Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide

Figure 1 Effects of Saiko-keishi -to (TJ-10) and/or an NO synthase inhibitor (N^G- monomethyl-L-arginine, L- NMMA) on the number of stationary leukocytes, plasma TNF-α levels, serum endotoxin levels, and plasma ALT activities. A: In each region (the midzonal and pericentral regions) (panel A) and the entire (combined) liver lobule (panel B) after 30 min of gut ischemia and 60 min of reperfusion; B: Plasma TNF-α levels at 60 min after gut I/R; C: Serum endotoxin levels at 60 min after gut I/R; D: Plasma ALT activities at 6 h after gut I/R.