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Ikeue K, Kato H, Tanaka M, Yamakage H, Kato S, Iwasa M, Oishi K, Yamamoto Y, Kanasaki M, Masuda I, Ishii K, Satoh‐Asahara N. Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population. J Cachexia Sarcopenia Muscle 2025; 16:e13820. [PMID: 40341877 PMCID: PMC12059471 DOI: 10.1002/jcsm.13820] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/17/2024] [Revised: 03/11/2025] [Accepted: 03/18/2025] [Indexed: 05/11/2025] Open
Abstract
BACKGROUND Sarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population. METHODS This was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53-70] and 100 women with a median age of 58 years [interquartile range = 49-68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height2, ASM/body mass index, handgrip strength (HGS), HGS/upper extremity skeletal muscle mass and phase angle (PhA). We examined the associations between these indices and cognitive function using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). RESULTS Higher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10-0.78], p = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (β = 0.27, p = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (r = 0.22, p = 0.031), which is one of the earliest manifestations of cognitive impairment. The PhA in men was also positively correlated with memory (r = 0.24, p = 0.002). CONCLUSIONS PhA is a potentially novel index for detecting the risk of sarcopenia and cognitive decline in the general population.
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Affiliation(s)
- Kentaro Ikeue
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
- Graduate School of Health and Sports ScienceDoshisha UniversityKyotoJapan
| | - Hisashi Kato
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
| | - Masashi Tanaka
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
- Department of RehabilitationHealth Science UniversityYamanashiJapan
| | - Hajime Yamakage
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
| | - Sayaka Kato
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
| | - Masayo Iwasa
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
| | - Kan Oishi
- Faculty of Health and Sports ScienceDoshisha UniversityKyotoJapan
| | - Yuiko Yamamoto
- Graduate School of Health and Sports ScienceDoshisha UniversityKyotoJapan
| | | | - Izuru Masuda
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
- Diabetes Medicine, Mitsubishi Kyoto HospitalKyotoJapan
| | - Kojiro Ishii
- Faculty of Health and Sports ScienceDoshisha UniversityKyotoJapan
| | - Noriko Satoh‐Asahara
- Department of Endocrinology, Metabolism, and Hypertension ResearchClinical Research Institute, NHO Kyoto Medical CenterKyotoJapan
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Quizzini GH, Pereira CGDS, Dos Santos VR, Batista VC, Silva BSDA, Lira FS, Ribeiro AS, Gobbo LA. Bioelectrical Impedance Vectors Analysis of Sarcopenic Older Adults Submitted to a Resistance Training Program. Adv Biol (Weinh) 2025; 9:e2400276. [PMID: 39164221 DOI: 10.1002/adbi.202400276] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/23/2024] [Revised: 08/01/2024] [Indexed: 08/22/2024]
Abstract
The objective of the present study is to analyze the changes in bioimpedance vector analysis (BIVA) and phase angle (PhA) in sarcopenic older people submitted to a 12-week resistance training (RT) program according to classic and specific analyses. To this end, 20 sarcopenic older adults of both sexes, invited through media, underwent bioimpedance analysis before and after the RT carried out three times a week, for 12 weeks. The mean impedance vectors of the groups established for the confidence ellipses (95% of the confidence ellipse) are compared using Hotelling's T2 test. The distance D from Mahalanobis is also calculated. Classic and Specific BIVA are presented. The resistance values for the classical analyses (R/H) decreased across all groups (whole group, women and men, p < 0.05), with approximate decreases ranging from 9.4% to 10%, while the classic reactance (Xc/H) decreased (p < 0.05) only for the whole group (5.9%) and men (7.7%). For the specific BIVA, trends are verified for the whole sample, with a decrease in resistance (R.sp) and an increase in reactance (Xc.sp). In conclusion, the RT program in sarcopenic individuals promoted a reduction in resistance values in classical analyses, indicating a possible increase in hydration status and, consequently, musculoskeletal mass.
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Affiliation(s)
- Giovanni Henrique Quizzini
- Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
| | - Caroline Galan de Souza Pereira
- Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
| | - Vanessa Ribeiro Dos Santos
- Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
| | - Vitor Cabrera Batista
- Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
| | - Bruna Spolador de Alencar Silva
- Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
| | - Fábio Santos Lira
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
| | - Alex Silva Ribeiro
- Research Unit for Sport and Physical Activity, Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, 3040248, Portugal
| | - Luís Alberto Gobbo
- Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
- Graduation Program in Movement Sciences, School of Technology and Sciences, São Paulo State University, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, 19060-900, Brazil
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Guerrini A, Rovere LD, Fernández-Jiménez R, Hardy-Añón C, Herola-Cobos C, Garcia-Olivares M, Fernández JA, Sánchez FH, Jiménez VM, Aguilar IV, Castro AA, Khazrai YM, Campa F, García-Almeida JM. The usefulness of the updated bioelectrical impedance vector analysis references for assessing malnutrition, sarcopenia and predicting mortality in hospitalized patients. Clin Nutr 2025; 47:187-195. [PMID: 40037113 DOI: 10.1016/j.clnu.2025.02.025] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2025] [Accepted: 02/19/2025] [Indexed: 03/06/2025]
Abstract
BACKGROUND & AIMS The application of validated pre-screening tools is crucial in clinical practice to identify patients at risk for disease. Bioelectrical Impedance Vector Analysis (BIVA) has gained recognition as a qualitative method for monitoring body composition and assessing the health status of hospitalized patients. This study investigates the utility of updated BIVA reference standards in evaluating malnutrition, sarcopenia, and mortality among hospitalized individuals. MATERIAL AND METHOD This retrospective observational study included 2.872 patients admitted to Quironsalud Málaga Hospital between January 2019 and January 2024. Malnutrition and sarcopenia were diagnosed using the Global Leadership Initiative on Malnutrition (GLIM) and the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) guidelines. Mortality was defined as death within one year of their initial discharge or later admissions. BIVA was performed using the former and the new 50th, 75th, and 95th reference tolerance ellipses of general population. RESULTS BIVA revealed significant differences in bioimpedance vectors between malnourished (n = 1187, 544 women) and non-malnourished patients, sarcopenic (n = 136, 51 women) and non-sarcopenic patients, and non-survivors (n = 317, 160 women) compared to survivors. When previous BIVA references (Piccoli 1995) were applied, the bioimpedance vectors for malnourished, sarcopenic, and non-surviving patients fell within the 75th tolerance ellipses. However, with updated references, these vectors shifted rightward, moving outside the 75th and 95th tolerance ellipses. Univariate Cox analysis showed that participants with vectors outside the new 95th tolerance ellipses faced significantly higher mortality risk (HR = 6.22 [95 % CI 4.40-8.80], p < 0.001) and lower survival rates (log-rank test p < 0.001) compared to those within the 75th ellipses. These trends persisted even after adjusting for age, sex, and BMI (HR = 4.79 [95 % CI 3.29-6.97], p < 0.001). The new reference ellipses demonstrated greater prognostic accuracy compared to the older ones, emphasizing their value in identifying high-risk patients. CONCLUSION The implementation of BIVA with newly established reference tolerance ellipses significantly enhances the evaluation of body composition and overall health in hospitalized patients. These updated tolerance ellipses are instrumental in accurately identifying malnutrition, sarcopenia, and heightened mortality risks. The delineation of specific mortality risk zones underscores the potential of incorporating these advanced BIVA ellipses into routine pre-screening protocols, thereby optimizing clinical nutritional assessments and interventions.
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Affiliation(s)
- Alessandro Guerrini
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy; Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Lara Dalla Rovere
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; Department of Medicine and Dermatology, Málaga University, 29016 Málaga, Spain
| | - Rocío Fernández-Jiménez
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; Department of Medicine and Dermatology, Málaga University, 29016 Málaga, Spain; Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Málaga, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain
| | - Carmen Hardy-Añón
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain
| | - Cristina Herola-Cobos
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain
| | - Maria Garcia-Olivares
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; Department of Medicine and Dermatology, Málaga University, 29016 Málaga, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain
| | - José Abuín Fernández
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain
| | - Francisco Hevilla Sánchez
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain
| | - Virginia Morilla Jiménez
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain
| | - Isabel Vegas Aguilar
- Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Málaga, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain
| | - Abelardo Adarve Castro
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain
| | - Yeganeh Manon Khazrai
- Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Francesco Campa
- Department of Biomedical Sciences, University of Padua, Padua, Italy
| | - José Manuel García-Almeida
- Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Málaga, Spain; Department of Medicine and Dermatology, Málaga University, 29016 Málaga, Spain; Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Málaga, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 Málaga, Spain; Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, CIBEROBN, Carlos III Health Institute (ISCIII), University of Málaga, 29016 Málaga, Spain.
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Bennouar S, Bachir Cherif A, Raaf N, Hani HM, Kessira A, Abdi S. Raw bioelectrical impedance parameters and vector analysis in the screening of low muscle mass and low muscle mass associated with obesity in adult healthy subjects. Intern Emerg Med 2025; 20:709-722. [PMID: 39812907 DOI: 10.1007/s11739-025-03857-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/20/2024] [Accepted: 12/31/2024] [Indexed: 01/16/2025]
Abstract
The aim was to estimate the prevalence of low muscle mass (LMM) and low muscle mass associated with obesity (LMM-O) in healthy adult, and to verify the performance of raw bioelectrical impedance parameters (BIA) and vector analysis (BIVA) in the screening of this tow conditions. This is a cross-sectional study including 1025 healthy adults. Body composition was assessed by the BIA technique. The appendicular skeletal muscle mass index (ASMMI) and body fat percentage (BF%) were used for the screening of LMM and LMM-O. The raw BIA parameters were: resistance (R), reactance (Xc), phase angle (PhA), and impedance (Z). The vectors, R and Xc, were adjusted for height and projected on the RXc graph. Associations were checked by the correlation test, binary logistic regression, adjusted for age and body water, and ROC curve. LMM was found in 30.8% of the subjects, and 20.9 and 21.4% of the men and women were with LMM-O. PhA and R/H were the most powerful discriminators of LMM with a sensitivity of 62-100% and a specificity of 71-90%. Cutoff values of PhA ranged between 4.95° and 5.75° for women and men. The RXc graph was able to identify LMM subjects, with clustering on the right side: area of low cellularity, high R/H and low-phase angle. Traditional anthropometric indices were the least effective in identifying LMM-O. The BIVA approach, PhA, R and R/H are effective in the screening of LMM and LMM-O, irrespective of age, gender, intra- and extracellular hydration status.
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Affiliation(s)
- Salam Bennouar
- Central Laboratory of Clinical Biology, Frantz Fanon Hospital, University Hospital Center of Blida, 9000, Blida, Algeria.
| | | | - Nabil Raaf
- University of Algiers, 16000, Algiers, Algeria
| | | | - Amel Kessira
- Department of Hemobiology and Blood Transfusion, University Hospital Center of Annaba, 23000, Annaba, Algeria
| | - Samia Abdi
- Central Laboratory of Clinical Biology, Frantz Fanon Hospital, University Hospital Center of Blida, 9000, Blida, Algeria
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Guerrini A, Siotto M, Cocco C, Germanotta M, Cipollini V, Cortellini L, Pavan A, Lattanzi S, Insalaco S, Khazrai YM, Aprile IG. Usefulness of body composition assessment by bioelectrical impedance vector analysis in subacute post-stroke patients in rehabilitation. Sci Rep 2025; 15:1774. [PMID: 39800724 PMCID: PMC11725591 DOI: 10.1038/s41598-024-84968-y] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2024] [Accepted: 12/30/2024] [Indexed: 01/16/2025] Open
Abstract
Bioelectrical Impedance Vector Analysis (BIVA) is a valuable tool for evaluating hydration and body composition, but its application in subacute post-stroke patients remains unexplored. This study aimed to fill this gap by analyzing BIVA in a cohort of 87 subacute post-stroke patients (42 women, mean age 69 ± 12) undergoing rehabilitation. At admission (T0), diagnosis of malnutrition with GLIM criteria and of sarcopenia with EWGSOP2 was done, and patients were analyzed with BIVA. The change in modified Barthel Index (mBIT1-mBIT0) was assessed to evaluate the improvement in functional recovery. BIVA revealed that both adult patients (< 65 years, n = 29) and elderly patients (≥ 65 years, n = 58) exhibited high body fluid overload and low muscle mass. Additionally, BIVA revealed a significant rightward shift of the bioimpedance vectors in malnourished (n = 37) versus non-malnourished patients (T2 = 56.9, p < 0.001, D = 1.68) and in sarcopenic (n = 24) versus non-sarcopenic patients (T2 = 36.4, p < 0.001, D = 1.5). Lastly, the BIVA distinguished patients with greater improvement (n = 53) from patients with lower improvement (n = 34) (T2 = 10.6, p = 0.007, D = 0.7). In conclusion, BIVA is an effective, easy-to-use tool for evaluating hydration, nutritional status, and recovery in post-stroke rehabilitation.
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Affiliation(s)
- Alessandro Guerrini
- IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143, Florence, Italy
- Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy
| | | | - Carola Cocco
- IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143, Florence, Italy
| | - Marco Germanotta
- IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143, Florence, Italy
| | | | - Laura Cortellini
- IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143, Florence, Italy
| | - Arianna Pavan
- IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143, Florence, Italy
| | | | - Sabina Insalaco
- IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143, Florence, Italy
| | - Yeganeh Manon Khazrai
- Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, 00128, Rome, Italy
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Luo X, Jin W. Age-related changes in bioelectrical impedance analysis-derived phase angle (PhA) and the association between PhA and sarcopenic obesity in Chinese adults. Medicine (Baltimore) 2025; 104:e41122. [PMID: 39792740 PMCID: PMC11730410 DOI: 10.1097/md.0000000000041122] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/17/2024] [Accepted: 12/11/2024] [Indexed: 01/12/2025] Open
Abstract
There are limited studies on the phase angle (PhA) and sarcopenic obesity (SO) in the Chinese population. This study aimed to establish 50 kHz-PhA reference data for SO population, and to evaluate the correlation between 50 kHz-PhA and SO. A total of 10,312 participants including 5415 men and 4897 women were enrolled in this study, and their resistance and reactance at 50 kHz, and body composition parameters were measured a segmental multifrequency bioelectrical impedance analysis device (InBody 720). Participants were compared between the SO and non-SO groups. Then, age and fat parameters related changes in PhA were evaluated. Furthermore, Receiver Operating Characteristic (ROC) curves were used to identify the optimal PhA cutoff values for detecting SO in males and females. The results showed significant differences in PhA and body composition parameters between the SO group and the non-SO group in both sexes (P < .001), and the prevalence rates of SO increase with age in both sexes (P < .001). The PhA values decrease with age, with a significant decrease beginning at age 65 years for males and 66 years for females. The accumulation of excess adipose tissue was also found to be associated with decrease in 50 kHz-PhA value. Furthermore, PhA was negatively associated with SO, independent of age and sex. The area under the ROC curve (AUC) of PhA for SO was 0.790 (95% CI: 0.746-0.833, P < .001) in males and 0.763 (95% CI: 0.702-0.825, P < .001) in females. The optimal cutoff value was ≤ 5.55° (specificity 0.693, sensitivity 0.759) for males and ≤4.79° (specificity 0.687, sensitivity 0.738) for females. In conclusion, 50 kHz-PhA can be used as a predictor of SO, with cutoff values of ≤5.55° for males and ≤4.79° for females. This simple and practical method of using 50 kHz-PhA to predict SO could be valuable in clinical practice.
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Affiliation(s)
- Xi Luo
- Department of Clinical Nutrition, Tongde Hospital of Zhejiang Province, Hangzhou, China
| | - Weiwei Jin
- Department of Clinical Nutrition, Tongde Hospital of Zhejiang Province, Hangzhou, China
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7
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Pigłowska M, Corsonello A, Kostka T, Roller-Wirnsberger R, Wirnsberger G, Ärnlöv J, Carlsson AC, Tap L, Mattace-Raso F, Formiga F, Moreno-González R, Kob R, Sieber C, Gil P, Martinez SL, Ben-Romano R, Melzer I, Fabbietti P, Lattanzio F, Guligowska A. Limited predictive value of bioelectrical phase angle for the development of sarcopenia in older Europeans. J Nutr Health Aging 2024; 28:100386. [PMID: 39413686 DOI: 10.1016/j.jnha.2024.100386] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/24/2024] [Revised: 09/18/2024] [Accepted: 10/02/2024] [Indexed: 10/18/2024]
Abstract
BACKGROUND Despite the emerging interest in phase angle (PhA), a non-invasive marker of cell hydration and nutritional status, no previous study has reported the prospective association between PhA and incident sarcopenia. Therefore, the aim of our study was to evaluate the association of baseline PhA in older subjects without sarcopenia with the development of new sarcopenia as outcome. METHODS Six-hundred ninety-six subjects without sarcopenia aged ≥75 years enrolled in an international multicenter observational study were included. Sarcopenia was assessed according to the revised EWGSOP2 criteria at baseline and in follow-up visits at 12 and 24 months. Muscle strength was assessed through the handgrip strength test using a hydraulic grip strength dynamometer, muscle mass was assessed by bioimpedance analysis (BIA) and appendicular skeletal muscle mass (ASMM) was estimated. Physical performance was assessed by Short Physical Performance Battery (SPPB). RESULTS Participants who developed sarcopenia were older, less educated, had higher prevalence of osteoporosis, and lower baseline cognitive function, SPPB, handgrip strength and ASMM than those without sarcopenia. Baseline PhA was significantly lower in subjects developing sarcopenia. Nevertheless, after adjusting for all potential covariates including baseline components of sarcopenia in multiple logistic regression, neither PhA as continuous variable nor different levels of PhA were any more significant predictors of sarcopenia. CONCLUSIONS As an indicator of cells function, PhA could be a potential useful early marker in identifying older people at risk of developing sarcopenia but its practical applicability remains uncertain with the present data.
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Affiliation(s)
| | - Andrea Corsonello
- Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy; Center for Biostatistic and Applied Geriatric Clinical Epidemiology (IRCCS INRCA), National Institute of Health and Science on Ageing, Cosenza, Ancona, Italy
| | - Tomasz Kostka
- Department of Geriatrics, Medical University of Lodz, Poland
| | | | - Gerhard Wirnsberger
- Medical University of Graz, Division of Nephrology, Department of Internal Medicine, Austria
| | - Johan Ärnlöv
- School of Health and Social Studies, Dalarna University, Falun, Sweden; Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
| | - Axel C Carlsson
- Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden
| | - Lisanne Tap
- Department of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
| | - Francesco Mattace-Raso
- Department of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
| | - Francesc Formiga
- Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital - IDIBELL - L'Hospitalet de Llobregat, Barcelona, Spain
| | - Rafael Moreno-González
- Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital - IDIBELL - L'Hospitalet de Llobregat, Barcelona, Spain
| | - Robert Kob
- Department of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
| | - Cornel Sieber
- Department of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
| | - Pedro Gil
- Department of Geriatric Medicine, Hospital Clinico San Carlos, Madrid, Spain
| | | | - Ronit Ben-Romano
- Recanati School for Community Health Professions at the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-sheva, Israel
| | - Itshak Melzer
- Recanati School for Community Health Professions at the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-sheva, Israel
| | - Paolo Fabbietti
- Center for Biostatistic and Applied Geriatric Clinical Epidemiology (IRCCS INRCA), National Institute of Health and Science on Ageing, Cosenza, Ancona, Italy.
| | - Fabrizia Lattanzio
- Italian National Research Center on Aging (IRCCS INRCA), Fermo and Cosenza, Ancona, Italy
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Duarte Martins A, Paulo Brito J, Fernandes O, Oliveira R, Gonçalves B, Batalha N. Effects of a 16-week High-Speed Resistance Training program on body composition in community-dwelling independent older adults: A clinical trial. Clin Nutr ESPEN 2024; 63:84-91. [PMID: 38935496 DOI: 10.1016/j.clnesp.2024.06.010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2024] [Revised: 06/04/2024] [Accepted: 06/06/2024] [Indexed: 06/29/2024]
Abstract
BACKGROUND & AIMS Aging frequently causes changes in body composition, such as a loss of strength and muscular mass and an increase in fat mass. Exercise training programs have been suggested as effective strategies to mitigate or prevent age-related declines in body composition. Therefore, this study examined the effects of a sixteen-week High-Speed Resistance Training (HSRT) program on body composition parameters in community-dwelling independent older adults. METHODS The present clinical trial included 79 older adults, who were divided into two groups: intervention group (IG, N = 40, age, 68.50 ± 3.54 years; weight, 68.65 ± 11.36 kg) and control group (CG, N = 39, age, 72.08 ± 5.89 years; weight, 67.04 ± 10.69 kg). IG performed the supervised HSRT for 16 weeks, with 3 sessions per week of 60-70min, each session of 5-6 exercises, 2-3 sets, and 6-10 reps/exercise, while CG did not perform any exercise training program. Body composition parameters were assessed using a multifrequency tetrapolar bioelectrical impedance analyzer (InBody® S10). The level of physical activity and the dietary intake were evaluated by the International Physical Activity Questionnaire (IPAQ-SF) and the Food Frequency Questionnaire, respectively. Statistical analyses were performed using the analysis of covariance (ANCOVA), and effect size (Cohen's dunbiased). RESULTS The analysis showed significant effects of the group factor for IG on phase angle (F(1) = 14.39, p < 0.001, η2p = 0.159). Additionally, results from Δ changes (post-minus pre-values) revealed small and medium effects in favor to IG for body cell mass (t(77) = 1.21, p = 0.230, dunb = 0.27 [-0.17, 0.71]) and phase angle (t(77) = 2.82, p = 0.006, dunb = 0.63 [0.18, 1.08]), respectively. CONCLUSIONS The HSRT could effectively prevent the decline in cellular health and cell integrity in older adults, as evidenced by the significant improvements in the phase angle. REGISTRATION Clinicaltrial.gov (ID: NCT05586087).
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Affiliation(s)
- Alexandre Duarte Martins
- Comprehensive Heallth Research Centre (CHRC), Sport and Health Department, School of Health and Human Development, University of Evora, Evora 7000-671, Portugal; Life Quality Research Center (CIEQV), Santarém Polytechnic University, Complexo Andaluz, Apartado 279, 2001-904 Santarém, Portugal; Santarém Polytechnic University, School of Sport, Av. Dr. Mário Soares, 2040-413 Rio Maior, Portugal.
| | - João Paulo Brito
- Life Quality Research Center (CIEQV), Santarém Polytechnic University, Complexo Andaluz, Apartado 279, 2001-904 Santarém, Portugal; Santarém Polytechnic University, School of Sport, Av. Dr. Mário Soares, 2040-413 Rio Maior, Portugal; Research Center in Sport Sciences, Health and Human Development (CIDESD), Santarém Polytechnic University, Av. Dr. Mário Soares, 2040-413 Rio Maior, Portugal
| | - Orlando Fernandes
- Comprehensive Heallth Research Centre (CHRC), Sport and Health Department, School of Health and Human Development, University of Evora, Evora 7000-671, Portugal
| | - Rafael Oliveira
- Life Quality Research Center (CIEQV), Santarém Polytechnic University, Complexo Andaluz, Apartado 279, 2001-904 Santarém, Portugal; Santarém Polytechnic University, School of Sport, Av. Dr. Mário Soares, 2040-413 Rio Maior, Portugal; Research Center in Sport Sciences, Health and Human Development (CIDESD), Santarém Polytechnic University, Av. Dr. Mário Soares, 2040-413 Rio Maior, Portugal
| | - Bruno Gonçalves
- Comprehensive Heallth Research Centre (CHRC), Sport and Health Department, School of Health and Human Development, University of Evora, Evora 7000-671, Portugal
| | - Nuno Batalha
- Comprehensive Heallth Research Centre (CHRC), Sport and Health Department, School of Health and Human Development, University of Evora, Evora 7000-671, Portugal
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Zanotelli A, Rossi AP, Del Monte L, Vantini G, Stabile G, Urbani S, Giani A, Zoico E, Babbanini A, Fantin F, Zamboni M, Mazzali G. The Role of Combined Muscle Ultrasound and Bioimpedentiometry Parameters for Sarcopenia Diagnosis in a Population of Hospitalized Older Adults. Nutrients 2024; 16:2429. [PMID: 39125310 PMCID: PMC11313821 DOI: 10.3390/nu16152429] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/23/2024] [Revised: 07/22/2024] [Accepted: 07/24/2024] [Indexed: 08/12/2024] Open
Abstract
BACKGROUND For the study of quantitative and qualitative muscle parameters, ultrasound and bioelectric impedance analysis are reliable, non-invasive, and reproducible. The aim of this study was to test the combined role of those techniques for the diagnosis of sarcopenia in a population of hospitalized older males and females. METHODS A total of 70 subjects were recruited, including 10 healthy adults and 60 hospitalized elderly patients with a good level of independence and cooperation, with and without sarcopenia. The rectus femoris cross-sectional area (CSA), thickness, echogenicity, and compressibility were measured with ultrasound echography. The phase angles (PhAs) and skeletal muscle mass were calculated by bioimpedence analysis. The muscle quality index (MQI) was calculated as the product of CSA and PhA. RESULTS Muscle compressibility was greater and PhA was lower in sarcopenic when compared with non-sarcopenic subjects. The threshold values for sarcopenia diagnosis in both sexes of CSA, of PhA, and of the MQI were identified. The obtained CSA values showed an AUC of 0.852 for women and 0.867 for men, PhA of 0.792 in women and 0.898 in men, while MQI was 0.900 for women and 0.969 for men. CONCLUSIONS The newly calculated cut-off values of CSA, PhA, and MQI predicted the presence of sarcopenia with good sensitivity and specificity values. The use of the MQI proved to be more promising than the separate use of CSA and PhA in both male and female subjects.
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Affiliation(s)
- Alfredo Zanotelli
- Section of Geriatric Medicine, Ospedale Santa Maria del Carmine, 38068 Rovereto, Italy;
| | - Andrea P. Rossi
- Division of Geriatrics, Department of Medicine, Ospedale Cà Foncello, 31100 Treviso, Italy
| | - Letizia Del Monte
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Gianluca Vantini
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Giovanni Stabile
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Silvia Urbani
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Anna Giani
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Elena Zoico
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Alessio Babbanini
- Division of Geriatrics, Department of Medicine, Dentistry, Pediatric and Gynecology, Healthy Aging Center, University of Verona, 37126 Verona, Italy;
| | - Francesco Fantin
- Division of Geriatrics, University of Trento, 38100 Trento, Italy;
| | - Mauro Zamboni
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
| | - Gloria Mazzali
- Department of Medicine, Geriatrics Division, University of Verona, 37100 Verona, Italy; (L.D.M.); (G.V.); (G.S.); (S.U.); (A.G.); (E.Z.); (M.Z.); (G.M.)
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10
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Sales WB, Mâcedo SGGF, Gonçalves RSDSA, Andrade LELD, Ramalho CST, de Souza GF, Maciel ÁCC. Use of electrical bioimpedance in the assessment of sarcopenia in the older aldults: A scoping review. J Bodyw Mov Ther 2024; 39:373-381. [PMID: 38876654 DOI: 10.1016/j.jbmt.2024.02.015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2022] [Revised: 01/14/2024] [Accepted: 02/25/2024] [Indexed: 06/16/2024]
Abstract
OBJECTIVE to map and synthesize the main evidence on the use of bioelectrical impedance (BIA) and its variables in the assessment of sarcopenia in community-dwelling older adults. METHODS This is a scoping review carried out by searching for articles available in four databases: PUBMED, LILACS, Web of Science and CINAHL, with the following search strategy: Body Composition AND Sarcopenia AND ″electric impedance'' OR ″bioelectrical impedance analysis'' AND Aged. RESULTS A total of 27,660 older adults made up the sum of the samples of the included studies. Most studies included participants of both sexes (75.6%), used the variable skeletal and/or appendicular skeletal muscle mass (ASMM) (75.6%), followed by body fat (8.1%), and phase angle (8.1%) in the assessment of the body composition of subjects with sarcopenia. CONCLUSION The data from this research show that ASMM and phase angle are the main variables related to sarcopenia screening in community-dwelling older adults. Whereas total extracellular water/body water is still considered a confounding variable in the screening of sarcopenia in the elderly, but it can be considered useful regarding the health conditions of the elderly in the community.
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Affiliation(s)
- Weslley Barbosa Sales
- Department of Physical Therapy, Universidade Federal do Rio Grande do Norte, Avenida Senador Salgado, Filho, 3000, Brazil.
| | | | | | - Luiz Eduardo Lima de Andrade
- Department of Physical Therapy, Universidade Federal do Rio Grande do Norte, Avenida Senador Salgado, Filho, 3000, Brazil.
| | - Caroline Sousa Truta Ramalho
- Department of Physical Therapy, Universidade Federal do Rio Grande do Norte, Avenida Senador Salgado, Filho, 3000, Brazil.
| | - Gérson Fonseca de Souza
- Department of Physical Therapy, Universidade Federal do Rio Grande do Norte, Avenida Senador Salgado, Filho, 3000, Brazil.
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11
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Cebrián-Ponce Á, Serafini S, Petri C, Carrasco-Marginet M, Izzicupo P, Mascherini G. Somatotype and bioelectrical impedance vector analysis of Italian CrossFit® practitioners. Heliyon 2024; 10:e29139. [PMID: 38655297 PMCID: PMC11035999 DOI: 10.1016/j.heliyon.2024.e29139] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2023] [Revised: 03/30/2024] [Accepted: 04/01/2024] [Indexed: 04/26/2024] Open
Abstract
Objectives CrossFit® is a high-intensity sport characterized by various workouts that require strength, speed, endurance, or agility, impacting participants' body composition. This observational study aimed to determine the morphological (anthropometrical and bioelectrical) profile of CrossFit® athletes and to compare them with other athletic populations. Methods Anthropometrical measurements and bioelectrical vector analysis (classic and specific approaches) were performed on 145 CrossFit® practitioners (107 men aged 30.7 ± 8.4 years and 38 women aged 28.1 ± 6.7 years). Each participant's relative somatotype was calculated and compared between sexes and with a Spanish CrossFit® athletes' group. Resistance-reactance graphs and Hotelling's T2 test were applied to characterize the sample, compare them with an athletes' reference population, and identify differences between somatotype groups. Results The most represented somatotype in both groups was the balanced mesomorph (male 3.5-5.2 - 1.7 and female 4.4-4.5 - 1.8). Compared with Spanish CrossFit® athletes, significant differences were denoted for men but not women (SAD = 2.3). The bioelectrical graphs indicated that the distribution of CrossFit® athletes is quite heterogeneous and within average values for the athlete's reference. The mesomorphic and endomorphic components were associated with a higher phase angle. Conclusions CrossFit® practitioners predominantly present a mesomorphic component and show a body type like other power athletes, although with less pronounced characteristics. The somatotype may influence the vector's position in the RXc graphs. This study provided the bioelectrical tolerance ellipses for CrossFit® practitioners in classic and specific approaches for the first time.
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Affiliation(s)
- Álex Cebrián-Ponce
- INEFC-Barcelona Sports Sciences Research Group, Institut Nacional d’Educació Física de Catalunya (INEFC), University of Barcelona (UB), 08038, Barcelona, Spain
| | - Sofia Serafini
- Department of Medicine and Aging Sciences, University “G. D'Annunzio” of Chieti-Pescara, 66100, Chieti, Italy
| | - Cristian Petri
- Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, 41013, Seville, Spain
| | - Marta Carrasco-Marginet
- INEFC-Barcelona Sports Sciences Research Group, Institut Nacional d’Educació Física de Catalunya (INEFC), University of Barcelona (UB), 08038, Barcelona, Spain
| | - Pascal Izzicupo
- Department of Medicine and Aging Sciences, University “G. D'Annunzio” of Chieti-Pescara, 66100, Chieti, Italy
| | - Gabriele Mascherini
- Exercise Science Laboratory Applied to Medicine “Mario Marella”, Department of Experimental and Clinical Medicine, University of Florence, 50134, Florence, Italy
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12
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Liu S, Zhang S, Cheng X, Wu D, Chen J, Liang W, Qian S, Zhang J, Jiang F. A meta-analysis on the impact of resistance training on phase angle in middle-aged and older individuals. Arch Gerontol Geriatr 2024; 119:105318. [PMID: 38194828 DOI: 10.1016/j.archger.2023.105318] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2023] [Revised: 12/14/2023] [Accepted: 12/17/2023] [Indexed: 01/11/2024]
Abstract
PURPOSE To determine the impact of resistance training (RT) on phase angle (PhA) in middle-aged and older individuals via meta-analysis, explore effects in subgroups, and identify optimal RT protocol. MATERIALS AND METHODS We searched five databases using predefined criteria, assessed literature quality per Cochrane 5.1 Handbook, and used Revman 5.3 for effect size aggregation, bias assessment, sensitivity analysis, and subgroup analysis. RESULTS RT improved PhA in middle-aged and older individuals (d = 0.34, 95 % CI: 0.27-0.40, P < 0.05). Effective subgroups included Suspension (d = 0.62, 95 % CI: 0.33-0.90, P < 0.05), free-weights and machine (d = 0.36, 95 % CI: 0.28-0.45, P < 0.05), equipment training (d = 0.24, 95 % CI: 0.13-0.36, P < 0.05), and moderate-intensity RT (d = 0.34, 95 % CI: 0.27-0.42, P < 0.05). RT was conducted 2-3 times/week (d = 0.20, 95 % CI: 0.01-0.38, P < 0.05) or (d = 0.38, 95 % CI: 0.30-0.47, P < 0.05). PhA improved after 8 weeks (d = 0.37, 95 % CI: 0.23-0.51, P < 0.05), 12 weeks (d = 0.35, 95 % CI: 0.26-0.44, P < 0.05), and ≥ 24 weeks (d = 0.26, 95 % CI: 0.11-0.41, P < 0.05) of RT in aged and older individuals. Low- and high-intensity RT, elastic band training, and weekly exercises did not significantly improve PhA. CONCLUSIONS RT enhances PhA in middle-aged and older adults. For optimal results, we recommend 2-3 weekly sessions of free weights and machine training lasting at least 8 weeks.
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Affiliation(s)
- Siqi Liu
- School of Physical Education, Hunan Normal University, Changsha, 410012, China
| | - Siqing Zhang
- School of Physical Education, Huazhong University of Science and Technology, Wuhan, 430074, China
| | - Xuejing Cheng
- School of Physical Education, Hunan Normal University, Changsha, 410012, China
| | - Danting Wu
- Department of Physical Education, Tongji University, Shanghai, 200092, China
| | - Jiongxun Chen
- School of Physical Education, Hunan Normal University, Changsha, 410012, China
| | - Wenqi Liang
- School of Physical Education & Sports Science, South China Normal University, Guangzhou, 510006, China
| | - Siyu Qian
- School of Physical Education, Hunan Normal University, Changsha, 410012, China
| | - Jisheng Zhang
- School of Physical Education, Hunan Normal University, Changsha, 410012, China.
| | - Fanglin Jiang
- School of Physical Education, Hunan Normal University, Changsha, 410012, China.
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13
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Marini E, Sulis S, Vorobel'ová L, Stagi S. Specific bioelectrical vectors pattern in individuals with sarcopenic obesity. Clin Nutr 2024; 43:620-628. [PMID: 38306890 DOI: 10.1016/j.clnu.2024.01.024] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/03/2023] [Revised: 12/31/2023] [Accepted: 01/22/2024] [Indexed: 02/04/2024]
Abstract
BACKGROUND Sarcopenic obesity is a common condition in the elderly associated with excessive adiposity and low muscle mass and strength. AIMS This study aims to establish a method for detecting bioelectrical characteristics in individuals with sarcopenic obesity through specific Bioelectrical Impedance Vector Analysis (specific BIVA), while considering the characteristics of individuals with healthy, sarcopenic, and obese conditions. METHODS The sample was composed by 915 Italian adults over 50 years of age (men: 74.6 ± 8.8 y; women:76.3 ± 8.8 y) living in Sardinia (Italy). A dataset of 1590 US adults aged 21 - 49 years retrieved from the 2003 - 2004 National Health and Nutrition Examination Survey was also considered in a final step of the study. Anthropometric (stature, weight, waist, arm, and calf circumferences) and whole-body bioelectrical variables were taken. In the Italian sample, bioelectrical impedance was applied to estimate the relative content of fat mass and skeletal muscle mass. Groups with healthy body composition (NS-NO), or consistent with sarcopenia (S), sarcopenic obesity (S-O), and obesity (O) were defined based on the cut-offs suggested by European expert guidelines (EWGSOP2 and ESPEN-EASO). Specific BIVA was applied to compare groups and to identify the area for sarcopenic obesity within young-adults tolerance ellipses. The position of the specific vector of US individuals with S-O, selected on the basis of DXA measurements, was also considered. RESULTS In both sexes of the Italian sample, the bioelectrical characteristics of the four groups were different (p < 0.001). The differences were mainly related to vector length, indicative of higher fat mass, which was longer in the O and S-O groups, and phase angle, a proxy of intracellular/extracellular water and muscle mass, lower in the sarcopenic groups. Bioelectrical vectors of the S-O group fell in the right quadrant, outside of the 95 % tolerance ellipses of young adults. The mean vector of the US sample with S-O fell in the same area. Within the S-O area, women had similar bioelectrical values, while men showed phase angle variability, which was related to the severity of the condition. CONCLUSIONS Specific BIVA detects body composition peculiarities of individuals with sarcopenic obesity, thus allowing their diagnosis when associated with low handgrip strength values.
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Affiliation(s)
- Elisabetta Marini
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy.
| | - Simona Sulis
- Department of Anthropology, Comenius University, 84104, Bratislava, Slovakia
| | - Lenka Vorobel'ová
- Department of Anthropology, Comenius University, 84104, Bratislava, Slovakia
| | - Silvia Stagi
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy
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14
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Silva AM, Campa F, Stagi S, Gobbo LA, Buffa R, Toselli S, Silva DAS, Gonçalves EM, Langer RD, Guerra-Júnior G, Machado DRL, Kondo E, Sagayama H, Omi N, Yamada Y, Yoshida T, Fukuda W, Gonzalez MC, Orlandi SP, Koury JC, Moro T, Paoli A, Kruger S, Schutte AE, Andreolli A, Earthman CP, Fuchs-Tarlovsky V, Irurtia A, Castizo-Olier J, Mascherini G, Petri C, Busert LK, Cortina-Borja M, Bailey J, Tausanovitch Z, Lelijveld N, Ghazzawi HA, Amawi AT, Tinsley G, Kangas ST, Salpéteur C, Vázquez-Vázquez A, Fewtrell M, Ceolin C, Sergi G, Ward LC, Heitmann BL, da Costa RF, Vicente-Rodriguez G, Cremasco MM, Moroni A, Shepherd J, Moon J, Knaan T, Müller MJ, Braun W, García-Almeida JM, Palmeira AL, Santos I, Larsen SC, Zhang X, Speakman JR, Plank LD, Swinburn BA, Ssensamba JT, Shiose K, Cyrino ES, Bosy-Westphal A, Heymsfield SB, Lukaski H, Sardinha LB, Wells JC, Marini E. The bioelectrical impedance analysis (BIA) international database: aims, scope, and call for data. Eur J Clin Nutr 2023; 77:1143-1150. [PMID: 37532867 DOI: 10.1038/s41430-023-01310-x] [Citation(s) in RCA: 9] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/22/2022] [Revised: 07/10/2023] [Accepted: 07/12/2023] [Indexed: 08/04/2023]
Abstract
BACKGROUND Bioelectrical impedance analysis (BIA) is a technique widely used for estimating body composition and health-related parameters. The technology is relatively simple, quick, and non-invasive, and is currently used globally in diverse settings, including private clinicians' offices, sports and health clubs, and hospitals, and across a spectrum of age, body weight, and disease states. BIA parameters can be used to estimate body composition (fat, fat-free mass, total-body water and its compartments). Moreover, raw measurements including resistance, reactance, phase angle, and impedance vector length can also be used to track health-related markers, including hydration and malnutrition, and disease-prognostic, athletic and general health status. Body composition shows profound variability in association with age, sex, race and ethnicity, geographic ancestry, lifestyle, and health status. To advance understanding of this variability, we propose to develop a large and diverse multi-country dataset of BIA raw measures and derived body components. The aim of this paper is to describe the 'BIA International Database' project and encourage researchers to join the consortium. METHODS The Exercise and Health Laboratory of the Faculty of Human Kinetics, University of Lisbon has agreed to host the database using an online portal. At present, the database contains 277,922 measures from individuals ranging from 11 months to 102 years, along with additional data on these participants. CONCLUSION The BIA International Database represents a key resource for research on body composition.
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Affiliation(s)
- Analiza M Silva
- Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, 1499-002, Lisbon, Portugal.
| | - Francesco Campa
- Department of Biomedical Science, University of Padova, 35100, Padova, Italy
| | - Silvia Stagi
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042, Cagliari, Italy
| | - Luís A Gobbo
- Skeletal Muscle Assessment Laboratory, Physical Education Department, School of Technology and Science, São Paulo State University, Presidente Prudente, 19060-900, Brazil
| | - Roberto Buffa
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042, Cagliari, Italy
| | - Stefania Toselli
- Department for Life Quality Studies, University of Bologna, 47921, Rimini, Italy
| | - Diego Augusto Santos Silva
- Research Center of Kinanthropometry and Human Performance, Sports Center, Universidade Federal de Santa Catarina, Florianópolis, Brazil
| | - Ezequiel M Gonçalves
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, 13083-887, Brazil
| | - Raquel D Langer
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, 13083-887, Brazil
| | - Gil Guerra-Júnior
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, 13083-887, Brazil
| | - Dalmo R L Machado
- Laboratory of Kinanthropometry and Human Performance, School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, 05508-030, São Paulo, Brazil
| | - Emi Kondo
- Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8574, Japan
| | - Hiroyuki Sagayama
- Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8574, Japan
| | - Naomi Omi
- Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8574, Japan
| | - Yosuke Yamada
- National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, 566-0002, Japan
| | - Tsukasa Yoshida
- National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, 566-0002, Japan
| | - Wataru Fukuda
- Yokohama Sports Medical Center, Yokohama Sport Association, Kanagawa, 222-0036, Japan
| | - Maria Cristina Gonzalez
- Postgraduate Program in Nutrition and Food, Federal University of Pelotas, 96010-610 Pelotas, Brazil
| | - Silvana P Orlandi
- Nutrition Department, Federal University of Pelotas, 96010-610, Pelotas, Brazil
| | - Josely C Koury
- Nutrition Institute, State University of Rio de Janeiro, 20550-013, Rio de Janeiro, Brazil
| | - Tatiana Moro
- Department of Biomedical Science, University of Padova, 35100, Padova, Italy
| | - Antonio Paoli
- Department of Biomedical Science, University of Padova, 35100, Padova, Italy
| | - Salome Kruger
- Centre of Excellence for Nutrition, North-West University, Potchefstroom, 2520, South Africa
| | - Aletta E Schutte
- School of Population Health, University of New South Wales, The George Institute for Global Health, Sydney, NSW, Australia
| | | | | | | | - Alfredo Irurtia
- National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
| | - Jorge Castizo-Olier
- School of Health Sciences, TecnoCampus, Pompeu Fabra University, Barcelona, Spain
| | - Gabriele Mascherini
- Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy
| | - Cristian Petri
- Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Seville, Spain
| | - Laura K Busert
- Population, Policy & Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK
| | - Mario Cortina-Borja
- Population, Policy & Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK
| | | | | | | | - Hadeel Ali Ghazzawi
- Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman, Jordan
| | - Adam Tawfiq Amawi
- Department of Physical and Health Education, Faculty of Educational Sciences, Al-Ahliyya Amman University, Al-Salt, Jordan
| | - Grant Tinsley
- Energy Balance & Body Composition Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX, 79409, USA
| | - Suvi T Kangas
- International Rescue Committee, New York, NY, 10168, USA
| | - Cécile Salpéteur
- Department of Expertise and Advocacy, Action contre la Faim, 93358, Montreuil, France
| | - Adriana Vázquez-Vázquez
- Population, Policy & Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK
| | - Mary Fewtrell
- Population, Policy & Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK
| | - Chiara Ceolin
- Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, 35128, Italy
| | - Giuseppe Sergi
- Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, 35128, Italy
| | - Leigh C Ward
- School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia
| | - Berit L Heitmann
- Research Unit for Dietary Studies, The Parker Institute, Frederiksberg and Bispebjerg Hospital, Copenhagen, Denmark
- Section for general Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
| | - Roberto Fernandes da Costa
- Department of Physical Education, Research Group in Physical Activity and Health, Federal University of Rio Grande do Norte, Natal, Brazil
| | - German Vicente-Rodriguez
- Faculty of Health and Sport Science FCSD, Department of Physiatry and Nursing, University of Zaragoza, 50009, Zaragoza, Spain
| | - Margherita Micheletti Cremasco
- Laboratory of Anthropology, Anthropometry and Ergonomics, Department of Life Sciences and Systems Biology, University of Torino, 10123, Torino, Italy
| | - Alessia Moroni
- Laboratory of Anthropology, Anthropometry and Ergonomics, Department of Life Sciences and Systems Biology, University of Torino, 10123, Torino, Italy
| | - John Shepherd
- University of Hawaii Cancer Center, Honolulu, HI, USA
| | - Jordan Moon
- United States Sports Academy, Daphne, AL, 36526, USA
| | - Tzachi Knaan
- Weight Management, Metabolism & Sports Nutrition Clinic, Metabolic Lab, Tel-Aviv, Tel Aviv-Yafo, Israel
| | - Manfred J Müller
- Department of Human Nutrition, Institute of Human Nutrition and Food Sciences, Christian-Albrechts University, 24105, Kiel, Germany
| | - Wiebke Braun
- Department of Human Nutrition, Institute of Human Nutrition and Food Sciences, Christian-Albrechts University, 24105, Kiel, Germany
| | - José M García-Almeida
- Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Malaga University, 29010, Malaga, Spain
| | | | - Inês Santos
- Laboratório de Nutrição, Faculdade de Medicina, Centro Académico de Medicina de Lisboa, Universidade de Lisboa, Lisboa, Portugal
| | - Sofus C Larsen
- Research Unit for Dietary Studies at the Parker Institute, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark
- The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
| | - Xueying Zhang
- Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
| | - John R Speakman
- Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
- School of Biological Sciences, University of Aberdeen, Aberdeen, UK
| | - Lindsay D Plank
- Department of Surgery, University of Auckland, Auckland, New Zealand
| | - Boyd A Swinburn
- School of Population Health, University of Auckland, Auckland, New Zealand
| | - Jude Thaddeus Ssensamba
- Center for Innovations in Health Africa (CIHA Uganda), Kampala, Uganda
- Makerere University Walter Reed Project, Kampala, Uganda
| | - Keisuke Shiose
- Faculty of Education, University of Miyazaki, Miyazaki, Japan
| | - Edilson S Cyrino
- Metabolism, Nutrition, and Exercise Laboratory. Physical Education and Sport Center, State University of Londrina, Rod. Celso Garcia Cid, Km 380, 86057-970, Londrina-PR, Brazil
| | - Anja Bosy-Westphal
- Department of Human Nutrition, Institute of Human Nutrition and Food Sciences, Christian-Albrechts University, 24105, Kiel, Germany
| | | | - Henry Lukaski
- Department of Kinesiology and Public Health Education, Hyslop Sports Center, University of North Dakota Grand Forks, Grand Forks, ND, 58202, USA
| | - Luís B Sardinha
- Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, 1499-002, Lisbon, Portugal
| | - Jonathan C Wells
- Population, Policy & Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK
| | - Elisabetta Marini
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042, Cagliari, Italy
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15
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Campa F, Coratella G, Cerullo G, Stagi S, Paoli S, Marini S, Grigoletto A, Moroni A, Petri C, Andreoli A, Ceolin C, Degan R, Izzicupo P, Sergi G, Mascherini G, Micheletti Cremasco M, Marini E, Toselli S, Moro T, Paoli A. New bioelectrical impedance vector references and phase angle centile curves in 4,367 adults: The need for an urgent update after 30 years. Clin Nutr 2023; 42:1749-1758. [PMID: 37544246 DOI: 10.1016/j.clnu.2023.07.025] [Citation(s) in RCA: 33] [Impact Index Per Article: 16.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/27/2023] [Revised: 07/25/2023] [Accepted: 07/27/2023] [Indexed: 08/08/2023]
Abstract
BACKGROUND & AIMS The bioelectrical impedance vector analysis (BIVA) represents a qualitative analysis of body composition. The vector, defined by resistance (R) and reactance (Xc) standardized by stature, can be evaluated compared to the 50%,75%, and 95% tolerance ellipses representative of the reference populations. The tolerance ellipses for healthy adults have been provided in 1995 and were developed by mixing underage, adult, and elderly subjects, possibly misrepresenting the actual adult population. The current multicentric, cross-sectional study aimed to provide new tolerance ellipses specific for the general adult population and as a secondary aim to present centile curves for the bioelectrical phase angle. METHODS R, Xc, and phase angle were measured in 2137 and 2230 males and females using phase-sensitive foot-to-hand analyzers at 50 kHz. A minimum of 35 subjects were included for each sex and age category from 18 to 65 years. RESULTS The new mean vectors showed a leftward shift on the R-Xc graph with respect to the former reference values (males: F = 75.3; p < 0.001; females: F = 36.6, p < 0.001). The results provided new 3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th, and 97th percentile curves for phase angle, identifying time point phases of decrement (males: -0.03° per year at 33.0-51.0 years and -0.05° per year after 51 years; females: -0.03° per year from 37.2 to 57.9 years). CONCLUSIONS Compared to the original references, the new data are characterized by a different distribution within the R-Xc graph with a higher phase angle. Thirty years after the BIVA invention, the current study presents new tolerance ellipses and phase angle reference values for the adult population.
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Affiliation(s)
- Francesco Campa
- Department of Biomedical Sciences, University of Padua, Padua, Italy
| | - Giuseppe Coratella
- Department of Biomedical Sciences for Health, Università Degli Studi di Milano, Milano, Italy.
| | - Giuseppe Cerullo
- Department of Biomedical Sciences, University of Padua, Padua, Italy
| | - Silvia Stagi
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy
| | - Samuele Paoli
- Department of Statistical Sciences, University of Padua, Padua, Italy
| | - Sofia Marini
- Department for Life Quality Studies, University of Bologna, Rimini, Italy
| | - Alessia Grigoletto
- Department for Life Quality Studies, University of Bologna, Rimini, Italy
| | - Alessia Moroni
- Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy
| | - Cristian Petri
- Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Seville, Spain
| | - Angela Andreoli
- Department of Systems Medicine, University of Tor Vergata, Rome, Italy
| | - Chiara Ceolin
- Department of Medicine, Geriatrics Division, University of Padua, Padua, Italy
| | - Raffaella Degan
- Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy
| | - Pascal Izzicupo
- Department of Medicine and Aging Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy
| | - Giuseppe Sergi
- Department of Medicine, Geriatrics Division, University of Padua, Padua, Italy
| | - Gabriele Mascherini
- Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
| | | | - Elisabetta Marini
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy
| | - Stefania Toselli
- Department for Life Quality Studies, University of Bologna, Rimini, Italy
| | - Tatiana Moro
- Department of Biomedical Sciences, University of Padua, Padua, Italy
| | - Antonio Paoli
- Department of Biomedical Sciences, University of Padua, Padua, Italy
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16
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Jiang FL, Tang S, Eom SH, Lee JY, Chae JH, Kim CH. Distribution of Bioelectrical Impedance Vector Analysis and Phase Angle in Korean Elderly and Sarcopenia. SENSORS (BASEL, SWITZERLAND) 2023; 23:7090. [PMID: 37631626 PMCID: PMC10458265 DOI: 10.3390/s23167090] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/22/2023] [Revised: 08/02/2023] [Accepted: 08/02/2023] [Indexed: 08/27/2023]
Abstract
PURPOSE This study aimed to verify whether bioelectrical impedance vector analysis (BIVA) can support the clinical evaluation of sarcopenia in elderly individuals and evaluate the relationships between phase angle (PhA), physical performance, and muscle mass. METHODS The sample comprised 134 free-living elderly individuals of both sexes aged 69-91 years. Anthropometric parameters, grip strength, dual-energy X-ray absorptiometry findings, bioimpedance analysis results, and physical performance were also measured. The impedance vector distributions were evaluated in elderly individuals using BIVA. RESULTS BIVA revealed significant differences between the sarcopenia and non-sarcopenia groups (both sexes). The sarcopenia group had a significantly lower PhA than the non-sarcopenia group in both sexes (p < 0.05). PhA was significantly correlated with age, appendicular skeletal muscle (ASM), handgrip strength (HGS), and muscle quality in both sexes and significantly correlated with ASM/Height2 and physical performance in males. CONCLUSION BIVA can be used as a field assessment method in elderly Koreans with sarcopenia. PhA is a good indicator of muscle strength, muscle quality, and physical performance in males. These methods can help diagnose sarcopenia in elderly individuals with reduced mobility.
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Affiliation(s)
- Fang-Lin Jiang
- Department of Wushu and Traditional National Sports, College of Physical Education, Hunan Normal University, Changsha 410012, China;
| | - Saizhao Tang
- Department of Sports Medicine, Soonchunhyang University, Asan 31538, Republic of Korea; (S.T.); (S.-H.E.); (J.-Y.L.); (J.H.C.)
| | - Seon-Ho Eom
- Department of Sports Medicine, Soonchunhyang University, Asan 31538, Republic of Korea; (S.T.); (S.-H.E.); (J.-Y.L.); (J.H.C.)
| | - Jae-Young Lee
- Department of Sports Medicine, Soonchunhyang University, Asan 31538, Republic of Korea; (S.T.); (S.-H.E.); (J.-Y.L.); (J.H.C.)
| | - Ji Heon Chae
- Department of Sports Medicine, Soonchunhyang University, Asan 31538, Republic of Korea; (S.T.); (S.-H.E.); (J.-Y.L.); (J.H.C.)
| | - Chul-Hyun Kim
- Department of Sports Medicine, Soonchunhyang University, Asan 31538, Republic of Korea; (S.T.); (S.-H.E.); (J.-Y.L.); (J.H.C.)
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Gortan Cappellari G, Guillet C, Poggiogalle E, Ballesteros Pomar MD, Batsis JA, Boirie Y, Breton I, Frara S, Genton L, Gepner Y, Gonzalez MC, Heymsfield SB, Kiesswetter E, Laviano A, Prado CM, Santini F, Serlie MJ, Siervo M, Villareal DT, Volkert D, Voortman T, Weijs PJ, Zamboni M, Bischoff SC, Busetto L, Cederholm T, Barazzoni R, Donini LM. Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) - Proceedings from the SOGLI consortium meeting in rome November 2022. Clin Nutr 2023; 42:687-699. [PMID: 36947988 DOI: 10.1016/j.clnu.2023.02.018] [Citation(s) in RCA: 52] [Impact Index Per Article: 26.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2023] [Accepted: 02/17/2023] [Indexed: 02/26/2023]
Abstract
The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) launched the Sarcopenic Obesity Global Leadership Initiative (SOGLI) to reach expert consensus on a definition and diagnostic criteria for Sarcopenic Obesity (SO). The present paper describes the proceeding of the Sarcopenic Obesity Global Leadership Initiative (SOGLI) meeting that was held on November 25th and 26th, 2022 in Rome, Italy. This consortium involved the participation of 50 researchers from different geographic regions and countries. The document outlines an agenda advocated by the SOGLI expert panel regarding the pathophysiology, screening, diagnosis, staging and treatment of SO that needs to be prioritized for future research in the field.
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Affiliation(s)
| | - Christelle Guillet
- University of Clermont Auvergne, INRA, CRNH, CHU Clermont-Ferrand, Clermont-Ferrand, France
| | | | | | - John A Batsis
- University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
| | - Yves Boirie
- University of Clermont Auvergne, INRA, CRNH, CHU Clermont-Ferrand, Clermont-Ferrand, France
| | - Irene Breton
- Hospital General Universitario Gregorio Marañón, Madrid, Spain
| | - Stefano Frara
- Università Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy
| | | | | | | | | | - Eva Kiesswetter
- Institute for Evidence in Medicine, Medical Center & Faculty of Medicine, University of Freiburg, Freiburg, Germany
| | | | | | | | | | | | | | - Dorothee Volkert
- Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany
| | - Trudy Voortman
- Erasmus University Medical Center, Rotterdam, the Netherlands
| | - Peter Jm Weijs
- Amsterdam University Medical Centers, Amsterdam, the Netherlands; Amsterdam University of Applied Sciences, Amsterdam, Netherlands
| | | | | | | | - Tommy Cederholm
- Uppsala University and Karolinska University Hospital, Stockholm, Sweden
| | - Rocco Barazzoni
- Department of Medical Sciences, University of Trieste, Trieste, Italy
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Chen Y, Wu J, Ran L, Yu D, Chen X, Liu M. The combination of phase angle and age has a good diagnostic value for sarcopenia in continuous ambulatory peritoneal dialysis patients. Front Nutr 2022; 9:1036796. [DOI: 10.3389/fnut.2022.1036796] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2022] [Accepted: 10/25/2022] [Indexed: 11/17/2022] Open
Abstract
AimsThere are limited studies on phase angle and sarcopenia in continuous ambulatory peritoneal dialysis patients. So, we want to explore the association between phase angle and sarcopenia and find a more sensitive indicator for diagnosing sarcopenia.MethodsWe included 101 continuous ambulatory peritoneal dialysis patients from March 2022 to August 2022 and measured the phase angle and body composition by bioelectrical impedance analysis. All patients had their handgrip strength measured. Then, we divided patients into the sarcopenia (n = 30) group and non-sarcopenia (n = 71) group according to the sarcopenia diagnostic strategy formulated by the Asian Working Group for Sarcopenia. We used logistic regression to explore the risk factors of sarcopenia. We applied Receiver-operating characteristics curves to determine the diagnostic accuracy of these risk factors.ResultsAfter adjustments for sex, age, diabetes, BMI, extracellular water ratio, extra water, serum creatinine, total kt/v, and residual kt/v, phase angle correlated to handgrip strength and lowered limb muscle mass but not to skeletal muscle mass, upper arm muscle circumference, upper limb muscle mass and appendicular skeletal muscle mass index. In the multivariate logistic model, low phase angle and older age are risk factors for sarcopenia. The AUROC of phase angle for sarcopenia is 0.79 (95%CI, 0.70–0.86, P < 0.01) for both sexes, 0.70 and 0.85 for females and males. After we combined age and phase angle as diagnostic indicators of sarcopenia, the AUROC is 0.91 (95%CI, 0.83–0.96, P < 0.0001) in both sexes, 0.89 and 0.93 for females and males.ConclusionThis study illustrates that age 52 or older is an independent risk factor for sarcopenia in continuous ambulatory peritoneal dialysis patients. Phase angle can act as a predictor of sarcopenia in those patients. But the combination of age and phase angle is more valuable in diagnosing sarcopenia.
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Rossini-Venturini AC, Abdalla PP, Fassini PG, dos Santos AP, Tasinafo Junior MF, Alves TC, Gomide EBG, de Pontes TL, Pfrimer K, Ferriolli E, Mota J, Beltran-Valls MR, Machado DRL. Association between classic and specific bioimpedance vector analysis and sarcopenia in older adults: a cross-sectional study. BMC Sports Sci Med Rehabil 2022; 14:170. [PMID: 36104722 PMCID: PMC9476257 DOI: 10.1186/s13102-022-00559-2] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2022] [Accepted: 08/25/2022] [Indexed: 11/10/2022] Open
Abstract
Background To verify (1) the association between classic and specific bioelectrical impedance vector analysis (BIVA) with body composition, hydration, and physical performance in older adults with and without sarcopenia; (2) which BIVA most accurately distinguishes sarcopenia. Methods A sample of 94 older adults with and without sarcopenia (29 men and 65 women, 60–85 years) was evaluated. The classic and specific BIVA procedures, Dual energy X-ray absorptiometry (DXA), and deuterium dilution were performed. Sarcopenia was defined by muscle weakness and low skeletal muscle index, while severity was indicated by low physical performance. Results The BIVA's potential to monitor hydration and muscle mass loss in older adults seems feasible. Classic and specific BIVA were able to distinguish sarcopenia in women (p < 0.001), but not in men. When the sarcopenia criteria were individually analyzed, both classic and specific BIVA were able to distinguish low skeletal muscle index in women, while only classic BIVA did for men. For the criterion of slow physical performance, only the classic BIVA showed severity differences for women. The vectors of adults without sarcopenia of both sexes tended to be positioned in the left region of the ellipses, revealing a predominance of soft tissues. Conclusions Classic BIVA has a distinct sarcopenic association with body composition, hydration, and physical performance in older adults, while specific BIVA was similar between groups. Both BIVAs are sensible to detect female morphological changes (skeletal muscle index) but not for functional (handgrip, 6-min walk test) sarcopenia criteria. These procedures are promising tools for monitoring sarcopenia risks during aging.
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Sarcopenia in knee osteoarthritis: the association with clinical and sonographic findings, physical function, and nutrition. Ir J Med Sci 2022:10.1007/s11845-022-03141-4. [PMID: 36050588 DOI: 10.1007/s11845-022-03141-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2022] [Accepted: 08/24/2022] [Indexed: 10/14/2022]
Abstract
OBJECTIVE The purposes of this study were to examine to (1) the relation between OA and sarcopenia and to identify the most practical, easily accessible, and inexpensive method for investigating sarcopenia; (2) evaluation of sarcopenia risk factors in patients with OA. DESIGN One hundred two patients with clinical and radiological diagnosis of knee osteoarthritis and 33 healthy control subjects were included in the study and all subjects were evaluated for sarcopenia. Dual-X-ray absorptiometry (DEXA) is used to measure body composition parameters and muscle thickness measurements with ultrasonography for diagnosis of sarcopenia. RESULTS The mean age of the group with sarcopenia was statistically higher than the other two groups (p < 0.001). The weight, body mass index (BMI), waist circumference, upper-mid-arm circumference, thigh, and leg circumference of osteoarthritis (OA) patients with sarcopenia were statistically lower than those of non-sarcopenic and control group (p < 0.01, p < 0.001). Body composition parameter results showed that sarcopenic patients had statistically lower values as fat mass, lean body mass, and skeletal muscle index (p < 0.001, p = 0.001, p < 0.001, respectively) than those of non-sarcopenic and control group and fat mass index values (p = 0.012) are lower than the non-sarcopenic group. With respect to sarcopenia, the effect of adiponectin and leptin levels were not detected. It was determined that body composition values measured with DEXA, ultrasonographic measures, isokinetic muscle strength assessment, handgrip strength, and gait speed had predictive values for sarcopenia. CONCLUSIONS We found that patients with sarcopenic OA were older, weaker, undernourished, and restricted in their level of physical activity in the study. Among the methods of determining sarcopenia, ultrasound becomes prominent with its practical, cheap, and easily accessible features. We think that our results will increase the awareness of the presence of sarcopenia in OA patients.
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DeMik DE, Marinier MC, Glass NA, Elkins JM. Prevalence of Sarcopenia and Sarcopenic Obesity in an Academic Total Joint Arthroplasty Practice. Arthroplast Today 2022; 16:124-129. [PMID: 35677943 PMCID: PMC9168043 DOI: 10.1016/j.artd.2022.05.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/08/2022] [Revised: 04/24/2022] [Accepted: 05/01/2022] [Indexed: 10/29/2022] Open
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Saito H, Matsue Y, Kamiya K, Kagiyama N, Maeda D, Endo Y, Ueno H, Yoshioka K, Mizukami A, Saito K, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Jujo K, Wada H, Hiki M, Dotare T, Sunayama T, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Wakaume K, Oka K, Momomura SI, Minamino T. Sarcopenic obesity is associated with impaired physical function and mortality in older patients with heart failure: insight from FRAGILE-HF. BMC Geriatr 2022; 22:556. [PMID: 35787667 PMCID: PMC9254413 DOI: 10.1186/s12877-022-03168-3] [Citation(s) in RCA: 19] [Impact Index Per Article: 6.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/03/2021] [Accepted: 05/16/2022] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND The purpose of this study was to clarify the prevalence, association with frailty and exercise capacity, and prognostic implication of sarcopenic obesity in patients with heart failure. METHODS The present study included 779 older adults hospitalized with heart failure (median age: 81 years; 57.4% men). Sarcopenia was diagnosed based on the guidelines by the Asian Working Group for Sarcopenia. Obesity was defined as the percentage of body fat mass (FM) obtained by bioelectrical impedance analysis. The FM cut-off points for obesity were 38% for women and 27% for men. The primary endpoint was 1-year all-cause death. We assessed the associations of sarcopenic obesity occurrence with the short physical performance battery (SPPB) score and 6-minute walk distance (6MWD). RESULTS The rates of sarcopenia and obesity were 19.3 and 26.2%, respectively. The patients were classified into the following groups: non-sarcopenia/non-obesity (58.5%), non-sarcopenia/obesity (22.2%), sarcopenia/non-obesity (15.3%), and sarcopenia/obesity (4.0%). The sarcopenia/obesity group had a lower SPPB score and shorter 6MWD, which was independent of age and sex (coefficient, - 0.120; t-value, - 3.74; P < 0.001 and coefficient, - 77.42; t-value, - 3.61; P < 0.001; respectively). Ninety-six patients died during the 1-year follow-up period. In a Cox proportional hazard analysis, sarcopenia and obesity together were an independent prognostic factor even after adjusting for a coexisting prognostic factor (non-sarcopenia/non-obesity vs. sarcopenia/obesity: hazard ratio, 2.48; 95% confidence interval, 1.22-5.04; P = 0.012). CONCLUSION Sarcopenic obesity is a risk factor for all-cause death and low physical function in older adults with heart failure. TRIAL REGISTRATION University Hospital Information Network (UMIN-CTR: UMIN000023929 ).
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Affiliation(s)
- Hiroshi Saito
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
- Department of Rehabilitation, Kameda Medical Center, Chiba, Japan
| | - Yuya Matsue
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
- Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
| | - Kentaro Kamiya
- Department of Rehabilitation, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
| | - Nobuyuki Kagiyama
- Department of Cardiology, The Sakakibara Heart Institute of Okayama, Okayama, Japan
- Department of Digital Health and Telemedicine R&D, Juntendo University, Tokyo, Japan
- Department of Cardiovascular Biology and Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
| | - Daichi Maeda
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
- Department of Cardiology, Osaka Medical and Pharmaceutical University, Osaka, Japan
| | - Yoshiko Endo
- Department of Rehabilitation, Kameda Medical Center, Chiba, Japan
| | - Hidenao Ueno
- Department of Rehabilitation, Kameda Medical Center, Chiba, Japan
| | - Kenji Yoshioka
- Department of Cardiology, Kameda Medical Center, Chiba, Japan
| | - Akira Mizukami
- Department of Cardiology, Kameda Medical Center, Chiba, Japan
| | - Kazuya Saito
- Department of Rehabilitation, The Sakakibara Heart Institute of Okayama, Okayama, Japan
| | - Yuki Ogasahara
- Department of Nursing, The Sakakibara Heart Institute of Okayama, Okayama, Japan
| | - Emi Maekawa
- Department of Cardiovascular Medicine, Kitasato University School of Medicine, Kanagawa, Japan
| | - Masaaki Konishi
- Division of Cardiology, Yokohama City University Medical Center, Kanagawa, Japan
| | - Takeshi Kitai
- Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan
| | - Kentaro Iwata
- Department of Rehabilitation, Kobe City Medical Center General Hospital, Hyogo, Japan
| | - Kentaro Jujo
- Department of Cardiology, Nishiarai Heart Center Hospital, Tokyo, Japan
| | - Hiroshi Wada
- Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan
| | - Masaru Hiki
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
| | - Taishi Dotare
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
| | - Tsutomu Sunayama
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
| | - Takatoshi Kasai
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
- Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
| | - Hirofumi Nagamatsu
- Department of Cardiology, Tokai University School of Medicine, Tokyo, Japan
| | - Tetsuya Ozawa
- Department of Rehabilitation, Odawara Municipal Hospital, Kanagawa, Japan
| | - Katsuya Izawa
- Department of Rehabilitation, Kasukabe Chuo General Hospital, Saitama, Japan
| | - Shuhei Yamamoto
- Department of Rehabilitation, Shinshu University Hospital, Nagano, Japan
| | - Naoki Aizawa
- Department of Cardiovascular Medicine, Nephrology and Neurology, University of Ryukyus, Okinawa, Japan
| | - Kazuki Wakaume
- Department of Rehabilitation, Kitasato University Medical Center, Saitama, Japan
| | - Kazuhiro Oka
- Department of Rehabilitation, Saitama Citizens Medical Center, Saitama, Japan
| | | | - Tohru Minamino
- Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan
- Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo, Japan
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23
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DeMik DE, Marinier MC, Gulbrandsen TR, Glass NA, Elkins JM. Does Isolated Unilateral Hip or Knee Osteoarthritis Lead to Adverse Changes in Extremity Composition? THE IOWA ORTHOPAEDIC JOURNAL 2022; 42:163-167. [PMID: 35821924 PMCID: PMC9210432] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Subscribe] [Scholar Register] [Indexed: 06/15/2023]
Abstract
BACKGROUND While muscle atrophy is a function of normal aging, loss of muscle in the setting of hip and knee osteoarthritis (OA) has been observed using radiographic studies. There is limited data available regarding changes in extremity composition using bioimpedance (BIA). The purpose of this study was to assess the changes in extremity composition in patients with isolated, unilateral hip or knee OA using BIA. METHODS Patients presenting to our institution's adult reconstruction clinic from February 2020 to April 2021 were retrospectively reviewed to identify those with isolated, unilateral hip and knee OA. The InBody 770 Body Composition Analyzer (InBody USA, Cerritos, California) was used to perform a complete body composition assessment, per protocol. Lean extremity mass (LEM), fat mass (FM), intracellular water (ICW), extremity body water (EBW = ICW + extracellular water (ECW)) and phase angle (PA) were determined. Differences between the affected (OA) and unaffected (no OA) extremities were compared using t-tests. RESULTS 38 patients had isolated hip OA. The mean age was 60.8 (±11.7) years, mean BMI was 31.7 (±6.8) kg/m2, and 39.5% were female. LEM, FM, EBW, ICW, and PA were significantly decreased in the hip OA extremity (LEM: 20.0 vs. 20.4 kg, p=0.0008, FM: 8.8 vs. 8.9 kg, p=0.0049, EBW: 15.7 vs 16.0, p=0.0011, ICW: 9.5 vs. 9.7 L, p=0.0004, PA: 4.5 vs 4.9º, p<0.0001). There were 25 patients with isolated knee OA. Mean age was 62.8 (±11.3) years, mean BMI was 33.6 (±6.9) kg/m2, and 52.0% were female. FM and PA were significantly lower in the knee OA extremity (11.3 vs 11.4 kg, p=0.0291, 4.5 vs 4.9º, p<0.0001). There were no significant differences in LEM, EBW, and ICW between the knee OA extremity and the unaffected extremity. CONCLUSION Patients with isolated, unilateral hip OA had decreased LEM, FM, EBW, and ICW in the affected extremity. Both unilateral hip and knee OA was associated with decreased PA, suggestive of greater underlying dysfunction in muscle or cellular performance. Further study is needed to better define when these abnormalities develop, how they progress over time, and the impact of targeted interventions in reversing these changes. Level of Evidence: III.
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Affiliation(s)
- David E. DeMik
- Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
| | - Michael C. Marinier
- Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
| | - Trevor R. Gulbrandsen
- Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
| | - Natalie A. Glass
- Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
| | - Jacob M. Elkins
- Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
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24
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Moroni A, Vardè C, Giustetto A, Stagi S, Marini E, Micheletti Cremasco M. Bioelectrical Impedance Vector Analysis (BIVA) for the monitoring of body composition in pregnancy. Eur J Clin Nutr 2022; 76:604-609. [PMID: 34363054 DOI: 10.1038/s41430-021-00990-7] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2021] [Revised: 07/07/2021] [Accepted: 07/09/2021] [Indexed: 02/07/2023]
Abstract
BACKGROUND/OBJECTIVES During pregnancy, body composition alterations can be considered as markers of complications and in this context, a non-invasive and low-cost method such as Bioelectrical Impedance Vector Analysis (BIVA), can be employed to monitor such changes. This study aimed at identifying body compartments trend during physiological pregnancy. SUBJECTS/METHODS Classic and specific BIVA variables have been measured in a sample of 37 pregnant women approximately every 4 weeks of gestation and once postpartum. Researchers used both longitudinal and cross-sectional approach. The first case included data of women from the 11th to the 15th week along with data from the 28th to the 32nd week of gestation. The cross-sectional approach regarded two more specific moments (11th-12th weeks and 30th-31st weeks) and data within two months postpartum RESULTS: The longitudinal approach showed a significant decrease in classic BIVA variables (R/H, Xc/H, Z/H p < 0.001) and a shortening of the vector, pointing out that TBW and hydration increased significantly. Specific vector length increased significantly, indicating a physiological gain of FM% (p < 0.01). The cross-sectional approach showed lower values of R/H, Xc/H, Z/H between 12th-13th and 30th-31st weeks (p < 0.01), while in the postpartum period values tended to those registered at the beginning of pregnancy. No changes have been found for the phase angle in both approaches, indicating that ECW/ICW ratio remained constant CONCLUSIONS: Among physiological pregnancies, bioelectric values showed a coherent trend and these results represent a first contribution to support routine exams, leading to an early detection of anomalous values potentially correlated to pathologies.
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Affiliation(s)
- A Moroni
- Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy
| | - C Vardè
- Edoardo Agnelli Hospital, Gynaecology and Obstetrics Division, Pinerolo, Italy
| | - A Giustetto
- Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy
| | - S Stagi
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella di Monserrato, Cagliari, Italy
| | - E Marini
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella di Monserrato, Cagliari, Italy
| | - M Micheletti Cremasco
- Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy.
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25
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Espinosa-Marrón A, Rubio-Blancas A, Quiñones-Capistran CA, Camacho-Zamora A, Salcedo-Grajales I, Bravo-García AP, Bourlon MT, Castillejos-Molina RA, Dias JA, Del Pilar Milke-García M. Muscle wasting assessment tools for prostate cancer. Sci Rep 2022; 12:4662. [PMID: 35304535 PMCID: PMC8933481 DOI: 10.1038/s41598-022-08501-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/05/2021] [Accepted: 03/03/2022] [Indexed: 11/14/2022] Open
Abstract
Prostate cancer and its treatment may induce muscle wasting. Body composition and muscle functionality are rarely assessed in patients with prostate cancer from developing countries due to the limited availability of high-quality equipment for routine diagnosis. This cross-sectional study evaluated the association between several simplistic techniques for assessing muscle mass and function with a more complex standard of reference for muscle wasting among Mexican men with prostate cancer. Muscle wasting was highly prevalent, yet it was presumably associated with aging rather than cancer and its treatment itself. The restricted availability of specific equipment in clinical settings with technological limitations supports using unsophisticated techniques as surrogate measurements for muscle wasting. The left-arm handgrip dynamometry displayed the highest correlation with the standard of reference and exhibited an acceptable predicted probability for muscle estimation. Combining several simplistic techniques may be preferable. We also developed and internally validated a manageable model that helps to identify elderly patients with prostate cancer at risk of muscle depletion and impairment. These findings promote the early recognition and treatment of muscle wasting alterations occurring among older adults with prostate cancer.
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Affiliation(s)
- Alan Espinosa-Marrón
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
| | | | | | | | - Itzel Salcedo-Grajales
- Division of Nutrition, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico
| | - Ana Paula Bravo-García
- Division of Nutrition, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico
| | - Maria T Bourlon
- Department of Hematology and Oncology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico
| | - Ricardo A Castillejos-Molina
- Department of Urology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico
| | - Julie-Alexia Dias
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
| | - María Del Pilar Milke-García
- Division of Nutrition, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico.
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26
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Gobbo LA, Langer RD, Marini E, Buffa R, Borges JH, Pascoa MA, Cirolini VX, Guerra-Júnior G, Gonçalves EM. Effect of Physical Training on Body Composition in Brazilian Military. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:ijerph19031732. [PMID: 35162755 PMCID: PMC8834877 DOI: 10.3390/ijerph19031732] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/15/2021] [Revised: 01/24/2022] [Accepted: 01/29/2022] [Indexed: 01/10/2023]
Abstract
The military are selected on the basis of physical standards and are regularly involved in strong physical activities, also related to particular sports training. The aims of the study were to analyze the effect of a 7-month military training program on body composition variables and the suitability of specific ‘bioelectrical impedance vector analysis’ (spBIVA), compared to DXA, to detect the changes in body composition. A sample of 270 male Brazilian cadets (19.1 ± 1.1 years), composed of a group practicing military physical training routine only (MT = 155) and a group involved in a specific sport training (SMT = 115), were measured by body composition assessments (evaluated by means of DXA and spBIVA) at the beginning and the end of the military routine year. The effect of training on body composition was similar in SMT and MT groups, with an increase in LST. DXA and spBIVA were correlated, with specific resistance (Rsp) and reactance (Xcsp) positively related to fat mass (FM), FM%, LST, and lean soft tissue index (LSTI), and phase angle positively related to LST and LSTI. Body composition variations due to physical training were recognized by spBIVA: the increase in muscle mass was indicated by the phase angle and Xcsp increase, and the stability of FM% was consistent with the unchanged values of Rsp. Military training produced an increase in muscle mass, but no change in FM%, independently of the sample characteristics at baseline and the practice of additional sports. SpBIVA is a suitable technique for the assessment of body composition in military people.
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Affiliation(s)
- Luis Alberto Gobbo
- Skeletal Muscle Assessment Laboratory (LABSIM), School of Technology and Science, São Paulo State University (UNESP), Presidente Prudente 19060-900, SP, Brazil;
| | - Raquel David Langer
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil; (R.D.L.); (J.H.B.); (M.A.P.); (V.X.C.); (G.G.-J.); (E.M.G.)
| | - Elisabetta Marini
- Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy;
- Correspondence: ; Tel.: +39-070-675-6607
| | - Roberto Buffa
- Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy;
| | - Juliano Henrique Borges
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil; (R.D.L.); (J.H.B.); (M.A.P.); (V.X.C.); (G.G.-J.); (E.M.G.)
| | - Mauro A. Pascoa
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil; (R.D.L.); (J.H.B.); (M.A.P.); (V.X.C.); (G.G.-J.); (E.M.G.)
| | - Vagner X. Cirolini
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil; (R.D.L.); (J.H.B.); (M.A.P.); (V.X.C.); (G.G.-J.); (E.M.G.)
| | - Gil Guerra-Júnior
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil; (R.D.L.); (J.H.B.); (M.A.P.); (V.X.C.); (G.G.-J.); (E.M.G.)
| | - Ezequiel Moreira Gonçalves
- Growth and Development Laboratory, Center for Investigation in Pediatrics (CIPED), School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-887, SP, Brazil; (R.D.L.); (J.H.B.); (M.A.P.); (V.X.C.); (G.G.-J.); (E.M.G.)
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27
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Stäuber A, Heydenreich M, Wright PR, Großmann S, Grusdat N, Zermann DH, Schulz H. Bioelectrical Impedance Vector Pattern and Biomarkers of Physical Functioning of Prostate Cancer Survivors in Rehabilitation. Rehabil Process Outcome 2022; 10:11795727211064156. [PMID: 34987305 PMCID: PMC8689438 DOI: 10.1177/11795727211064156] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/05/2021] [Accepted: 11/04/2021] [Indexed: 11/21/2022] Open
Abstract
Background: Knowledge of clinically established factors of physical function such as body
composition, bioelectrical phase angle (PhA) and handgrip strength (HGS)
with mortality predictive and health-related relevance is limited in
prostate cancer survivors (PCS). Therefore, the aim of this study was to
characterise and compare body composition data of PCS with extensive
reference data as well as to analyse PhA and HGS and the prevalence of
critical prognostic values at an early stage of cancer survivorship. Methods: One hundred and forty-eight PCS were examined at the start (T1) and end (T2)
of a 3-week hospitalised urooncological rehabilitation, which began median
28 days after acute cancer therapy. Examinations included a bioimpedance
analysis and HGS test. Comparison of body composition between PCS and
reference data was performed using bioimpedance vector analysis (BIVA). Results: BIVA of the whole PCS group showed abnormal physiology with a cachectic state
and a state of overhydration/oedema, without significant changes between T1
and T2. The age- and BMI-stratified subgroup analysis showed that PCS aged
60 years and older had this abnormal pattern compared to the reference
population. HGS (T1: 38.7 ± 8.9 vs T2: 40.8 ± 9.4, kg), but not PhA (T1/T2:
5.2 ± 0.7, °), changed significantly between T1 and T2. Values below a
critical threshold reflecting a potentially higher risk of mortality and
impaired function were found for PhA in 20% (T1) and 22% (T2) of PCS and in
41% (T1) and 29% (T2) for HGS. Conclusions: BIVA pattern and the prevalence of critically low HGS and PhA values
illustrate the necessity for intensive continuation of rehabilitation and
survivorship care especially in these ‘at risk’ cases. The routine
assessment of body composition, PhA and HGS offer the opportunity to conduct
a risk stratification for PCS and could help personalising and optimising
treatment in rehabilitation and ongoing survivorship care.
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Affiliation(s)
- Alexander Stäuber
- Professorship of Sports Medicine/Sports Biology, Chemnitz University of Technology, Chemnitz, Germany
| | - Marc Heydenreich
- Division of Sports and Training Science, Vogtland-Klinik Bad Elster, Bad Elster, Germany
| | - Peter R Wright
- Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Oxford, UK
| | - Steffen Großmann
- Professorship of Sports Medicine/Sports Biology, Chemnitz University of Technology, Chemnitz, Germany
| | - Niklas Grusdat
- Professorship of Sports Medicine/Sports Biology, Chemnitz University of Technology, Chemnitz, Germany
| | - Dirk-Henrik Zermann
- Division of Sports and Training Science, Vogtland-Klinik Bad Elster, Bad Elster, Germany.,Department of Urology & Urooncology, Vogtland-Klinik Bad Elster, Bad Elster, Germany
| | - Henry Schulz
- Professorship of Sports Medicine/Sports Biology, Chemnitz University of Technology, Chemnitz, Germany
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Do JY, Kim AY, Kang SH. Association Between Phase Angle and Sarcopenia in Patients Undergoing Peritoneal Dialysis. Front Nutr 2021; 8:742081. [PMID: 34631771 PMCID: PMC8497817 DOI: 10.3389/fnut.2021.742081] [Citation(s) in RCA: 23] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2021] [Accepted: 08/23/2021] [Indexed: 12/15/2022] Open
Abstract
Introduction: There is limited data on the association between phase angle (PhA) and sarcopenia using both muscle strength and muscle mass in patients undergoing peritoneal dialysis (PD). We aimed to evaluate the association between PhA and sarcopenia in patients undergoing PD. Methods: We enrolled prevalent patients undergoing PD (n = 200). The patients were divided into tertiles based on their PhA level: low (n = 66; 1.9–4°), middle (n = 68; 4.1–4.9°), and high tertiles (n = 66; 5–8°). PhA was measured by a bioimpedance analysis. Handgrip strength (HGS) was measured in all the patients. Body compositions were measured by dual energy x-ray absorptiometry (DXA). Results: Handgrip strength (HGS) and/or lean mass indices showed poorer trends in the low tertile than in the other tertiles. PhA was positively associated with HGS and/or muscle mass index. Multivariate analyses showed that the patients in the low tertile had an odds ratio of 9.8 (p = 0.001) and 52.79 (p < 0.001) for developing sarcopenia compared with those in the middle and high tertiles, respectively. Subgroup analyses using these variables yielded results similar to those from the total cohort. Conclusion: This study demonstrated that PhA is independently associated with muscle mass, strength, and sarcopenia in patients undergoing PD. This result suggests that PhA can be used as a valuable and simple predictor for identifying patients undergoing PD who are at risk of sarcopenia.
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Affiliation(s)
- Jun Young Do
- Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, South Korea
| | - A Young Kim
- Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, South Korea
| | - Seok Hui Kang
- Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, South Korea
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29
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Petroni ML, Brodosi L, Marchignoli F, Sasdelli AS, Caraceni P, Marchesini G, Ravaioli F. Nutrition in Patients with Type 2 Diabetes: Present Knowledge and Remaining Challenges. Nutrients 2021; 13:2748. [PMID: 34444908 PMCID: PMC8401663 DOI: 10.3390/nu13082748] [Citation(s) in RCA: 38] [Impact Index Per Article: 9.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/12/2021] [Revised: 08/03/2021] [Accepted: 08/06/2021] [Indexed: 02/07/2023] Open
Abstract
Unhealthy behaviours, including diet and physical activity, coupled with genetic predisposition, drive type 2 diabetes (T2D) occurrence and severity; the present review aims to summarise the most recent nutritional approaches in T2D, outlining unmet needs. Guidelines consistently suggest reducing energy intake to counteract the obesity epidemic, frequently resulting in sarcopenic obesity, a condition associated with poorer metabolic control and cardiovascular disease. Various dietary approaches have been proposed with largely similar results, with a preference for the Mediterranean diet and the best practice being the diet that patients feel confident of maintaining in the long term based on individual preferences. Patient adherence is indeed the pivotal factor for weight loss and long-term maintenance, requiring intensive lifestyle intervention. The consumption of nutritional supplements continues to increase even if international societies do not support their systematic use. Inositols and vitamin D supplementation, as well as micronutrients (zinc, chromium, magnesium) and pre/probiotics, result in modest improvement in insulin sensitivity, but their use is not systematically suggested. To reach the desired goals, patients should be actively involved in the collaborative development of a personalised meal plan associated with habitual physical activity, aiming at normal body weight and metabolic control.
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Affiliation(s)
- Maria Letizia Petroni
- IRCCS-Azienda Ospedaliera di Bologna Sant’Orsola-Malpighi, I-40138 Bologna, Italy; (M.L.P.); (L.B.); (F.M.); (A.S.S.); (P.C.); (F.R.)
- Department of Medical and Surgical Sciences, Alma Mater University of Bologna, I-40138 Bologna, Italy
| | - Lucia Brodosi
- IRCCS-Azienda Ospedaliera di Bologna Sant’Orsola-Malpighi, I-40138 Bologna, Italy; (M.L.P.); (L.B.); (F.M.); (A.S.S.); (P.C.); (F.R.)
- Department of Medical and Surgical Sciences, Alma Mater University of Bologna, I-40138 Bologna, Italy
| | - Francesca Marchignoli
- IRCCS-Azienda Ospedaliera di Bologna Sant’Orsola-Malpighi, I-40138 Bologna, Italy; (M.L.P.); (L.B.); (F.M.); (A.S.S.); (P.C.); (F.R.)
| | - Anna Simona Sasdelli
- IRCCS-Azienda Ospedaliera di Bologna Sant’Orsola-Malpighi, I-40138 Bologna, Italy; (M.L.P.); (L.B.); (F.M.); (A.S.S.); (P.C.); (F.R.)
| | - Paolo Caraceni
- IRCCS-Azienda Ospedaliera di Bologna Sant’Orsola-Malpighi, I-40138 Bologna, Italy; (M.L.P.); (L.B.); (F.M.); (A.S.S.); (P.C.); (F.R.)
- Department of Medical and Surgical Sciences, Alma Mater University of Bologna, I-40138 Bologna, Italy
| | - Giulio Marchesini
- Department of Medical and Surgical Sciences, Alma Mater University of Bologna, I-40138 Bologna, Italy
| | - Federico Ravaioli
- IRCCS-Azienda Ospedaliera di Bologna Sant’Orsola-Malpighi, I-40138 Bologna, Italy; (M.L.P.); (L.B.); (F.M.); (A.S.S.); (P.C.); (F.R.)
- Department of Medical and Surgical Sciences, Alma Mater University of Bologna, I-40138 Bologna, Italy
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30
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Rosas-Carrasco O, Ruiz-Valenzuela RE, López-Teros MT. Phase Angle Cut-Off Points and Their Association With Sarcopenia and Frailty in Adults of 50-64 Years Old and Older Adults in Mexico City. Front Med (Lausanne) 2021; 8:617126. [PMID: 33791322 PMCID: PMC8005522 DOI: 10.3389/fmed.2021.617126] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/14/2020] [Accepted: 02/12/2021] [Indexed: 12/13/2022] Open
Abstract
Background: In recent studies, the usefulness of the phase angle (PA) to assess geriatric conditions such as sarcopenia and frailty has been evaluated. However, there are no useful cut-off points for clinical research and/or practice. Objective: To analyze PA cut-off points associated with sarcopenia and frailty in adults of 50-64 years old and older adults in Mexico City. Design: Cross-sectional analysis of the FraDySMex cohort study (Frailty, Dynapenia, and Sarcopenia in Mexican Adults). Setting and Participants: 498 people were included, 78.7% women, aged 71.1 ± 9.5 years. Methods: The sarcopenia measurements were made according to the European Working Group on Sarcopenia in Older People (EWGSOP) (2019) (by dynamometer to evaluate hand grip strength and dual energy X-ray absorptiometry (DXA) for appendicular muscle mass), and the frailty through the physical frailty phenotype with cut-off points adjusted to the Mexican population. The PA was evaluated by bioelectrical impedance analysis (BIA), tetrapolar to 50 Hz, other variables such as socio-demographic, comorbidity, cognitive status, and functional dependence were evaluated. Results: The prevalence of frailty was 10.6% and sarcopenia 10.0%. The mean of the PA was 4.6° ± 0.70°. The PA cut-off point for frailty in adults 50 to 64 years was ≤4.3° [sensitivity (S) = 91.95%, specificity (Sp) 66.77%, AUROC (Area Under the Receiver Operating Characteristic) curve = 0.9273 95% CI (0.8720-0.9825)]; the PA cut-off point for sarcopenia was ≤4.3 [S = 91.95%, Sp = 66.77%, AUROC = 0.9306 95% CI (0.8508-1.000)]. The PA cut-off for frailty in adults ≥ 65 years was ≤4.1° [S = 72.37%, Sp 71.43%, AUROC = 0.7925 95%, CI (0.7280-0.8568)] for sarcopenia was ≤4.1° [S = 72.76%, Sp 73.81%, AUROC = 0.7930 95% CI (0.7272-0.8587)]. These cut-off points showed a significant association between PA with frailty (OR 4.84; 95% CI 2.61-8.99) and sarcopenia (OR 8.44; 95% CI 3.85-18.4) after adjusted by age, sex, BMI, comorbidity index and cognitive impairment. Conclusions and Implications: These cut-off points of PA could be useful for the screening of sarcopenia and frailty in Mexican adults of 50 years and older in centers that have BIA.
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Affiliation(s)
- Oscar Rosas-Carrasco
- Health Department, Ibero American University, Mexico City, Mexico
- Instituto Nacional de Geriatría, Mexico City, Mexico
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31
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Stagi S, Irurtia A, Rosales Rafel J, Cabras S, Buffa R, Carrasco-Marginet M, Castizo-Olier J, Marini E. Segmental body composition estimated by specific BIVA and dual-energy X-ray absorptiometry. Clin Nutr 2021; 40:1621-1627. [PMID: 33752150 DOI: 10.1016/j.clnu.2021.02.043] [Citation(s) in RCA: 16] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2021] [Revised: 02/25/2021] [Accepted: 02/27/2021] [Indexed: 11/19/2022]
Abstract
AIMS The aim of this study was to analyse the association between specific bioelectric impedance vector analysis (BIVA) and dual-energy X-ray absorptiometry (DXA) to assess segmental body composition using DXA as the reference technique. METHODS The sample comprised 50 young active students who practised or played different sports (25 men, age: 24.37 ± 4.79 y; 25 women, age: 24.32 ± 4.43 y) from the National Institute of Physical Education of Catalonia (INEFC). Anthropometric data (height, weight, arm, waist, and calf circumferences) and bioelectrical measurements (R, ohm; Xc, ohm) were recorded. Body composition was analysed with specific BIVA. DXA was used as the reference method to assess body composition of the whole-body, the trunk, and the limbs. The percentage of fat mass (%FMDXA) and fat-free mass index (FFMIDXA = FFM/length2) were calculated. The agreement between specific BIVA and DXA was evaluated by a depth-depth analysis, two-way ANOVA, and Pearson's correlations. RESULTS The depth-depth analysis showed a good agreement between DXA and BIVA (F = 14.89, p < 0.001) in both sexes and all body segments. Specific vector length (Zsp; i.e. indicative of %FM) was correlated with %FMDXA in the whole body and all body segments, and the phase angle was correlated with FFMIDXA, with he trunk in women as the only exception. Specific BIVA demonstrated to balance the effect of body size on bioelectrical measurements in both whole and segmental approaches. CONCLUSIONS Segmental specific BIVA and DXA provided a consistent evaluation of body composition in both sexes, of the whole body and each body segment. The indices %FM and FFMI obtained with DXA were correlated to vector length and phase angle in each segment, respectively. Specific BIVA represents a promising technique for monitoring segmental body composition changes in sport science and clinical applications.
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Affiliation(s)
- Silvia Stagi
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, 09042, Italy.
| | - Alfredo Irurtia
- Department of Sports Performance, National Institute of Physical Education of Catalonia, University of Barcelona, Barcelona, Spain
| | - Joaquim Rosales Rafel
- Faixat Body Scan Sport Department, Avinguda de L'Estadi, 12-22, Barcelona, 08038, Spain
| | - Stefano Cabras
- Department of Statistics, Universidad Carlos III de Madrid, Getafe, Spain
| | - Roberto Buffa
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, 09042, Italy
| | - Marta Carrasco-Marginet
- Department of Health and Applied Sciences, National Institute of Physical Education of Catalonia, University of Barcelona, Barcelona, Spain
| | - Jorge Castizo-Olier
- School of Health Sciences, Tecnocampus Mataró-Maresme, Pompeu Fabra University, Mataró, Spain
| | - Elisabetta Marini
- Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, 09042, Italy.
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Pisano C, Polisano D, Balistreri CR, Altieri C, Nardi P, Bertoldo F, Trombetti D, Asta L, Ferrante MS, Buioni D, Foti C, Ruvolo G. Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery. Nutrients 2021; 13:nu13020517. [PMID: 33562449 PMCID: PMC7915488 DOI: 10.3390/nu13020517] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2020] [Revised: 01/27/2021] [Accepted: 01/29/2021] [Indexed: 12/16/2022] Open
Abstract
Frailty is the major expression of accelerated aging and describes a decreased resistance to stressors, and consequently an increased vulnerability to additional diseases in elderly people. The vascular aging related to frail phenotype reflects the high susceptibility for cardiovascular diseases and negative postoperative outcomes after cardiac surgery. Sarcopenia can be considered a biological substrate of physical frailty. Malnutrition and physical inactivity play a key role in the pathogenesis of sarcopenia. We searched on Medline (PubMed) and Scopus for relevant literature published over the last 10 years and analyzed the strong correlation between frailty, sarcopenia and cardiovascular diseases in elderly patient. In our opinion, a right food intake and moderate intensity resistance exercise are mandatory in order to better prepare patients undergoing cardiac operation.
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Affiliation(s)
- Calogera Pisano
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
- Correspondence: ; Tel.: +39-328-329-7692; Fax: +39-(06)-2090-3538
| | - Daniele Polisano
- Physical and Rehabilitation Medicine, Tor Vergata University of Rome, 00133 Rome, Italy; (D.P.); (C.F.)
| | - Carmela Rita Balistreri
- Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90133 Palermo, Italy;
| | - Claudia Altieri
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Paolo Nardi
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Fabio Bertoldo
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Daniele Trombetti
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Laura Asta
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Maria Sabrina Ferrante
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Dario Buioni
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
| | - Calogero Foti
- Physical and Rehabilitation Medicine, Tor Vergata University of Rome, 00133 Rome, Italy; (D.P.); (C.F.)
| | - Giovanni Ruvolo
- Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy; (C.A.); (P.N.); (F.B.); (D.T.); (L.A.); (M.S.F.); (D.B.); (G.R.)
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Di Battista M, Barsotti S, Monaco A, Rossi A, Della Rossa A, Mosca M. Bioelectrical Impedance Vector Analysis for Nutritional Status Assessment in Systemic Sclerosis and Association With Disease Characteristics. J Rheumatol 2020; 48:728-734. [PMID: 33060305 DOI: 10.3899/jrheum.200964] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 10/06/2020] [Indexed: 01/10/2023]
Abstract
OBJECTIVE To use bioelectrical impedance vector analysis (BIVA) in a cohort of patients with systemic sclerosis (SSc) in order to assess their nutritional status in comparison to other groups of patients and to find any correlation with clinical characteristics and outcome of the disease. METHODS We retrospectively collected data from 50 SSc patients who underwent BIVA for clinical suspicion of malnutrition and compared them with patients affected by other chronic autoimmune rheumatic diseases (OCAD, n = 27) and those who were only symptomatic of malnutrition but without autoimmune features (n = 15), and with 50 healthy controls (HC). RESULTS Patients with SSc presented significantly lower values of phase angle (PhA), basal metabolic rate (BMR), and body cellular mass (BCM), and an increase in extracellular water (ECW; P < 0.01 for all) than HC; instead, there were no significant differences for BMI. No significant differences were found between SSc and OCAD. Among patients with SSc, age directly correlated with ECW (ρ = 0.342, P = 0.015) and inversely with PhA (ρ = -0.366, P = 0.009). Female sex, anemia, hypoalbuminemia, reflux, and early satiety/abdominal distension associated with relevant alterations in BIVA results. BIVA variables were significantly different when cardiopulmonary and microvascular involvement was present. Four patients died during the study: they had significantly (P ≤ 0.01) lower PhA, BMR, and BCM, with an increased ECW. CONCLUSION BIVA, unlike BMI, allowed an accurate characterization of SSc patients at risk of malnutrition, correlating with serological malnutrition markers, with SSc-specific organ manifestations (cardiopulmonary involvement and microvascular damage), and with mortality. BIVA variables might represent a surrogate marker of damage accrual that leads to malnutrition, thus playing a leading role in the prognostic stratification of SSc patients.
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Affiliation(s)
- Marco Di Battista
- M. Di Battista, MD, S. Barsotti, MD, PhD, A. Monaco, MD, A. Rossi, MD, A. Della Rossa, MD, PhD, M. Mosca, MD, PhD, Professor, Rheumatology Unit, University of Pisa, Pisa, Italy
| | - Simone Barsotti
- M. Di Battista, MD, S. Barsotti, MD, PhD, A. Monaco, MD, A. Rossi, MD, A. Della Rossa, MD, PhD, M. Mosca, MD, PhD, Professor, Rheumatology Unit, University of Pisa, Pisa, Italy
| | - Alessia Monaco
- M. Di Battista, MD, S. Barsotti, MD, PhD, A. Monaco, MD, A. Rossi, MD, A. Della Rossa, MD, PhD, M. Mosca, MD, PhD, Professor, Rheumatology Unit, University of Pisa, Pisa, Italy
| | - Alessandra Rossi
- M. Di Battista, MD, S. Barsotti, MD, PhD, A. Monaco, MD, A. Rossi, MD, A. Della Rossa, MD, PhD, M. Mosca, MD, PhD, Professor, Rheumatology Unit, University of Pisa, Pisa, Italy
| | - Alessandra Della Rossa
- M. Di Battista, MD, S. Barsotti, MD, PhD, A. Monaco, MD, A. Rossi, MD, A. Della Rossa, MD, PhD, M. Mosca, MD, PhD, Professor, Rheumatology Unit, University of Pisa, Pisa, Italy.
| | - Marta Mosca
- M. Di Battista, MD, S. Barsotti, MD, PhD, A. Monaco, MD, A. Rossi, MD, A. Della Rossa, MD, PhD, M. Mosca, MD, PhD, Professor, Rheumatology Unit, University of Pisa, Pisa, Italy
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Marini E, Buffa R, Gobbo LA, Salinas-Escudero G, Stagi S, García-Peña C, Sánchez-García S, Carrillo-Vega MF. Interpopulation Similarity of Sex and Age-Related Body Composition Variations Among Older Adults. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2020; 17:ijerph17176047. [PMID: 32825260 PMCID: PMC7503589 DOI: 10.3390/ijerph17176047] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/17/2020] [Revised: 08/12/2020] [Accepted: 08/16/2020] [Indexed: 02/03/2023]
Abstract
The aim of the study was to analyze sex and age-related body composition variations among older adults from the Brazilian, Italian, and Mexican population. A cross-sectional analysis was conducted in 1103 community-dwelling older adults (634 women and 469 men), aged 60 to 89 years, living in Brazil (n = 176), Italy (n = 554), and Mexico (n = 373). Anthropometric measurements were taken, BMI was calculated, and impedance measurements were obtained (resistance, R, reactance, Xc). Specific bioelectrical impedance vector analysis (specific BIVA) was applied, with the specific vector defined by impedance, or vector length (Z = (Rsp2 + Xcsp)0.5), and phase angle (PA = arctan Xc/R 180/π). Population, sex, and age differences in anthropometric and bioelectrical variables were evaluated by means of a two way ANOVA. The mean bioelectrical vectors were graphed by confidence ellipses and statistically compared by the Hotelling's T2 test. The three population groups showed differences in body mass and composition (p < 0.001): the Brazilian sample was characterized by greater body dimensions, longer vectors (higher relative content of fat mass), and lower phase angles (lower skeletal muscle mass). Men were taller and heavier than women (p < 0.001) but had a similar BMI (p = 0.102). They also had higher phase angle (higher skeletal muscle mass) (p < 0.001) and lower vector length (lower %FM) (p < 0.001). In the three population groups, the oldest individuals showed lower anthropometric and phase angle values with respect to the youngest ones (p < 0.001), whereas the vector length did not change significantly with age (p = 0.665). Despite the differences between sexes and among populations, the trend of age-related variations was similar in the Brazilian, Italian, and Mexican older adults.
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Affiliation(s)
- Elisabetta Marini
- Department of Life and Environmental Science, Neuroscience and Anthropological Section, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy; (E.M.); (R.B.); (S.S.)
| | - Roberto Buffa
- Department of Life and Environmental Science, Neuroscience and Anthropological Section, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy; (E.M.); (R.B.); (S.S.)
| | - Luis Alberto Gobbo
- Department of Physical Education, School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, São Paulo 19060-900, Brazil;
| | - Guillermo Salinas-Escudero
- Center for Economic and Social Studies in Health, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico;
| | - Silvia Stagi
- Department of Life and Environmental Science, Neuroscience and Anthropological Section, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy; (E.M.); (R.B.); (S.S.)
| | - Carmen García-Peña
- Research Department, Instituto Nacional de Geriatría, Mexico City 10200, Mexico;
| | - Sergio Sánchez-García
- Epidemiology and Health Services Research Unit, Aging Area, IMSS, Mexico City 06720, Mexico;
| | - María Fernanda Carrillo-Vega
- Geriatric Epidemiology Unit, Research Department, National Institute of Geriatrics, Instituto Nacional de Geriatría, Mexico City 10200, Mexico
- Correspondence:
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Effects of Resistance Training with Different Pyramid Systems on Bioimpedance Vector Patterns, Body Composition, and Cellular Health in Older Women: A Randomized Controlled Trial. SUSTAINABILITY 2020. [DOI: 10.3390/su12166658] [Citation(s) in RCA: 17] [Impact Index Per Article: 3.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/21/2022]
Abstract
Bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been widely used to monitor changes in health-related parameters in older adults, while resistance training (RT) is one of the potential strategies to mitigate the adverse effects of aging. The purpose of this study was to compare the effects of the crescent pyramid RT system with two repetition zones on BIVA patterns and PhA. Fifty-five older women (≥60 years) were randomly assigned into three groups: control (CON, n = 18), narrow pyramid (NPR, n = 19), and wide pyramid (WPR, n = 18). The RT was performed for eight weeks, three times per week, in eight exercises for the whole body with three sets of 12/10/8 (NPR) or 15/10/5 repetitions (WPR). Bioimpedance spectroscopy (50 kHz frequency) was assessed. After the intervention period, both training groups showed significant changes in BIVA patterns compared to CON (p < 0.001); resistance decreased and reactance increased, which resulted in a BIVA-vector displacement over time (p < 0.001). Changes in PhA were greater for WPR (∆% = 10.6; effect size [ES] = 0.64) compared to NPR (∆% = 5.3; ES = 0.41) and CON (∆% = −6.4; ES = −0.40). The results suggest that the crescent pyramid RT system with both repetition zones (WPR and NPR) is effective for inducing improvements in BIVA patterns and PhA in older women, although WPR elicits greater increases in PhA than NPR.
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Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review. Clin Nutr 2020; 39:2368-2388. [DOI: 10.1016/j.clnu.2019.11.024] [Citation(s) in RCA: 203] [Impact Index Per Article: 40.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/24/2019] [Revised: 11/06/2019] [Accepted: 11/06/2019] [Indexed: 12/12/2022]
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Wells JC, Williams JE, Ward LC, Fewtrell MS. Utility of specific bioelectrical impedance vector analysis for the assessment of body composition in children. Clin Nutr 2020; 40:1147-1154. [PMID: 32788087 PMCID: PMC7957362 DOI: 10.1016/j.clnu.2020.07.022] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/17/2020] [Revised: 07/07/2020] [Accepted: 07/17/2020] [Indexed: 11/29/2022]
Abstract
Background & aims Bioelectrical impedance analysis (BIA) is widely considered a body composition technique suitable for routine application. However, its utility in sick or malnourished children is complicated by variability in hydration. A BIA variant termed vector analysis (BIVA) aims to resolve this, by differentiating hydration from cell mass. However, the model was only partially supported by children's data. To improve accuracy, further adjustment for body shape variability has been proposed, known as specific BIVA (BIVAspecific). Methods We re-analysed body composition data from 281 children and adolescents (46% male) aged 4–20 years of European ancestry. Measurements included anthropometry, conventional BIA, BIVA outcomes adjusted either for height (BIVAconventional), or for height and body cross-sectional area (BIVAspecific), and fat-free mass (FFM) and fat mass (FM) by the criterion 4-component model. Graphic analysis and regression analysis were used to evaluate different BIA models for predicting FFM and FM. Results Age was strongly correlated with BIVAconventional parameters, but weakly with BIVAspecific parameters. FFM correlated more strongly with BIVAconventional than with BIVAspecific parameters, whereas the opposite pattern was found for FM. In multiple regression analyses, the best prediction models combined conventional BIA with BIVAspecific parameters, explaining 97.0% and 89.8% of the variance in FFM and FM respectively. These models could be further improved by incorporating body weight. Conclusions The prediction of body composition can be improved by combining two different theoretical models, each of which appears to provide different information about the two components FFM and FM. Further work should test the utility of this approach in pediatric patients.
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Affiliation(s)
- Jonathan Ck Wells
- Childhood Nutrition Research Centre, Population, Policy and Practice Reseach and Teaching Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
| | - Jane E Williams
- Childhood Nutrition Research Centre, Population, Policy and Practice Reseach and Teaching Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
| | - Leigh C Ward
- School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
| | - Mary S Fewtrell
- Childhood Nutrition Research Centre, Population, Policy and Practice Reseach and Teaching Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
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Streb AR, Hansen F, Gabiatti MP, Tozetto WR, Del Duca GF. Phase angle associated with different indicators of health-related physical fitness in adults with obesity. Physiol Behav 2020; 225:113104. [PMID: 32712208 DOI: 10.1016/j.physbeh.2020.113104] [Citation(s) in RCA: 26] [Impact Index Per Article: 5.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/21/2020] [Revised: 07/06/2020] [Accepted: 07/22/2020] [Indexed: 12/20/2022]
Abstract
In obese populations, the exacerbated increase in adipose tissue results in a significant reduction of health-related physical fitness and can affect the phase angle (PhA), a promising health indicator of cell health and integrity. The aim of this study was to investigate the association of PhA with health-related physical fitness indicators in obese adults. This cross-sectional study had a non-probabilistic sample and was conducted from April to June 2018. The PhA was obtained by a bioelectrical impedance analysis, and the health-related physical fitness indicators evaluated were percentage of body fat (%BF), lower- and upper-body maximal strength, cardiorespiratory fitness (relative V̇O2peak), and flexibility. Pearson and Spearman´s linear correlations, crude and adjusted linear regression analyses were performed. A total of 69 obese adults (60.8% female; BMI = 33.5 ± 2.8 kg/m2) with a mean age of 34.6 ± 7.1 years were studied. The PhA means were 5.8 (±0.6º) and had an inverse correlation with %BF (r=-0.74; p<0.001) and positive correlation with V̇O2peak (r=0.50; p<0.001), lower- and upper-body maximal strength (r=0.65; r=0.70; p<0.001, respectively). After adjustment, %BF (β=-0.065, adjusted R2=0.53; p<0.001), lower- and upper-body maximal strength (β=0.004; adjusted R2=0.46; p<0.001, and β=0.024; adjusted R2=0.50; p<0.001, respectively) were predictors of PhA. Our results suggest the favorable role of PhA as a clinically viable tool to screen and identify the physical fitness variables and functional status of obese adults.
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Affiliation(s)
- Anne Ribeiro Streb
- Center of Sports - CDS, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil.
| | - Fernanda Hansen
- Health Sciences Center - CCS, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil
| | - Mariana Papini Gabiatti
- Health Sciences Center - CCS, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil
| | - Willen Remon Tozetto
- Center of Sports - CDS, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil
| | - Giovani Firpo Del Duca
- Center of Sports - CDS, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil
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Barrea L, Pugliese G, de Alteriis G, Colao A, Savastano S, Muscogiuri G. Phase Angle: Could Be an Easy Tool to Detect Low-Grade Systemic Inflammation in Adults Affected by Prader-Willi Syndrome? Nutrients 2020; 12:E2065. [PMID: 32664600 PMCID: PMC7400955 DOI: 10.3390/nu12072065] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/11/2020] [Revised: 07/01/2020] [Accepted: 07/07/2020] [Indexed: 02/06/2023] Open
Abstract
Prader-Willi syndrome (PWS) is the most common genetic inherited obesity syndrome. Obesity-related complications, mostly related to chronic low-grade systemic inflammation (LGI), are the commonest cause of mortality and morbidity in PWS adults. Phase angle (PhA) is an easy tool to screen a state of LGI in healthy subjects and in subjects with obesity and is obtained from bioelectrical impedance analysis (BIA). The aim of this study was to validate the PhA in PWS adults as a potential biomarker of LGI. In this single-center, cross-sectional study, fifteen PWS adults (six males, aged 19-41 years, and body mass index (BMI) 31.0-68.0 Kg/m2) and fifteen control subjects matched by gender, age, and BMI were evaluated. PhA values were significantly lower (p < 0.001), while high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher (p < 0.001) in PWS adults compared with controls (p < 0.001), without a gender difference in the latter. After adjustment for gender, BMI, and waist circumference, significant correlation was found between PhA and hs-CRP levels (r = -0.69, p = 0.01). At the ROC analysis, the threshold value of PhA predicting the highest hs-CRP levels above the median value was found at PhA ≤ 4.8° (p = 0.01; AUC, 0.82; standard error, 0.12; 95% CI, 0.58 to 1.00). These results suggest that PWS adults had a significant higher degree of LGI compared with their counterparts. Moreover, our finding suggest that PhA is a valid biomarker of LGI also in PWS adults.
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Affiliation(s)
- Luigi Barrea
- Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy; (G.P.); (G.d.A.); (A.C.); (S.S.); (G.M.)
- Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
| | - Gabriella Pugliese
- Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy; (G.P.); (G.d.A.); (A.C.); (S.S.); (G.M.)
- Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
| | - Giulia de Alteriis
- Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy; (G.P.); (G.d.A.); (A.C.); (S.S.); (G.M.)
| | - Annamaria Colao
- Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy; (G.P.); (G.d.A.); (A.C.); (S.S.); (G.M.)
- Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
- Cattedra Unesco “Educazione alla Salute e allo Sviluppo Sostenibile”, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
| | - Silvia Savastano
- Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy; (G.P.); (G.d.A.); (A.C.); (S.S.); (G.M.)
- Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
| | - Giovanna Muscogiuri
- Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy; (G.P.); (G.d.A.); (A.C.); (S.S.); (G.M.)
- Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
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Battaglia Y, Ullo I, Massarenti S, Esposito P, Prencipe M, Ciancio G, Provenzano M, Fiorini F, Andreucci M, Storari A, Sabatino A, Fiaccadori E, Granata A, On behalf of the Ultrasound Study Group of the Italian Society of Nephrology. Ultrasonography of Quadriceps Femoris Muscle and Subcutaneous Fat Tissue and Body Composition by BIVA in Chronic Dialysis Patients. Nutrients 2020; 12:1388. [PMID: 32408709 PMCID: PMC7285004 DOI: 10.3390/nu12051388] [Citation(s) in RCA: 27] [Impact Index Per Article: 5.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2020] [Revised: 04/28/2020] [Accepted: 05/08/2020] [Indexed: 02/07/2023] Open
Abstract
Protein Energy Wasting (PEW) in hemodialysis (HD) patients is a multifactorial condition due to specific pathology-related pathogenetic mechanisms, leading to loss of skeletal muscle mass in HD patients. Computed Tomography and Magnetic Resonance Imaging still represent the gold standard techniques for body composition assessment. However, their widespread application in clinical practice is difficult and body composition evaluation in HD patients is mainly based on conventional anthropometric nutritional indexes and bioelectrical impedance vector analysis (BIVA). Little data is currently available on ultrasound (US)-based measurements of muscle mass and fat tissue in this clinical setting. The purpose of our study is to ascertain: (1) if there are differences between quadriceps rectus femoris muscle (QRFM) thickness and abdominal/thigh subcutaneous fat tissue (SFT) measured by US between HD patients and healthy subjects; (2) if there is any correlation between QRFM and abdominal/thigh SFT thickness by US, and BIVA/conventional nutritional indexes in HD patients. We enrolled 65 consecutive HD patients and 33 healthy subjects. Demographic and laboratory were collected. The malnutrition inflammation score (MIS) was calculated. Using B-mode US system, the QRFM and SFT thicknesses were measured at the level of three landmarks in both thighs (superior anterior iliac spine, upper pole of the patella, the midpoint of the tract included between the previous points). SFT was also measured at the level of the periumbilical point. The mono frequency (50 KHz) BIVA was conducted using bioelectrical measurements (Rz, resistance; Xc, reactance; adjusted for height, Rz/H and Xc/H; PA, phase angle). 58.5% were men and the mean age was 69 (SD 13.7) years. QRFM and thigh SFT thicknesses were reduced in HD patients as compared to healthy subjects (p < 0.01). Similarly, also BIVA parameters, expression of lean body mass, were lower (p < 0.001), except for Rz and Rz/H in HD patients. The average QRFM thickness of both thighs at top, mid, lower landmarks were positively correlated with PA and body cell mass (BCM) by BIVA, while negatively correlated with Rz/H (p < 0.05). Abdominal SFT was positively correlated with PA, BCM and basal metabolic rate (BMR) (p < 0.05). Our study shows that ultrasound QRFM and thigh SFT thicknesses were reduced in HD patients and that muscle ultrasound measurements were significantly correlated with BIVA parameters.
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Affiliation(s)
- Yuri Battaglia
- Division of Nephrology and Dialysis, St. Anna University Hospital, 44121 Ferrara, Italy;
| | - Ines Ullo
- Division of Nephrology, ASST Sette Laghi, 21100 Varese, Italy;
| | - Sara Massarenti
- Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, 44121 Ferrara, Italy;
| | - Pasquale Esposito
- Division of Nephrology, Dialysis and Transplantation, University of Genoa and IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy;
| | - Michele Prencipe
- Division of Nephrology, Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71100 Foggia, Italy;
| | - Giovanni Ciancio
- Division of Rheumatology, University of Ferrara, 44121 Ferrara, Italy;
| | - Michele Provenzano
- Division of Nephrology and Dialysis, Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy; (M.P.); (M.A.)
| | - Fulvio Fiorini
- Division of Nephrology and Dialysis, “Santa Maria della Misericordia” Hospital, 45100 Rovigo, Italy;
| | - Michele Andreucci
- Division of Nephrology and Dialysis, Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy; (M.P.); (M.A.)
| | - Alda Storari
- Division of Nephrology and Dialysis, St. Anna University Hospital, 44121 Ferrara, Italy;
| | - Alice Sabatino
- Nephrology Unit, Department of Medicine and Surgery, Parma University Hospital, 43121 Parma, Italy; (A.S.); (E.F.)
| | - Enrico Fiaccadori
- Nephrology Unit, Department of Medicine and Surgery, Parma University Hospital, 43121 Parma, Italy; (A.S.); (E.F.)
| | - Antonio Granata
- Division of Nephrology, San Giovanni di Dio Hospital, 92100 Agrigento, Italy;
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Heo CM, Kim TJ, Lee H, Pyo JH, Min YW, Min BH, Lee JH, Son HJ, Baek SY, Kim K, Ryu S, Rhee PL, Kim JJ. [Impact of Sarcopenia on the Risk of Erosive Esophagitis]. THE KOREAN JOURNAL OF GASTROENTEROLOGY 2020; 75:132-140. [PMID: 32209801 DOI: 10.4166/kjg.2020.75.3.132] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/31/2018] [Revised: 01/12/2020] [Accepted: 01/13/2020] [Indexed: 12/13/2022]
Abstract
Background/Aims An association between obesity and erosive esophagitis has been reported, but the effects of sarcopenia and obesity on erosive esophagitis are unknown. This study examined the relationship between obesity, sarcopenia, sarcopenic obesity, and erosive esophagitis in a large population of asymptomatic men and women. Methods This study analyzed 32,762 subjects who underwent a comprehensive health check-up, which included upper gastrointestinal endoscopy, from August 2006 to December 2011 by a cross-sectional study. Sarcopenia was defined as a decrease in the appendicular skeletal muscle mass (ASM)/body weight value of two SD or more below the normal means for a younger reference group. Results The study was carried out on four groups according to obesity and sarcopenic status: normal, obesity, sarcopenic, and sarcopenic obese group. In a multivariable model, the risk of erosive esophagitis was higher in the obese (adjusted OR [aOR] 1.35, 95% CI 1.22-1.49), sarcopenic (aOR 2.12, 95% CI 1.40-3.19), and sarcopenic obese groups (aOR 1.54, 95% CI 1.27-1.87) than in the normal group. The risk of erosive esophagitis was higher in the sarcopenic and sarcopenic obese groups than the obese group; the ORs were 1.63 (95% CI 1.08-2.47) and 1.22 (95% CI 1.01-1.46), respectively. In dose-response analysis, increasing sarcopenia severity showed a positive and graded relationship with the overall, Los Angeles (LA)-B or higher grade, and LA-C erosive esophagitis. Conclusions This study suggests that sarcopenia is strongly and progressively associated with erosive esophagitis.
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Affiliation(s)
- Chan Mi Heo
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Tae Jun Kim
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Hyuk Lee
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Jeung Hui Pyo
- Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Yang Won Min
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Byung-Hoon Min
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Jun Haeng Lee
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Hee Jung Son
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.,Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Sun-Young Baek
- Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Kyunga Kim
- Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Seungho Ryu
- Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Poong-Lyul Rhee
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Jae J Kim
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Mascherini G, Ringressi MN, Castizo-Olier J, Badicu G, Irurtia A, Stefani L, Galanti G, Taddei A. Preliminary Results of an Exercise Program After Laparoscopic Resective Colorectal Cancer Surgery in Non-Metastatic Adenocarcinoma: A Pilot Study of a Randomized Control Trial. ACTA ACUST UNITED AC 2020; 56:medicina56020078. [PMID: 32075185 PMCID: PMC7073662 DOI: 10.3390/medicina56020078] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/24/2020] [Revised: 02/11/2020] [Accepted: 02/12/2020] [Indexed: 02/08/2023]
Abstract
Background and objectives: Performing physical exercise after a colorectal cancer diagnosis is associated with lower mortality related to the tumor itself. In order to improve physical recovery after elective surgery, there are no specific exercise protocols after discharge from the hospital. The purpose of this study is to show the preliminary results of an exercise program after colorectal cancer surgery. Materials and Methods: Six patients with non-metastatic colorectal adenocarcinoma addressed to respective laparoscopic were randomly assigned to a mixed supervised/home-based exercise program for six months and compared to a control group without exercise. To assess the effectiveness of the program, functional and body composition parameters were evaluated. Results: Three months after surgery, the exercise group increased flexibility (p <0.01, ES = 0.33), strength of lower limbs (p <0.01, ES = 0.42) and aerobic capacity (p <0.01, ES = 0.28). After surgery, the six patients experienced a significant reduction in body mass index (BMI) and free fat mass. More specifically, fat mass reached the lowest values, with a concomitant increase in cell mass after six months (p <0.01, ES = 0.33). This did not occur in the control group. Conclusions: Colorectal cancer treatment induces a reduction in physical function, particularly during the first six months after treatment. A mixed exercise approach appears promising in countering this process after colorectal cancer surgery.
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Affiliation(s)
- Gabriele Mascherini
- Sport and Exercise Medicine Unit, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, 50134 Firenze, Italy; (G.M.); (L.S.); (G.G.)
| | - Maria Novella Ringressi
- Multidisciplinary Oncology Group, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, 50134 Firenze, Italy; (M.N.R.); (A.T.)
| | - Jorge Castizo-Olier
- Tecno Campus Mataró-Maresme, EscuelaSuperior de Ciencias de la Salud, 08302 Mataró, Barcelona, Spain
| | - Georgian Badicu
- Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University of Brasov, 500068 Brasov, Romania
- Correspondence: ; Tel.: +40-769-219-271
| | - Alfredo Irurtia
- Departament de la Presidència, InstitutNacional d’EducacióFísica de Catalunya (INEFC), 08038 Barcelona, Spain;
| | - Laura Stefani
- Sport and Exercise Medicine Unit, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, 50134 Firenze, Italy; (G.M.); (L.S.); (G.G.)
| | - Giorgio Galanti
- Sport and Exercise Medicine Unit, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, 50134 Firenze, Italy; (G.M.); (L.S.); (G.G.)
| | - Antonio Taddei
- Multidisciplinary Oncology Group, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, 50134 Firenze, Italy; (M.N.R.); (A.T.)
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Zanforlini BM, Trevisan C, Bertocco A, Piovesan F, Dianin M, Mazzochin M, Alessi A, Zoccarato F, Manzato E, Sergi G. Phase angle and metabolic equivalents as predictors of frailty transitions in advanced age. Exp Gerontol 2019; 122:47-52. [DOI: 10.1016/j.exger.2019.04.016] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/11/2019] [Revised: 04/15/2019] [Accepted: 04/23/2019] [Indexed: 10/27/2022]
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Peluso R, Caso F, Tasso M, Sabbatino V, Lupoli R, Dario Di Minno MN, Ursini F, Costa L, Scarpa R. Biomarkers of subclinical atherosclerosis in patients with psoriatic arthritis. Open Access Rheumatol 2019; 11:143-156. [PMID: 31388317 PMCID: PMC6607207 DOI: 10.2147/oarrr.s206931] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/27/2019] [Accepted: 04/15/2019] [Indexed: 12/14/2022] Open
Abstract
Background: Psoriatic arthritis (PsA) is a chronic immune-mediated disease. It is associated with an increase in cardiovascular risk factors (obesity, hypertension, diabetes, and dyslipidemia), giving a higher risk of major adverse cardiovascular events. Patients with PsA have an increased incidence of subclinical atherosclerosis and endothelial dysfunction. The aim of this study is to perform a review of the biomarkers of subclinical atherosclerosis in patients with PsA. Methods: A search was performed in the electronic databases (PubMed, Web of Science, Scopus, and Embase) up until July 2017. Studies were considered if they included data on biomarkers of subclinical atherosclerosis in PsA, and each article was then reviewed for quality and clinical relevance. After completing the literature search, all screened literature was summarized and discussed in our study group (CaRRDs study group). Results: The initial search produced 532 abstracts, which were limited to 258 potentially relevant articles by preliminary review of the titles and by excluding review articles and case reports (n=274). A further 102 articles were deemed ineligible after examining the abstracts. Full texts of the remaining 156 articles were retrieved. Most articles were excluded because they were not relevant to the biomarkers of subclinical atherosclerosis in psoriasis and/or PsA. In the end, 54 articles were deemed eligible for this review. Conclusion: Patients with PsA showed more severe atherosclerotic disease compared with patients with only psoriasis. This may have been due to the higher systemic inflammatory burden from the combination of both diseases. In patients with PsA some molecules may be considered as markers of atherosclerotic disease, and their detection may be a prognostic marker, in addition to imaging procedures, for the development of atherosclerotic disease, and could be suitable for the management of patients with PsA.
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Affiliation(s)
- Rosario Peluso
- Department of Clinical Medicine and Surgery, Rheumatology Research Unit, Federico II University, Naples, Italy
| | - Francesco Caso
- Department of Clinical Medicine and Surgery, Rheumatology Research Unit, Federico II University, Naples, Italy
| | - Marco Tasso
- Department of Clinical Medicine and Surgery, Rheumatology Research Unit, Federico II University, Naples, Italy
| | - Vincenzo Sabbatino
- Department of Clinical Medicine and Surgery, Rheumatology Research Unit, Federico II University, Naples, Italy
| | - Roberta Lupoli
- Department of Clinical Medicine and Surgery, Division of Internal Medicine, Federico II University, Naples, Italy
| | | | - Francesco Ursini
- Internal Medicine Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy
| | - Luisa Costa
- Department of Clinical Medicine and Surgery, Rheumatology Research Unit, Federico II University, Naples, Italy
| | - Raffaele Scarpa
- Department of Clinical Medicine and Surgery, Rheumatology Research Unit, Federico II University, Naples, Italy
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Anastácio LR, Ferreira LG, Ribeiro HS, Diniz KGD, Lima AS, Correia MITD, Vilela EG. SARCOPENIA, OBESITY AND SARCOPENIC OBESITY IN LIVER TRANSPLANTATION: A BODY COMPOSITION PROSPECTIVE STUDY. ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA : ABCD = BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY 2019; 32:e1434. [PMID: 31038559 PMCID: PMC6488274 DOI: 10.1590/0102-672020190001e1434] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 08/01/2018] [Accepted: 01/17/2019] [Indexed: 12/22/2022]
Abstract
BACKGROUND Sarcopenia is prevalent before liver transplantation, and it is considered to be a risk factor for morbidity/mortality. After liver transplantation, some authors suggest that sarcopenia remains, and as patients gain weight as fat, they reach sarcopenic obesity status. AIM Prospectively to assess changes in body composition, prevalence and associated factors with respect to sarcopenia, obesity and sarcopenic obesity after transplantation. METHODS Patients were evaluated at two different times for body composition, 4.0±3.2y and 7.6±3.1y after transplantation. Body composition data were obtained using bioelectrical impedance. The fat-free mass index and fat mass index were calculated, and the patients were classified into the following categories: sarcopenic; obesity; sarcopenic obesity. RESULTS A total of 100 patients were evaluated (52.6±13.3years; 57.0% male). The fat-free mass index decreased (17.9±2.5 to 17.5±3.5 kg/m2), fat mass index increased (8.5±3.5 to 9.0±4.0; p<0.05), prevalence of sarcopenia (19.0 to 22.0%), obesity (32.0 to 37.0%) and sarcopenic obesity (0 to 2.0%) also increased, although not significantly. The female gender was associated with sarcopenia. CONCLUSION The fat increased over the years after surgery and the lean mass decreased, although not significantly. Sarcopenia and obesity were present after transplantation; however, sarcopenic obesity was not a reality observed in these patients.
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Affiliation(s)
| | - Lívia Garcia Ferreira
- Nutrition and Health Post-Graduation Program, Universidade Federal de Lavras, Lavras, MG
| | - Helem Sena Ribeiro
- Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte,MG
| | - Kiara Gonçalves Dias Diniz
- Adult Health Post-Graduation Program, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG
| | - Agnaldo Soares Lima
- Surgery Post-Graduation Program, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG Brazil
| | | | - Eduardo Garcia Vilela
- Surgery Post-Graduation Program, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG Brazil
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Hong JT, Kim TJ, Pyo JH, Kim ER, Hong SN, Kim YH, Ahn HS, Sohn I, Chang DK. Impact of sarcopenia on the risk of advanced colorectal neoplasia. J Gastroenterol Hepatol 2019; 34:162-168. [PMID: 29877584 DOI: 10.1111/jgh.14309] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/15/2017] [Revised: 05/15/2018] [Accepted: 05/29/2018] [Indexed: 12/11/2022]
Abstract
BACKGROUND AND AIM Sarcopenia is a pathological condition characterized by the progressive loss of muscle mass and increased amount of visceral fat. Recent evidence has revealed that sarcopenia is associated with certain diseases. However, the impact of sarcopenia on colorectal neoplasia has not been documented clearly. We studied the association between sarcopenia and advanced colorectal neoplasia in a large screening population. METHODS This cross-sectional study included 14 024 asymptomatic adults who underwent first-time screening colonoscopy. Sarcopenia (class II) was defined as an appendicular skeletal muscle mass (ASM)/bodyweight (%) value more than two standard deviations below the mean for healthy young adults. ASM was estimated using bioelectrical impedance analysis. RESULTS In a multivariable model adjusted for age, sex, obesity (body mass index ≥ 25), smoking status, alcohol intake, regular exercise, and family history of colorectal cancer, the odds ratio (OR) for advanced colorectal neoplasia on comparing participants with sarcopenia (class II) to those without sarcopenia (class I + II) was 1.52 (95% confidence interval [CI], 1.23-1.86). Further adjustment for metabolic parameters attenuated this association, but the association was still significant (OR, 1.34; 95% CI, 1.07-1.68). Furthermore, the multivariable (traditional risk factors)-adjusted OR associated with a 1% decrease on the introduction of ASM/weight% as a continuous variable in regression models was 1.04 (95% CI, 1.01-1.07) for advanced colorectal neoplasia. CONCLUSIONS Our findings indicate that sarcopenia is significantly and progressively associated with the risk of advanced colorectal neoplasia. This association might be explained by metabolic factors that could be potential mediators of the effect of sarcopenia.
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Affiliation(s)
- Ji Taek Hong
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Tae Jun Kim
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Jeung Hui Pyo
- Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Eun Ran Kim
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Sung Noh Hong
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Young-Ho Kim
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Hyeon Seon Ahn
- Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Insuk Sohn
- Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
| | - Dong Kyung Chang
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Mullie L, Obrand A, Bendayan M, Trnkus A, Ouimet M, Moss E, Chen‐Tournoux A, Rudski LG, Afilalo J. Phase Angle as a Biomarker for Frailty and Postoperative Mortality: The BICS Study. J Am Heart Assoc 2018; 7:e008721. [PMID: 30371163 PMCID: PMC6201414 DOI: 10.1161/jaha.118.008721] [Citation(s) in RCA: 55] [Impact Index Per Article: 7.9] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/01/2018] [Accepted: 07/02/2018] [Indexed: 01/19/2023]
Abstract
Background Phase angle (PA) is a bioimpedance measurement that is determined lean body mass and hydration status. Patients with low PA values are more likely to be frail, sarcopenic, or malnourished. Previous work has shown that low PA predicts adverse outcomes after cardiac surgery, but the effect of PA on survival has not previously been assessed in this setting. Methods and Results The BICS (Bioimpedance in Cardiac Surgery) study recruited 277 patients undergoing major cardiac surgery at 2 university-affiliated hospitals in Montreal, QC, Canada. Bioimpedance measurements as well as frailty and nutritional assessments were performed preoperatively. The primary outcome was all-cause mortality. Secondary outcomes were 30-day mortality, postoperative morbidity, and hospital length of stay. There were 10 deaths at 1 month of follow-up and 16 deaths at 12 months of follow-up. PA was associated with age, sex, body mass index, comorbidities, and frailty, as measured by the Short Physical Performance Battery and Fried scales. After adjusting for Society of Thoracic Surgeons-predicted mortality, lower PA was associated with higher mortality at 1 month (adjusted odds ratio, 3.57 per 1° decrease in PA ; 95% confidence interval, 1.35-9.47) and at 12 months (adjusted odds ratio, 3.03 per 1° decrease in PA ; 95% confidence interval, 1.30-7.09), a higher risk of overall morbidity (adjusted hazard ratio, 2.51 per 1° decrease in PA ; 95% confidence interval, 1.32-4.75), and a longer hospital length of stay (adjusted β, 4.8 days per 1° decrease in PA ; 95% confidence interval, 1.3-8.2 days). Conclusions Low PA is associated with frailty and is predictive of mortality, morbidity, and length of stay after major cardiac surgery. Further work is needed to determine the responsiveness of PA to interventions aimed at reversing frailty.
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Affiliation(s)
- Louis Mullie
- Centre for Clinical EpidemiologyLady Davis InstituteMcGill UniversityMontrealQuebecCanada
- Division of Internal MedicineMcGill UniversityMontrealQuebecCanada
| | - Alexandrine Obrand
- Centre for Clinical EpidemiologyLady Davis InstituteMcGill UniversityMontrealQuebecCanada
- School of EngineeringMassachusetts Institute of TechnologyCambridgeMA
| | - Melissa Bendayan
- Centre for Clinical EpidemiologyLady Davis InstituteMcGill UniversityMontrealQuebecCanada
- Division of Experimental MedicineFaculty of MedicineMcGill UniversityMontrealQuebecCanada
| | - Amanda Trnkus
- Centre for Clinical EpidemiologyLady Davis InstituteMcGill UniversityMontrealQuebecCanada
| | - Marie‐Claude Ouimet
- Centre for Innovative MedicineMcGill University Health CentreMcGill UniversityMontrealQuebecCanada
| | - Emmanuel Moss
- Division of Cardiac SurgeryJewish General HospitalMcGill UniversityMontrealQuebecCanada
| | | | - Lawrence G. Rudski
- Centre for Clinical EpidemiologyLady Davis InstituteMcGill UniversityMontrealQuebecCanada
- Division of CardiologyJewish General HospitalMcGill UniversityMontrealQuebecCanada
| | - Jonathan Afilalo
- Centre for Clinical EpidemiologyLady Davis InstituteMcGill UniversityMontrealQuebecCanada
- Division of Experimental MedicineFaculty of MedicineMcGill UniversityMontrealQuebecCanada
- Division of CardiologyJewish General HospitalMcGill UniversityMontrealQuebecCanada
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Castizo-Olier J, Irurtia A, Jemni M, Carrasco-Marginet M, Fernández-García R, Rodríguez FA. Bioelectrical impedance vector analysis (BIVA) in sport and exercise: Systematic review and future perspectives. PLoS One 2018; 13:e0197957. [PMID: 29879146 PMCID: PMC5991700 DOI: 10.1371/journal.pone.0197957] [Citation(s) in RCA: 82] [Impact Index Per Article: 11.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2017] [Accepted: 05/13/2018] [Indexed: 01/10/2023] Open
Abstract
Background Bioelectrical impedance vector analysis (BIVA) is a general concept that includes all methodologies used in the analysis of the bioelectrical vector, whereas the "classic" BIVA is a patented methodology included among these methods of analysis. Once this was clarified, the systematic review of the literature provides a deeper insight into the scope and range of application of BIVA in sport and exercise. Objective The main goal of this work was to systematically review the sources on the applications of BIVA in sport and exercise and to examine its usefulness and suitability as a technique for the evaluation of body composition, hydration status, and other physiological and clinical relevant characteristics, ultimately to trace future perspectives in this growing area, including a proposal for a research agenda. Methods Systematic literature searches in PubMed, SPORTDiscus and Scopus databases up to July, 2017 were conducted on any empirical investigations using phase-sensitive bioimpedance instruments to perform BIVA within exercise and sport contexts. The search included healthy sedentary individuals, physically active subjects and athletes. Result Nineteen eligible papers were included and classified as sixteen original articles and three scientific conference communications. Three studies analysed short-term variations in the hydration status evoked by exercise/training through whole-body measurements, eleven assessed whole-body body composition changes induced by long-term exercise, four compared athletic groups or populations using the whole-body assessment, and two analysed bioelectrical patterns of athletic injuries or muscle damage through localised bioimpedance measurements. Conclusions BIVA is a relatively new technique that has potential in sport and exercise, especially for the assessment of soft-tissue injury. On the other hand, the current tolerance ellipses of “classic” BIVA are not a valid method to identify dehydration in individual athletes and a new approach is needed. “Specific” BIVA, a method which proposes a correction of bioelectrical values for body geometry, emerges as the key to overcome “classic” BIVA limitations regarding the body composition assessment. Further research establishing standardised testing procedures and investigating the relationship between physiology and the bioelectrical signal in sport and exercise is needed.
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Affiliation(s)
- Jorge Castizo-Olier
- INEFC-Barcelona Sport Sciences Research Group, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
- Catalan School of Kinanthropometry, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
| | - Alfredo Irurtia
- INEFC-Barcelona Sport Sciences Research Group, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
- Catalan School of Kinanthropometry, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
- * E-mail:
| | - Monèm Jemni
- Department of Sport Science, Qatar University, Doha, Qatar
| | - Marta Carrasco-Marginet
- INEFC-Barcelona Sport Sciences Research Group, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
- Catalan School of Kinanthropometry, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
| | - Raúl Fernández-García
- Department of Electronic Engineering, Polytechnic University of Catalonia, Barcelona, Spain
| | - Ferran A. Rodríguez
- INEFC-Barcelona Sport Sciences Research Group, National Institute of Physical Education of Catalonia (INEFC), University of Barcelona (UB), Barcelona, Spain
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da Silva AT, Hauschild DB, Moreno YMF, Bastos JLD, Wazlawik E. Diagnostic Accuracy of Bioelectrical Impedance Analysis Parameters for the Evaluation of Malnutrition in Patients Receiving Hemodialysis. Nutr Clin Pract 2018; 33:831-842. [PMID: 29786896 DOI: 10.1002/ncp.10098] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/25/2023] Open
Abstract
BACKGROUND In the absence of a gold standard technique for assessing nutrition status in patients receiving hemodialysis (HD), we aimed to determine the diagnostic accuracy of single-frequency (50 kHz) bioelectrical impedance analysis parameters, resistance/height (R/H), reactance/height (Xc/H), and impedance/height (Z/H), and their cutoff points for malnutrition. METHODS The reference standards, Subjective Global Assessment (SGA), Malnutrition Inflammation Score, and Nutritional Risk Screening 2002, were performed at baseline and then once a year for 2 years. At least 2 assessments for each reference standard were performed during the monitoring period, and those patients who were assessed as malnourished on at least 2 consecutive occasions were classified as malnourished. RESULTS A total 101 patients receiving HD were evaluated. R/H and Z/H demonstrated low to moderate accuracy to diagnose malnutrition in men and low accuracy in women, whereas the accuracy of Xc/H was uncertain. The cutoff points of bioelectrical impedance vector analysis (BIVA) parameters, determined based on the SGA to maximize sensitivity and specificity simultaneously, were: R/H ≥330.05 and ≥420.92 ohms/m for men and women, respectively; Z/H ≥332.71 and ≥423.19 ohms/m for men and women, respectively. In men, sensitivity based on the cutoff points of R/H and Z/H together ranged from 73% to 89% and specificity ranged from 49% to 50%. In women, sensitivity ranged from 58% to 80% and specificity from 48% to 55%. CONCLUSION BIVA parameters demonstrated low to moderate accuracy in men and low accuracy in women for the diagnosis of malnutrition.
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Affiliation(s)
- Angela Teodósio da Silva
- Federal University of Santa Catarina, Health Sciences Center, Post-Graduate Program in Nutrition, Trindade Florianópolis, Santa Catarina, Brazil
| | - Daniela Barbieri Hauschild
- Federal University of Santa Catarina, Health Sciences Center, Post-Graduate Program in Nutrition, Trindade Florianópolis, Santa Catarina, Brazil
| | - Yara Maria Franco Moreno
- Federal University of Santa Catarina, Health Sciences Center, Post-Graduate Program in Nutrition, Trindade Florianópolis, Santa Catarina, Brazil
| | - João Luiz Dornelles Bastos
- Federal University of Santa Catarina, Health Sciences Center, Public Health Department, Trindade Florianópolis, Santa Catarina, Brazil
| | - Elisabeth Wazlawik
- Federal University of Santa Catarina, Health Sciences Center, Post-Graduate Program in Nutrition, Trindade Florianópolis, Santa Catarina, Brazil
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Prevalence of dynapenia and presarcopenia related to aging in adult community-dwelling Mexicans using two different cut-off points. Eur Geriatr Med 2018; 9:219-225. [DOI: 10.1007/s41999-018-0032-8] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2017] [Accepted: 01/23/2018] [Indexed: 01/04/2023]
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