kg, the mucosa recovered (HE, ×100).