Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma

Figure 1 Endoscopic examination revealed a small submucosal tumor on rectum.

Figure 2 Double-contrast barium enema revealed no definite deformity of the GI wall at the lesion.

Figure 3 Endoscopic ultrasonography showed that the tumor was confined at the second layer of the colonic wall.

Figure 4 Histopathological studies showed aggregated atypical lymphocytes (A). Immunohistochemical analysis revealed that these lymphocytes were positive for CD20 and BCL2 (B and C).

Figure 5 T-FISH detected fusion signals of IGH and BCL2 genes in nuclei as indicated by arrows.