Basic Research
Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jul 28, 2008; 14(28): 4462-4472
Published online Jul 28, 2008. doi: 10.3748/wjg.14.4462
Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction
Taru K Pilvi, Tuulikki Seppänen-Laakso, Helena Simolin, Piet Finckenberg, Anne Huotari, Karl-Heinz Herzig, Riitta Korpela, Matej Orešič, Eero M Mervaala
Taru K Pilvi, Piet Finckenberg, Riitta Korpela, Eero M Mervaala, Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, PO Box 63, FI-00014 University of Helsinki, Helsinki FI-00390, Finland
Taru K Pilvi, Riitta Korpela, Foundation for Nutrition Research, PO Box 30, Helsinki FI-00390, Finland; Valio Ltd, Research Center, PO Box 30, Valio, Helsinki FI-00039, Finland
Tuulikki Seppänen-Laakso, Helena Simolin, Matej Orešič, VTT Technical Research Centre of Finland, Tietotie 2, VTT FI-02044, Finland
Anne Huotari, Karl-Heinz Herzig, A. I. Virtanen Institute for Molecular Sciences, PO Box 1627, University of Kuopio, Kuopio FI-70211, Finland
Karl-Heinz Herzig, Department of Internal Medicine, Kuopio University Hospital, PO Box 1777, Kuopio FI-70211, Finland; Institute of Biomedicine, Department of Physiology, and Biocenter of Oulu PO Box 5000, University of Oulu, Oulu FI-90014, Finland
Author contributions: Pilvi TK designed and conducted the study, analysed the data and prepared the manuscript. Seppänen-Laakso T, Simolin H and Orešič M did the metabolomic analyses. Huotari A and Herzig KH conducted the metabolic performance and calorimetry tests. Korpela R and Mervaala EM were involved in designing the study, reviewing and interpreting the results and all authors were involved in drafting the manuscript.
Correspondence to: Eero M Mervaala, MD, Professor, Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, PO Box 63, University of Helsinki, Helsinki FI-00390, Finland. eero.mervaala@helsinki.fi
Telephone: +358-9-19125355
Fax: +358-9-19125364
Received: April 16, 2008
Revised: June 23, 2008
Accepted: June 30, 2008
Published online: July 28, 2008
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