Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

doi:10.3748/wjg.14.2029

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Apr 7, 2008; 14(13): 2029-2036
Published online Apr 7, 2008. doi: 10.3748/wjg.14.2029

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Riina A Kekkonen, Netta Lummela, Heli Karjalainen, Sinikka Latvala, Soile Tynkkynen, Salme Järvenpää, Hannu Kautiainen, Ilkka Julkunen, Heikki Vapaatalo, Riitta Korpela

Riina A Kekkonen, Riitta Korpela, University of Helsinki, Institute of Biomedicine, Pharmacology, PO Box 63, 00014 Helsinki, Finland and Valio Ltd, Research Centre, Meijeritie 4, Helsinki 00370, Finland

Netta Lummela, Heli Karjalainen, Soile Tynkkynen, Valio Ltd, Research Centre, Meijeritie 4, Helsinki 00370, Finland

Sinikka Latvala, Ilkka Julkunen, National Public Health Institute, Department of Viral Diseases and Immunology, Mannerheimintie 166, Helsinki 00300, Finland

Salme Järvenpää, Hannu Kautiainen, Medcare Foundation, Äänekoski, Finland

Heikki Vapaatalo, University of Helsinki, Institute of Biomedicine, Pharmacology, PO Box 63, Helsinki 00014, Finland

Author contributions: Kekkonen RA designed and coordinated the study, did the PBMC analysis participated in the interpretation of the results and wrote the paper; Lummela N participated in planning the study, was responsible for the study visits and created the database; Latvala S helped in the PBMC analysis; Karjalainen H and Tynkkynen S were responsible for the microbiological analysis; Kautiainen H and Järvenpää S participated in planning the study, carried out the statistical analysis, participated in the interpretation of the results and revised the manuscript; Julkunen I offered expertise in immunology and revised the manuscript; Vapaatalo H participated in planning the study and in the interpretation of the results, supervised the study and revised the manuscript; Korpela R initiated the study, participated in planning the study and the interpretation of the results, was responsible for the management of the study, and revised the manuscript.

Correspondence to: Riitta Korpela, PhD, Assistant Professor, Institute of Biomedicine, Pharmacology, PO Box 63, 00014 Univ-ersity of Helsinki, Helsinki 00014, Finland. riitta.korpela@valio.fi

Telephone: +35-810-3813026

Fax: +35-810-3813019

Received: December 11, 2007
Revised: February 21, 2008
Published online: April 7, 2008

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