Clinical Research
Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Jun 21, 2008; 14(23): 3650-3661
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3650
Partial overlap of anti-mycobacterial, and anti-Saccharomyces cerevisiae mannan antibodies in Crohn’s disease
Stefan Müller, Thomas Schaffer, Alain M Schoepfer, Annamarie Hilty, Thomas Bodmer, Frank Seibold
Stefan Müller, Thomas Schaffer, Alain M Schoepfer, Frank Seibold, Department of Clinical Research, Division of Gastroenterology, University of Bern, Bern CH-3010, Switzerland
Stefan Müller, Thomas Schaffer, Annamarie Hilty, Thomas Bodmer, Institute for Infectious Diseases, University of Bern, Bern CH-3010, Switzerland
Author contributions: Müller S and Schaffer T contributed equally to this work; Müller S contributed to the study design, planned experiments, carried through the animal part of the study and ELISAs with affinity purified sera, and wrote the paper; Schaffer T screened patients’ sera by ELISA, performed neutralization experiments and affinity purifications; Schoepfer AM provided clinical data and performed statistic analyses; Hilty A, and Bodmer T prepared and supervised mycobacterial cultures; and Seibold F had the original idea and designed the study.
Correspondence to: Frank Seibold, Department of Gastroenterology, Inselspital Bern, University Hospital, Freiburgstrasse 10, Bern CH-3010, Switzerland.
Telephone: +41-31-6328025
Fax: +41-31-63297 65
Received: February 11, 2008
Revised: April 14, 2008
Accepted: April 21, 2008
Published online: June 21, 2008
Core Tip