Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats

Figure 1 Actuarial allograft survival curves in the three study groups based on serum glucose levels, showing significantly prolonged survival in the two therapy arms in comparison to the controls.

Figure 2 Effect of MMF and CsA on the blood glucose levels of the recipients over time after transplantation.

Figure 3 Effect of MMF and CsA on the percentage of weight change of the recipients.

Figure 4 A: Three weak stained islets (long arrows) located into the exocrine tissue 12 d after transplantation without immunosuppression. A dilated pancreatic duct (short arrow) is also present (anti-insulin, ×200); B: Intact islets into the exocrine tissue (long arrows) 12 d after engraftment and immunosuppression with CsA. The insulin staining is positive and intense (anti-insulin, ×200); C: A well-developed and large islet (long arrow) into the exocrine tissue 12 d after transplantation and immunosuppression with MMF. Anti-insulin stain shows beta cell granulation within islets. At the lower right corner of the figure splenic parenchyma is present (short arrow) (anti-insulin, ×200).