Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

doi:10.3748/wjg.v17.i6.708

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2011; 17(6): 708-716
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.708

Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

Andi Utama, Marlinang Diarta Siburian, Sigit Purwantomo, Mariana Destila Bayu Intan, Tri Shinta Kurniasih, Rino Alvani Gani, Wenny Astuti Achwan, Arnelis, Syafruddin AR Lelosutan, Benyamin Lukito, Tantoro Harmono, Nasrul Zubir, Julius, Soewignjo Soemohardjo, Laurentius Adrianus Lesmana, Ali Sulaiman, Susan Tai

Andi Utama, Marlinang Diarta Siburian, Sigit Purwantomo, Mariana Destila Bayu Intan, Tri Shinta Kurniasih, Susan Tai, Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Lippo Karawaci, Tangerang, 15810, Indonesia

Rino Alvani Gani, Laurentius Adrianus Lesmana, Ali Sulaiman, Hepatology Division, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia

Wenny Astuti Achwan, Soewignjo Soemohardjo, Department of Internal Medicine, Mataram General Hospital, Mataram, 83127, Indonesia

Arnelis, Nasrul Zubir, Julius, Gastroentero-Hepatology Division, Department of Internal Medicine, Dr. M. Jamil Hospital, Padang, 25127, Indonesia

Syafruddin AR Lelosutan, Gastroentero-Hepatology Division, Department of Internal Medicine, Dr. Gatot Soebroto Hospital, Jakarta, 10410, Indonesia

Benyamin Lukito, Department of Internal Medicine, Siloam Hospital Lippo Village, Tangerang, 15810, Indonesia

Tantoro Harmono, Department of Internal Medicine, Dr. Moewardi Hospital, Surakarta, 57126, Indonesia

Author contributions: Utama A, Siburian MD and Purwantomo S designed and performed the experiments; Intan MDB and Kurniasih TS performed some experiments; Tai S was involved in experiment design and editing the manuscript; Gani RA, Achwan WA, Arnelis, Zubir N, Julius, Soemoharjo S, Lelosutan SAR, Lukito B, Harmono T, Lesmana LA and Sulaiman A coordinated and provided the collection of human materials and were involved in editing the manuscript.

Supported by MRIN Funding (Budget No. cc041/2009)

Correspondence to: Andi Utama, PhD, Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Jalan Boulevard Jend. Sudirman 1688, Lippo Karawaci, Tangerang 15810, Banten, Indonesia. autama@mrinstitute.org

Telephone: +62-21-54210123 Fax: +62-21-54210110

Received: September 1, 2010
Revised: November 25, 2010
Accepted: December 2, 2010
Published online: February 14, 2011

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