Inhibitory effects of berberine on ion channels of rat hepatocytes

Figure 1 Effects of berberine on I_K. A: Families of I_K recorded with changes in the absence or presence of berberine 30 μmol/L and 100 μmol/L. Dotted line indicates zero current level; B: Dose-response curve for effects of berberine on I_K; C: I-V relationship of I_K under control (●) and berberine 30 μmol/L (○). D: Families of I_K1 recorded with changes in the absence or presence of berberine 100 μmol/L. Dotted line indicates zero current level; E: I-V relationship of I_K1 under control (●) and berberine 100 μmol/L (○). F: Families of I_CRAC recorded with changes in the absence or presence of berberine 30 μmol/L. Dotted line indicates zero current level; G: Dose-response curve for effects of berberine on I_CRAC; H: I-V relationship of I_CRAC under control (●) and berberine 30 μmol/L (○). The voltage steps used to elicit I_K are shown in the inset. n = 8, mean ± SD, ^aP < 0.05, ^bP < 0.01 vs control.