Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients

Figure 1 Genes expressed differentially between livers without HCV and HCV-infected livers. The red and blue colors indicate relative extent of gene overexpression and underexpression, respectively, with darker colors indicating larger differences. HCV, hepatitis C virus; HCC, hepatocellular carcinoma; IFNA, interferon alpha; F, coagulation factor; IL2RA, interleukin 2 receptor alpha; TNFSF, tumor necrosis factor super family; CCR7, chemokine (C-C motif) receptor 7; IGFBP3, insulin-like growth factor-binding protein 3; PDK4, pyruvate dehydrogenase kinase 4; RPLP0, ribosomal protein large 0; CYP2C19, cytochrome P450 2C19; FABP1, fatty acid binding protein 1; COL, collagen.

Figure 2 Genes expressed differentially between livers with F1-2 and F3-4 fibrosis. The red and blue colors indicate relative extent of gene overexpression and underexpression, respectively, with darker colors indicating larger differences. GPCR, G protein-coupled receptor; HCC, hepatocellular carcinoma; B2M, beta-2-microglobulin; GRP25, G protein-coupled receptor 25; ADH1C, alcohol dehydrogenase 1C; AKR1D1, aldo-keto reductase 1D1; CYP2C8, cytochrome P450 2C8; ALB, albumin; FABP1, fatty acid binding protein 1; APO, apolipoprotein; NEO, neogenin homolog; ADMR, adrenomedullin receptor; GNG5, guanine nucleotide binding protein (G protein) gamma 5; ARL7, ADP-ribosylation factor-like 7; ARHGAP6, Rho GTPase activating protein 6; STK, serine/threonine kinase; GAA, glucosidase alpha acid; NR5A2, nuclear receptor subfamily 5A2; PGR, progesterone receptor; PRS2, protease serine 2; ACCN2, amiloride-sensitive cation channel 2; HOXC6, homeo box C6.

Figure 3 Genes expressed differentially between F3-4 cases with and without HCC. The red and blue colors indicate relative extent of gene overexpression and underexpression, respectively, with darker colors indicating larger differences. HCC, hepatocellular carcinoma; H2AFX, H2A histone family member X; GAA, glucosidase alpha acid; PFKFB1, 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1; IDUA, iduronidase alpha L; MMPL1, matrix metalloproteinase-like 1; ATP4B, ATPase H+/K+ exchanging beta polypeptide.