• nocturnal gastro‐oesophageal reflux
• sleep‐arousal

• Gastroesophageal Reflux/physiopathology
• Gastroesophageal Reflux/etiology
• Gastroesophageal Reflux/complications
• Humans
• Arousal/physiology
• Sleep Wake Disorders/physiopathology
• Sleep Wake Disorders/etiology
• Circadian Rhythm/physiology
• Quality of Life
• Sleep/physiology

• Barrett’s esophagus
• Diet
• Dietary habits
• Esophagitis

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Barrett Esophagus/epidemiology
• Barrett Esophagus/etiology
• Case-Control Studies
• Diet
• Dietary Fats
• Esophagitis/epidemiology
• Esophagitis/etiology
• Feeding Behavior
• Female
• Fruit
• Humans
• Italy/epidemiology
• Male
• Middle Aged
• Risk Factors
• Time Factors
• Young Adult

• Esophageal sphincter pressure
• Gastroesophageal reflux disease
• Gastroesophageal reflux disease-Q scale score
• Modified Xiaochaihu Decoction
• Traditional Chinese medicine

• Drugs, Chinese Herbal/adverse effects
• Esophageal Sphincter, Lower
• Gastroesophageal Reflux/drug therapy
• Humans
• Manometry
• Prospective Studies

• drug interaction
• hypothyroidism
• levothyroxine

• Humans
• Hypothyroidism/drug therapy
• Proton Pump Inhibitors
• Thyroxine

Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research has evaluated the association between eating habits and ulcerative colitis (UC). Thus, we investigate the association between eating behavior and clinical outcome in Japanese patients with UC.

Eating quickly, eating until full, and skipping breakfast data was obtained from a self-administered questionnaire. Information on clinical outcome was collected from medical records. Mucosal healing (MH) and partial MH was defined as a Mayo endoscopic subscore of 0 or 0–1, respectively. Age, sex, BMI, current smoking, current drinking, prednisolone use, and anti-TNFα monoclonal antibody use were selected a priori as potential confounding factors.

Study subjects consisted of 294 Japanese patients with UC. Eating at speed moderate and eating quickly were independently inversely associated with MH: the adjusted odds ratios (ORs) were 0.38 (95% confidence interval [CI] 0.16–0.85) and 0.38 (95% CI 0.17–0.81) (p for trend = 0.033). Eating until full was independently inversely associated with MH: the adjusted OR was 0.38 (95% CI 0.27–0.86). MH in patients who skipped breakfast was marginally lower than that in patients who did not skip breakfast. No association between eating habits and clinical remission or partial MH was found.

Among patients with UC, eating rate and eating until full may be independently inversely associated with MH but not clinical remission.

• Eating habits
• Eating quickly
• Eating until full
• Skipping breakfast
• Ulcerative colitis

The etiology of reflux esophagitis (RE) is multi-factorial. This study analyzed the relationship of depression, anxiety, lifestyle and eating habits with RE and its severity and further explored the impact of anxiety and depression on patients’ symptoms and quality of life.

From September 2016 to February 2018, a total of 689 subjects at Xuanwu Hospital Capital Medical University participated in this survey. They were divided into the RE group (patients diagnosed with RE on gastroscopy, n = 361) and the control group (healthy individuals without heartburn, regurgitation and other gastrointestinal symptoms, n = 328). The survey included general demographic information, lifestyle habits, eating habits, comorbidities, current medications, the gastroesophageal reflux disease (GERD) questionnaire (GerdQ), the Patient Health Questionnaire-9 depression scale and the General Anxiety Disorder-7 anxiety scale.

The mean age and sex ratio of the two groups were similar. Multivariate logistic regression analysis identified the following factors as related to the onset of RE (p < 0.05): low education level; drinking strong tea; preferences for sweets, noodles and acidic foods; sleeping on a low pillow; overeating; a short interval between dinner and sleep; anxiety; depression; constipation; history of hypertension; and use of oral calcium channel blockers. Ordinal logistic regression analysis revealed a positive correlation between sleeping on a low pillow and RE severity (p = 0.025). Depression had a positive correlation with the severity of symptoms (r_s = 0.375, p < 0.001) and patients’ quality of life (r_s = 0.306, p < 0.001), whereas anxiety showed no such association.

Many lifestyle factors and eating habits were correlated with the onset of RE. Notably, sleeping on a low pillow was positively correlated with RE severity, and depression was positively related to the severity of symptoms and patients’ quality of life.

The online version contains supplementary material available at 10.1186/s12876-021-01717-5.

• Anxiety
• Depression
• Eating habits
• Lifestyle
• Reflux esophagitis
• Severity of reflux esophagitis

• gastroesophageal reflux disease (GERD)
• proton pump inhibitors (PPIs)
• recurrence

• comportement alimentaire
• diabetes
• diabète
• eating behaviour
• epidemiology
• gastroesophageal reflux disease (GERD)
• late-night dinner
• reflux gastro-œsophagien (RGO) pathologique
• souper tardif
• épidémiologie

Several specific foods are known to precipitate gastroesophageal reflux disease (GERD) symptoms and GERD patients are usually advised to avoid such foods. However, foods consumed daily are quite variable according to regions, cultures, etc. This study was done to elucidate the food items which induce typical GERD symptoms in Korean patients.

One hundred and twenty-six Korean patients with weekly typical GERD symptoms were asked to mark all food items that induced typical GERD symptoms from a list containing 152 typical foods consumed daily in Korea. All patients underwent upper gastrointestinal endoscopy followed by 24-hour ambulatory esophageal pH monitoring. The definition of “GERD” was if either of the 2 studies revealed evidence of GERD, and “possible GERD” if both studies were negative.

One hundred and twenty-six cases (51 GERD and 75 possible GERD) were enrolled. In 19 (37.3%) of 51 GERD cases and in 17 (22.7%) of 75 possible GERD cases, foods inducing typical GERD symptoms were identified. In the GERD group (n = 19), frequent symptom-inducers were hot spicy stews, rice cakes, ramen noodles, fried foods, and topokki. In the possible GERD group (n = 17), frequent symptom-inducers were hot spicy stews, fried foods, doughnuts, breads, ramen noodles, coffee, pizza, topokki, rice cakes, champon noodles, and hotdogs.

In one-third of GERD patients, foods inducing typical symptoms were identified. Hot spicy stews, rice cakes, ramen noodles, fried foods, and topokki were the foods frequently inducing typical symptoms in Korea. The list of foods frequently inducing typical GERD symptoms needs to be modified based on their own local experiences.

• Food
• Gastroesophageal reflux
• Korea
• Symptom assessment

• Gastroesophageal Reflux
• Humans

• GERD
• LPR
• extraesophageal reflux
• mucosal impedance testing
• pH monitoring
• proton pump inhibitor therapy

To identify the relationship between dietary habits and childhood gastroesophageal reflux disease (GERD) in preschool children.

We performed a questionnaire study to analyze the relationship between dietary habits and GERD in 85 preschool children with GERD and 117 healthy children of the same age.

Irregular and picky eating were more p–revalent in the GERD group than in the control group (odds ratio [OR], 4.14; 95% confidence interval [CI], 1.37–12.54 and OR, 4.96; 95% CI, 1.88–13.14, respectively). The snack preferences and the late night eating habits were significantly more prevalent in the GERD group than in the control group (OR, 3.83; 95% CI, 1.23–11.87 and OR, 9.51; 95% CI, 2.55–35.49, respectively). A preference for liquid foods was significantly more prevalent in the GERD group (OR, 9.51; 95% CI, 2.548–35.485). The dinner-to-bedtime interval was significantly shorter in the GERD group than in the control group (157.06±48.47 vs. 174.62±55.10, P=0.020). In addition, the time between dinner and bedtime was shorter than 3 hours in 47 children (55.3%) of the GERD group and 44 (37.6%) of the control group. This difference was statistical significance (P=0.015).

Dietary habits such as picky and irregular eating, snack preference, a preference of liquid foods, late night eating, and a shorter dinner-to-bedtime interval had a significant correlation with GERD. Further large-scale studies are necessary to confirm our results.

• Child
• Dietary habits
• Gatroesophageal reflux
• Preschool child

• alcohol
• gastro-oesophageal reflux disease
• head of bed elevation
• lifestyle modification
• obesity
• posture
• smoking
• weight loss

Gastroesophageal reflux disease (GERD) is a common disease with a prevalence as high as 10%-20% in the western world. The disease can manifest in various symptoms which can be grouped into typical, atypical and extra-esophageal symptoms. Those with the highest specificity for GERD are acid regurgitation and heartburn. In the absence of alarm symptoms, these symptoms can allow one to make a presumptive diagnosis and initiate empiric therapy. In certain situations, further diagnostic testing is needed to confirm the diagnosis as well as to assess for complications or alternate causes for the symptoms. GERD complications include erosive esophagitis, peptic stricture, Barrett’s esophagus, esophageal adenocarcinoma and pulmonary disease. Management of GERD may involve lifestyle modification, medical therapy and surgical therapy. Lifestyle modifications including weight loss and/or head of bed elevation have been shown to improve esophageal pH and/or GERD symptoms. Medical therapy involves acid suppression which can be achieved with antacids, histamine-receptor antagonists or proton-pump inhibitors. Whereas most patients can be effectively managed with medical therapy, others may go on to require anti-reflux surgery after undergoing a proper pre-operative evaluation. The purpose of this review is to discuss the current approach to the diagnosis and treatment of gastroesophageal reflux disease.

• Gastroesophageal reflux disease
• Esophageal disease
• Acid suppression
• Fundoplication
• Upper gastrointestinal tract disorder