Dinucleotide microsatellite repeats are essential for the diagnosis of microsatellite instability in colorectal cancer in Asian patients

Figure 1 Illustration of MSI and loss of mismatch repair protein hMLH1. A: Microsatelllite instability analysis of normal mucosa for dinucleotide repeat microsatellite D5S346; B: MSI analysis of CRC for dinucleotide repeat microsatellite D5S346 in the same patient, with arrow indicating the area of instability; C: Analysis of hMLH1 protein expression by immunohistochemistry in the same CRC case, showing loss of protein expression; D: Analysis of hMLH1 protein expression by immunohistochemistry in a positive control case.