Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells

doi:10.3748/wjg.v17.i6.750

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Feb 14, 2011 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2011; 17(6): 750-759
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.750

Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells

Anna Oksaharju, Matti Kankainen, Riina A Kekkonen, Ken A Lindstedt, Petri T Kovanen, Riitta Korpela, Minja Miettinen

Anna Oksaharju, Petri T Kovanen, Wihuri Research Institute, Helsinki 00140, Finland

Matti Kankainen, VTT Technical Research Centre of Finland, Biosystems Modelling, Espoo 02044, Finland

Riina A Kekkonen, Riitta Korpela, Valio Ltd, Research Centre, Helsinki 00370, Finland

Riina A Kekkonen, Riitta Korpela, University of Helsinki, Institute of Biomedicine, Medical Nutrition Physiology, Helsinki 00290, Finland

Ken A Lindstedt, Wihuri Research Institute, Helsinki 00140, Finland and Orion Corporation, Orion Pharma, Nonclinical R&D, Espoo 02601, Finland

Minja Miettinen, National Institute for Health and Welfare, Department of Vaccines and Immune Protection, Helsinki 00580, Finland

Author contributions: Kekkonen RA, Korpela R, Lindstedt KA and Oksaharju A designed the research; Oksaharju A performed the experiments; Oksaharju A, Kankainen M and Miettinen M analyzed the data; Oksaharju A wrote the manuscript; Kankainen M, Kekkonen RA, Lindstedt KA, Kovanen PT, Korpela R and Miettinen M edited the manuscript.

Supported by Valio Research Centre, the Foundation for Nutrition Research, Academy of Finland Research Council for Biosciences and Environment, Grant No. 129954; and Finnish Funding Agency for Technology and Innovation (TEKES) grant No. 2243/31/05. Wihuri Research Institute is maintained by Jenny and Antti Wihuri Foundation

Correspondence to: Anna Oksaharju, MSc, Wihuri Research Institute, Kalliolinnantie 4, Helsinki 00140, Finland. anna.oksaharju@helsinki.fi

Telephone: +358-9-681411 Fax: +358-9-637476

Received: May 14, 2010
Revised: August 28, 2010
Accepted: September 5, 2010
Published online: February 14, 2011

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