Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis

Figure 1 A: Average CAI in the 19 patients at wk 5 and 10 following the start of LCAP treatment; B: Average CRP level in the 19 patients at wk 5 and 10 following the start of LCAP treatment; C: Average EI in 19 patients at wk 5 and 10 following the start of LCAP treatment.

Figure 2 A: The serum IL-6 concentrations in six patients at wk 1, 2, 3, 5, and 10 following the start of LCAP treatment; B: The serum IL-10 concentrations measured at the Cellsorba inflow (at the start of LCAP) and outflow (at the end of LCAP).

Figure 3 A: Percentage of reactive-oxygen-producing granulocytes in normal subjects (n = 6) and UC patients (n = 11); B: Percentage of reactive-oxygen-producing granulocytes in the peripheral blood of 10 patients before and after LCAP treatment.

Figure 4 Representative results of FACS analysis in the peripheral blood of one patient before (A) and after (B) LCAP treatment. The percentages of reactive-oxygen-producing cells in A and B were 22.9% and 7.1%, respectively.