Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 14, 2011; 17(6): 766-773
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.766
Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic
Patrícia Koehler-Santos, Patricia Izetti, Jamile Abud, Carlos Eduardo Pitroski, Silvia Liliana Cossio, Suzi Alves Camey, Cláudio Tarta, Daniel C Damin, Paulo Carvalho Contu, Mario Antonello Rosito, Patricia Ashton-Prolla, João Carlos Prolla
Patrícia Koehler-Santos, Patricia Izetti, Jamile Abud, Carlos Eduardo Pitroski, Silvia Liliana Cossio, Patricia Ashton-Prolla, Genomic Medicine Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil
Patrícia Koehler-Santos, Carlos Eduardo Pitroski, Patricia Ashton-Prolla, Post-Graduate Program in Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre - RS, 90035-003, Brazil
Patrícia Koehler-Santos, Silvia Liliana Cossio, Patricia Ashton-Prolla, National Institute for Populational Medical Genetics, Porto Alegre - RS, 90035-903, Brazil
Patricia Izetti, Medical School, Federal University of Rio Grande do Sul, Porto Alegre - RS, 90035-003, Brazil
Jamile Abud, João Carlos Prolla, Post-Graduate Program in Gastroenterological Sciences, Federal University of Rio Grande do Sul, Porto Alegre - RS, 90035-003, Brazil
Suzi Alves Camey, Department of Statistics, Federal University of Rio Grande do Sul, Porto Alegre - RS, 91501-970, Brazil
Suzi Alves Camey, Post-Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre - RS, 90035-003, Brazil
Suzi Alves Camey, Research and Post-Graduation Group, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil
Cláudio Tarta, Daniel C Damin, Paulo Carvalho Contu, Mario Antonello Rosito, Division of Coloproctology, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil
Cláudio Tarta, Daniel C Damin, Paulo Carvalho Contu, Mario Antonello Rosito, Department of Surgery, Federal University of Rio Grande do Sul, Porto Alegre - RS, 90035-003, Brazil
Patricia Ashton-Prolla, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil
Patricia Ashton-Prolla, Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre - RS, 91501-970, Brazil
João Carlos Prolla, Service of Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil
Author contributions: Koehler-Santos P identified and interviewed all consecutive colorectal cancer patients who agreed to participate in the study; Koehler-Santos P and Izetti P designed the database and performed the analysis under the supervision of Camey SA, and were directly involved in writing and editing the manuscript; Abud J, Pitroski CE and Cossio SL helped with acquisition of the data from patient databases; Tarta C, Damin DC, Contu PC and Rosito MA are the primary physicians of all patients and participated in patient identification; Prolla JC and Ashton-Prolla P were directly involved with the concept and design of the study, evaluation of patients at-risk and editing of the manuscript.
Correspondence to: Patricia Ashton-Prolla, MD, PhD, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre - RS, 90035-903, Brazil. pprolla@hcpa.ufrgs.br
Telephone: +55-51-33598011 Fax: +55-51-33598010
Received: February 8, 2010
Revised: March 23, 2010
Accepted: March 30, 2010
Published online: February 14, 2011
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