In this study, a medical decision support system is presented to assist physicians in epileptic focus detection by correlating MRI and EEG data of temporal lobe epilepsy patients.

By exploiting the asymmetry in the hippocampus in MRI images and using voxel-based morphometry analysis, gray matter reduction in the temporal and limbic lobes is detected, and epileptic focus prediction is realized. In addition, an epileptic focus is also determined by calculating the asymmetry score from EEG channels. Finally, epileptic focus detection was performed by associating MRI and EEG data with a decision tree.

The results obtained from the proposed algorithm provide 100% overlap with the physician's finding on the EEG data.

MRI and EEG correlation in epileptic focus detection was improved compared with physicians. The proposed algorithm can be used as a medical decision support system for epilepsy diagnosis, treatment, and surgery planning.

While many seizure detection methods have demonstrated great accuracy, their training necessitates a substantial volume of labeled data. To address this issue, we propose a novel method for unsupervised seizure anomaly detection called SAnoDDPM, which uses denoising diffusion probabilistic models (DDPM). We designed a novel pipeline that uses a variable lower bound on Markov chains to identify potential values that are unlikely to occur in anomalous data. The model is first trained on normal data, then anomalous data is input to the trained model. The model resamples the anomalous data and converts it to normal data. Finally, the presence of seizures can be determined by comparing the before and after data. Moreover, the input 2D spectrograms are encoded into vector-quantized representations, which enables powerful and efficient DDPM while maintaining its quality. Experimental comparisons on the publicly available datasets, CHB-MIT and TUH, show that our method delivers better results, significantly reduces inference time, and is suitable for deployment in a clinical environments. As far as we are aware, this is the first DDPM-based method for seizure anomaly detection. This novel approach significantly contributes to the progression of seizure detection algorithms, thereby augmenting their practicality in clinical settings.

This study addresses the challenge of differentiating between bipolar disorder II (BD II) and borderline personality disorder (BPD), which is complicated by overlapping symptoms. To overcome this, a multimodal machine learning approach was employed, incorporating both electroencephalography (EEG) patterns and cognitive abnormalities for enhanced classification. Data were collected from 45 participants, including 20 with BD II and 25 with BPD. Analysis involved utilizing EEG signals and cognitive tests, specifically the Wisconsin Card Sorting Test and Integrated Cognitive Assessment. The k-nearest neighbors (KNN) algorithm achieved a balanced accuracy of 93%, with EEG features proving to be crucial, while cognitive features had a lesser impact. Despite the strengths, such as diverse model usage, it's important to note limitations, including a small sample size and reliance on DSM diagnoses. The study suggests that future research should explore multimodal data integration and employ advanced techniques to improve classification accuracy and gain a better understanding of the neurobiological distinctions between BD II and BPD.

The present study is designed to explore the process of epileptic patterns' automatic detection, specifically, epileptic spikes and high-frequency oscillations (HFOs), via a selection of machine learning (ML) techniques. The primary motivation for conducting such a research lies mainly in the need to investigate the long-term electroencephalography (EEG) recordings' visual examination process, often considered as a time-consuming and potentially error-prone procedure, requiring a great deal of mental focus and highly experimented neurologists. On attempting to resolve such a challenge, a number of state-of-the-art ML algorithms have been evaluated and compare in terms of performance, to pinpoint the most effective algorithm fit for accurately extracting epileptic EEG patterns.

Based on intracranial as well as simulated EEG data, the attained findings turn out to reveal that the randomforest (RF) method proved to be the most consistently effective approach, significantly outperforming the entirety of examined methods in terms of EEG recordings epileptic-pattern identification. Indeed, the RF classifier appeared to record an average balanced classification rate (BCR) of 92.38 % in regard to spikes recognition process, and 78.77 % in terms of HFOs detection.

Compared to other approaches, our results provide valuable insights into the RF classifier's effectiveness as a powerful ML technique, fit for detecting EEG signals born epileptic bursts.

As a potential future work, we envisage to further validate and sustain our major reached findings through incorporating a larger EEG dataset. We also aim to explore the generative adversarial networks (GANs) application so as to generate synthetic EEG signals or combine signal generation techniques with deep learning approaches. Through this new vein of thought, we actually preconize to enhance and boost the automated detection methods' performance even more, thereby, noticeably enhancing the epileptic EEG pattern recognition area.

Detection and classification of epileptic seizures from the EEG signals have gained significant attention in recent decades. Among other signals, EEG signals are extensively used by medical experts for diagnosing purposes. So, most of the existing research works developed automated mechanisms for designing an EEG-based epileptic seizure detection system. Machine learning techniques are highly used for reduced time consumption, high accuracy, and optimal performance. Still, it limits by the issues of high complexity in algorithm design, increased error value, and reduced detection efficacy. Thus, the proposed work intends to develop an automated epileptic seizure detection system with an improved performance rate. Here, the Finite Linear Haar wavelet-based Filtering (FLHF) technique is used to filter the input signals and the relevant set of features are extracted from the normalized output with the help of Fractal Dimension (FD) analysis. Then, the Grasshopper Bio-Inspired Swarm Optimization (GBSO) technique is employed to select the optimal features by computing the best fitness value and the Temporal Activation Expansive Neural Network (TAENN) mechanism is used for classifying the EEG signals to determine whether normal or seizure affected. Numerous intelligence algorithms, such as preprocessing, optimization, and classification, are used in the literature to identify epileptic seizures based on EEG signals. The primary issues facing the majority of optimization approaches are reduced convergence rates and higher computational complexity. Furthermore, the problems with machine learning approaches include a significant method complexity, intricate mathematical calculations, and a decreased training speed. Therefore, the goal of the proposed work is to put into practice efficient algorithms for the recognition and categorization of epileptic seizures based on EEG signals. The combined effect of the proposed FLHF, FD, GBSO, and TAENN models might dramatically improve disease detection accuracy while decreasing complexity of system along with time consumption as compared to the prior techniques. By using the proposed methodology, the overall average epileptic seizure detection performance is increased to 99.6% with f-measure of 99% and G-mean of 98.9% values.

Electroencephalograms (EEG) is used to assess patients' clinical records of depression (EEG). The disorder of human thinking is a very complex problem caused by heavy-duty in daily life. We need some future and optimal classifier selection by using different techniques for depression data extraction using EEG. Intelligent decision support is a decision-making process that is automated based on some input information. The primary goal of this proposed work is to create an artificial intelligence-based fuzzy decision support system (AI-FDSS). Based on the given criteria, the AI-FDSS is considered for classifier selection for EEG under depression information. The proposed intelligent decision technique examines classifier alternatives such as Gaussian mixture models (GMM), k-nearest neighbor algorithm (k-NN), Decision tree (DT), Nave Bayes classification (NBC), and Probabilistic neural network (PNN). For analyzing optimal classifiers selection for EEG in depression patients, the proposed technique is criterion-based. First, we develop a general algorithm for intelligent decision systems based on non-linear Diophantine fuzzy numbers to examine the classifier selection technique using various criteria. We use classifier methods to obtain data from depression patients in normal and abnormal situations based on the given criteria. The proposed technique is criterion-based for analyzing optimal classifier selection for EEG in patients suffering from depression. The proposed model for analyzing classifier selection in EEG is compared to existing models.

Temporal lobe epilepsy, a neurological disease that causes seizures as a result of excessive neural activities in the brain, is the most common type of focal seizure, accounting for 30-35% of all epilepsies. Detection of epilepsy and localization of epileptic focus are essential for treatment planning and epilepsy surgery. Currently, epileptic focus is decided by expert physician by examining the EEG records and determining EEG channel where epileptic patterns begins and continues intensely during seizure. Examination of long EEG recordings is very time-consuming process, requires attention and decision can vary depending on physician. In this study, to assist physicians in detecting epileptic focus side from EEG recordings, a novel deep learning-based computer-aided diagnosis system is presented. In the proposed framework, ictal epochs are detected using long short-term memory network fed with EEG subband features obtained by discrete wavelet transform, and then, epileptic focus identification is realized by using asymmetry score. This algorithm was tested on EEG database obtained from the Ankara University hospital. Experimental results showed ictal and interictal epochs were classified with accuracy of 86.84%, sensitivity of 86.96% and specificity of 89.68% on Ankara University hospital dataset, and 96.67% success rate was obtained on Bonn EEG dataset. In addition, epileptic focus was identified with accuracy of 96.10%, sensitivity of 100% and specificity of 93.80% by using the proposed deep learning-based algorithm and university hospital dataset. These results showed that proposed method can be used properly in clinical applications, epilepsy treatment and surgical planning as a medical decision support system.

An epileptic seizure is a chronic disease with sudden abnormal discharge of brain neurons, which leads to transient brain dysfunction. To detect epileptic seizures, we propose a novel idea based on a dynamic graph embedding model. The dynamic graph is built by identifying the correlation among the multi-channel EEG signals. Graph entropy measurement is exploited to calculate the similarity among the graph at each time interval and construct the graph embedding space. Since the abnormal electrical brain activity causes the epileptic seizure, the graph entropy during the seizure time interval is different from other time intervals. Therefore, we propose an entropy-based dynamic graph embedding model to cluster the graphs, and the graphs with epileptic seizures are discriminated. We applied the proposed approach to the Children Hospital Boston-Massachusetts Institute of Technology Scalp EEG database. The results have shown that the proposed approach outperformed the baselines by 1.4% with respect to accuracy.

We propose a computationally efficient algorithm for seizure detection. Instead of using a purely data-driven approach, we develop a hybrid model-based/data-driven method, combining convolutional neural networks with factor graph inference. On the CHB-MIT dataset, we demonstrate that the proposed method can generalize well in a 6 fold leave-4-patient-out evaluation. Moreover, it is shown that our algorithm can achieve as much as 5% absolute improvement in performance compared to previous data-driven methods. This is achieved while the computational complexity of the proposed technique is a fraction of the complexity of prior work, making it suitable for real-time seizure detection.

This special issue of The Journal of Biomedical Research features novel studies on epileptic seizure detection and prediction based on advanced EEG signal processing and machine learning algorithms. The articles selected present important findings including new experimental results and theoretical studies.