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World J Gastroenterol. Nov 14, 2012; 18(42): 6096-6105
Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6096
Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6096
Quasispecies dynamics in main core epitopes of hepatitis B virus by ultra-deep-pyrosequencing
Maria Homs, Maria Buti, David Tabernero, Josep Quer, Rafael Esteban, Francisco Rodriguez-Frias, Network Medical Research Center, Hepatic and Digestive Diseases (CIBERehd), Institute of Health Carlos III, 08036 Barcelona, Spain
Maria Homs, David Tabernero, Noelia Corral, Francisco Rodriguez-Frias, Department of Biochemistry, Vall d’Hebron Hospital, Autonomous University of Barcelona, 08035 Barcelona, Spain
Maria Buti, Rafael Esteban, Department of Hepatology, Vall d’Hebron Hospital, Autonomous University of Barcelona, 08035 Barcelona, Spain
Alex Sanchez, Statistics and Bioinformatics Unit, Research Institute, Vall d’Hebron Hospital, 08035 Barcelona, Spain
Author contributions: Homs M and Rodriguez-Frias F designed the research; Homs M, Tabernero D and Corral N performed the experiments; Quer J contributed new analytic tools; Sanchez A analyzed the data; Homs M and Rodriguez-Frias F wrote the paper; Buti M, Esteban R and Rodriguez-Frias F contributed to the supervision of the manuscript writing.
Supported by A Grant from the Spanish Ministry of Health and Consumer Affairs, No. FIS PS09/00899 and SAF 2009-10403; CIBERehd Funded by Instituto Carlos III, Ministry of Health and Consumer Affairs
Correspondence to: Francisco Rodriguez-Frias, PhD, Department of Biochemistry, Vall d’Hebron Hospital, Autonomous University of Barcelona, Vall d’Hebron Avenue, 119-129, 08035 Barcelona, Spain. frarodri@vhebron.net
Telephone: +34-93-2746991 Fax: +34-93-2746831
Received: May 16, 2012
Revised: July 25, 2012
Accepted: July 28, 2012
Published online: November 14, 2012
Revised: July 25, 2012
Accepted: July 28, 2012
Published online: November 14, 2012
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