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Sibinga CTS. Immunoglobulin use - Helpful treatment or panacea? Transfus Apher Sci 2025; 64:104091. [PMID: 39951900 DOI: 10.1016/j.transci.2025.104091] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/17/2025]
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Graham BV, Master SR, Obstfeld AE, Wilson RB. A Multianalyte Machine Learning Model to Detect Wrong Blood in Complete Blood Count Tube Errors in a Pediatric Setting. Clin Chem 2025; 71:418-427. [PMID: 39797417 DOI: 10.1093/clinchem/hvae210] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/25/2024] [Accepted: 10/15/2024] [Indexed: 01/13/2025]
Abstract
BACKGROUND Multianalyte machine learning (ML) models can potentially identify previously undetectable wrong blood in tube (WBIT) errors, improving upon current single-analyte delta check methodology. However, WBIT detection model performance has not been assessed in a real-world, low-prevalence context. To estimate real-world positive predictive values, we propose a methodology to assess WBIT detection models by evaluating the impact of missing data and by using a "low prevalence" validation data set. METHODS We trained a range of model specifications using various predictors in a pediatric setting. We assessed the top-performing model on a modified, "low prevalence" validation data set across a range of probability thresholds. Model performance was also compared to a pre-positive patient identification (pre-PPID) dataset. RESULTS An Extreme Gradient Boosting (XGBoost) model with minimal preprocessing performed the best for both complete blood count with differential white cell count (CBC with Diff) tests (accuracy 0.9715) and complete blood count without differential white cell count (CBC without Diff) tests (accuracy 0.9647). Assessment on a downsampled, "low prevalence" validation data set resulted in estimated positive predictive values ranging from 0.01 to 0.67 (CBC with Diff) and 0.01 to 0.75 (CBC without Diff), depending on the probability threshold chosen. A comparison of prospective performance to PPID data demonstrated a large decrease in estimated WBIT errors. CONCLUSIONS We find that ML models can accurately predict WBITs in a primarily pediatric setting. Evaluating model performance across a range of probability thresholds minimizes the number of false positives while still providing added safety benefits. The decrease in estimated WBITS post-PPID implementation shows the potential safety benefits of a WBIT model for hospitals not using PPID when collecting laboratory specimens.
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Affiliation(s)
- Brendan V Graham
- Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States
| | - Stephen R Master
- Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States
- Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
| | - Amrom E Obstfeld
- Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States
- Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
| | - Robert B Wilson
- Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States
- Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States
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3
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Booth C, Davies P. Transfusion sample mislabelling and wrong blood in tube in the UK: Insights from the national comparative audits of blood transfusion in 2012 and 2022. Transfus Med 2025; 35:41-47. [PMID: 39191512 DOI: 10.1111/tme.13092] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/18/2023] [Revised: 07/28/2024] [Accepted: 08/19/2024] [Indexed: 08/29/2024]
Abstract
BACKGROUND Samples for transfusion rejected due to mislabelling can lead to harm when a patient has to be re-bled or has a transfusion or procedure delayed. Electronic labelling systems which scan the patient's identification band and generate a label at their side aim to reduce mislabelling and misidentification leading to wrong blood in tube (WBIT) errors. The 2022 National Comparative audit of sample collection aimed to compare national rates of sample mislabelling and WBIT to the 2012 audit and to examine the impact of electronic systems. METHOD All UK hospitals were invited to provide data on rejected transfusion samples and WBIT incidents in 1 month (October 2022) and were asked if they had electronic labelling. RESULTS Twenty-three thousand five hundred and eighty-four rejected samples were reported by 179 sites in 1 month. The rejection rate of 4.4% represents a 47% increase compared to 2012 (2.99%). There were 92 WBIT incidents, an incidence of 1 in 5882 samples-a 45% increase compared to 1 in 8547 in 2012. Twenty-three percent of sites can print a sample label at the patient's side, up by 224%. The six sites using only electronic sample labelling had a 46.9% lower rejection rate than sites using only hand-labelling but still reported WBIT. CONCLUSIONS The increase in sample rejection and WBIT may reflect pressures facing clinical staff, zero tolerance policies and the two-sample rule. A human factors approach to understanding and tackling underlying reasons locally is recommended. Electronic systems are associated with fewer labelling errors, but careful implementation and training is needed to maximise their safety benefits.
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Affiliation(s)
- Catherine Booth
- National Comparative Audit of Blood Transfusion, NHS Blood and Transplant, London, UK
| | - Paul Davies
- National Comparative Audit of Blood Transfusion, NHS Blood and Transplant, London, UK
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4
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Peng D, Wang X, Huang J. Establishment and discussion of autoverification rules for transfusion compatibility testing. Transfus Med 2024; 34:413-420. [PMID: 39128836 DOI: 10.1111/tme.13077] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2024] [Revised: 07/28/2024] [Accepted: 07/31/2024] [Indexed: 08/13/2024]
Abstract
OBJECTIVES To develop an automated verification workflow for transfusion compatibility testing (TCT) based on the AUTO10-A guidelines and blood group serology characteristics and to conduct a simulated validation of the test and subtest results by assessing the appropriateness of the autoverification rules. BACKGROUND The accuracy of TCT results is a fundamental prerequisite for ensuring the safety of blood transfusions. However, the verification of these results still requires manual intervention. MATERIALS AND METHODS Five autoverification rules and their standards were determined: agglutination intensity, normal results, logical relationships, delta checks and interlaboratory test comparisons. The established categories and standards for the five rules were retrospectively validated using 13 506 samples (requests) that had been manually verified in our laboratory from January 2020 to June 2023. RESULTS A total of 66 638 test items were involved in the autoverification, with 3844 items violating the verification rules, resulting in a pass rate of 96.10%. Considering individual test items, four tests had a pass rate of more than 90% in both the test item result table and the test subitem result table. However, there were significant differences in the pass rates between different tests. The same conclusion can be drawn when the unit is requests. The different standards set for the agglutination intensity and the delta check in the ABO typing testing subitems showed significant differences in pass rates. DISCUSSION The incorporation of manually verified results into the automated verification simulation indicated that the five rules established in this study have good applicability, and appropriate standards can lead to reasonable pass rates.
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Affiliation(s)
- Daobo Peng
- Department of Transfusion Medicine, Southern Medical University Nanfang Hospital, Guangzhou, China
- Department of Transfusion Medicine, Southern Medical University Nanfang Hospital Zengcheng Campus, Guangzhou, China
| | - Xiaohui Wang
- Department of Transfusion Medicine, Southern Medical University Nanfang Hospital Zengcheng Campus, Guangzhou, China
| | - Jie Huang
- Department of Transfusion Medicine, Southern Medical University Nanfang Hospital Zengcheng Campus, Guangzhou, China
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Raymond C, Dell'Osso L, Guerra D, Hernandez J, Rendon L, Fuller D, Villasante-Tezanos A, Garcia J, McCaffrey P, Zahner C. How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate. J Clin Pathol 2024; 77:647-650. [PMID: 38769001 DOI: 10.1136/jcp-2024-209544] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/15/2024] [Accepted: 04/26/2024] [Indexed: 05/22/2024]
Abstract
BACKGROUND Specimens with incorrect patient information are both a critical safety error and difficult to identify. Estimates of sample mislabelling rely on subjective identification of mislabelling, with the possibility that not all mislabelled samples are being caught. METHODS We determined the blood type of two or more complete blood count specimens with the same patient label and assessed for discrepancies. We additionally determined the rate of identified sample mislabelling for the study period. RESULTS We found a rate of 3.17 per 1000 discrepancies over the study period. These discrepancies most likely represent occult, or unidentified, mislabelled samples. In contrast, the rate of identified sample mislabelling was 1.15 per 1000. CONCLUSIONS This study suggests that specimens identified as, or known to be, mislabelled represent only a fraction of those mislabelled. These findings are currently being confirmed in our laboratory and are likely generalisable to other institutions.
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Affiliation(s)
- Caitlin Raymond
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - Liesel Dell'Osso
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - David Guerra
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - Julia Hernandez
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - Leonel Rendon
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - Donna Fuller
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | | | - JuanDavid Garcia
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - Peter McCaffrey
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
| | - Christopher Zahner
- Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA
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Simin D, Dolinaj V, Brestovački Svitlica B, Grujić J, Živković D, Milutinović D. Blood Transfusion Procedure: Assessment of Serbian Intensive Care Nurses' Knowledge. Healthcare (Basel) 2024; 12:720. [PMID: 38610143 PMCID: PMC11012219 DOI: 10.3390/healthcare12070720] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/26/2024] [Revised: 03/18/2024] [Accepted: 03/22/2024] [Indexed: 04/14/2024] Open
Abstract
Many patients require administering one or more blood components during hospitalisation in the Intensive Care Unit (ICU). Therefore, nurses' knowledge of who is responsible for immediately administering blood transfusions, monitoring patients, and identifying and managing transfusion reactions is crucial. This cross-sectional descriptive-analytical study aimed to assess the knowledge of ICU nurses in tertiary healthcare institutions about blood transfusion procedures. The questionnaire about the transfusion procedure was designed and reviewed by experts. The questionnaire consisted of 29 items divided into three domains. The scores on the knowledge test ranged from 10 to 27. Generally, 57.7% of nurses had moderate, 23.4% low, and 18.9% high levels of knowledge about the transfusion procedure. Most nurses answered correctly about refreezing fresh frozen plasma, verifying the transfusion product, and identifying the patient. Of the nurses, 91.0% would recognise mild allergic reactions, and 98.2% knew about the supervision of sedated patients. Nurses showed poor knowledge of the length of usage of the same transfusion system for red blood cells, labelling, and transfusion administration in febrile patients. Nurses with higher education and longer working experience had significantly better outcomes (p = 0.000) on the knowledge test. Continuous education of ICU nurses on safe transfusion usage is recommended.
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Affiliation(s)
- Dragana Simin
- Department of Nursing, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia; (V.D.); (B.B.S.); (D.Ž.); (D.M.)
| | - Vladimir Dolinaj
- Department of Nursing, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia; (V.D.); (B.B.S.); (D.Ž.); (D.M.)
- Department of Anesthesia and Intensive Care, University Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia
| | - Branislava Brestovački Svitlica
- Department of Nursing, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia; (V.D.); (B.B.S.); (D.Ž.); (D.M.)
- Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia
| | - Jasmina Grujić
- Department of Transfusiology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia;
- Vojvodina Blood Transfusion Institute, 21000 Novi Sad, Serbia
| | - Dragana Živković
- Department of Nursing, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia; (V.D.); (B.B.S.); (D.Ž.); (D.M.)
| | - Dragana Milutinović
- Department of Nursing, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia; (V.D.); (B.B.S.); (D.Ž.); (D.M.)
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7
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Crowe EP, Goel R, Al-Mozain N, Josephson CD. Neonatal Blood Banking Practices. Clin Perinatol 2023; 50:821-837. [PMID: 37866850 DOI: 10.1016/j.clp.2023.07.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2023]
Abstract
There is little formal guidance to direct neonatal blood banking practices and, as a result, practices vary widely across institutions. In this vulnerable patient population with a high transfusion burden, considerations for blood product selection include freshness, extended-storage media, pathogen inactivation, and other modifications. The authors discuss the potential unintended adverse impacts in the neonatal recipient. Concerns such as immunodeficiency, donor exposures, cytomegalovirus transmission, volume overload, transfusion-associated hyperkalemia, and passive hemolysis from ABO incompatibility have driven modifications of blood components to improve safety.
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Affiliation(s)
- Elizabeth P Crowe
- Department of Pathology, Johns Hopkins University School of Medicine, 1800 Orleans Street, Sheikh Zayed Tower, Room 3081-A, Baltimore, MD 21287, USA
| | - Ruchika Goel
- Corporate Medical Affairs, Vitalant National Office, Scottsdale, AZ, USA; Division of Hematology/Oncology, Department of Internal Medicine and Pediatrics, Simmons Cancer Institute at SIU School of Medicine, 704 Lismore Lane, Springfield, IL 62704, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
| | - Nour Al-Mozain
- Hematopathology & Transfusion Medicine, Department of Pathology & Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, 7652, Riyadh, Riyadh, 12713, Saudi Arabia; Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
| | - Cassandra D Josephson
- Department of Oncology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Cancer and Blood Disorders Institute, Blood Bank and Transfusion Medicine, Department of Pathology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
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Stephens LD, Allen ES, Bloch EM, Crowe EP, Campbell-Lee SA, Booth GS, Kopko P. How do we ensure a safe ABO recheck process? Transfusion 2023; 63:1789-1796. [PMID: 37660311 DOI: 10.1111/trf.17530] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2023] [Revised: 07/16/2023] [Accepted: 07/16/2023] [Indexed: 09/05/2023]
Abstract
BACKGROUND Collecting a patient's blood in a correctly labeled pretransfusion specimen tube is essential for accurate ABO typing and safe transfusion. Noncompliance with specimen collection procedures can lead to wrong blood in tube (WBIT) incidents with potentially fatal consequences. Recent WBIT events inspired the investigation of how various institutions currently reduce the risk of these errors and ensure accurate ABO typing of patient samples. MATERIALS AND METHODS This article describes the techniques employed at various institutions across the United States to mitigate the risk of misidentified pretransfusion patient specimens. Details and considerations for each of these measures are provided. RESULTS Several institutions require the order for an ABO confirmation specimen, if indicated, to be generated from the transfusion medicine (TM) laboratory. Others issue a dedicated collection tube that is available exclusively from the TM service. Many institutions employ barcoding for electronic positive patient identification. Some use a combination of these strategies, depending on the locations or service lines from which the specimens are collected. CONCLUSION The description of various WBIT mitigation strategies will inform TM services on practices that may be effective at their respective institutions. Irrespective of the method(s) utilized, institutions should continue to monitor and mitigate specimen misidentification errors to promote sustained safe transfusion practices.
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Affiliation(s)
- Laura D Stephens
- University of California San Diego Health, La Jolla, California, USA
| | - Elizabeth S Allen
- University of California San Diego Health, La Jolla, California, USA
| | - Evan M Bloch
- Johns Hopkins University School of Medicine Baltimore, Baltimore, Maryland, USA
| | - Elizabeth P Crowe
- Johns Hopkins University School of Medicine Baltimore, Baltimore, Maryland, USA
| | | | - Garrett S Booth
- Vanderbilt University Medical Center, Nashville, Tennessee, USA
| | - Patricia Kopko
- University of California San Diego Health, La Jolla, California, USA
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9
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Farrell CJ, Makuni C, Keenan A, Maeder E, Davies G, Giannoutsos J. A Machine Learning Model for the Routine Detection of "Wrong Blood in Complete Blood Count Tube" Errors. Clin Chem 2023; 69:1031-1037. [PMID: 37473426 DOI: 10.1093/clinchem/hvad100] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2023] [Accepted: 06/16/2023] [Indexed: 07/22/2023]
Abstract
BACKGROUND Current laboratory procedures may fail to detect wrong blood in tube (WBIT) errors. Machine learning models have the potential to improve WBIT error detection, as demonstrated by proof-of-concept studies. The models developed so far, however, are not appropriate for routine use because they are unable to handle missing values and have low positive predictive value (PPV). In this study, a machine learning model suitable for routine use was developed. METHODS A model was trained and a preliminary evaluation performed on a retrospective data set of 135 128 current and previous patient complete blood count (CBC) results. The model was then applied prospectively to routine samples tested in a public hospital laboratory over a period of 22 weeks. Each week, the 5 samples identified by the model as most likely to be WBIT errors underwent further investigation by testing blood group and red cell phenotype. The study assessed the number of WBIT errors that were missed by current procedures but detected by the model, as well as the PPV of the model. RESULTS The model was applied prospectively to 38 187 CBC results that had passed routine laboratory checks. One hundred and ten samples were identified for further testing and 12 WBIT errors were detected. The PPV of the model was 10.9%. CONCLUSION A machine learning model suitable for routine use was able to identify WBIT errors missed by the laboratory's current procedures. Machine learning models are valuable for the identification of WBIT errors, and their validation and deployment in clinical laboratories would improve patient safety.
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Affiliation(s)
| | - Charles Makuni
- Transfusion Department, NSW Health Pathology-Nepean Hospital, Sydney, Australia
| | - Aaron Keenan
- Transfusion Department, NSW Health Pathology-Nepean Hospital, Sydney, Australia
| | - Ellena Maeder
- Haematology Department, NSW Health Pathology-Nepean Hospital, Sydney, Australia
| | - Gareth Davies
- Haematology Department, NSW Health Pathology-Nepean Hospital, Sydney, Australia
| | - John Giannoutsos
- Transfusion Department, NSW Health Pathology-Nepean Hospital, Sydney, Australia
- Haematology Department, NSW Health Pathology-Nepean Hospital, Sydney, Australia
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10
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Al-Eshaq DH, Bradley RT, McBride ERA, Ford JC. Patient and specimen identification in a tertiary care pediatric hospital: Barcodes do not scan themselves. Transfusion 2023; 63:1310-1317. [PMID: 37226989 DOI: 10.1111/trf.17399] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2022] [Revised: 03/12/2023] [Accepted: 04/20/2023] [Indexed: 05/26/2023]
Abstract
BACKGROUND Despite the safety improvements linked to the use of barcodes for patient and specimen identification, patient misidentification remains a leading cause of transfusion-associated reactions including fatalities. A wealth of evidence supports the use of barcodes in general, but there is less published evidence of real-world barcode compliance. This project investigates barcode scanning compliance for patient and specimen identification at a tertiary care pediatric/maternity hospital. STUDY DESIGN AND METHODS Transfusion laboratory specimen collection noncompliance events between January 1, 2019, and December 31, 2019 were retrieved from the hospital laboratory information system. Data were analyzed including stratification of collections by collector role and collection event. A survey of blood collectors was conducted. RESULTS Collection compliance for 6285 blood typing specimens was evaluated. Full barcode scanning identification of both patient and specimen was utilized in only 33.6% of total collections. The remaining two thirds of collections were overridden by the blood collector: no barcode scanning occurred in 31.3%, while the specimen accession label was scanned but not the patient armband in 32.3% of total collections. There were significant differences between phlebotomists and nurses, with more phlebotomists performing the full scanning and specimen scanning only, while more nurses obtained specimens without patient or specimen scanning (p < .001). Blood collectors identified hardware challenges and training gaps as key contributors to barcode noncompliance. DISCUSSION Our study highlights an instance of poor barcode scanning compliance for patient and specimen identification. We formulated improvement strategies and launched a quality improvement project to address factors influencing noncompliance.
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Affiliation(s)
- Dana Hussain Al-Eshaq
- College of Health Sciences, Qatar University, Doha, Qatar
- Department of Pathology, Sidra Medicine, Doha, Qatar
| | | | | | - Jason C Ford
- Department of Pathology, Sidra Medicine, Doha, Qatar
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11
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Shaw B, Wood EM, Callum J, McQuilten ZK. Home Delivery: Transfusion Services When and Where They Are Needed. Transfus Med Rev 2022; 36:117-124. [DOI: 10.1016/j.tmrv.2022.06.003] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/11/2022] [Revised: 06/03/2022] [Accepted: 06/04/2022] [Indexed: 11/16/2022]
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12
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Passwater M, Huggins YM, Delvo Favre ED, Mukhtar F, Pelletier JPR. Adding Automation and Independent Dual Verification to Reduce Wrong Blood in Tube (WBIT) Events. Am J Clin Pathol 2022; 158:212-215. [PMID: 35304892 DOI: 10.1093/ajcp/aqac031] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2021] [Accepted: 02/08/2022] [Indexed: 11/13/2022] Open
Abstract
OBJECTIVES Transfusions remain a complicated procedure involving many disciplines performing various steps. Pretransfusion specimen identification errors remain a concern. Over the past two decades, system changes have been made and minimal improvements in the error rates have been seen. Wrong blood in tube (WBIT) events may lead to mistransfusions of components with life-threatening complications. METHODS A continuous quality improvement effort involving the introduction of electronic patient identification at the point of pretransfusion specimen collection (an automated system improvement), manual independent dual verification, and periodic education (human process system improvements) were implemented. RESULTS Both automated and human system process improvements resulted in greater than 10-fold reduction in WBIT events and a 47% reduction in mislabeled specimens. CONCLUSIONS Diligent improvement and implementation of combination automated system processes and human protocols with continuous monitoring led to great reductions in WBIT error rates and labeling discrepancies, leading to an increase in system safety. These combinations of improvement can lead to more decreased error rates if applied to other critical process steps in the transfusion process.
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Affiliation(s)
| | | | | | - Faisal Mukhtar
- UF Health Shands Hospital, Gainesville, FL, USA
- Department of Pathology, Immunology, Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
| | - J Peter R Pelletier
- UF Health Shands Hospital, Gainesville, FL, USA
- Department of Pathology, Immunology, Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
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13
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Farrell CJL, Giannoutsos J. Machine learning models outperform manual result review for the identification of wrong blood in tube errors in complete blood count results. Int J Lab Hematol 2022; 44:497-503. [PMID: 35274468 DOI: 10.1111/ijlh.13820] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2021] [Accepted: 02/23/2022] [Indexed: 11/29/2022]
Abstract
INTRODUCTION Wrong blood in tube (WBIT) errors are a significant patient-safety issue encountered by clinical laboratories. This study assessed the performance of machine learning models for the identification of WBIT errors affecting complete blood count (CBC) results against the benchmark of manual review of results by laboratory staff. METHODS De-identified current and previous (within seven days) CBC results were used in the computer simulation of WBIT errors. 101 015 sets of samples were used to develop machine learning models using artificial neural network, extreme gradient boosting, support vector machine, random forest, logistic regression, decision trees (one complex and one simple) and k-nearest neighbours algorithms. The performance of these models, and of manual review by laboratory staff, was assessed on a separate data set of 1940 samples. RESULTS Volunteers manually reviewing results identified WBIT errors with an accuracy of 85.7%, sensitivity of 80.1% and specificity of 92.1%. All machine learning models exceeded human-level performance (p-values for all metrics were <.001). The artificial neural network model was the most accurate (99.1%), and the simple decision tree was the least accurate (96.8%). Sensitivity for the machine learning models varied from 95.7% to 99.3%, and specificity varied from 96.3% to 98.9%. CONCLUSION This study provides preliminary evidence supporting the value of machine learning for detecting WBIT errors affecting CBC results. Although further work addressing practical issues is required, substantial patient-safety benefits await the successful deployment of machine learning models for WBIT error detection.
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Affiliation(s)
| | - John Giannoutsos
- New South Wales Health Pathology, Nepean Hospital, Penrith, NSW, Australia
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14
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Obaidallah N, Downie H, Colavecchia C, Callum J, Lin Y. Implementation of a blood bank generated tube for second blood group determination: Challenges, yield, and cost. Transfusion 2022; 62:784-790. [PMID: 35213739 PMCID: PMC9304256 DOI: 10.1111/trf.16838] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/26/2021] [Revised: 02/06/2022] [Accepted: 02/13/2022] [Indexed: 12/03/2022]
Abstract
Background The second blood group determination or group check sample is a process of verifying the ABO group with a second blood sample prior to transfusion. It has been used to detect errors related to wrong blood in tube (WBIT) events and reduce the risk of ABO‐incompatible transfusions. To prevent the clinical team from collecting the group check sample at the same time as the first sample, a tan top tube only available from the blood bank was introduced for second blood group determinations if drawn within 24 h of the first group and screen. Study design and methods This is a retrospective study analyzing data from 2005 to 2020 before and after the implementation of the blood bank supplied tan top tube for group check. The number of WBIT events, transfusion delays, and health care costs were determined. Results The number of WBIT events remained unchanged throughout the time period. No delays in transfusion or procedure were reported due to the tan top tube group check. There was no increase in group O transfusions over time. In comparison to using an ethylenediaminetetraacetic acid (EDTA) tube, the tan top tube was estimated to add an extra yearly cost of $790.79 Canadian dollars. Conclusion Second blood group determination using the blood bank supplied tan top tube did not increase the number of WBIT events detected but ensured an independent sample draw. A minimal incremental cost of implementing the tan top tube was noted with no delay in transfusions or procedures.
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Affiliation(s)
- Noora Obaidallah
- Department of Medicine, University of Toronto, Toronto, Ontario, Canada
| | - Helen Downie
- Division of Transfusion Medicine and Tissue Bank, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
| | - Connie Colavecchia
- Division of Transfusion Medicine and Tissue Bank, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
| | - Jeannie Callum
- Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.,University of Toronto Quality in Utilization, Education and Safety in Transfusion (QUEST) Research Program, Toronto, Ontario, Canada.,Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada
| | - Yulia Lin
- Division of Transfusion Medicine and Tissue Bank, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.,Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.,University of Toronto Quality in Utilization, Education and Safety in Transfusion (QUEST) Research Program, Toronto, Ontario, Canada
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15
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Crispin P, Akers C, Brown K, Delaforce A, Keegan A, King F, Ormerod A, Verrall T. A review of electronic medical records and safe transfusion practice for guideline development. Vox Sang 2022; 117:761-768. [PMID: 35089600 DOI: 10.1111/vox.13254] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/12/2021] [Revised: 10/22/2021] [Accepted: 11/26/2021] [Indexed: 11/30/2022]
Abstract
BACKGROUND AND OBJECTIVES Electronic medical records (EMRs) are often composed of multiple interlinking systems, each serving a particular task, including transfusion ordering and administration. Transfusion may not be prioritized when developing or implementing electronic platforms. Uniform guidelines may assist information technology (IT) developers, institutions and healthcare workforces to progress with shared goals. MATERIALS AND METHODS A narrative review of current clinical guidance, benefits and risks of electronic systems for clinical transfusion practice was combined with feedback from experienced transfusion practitioners. RESULTS There is opportunity to improve the safety, quality and efficiency of transfusion practice, particularly through decision support and better identification procedures, by incorporating transfusion practice into EMRs. However, these benefits should not be assumed, as poorly designed processes within the electronic systems and the critically important electronic-human process interfaces may increase risk while creating the impression of safety. CONCLUSION Guidelines should enable healthcare and IT industries to work constructively together so that each implementation provides assurance of safe practice.
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Affiliation(s)
- Philip Crispin
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,Department of Haematology, Canberra Hospital, Garran, ACT, Australia.,Australian National University Medical School, Acton, ACT, Australia
| | - Christine Akers
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,Victorian Department of Health and Human Services, Blood Matters Program, Melbourne, Victoria, Australia
| | - Kristen Brown
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,Medical Services, Murrumbidgee Area Health Service, Wagga Wagga, NSW, Australia
| | - Alana Delaforce
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,Mater Health Services, South Brisbane, QLD, Australia.,Mater Research Institute-UQ, South Brisbane, QLD, Australia.,School of Nursing and Midwifery, The University of Newcastle, Callaghan, NSW, Australia
| | - Anastazia Keegan
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,Transfusion Policy and Education, Australian Red Cross Lifeblood, Perth, Western Australia, Australia.,Department of Haematology, Nepean Hospital, New South Wales, Australia
| | - Fiona King
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,New Zealand Blood Service, Wellington, New Zealand
| | - Amanda Ormerod
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,Department of Haematology, Latrobe Regional Health, Traralgon, Victoria, Australia
| | - Trudi Verrall
- Clinical Practice Improvement Committee of Australian and New Zealand Society of Blood Transfusion, Sydney, NSW, Australia.,BloodSafe eLearning, Adelaide, South Australia, Australia
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16
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O' Herlihy N, Griffin S, Gaffney R, Henn P, Khashan AS, Ring M, Gallagher A, Cahill MR. Proficiency-based progression intern training to reduce critical blood sampling errors including ‘wrong blood in tube’. HRB Open Res 2021. [DOI: 10.12688/hrbopenres.13329.2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/20/2022] Open
Abstract
Background: Blood sampling errors including ‘wrong blood in tube’ (WBIT) may have adverse effects on clinical outcomes. WBIT errors occur when the blood sample in the tube is not that of the patient identified on the label. This study aims to determine the effect of proficiency-based progression (PBP) training in phlebotomy on the rate of blood sampling errors (including WBIT). Methods: A non-randomised controlled trial compared the blood sampling error rate of 43 historical controls who had not undergone PBP training in 2016 to 44 PBP trained interventional groups in 2017. In 2018, the PBP training programme was implemented and the blood sampling error rate of 46 interns was compared to the 43 historical controls in 2016. Data analysis was performed using logistic regression analysis adjusting for sample timing. Results: In 2016, 43 interns had a total blood sample error rate of 2.4%, compared to 44 interns in 2017, who had error rate of 1.2% (adjusted OR=0.50, 95% CI 0.36-0.70; <0.01). In 2018, 46 interns had an error rate of 1.9% (adjusted OR=0.89, 95% CI 0.65-1.21; p=0.46) when compared to the 2016 historical controls. There were three WBITs in 2016, three WBITs in 2017 and five WBITs in 2018. Conclusions: The study demonstrates that PBP training in phlebotomy has the potential to reduce blood sampling errors. Trial registration number: NCT03577561
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17
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Dunbar NM, Kaufman RM. Factors associated with wrong blood in tube errors: An international case series - The BEST collaborative study. Transfusion 2021; 62:44-50. [PMID: 34726274 DOI: 10.1111/trf.16716] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2021] [Revised: 09/03/2021] [Accepted: 10/11/2021] [Indexed: 12/01/2022]
Abstract
BACKGROUND A wrong blood in tube (WBIT) error signifies a blood sample that does not match the patient identified on the sample label. WBIT errors can result in ABO mistransfusions. STUDY DESIGN AND METHODS In this international, multicenter, descriptive study, healthcare facilities provided detailed information on WBIT errors occurring from 1/1/2019 to 12/31/2020. Factors contributing to WBIT errors were classified as protocol violations, knowledge gaps, and slips/lapses. RESULTS 331 WBIT errors were compiled from 36 centers in 11 countries. WBIT errors were most frequently detected through pretransfusion sample testing (191, 58%), with 38 (20%) detected by a second ("check") sample. WBIT errors were divided almost evenly between intended patient drawn/wrong label applied (166, 50%) and wrong patient drawn/intended label applied (158, 48%). Information on contributing factors was available for 260 WBIT errors; most involved a combination of protocol violations and slips/lapses (139, 53%). The most frequent contributing factor was another patient's sample labels or tubes being available during phlebotomy (61%). Protocol violations were more likely to result in wrong patient being drawn (p = .0007). In 43 WBIT errors, electronic positive patient identification (ePPID) was not used when available or was used incorrectly. CONCLUSIONS Protocol violations and slips/lapses frequently contribute to WBIT errors. Sample collection processes should be designed to minimize error opportunities; staff should be educated on why protocol compliance is critical for patient safety. Using ePPID does not eliminate all WBIT errors. Institutions using ePPID may elect to require check sample verification as an added safety measure.
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Affiliation(s)
- Nancy M Dunbar
- Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
| | - Richard M Kaufman
- Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA
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18
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Farrell CJL. Decision support or autonomous artificial intelligence? The case of wrong blood in tube errors. Clin Chem Lab Med 2021; 60:1993-1997. [PMID: 34717051 DOI: 10.1515/cclm-2021-0873] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/04/2021] [Accepted: 10/21/2021] [Indexed: 11/15/2022]
Abstract
OBJECTIVES Artificial intelligence (AI) models are increasingly being developed for clinical chemistry applications, however, it is not understood whether human interaction with the models, which may occur once they are implemented, improves or worsens their performance. This study examined the effect of human supervision on an artificial neural network trained to identify wrong blood in tube (WBIT) errors. METHODS De-identified patient data for current and previous (within seven days) electrolytes, urea and creatinine (EUC) results were used in the computer simulation of WBIT errors at a rate of 50%. Laboratory staff volunteers reviewed the AI model's predictions, and the EUC results on which they were based, before making a final decision regarding the presence or absence of a WBIT error. The performance of this approach was compared to the performance of the AI model operating without human supervision. RESULTS Laboratory staff supervised the classification of 510 sets of EUC results. This workflow identified WBIT errors with an accuracy of 81.2%, sensitivity of 73.7% and specificity of 88.6%. However, the AI model classifying these samples autonomously was superior on all metrics (p-values<0.05), including accuracy (92.5%), sensitivity (90.6%) and specificity (94.5%). CONCLUSIONS Human interaction with AI models can significantly alter their performance. For computationally complex tasks such as WBIT error identification, best performance may be achieved by autonomously functioning AI models.
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Affiliation(s)
- Christopher-John L Farrell
- Department of Biochemistry, New South Wales Health Pathology, Nepean Blue Mountains Pathology Service, Penrith, Australia
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19
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Abstract
Blood transfusions are generally safe but can carry considerable risks. This review summarizes the different types of transfusion reactions and ways to diagnose and manage them. Symptoms are often overlapping and nonspecific. When a reaction is suspected, it is critical to stop the transfusion immediately and report the reaction to the blood bank, as this can affect the patient's outcome. New evidence-based algorithms of transfusion, newer blood screening methods and donor policies and deferrals, new laboratory testing, electronic verification systems, and improved hemovigilance lead to the avoidance of unnecessary transfusions and decrease the incidence of serious transfusion reactions.
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Affiliation(s)
- Rim Abdallah
- Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
| | - Herleen Rai
- Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
| | - Sandhya R Panch
- Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.
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20
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O' Herlihy N, Griffin S, Gaffney R, Henn P, Khashan AS, Ring M, Gallagher A, Cahill MR. Proficiency-based progression intern training to reduce critical blood sampling errors including ‘wrong blood in tube’. HRB Open Res 2021. [DOI: 10.12688/hrbopenres.13329.1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/20/2022] Open
Abstract
Background: Blood sampling errors including ‘wrong blood in tube’ (WBIT) may have adverse effects on clinical outcomes. WBIT errors occur when the blood sample in the tube is not that of the patient identified on the label. This study aims to determine the effect of proficiency-based progression (PBP) training in phlebotomy on the rate of blood sampling errors (including WBIT). Methods: A non-randomised controlled trial compared the blood sampling error rate of 43 historical controls who had not undergone PBP training in 2016 to 44 PBP trained interventional groups in 2017. In 2018, the PBP training programme was implemented and the blood sampling error rate of 46 interns was compared to the 43 historical controls in 2016. Data analysis was performed using logistic regression analysis adjusting for sample timing. Results: In 2016, 43 interns had a total blood sample error rate of 2.4%, compared to 44 interns in 2017, who had error rate of 1.2% (adjusted OR=0.50, 95% CI 0.36-0.70; <0.01). In 2018, 46 interns had an error rate of 1.9% (adjusted OR=0.89, 95% CI 0.65-1.21; p=0.46) when compared to the 2016 historical controls. There were three WBITs in 2016, three WBITs in 2017 and five WBITs in 2018. Conclusions: The study demonstrates that PBP training in phlebotomy has the potential to reduce blood sampling errors. Trial registration number: NCT03577561
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21
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Dunbar NM, Delaney M, Murphy MF, Pagano MB, Saifee NH, Seheult J, Yazer M, Kaufman RM. Emergency departments are higher-risk locations for wrong blood in tube errors. Transfusion 2021; 61:2601-2610. [PMID: 34268775 DOI: 10.1111/trf.16588] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/29/2021] [Revised: 06/10/2021] [Accepted: 06/12/2021] [Indexed: 12/26/2022]
Abstract
BACKGROUND Wrong blood in tube (WBIT) errors can lead to ABO mistransfusions. It is unknown if WBIT errors are more likely in specific healthcare locations or if specific collection practices influence the commission of WBIT errors. STUDY DESIGN AND METHODS Data on pretransfusion samples from calendar year 2019 were collected retrospectively by 39 transfusion services in nine countries. We compared the proportion of WBIT errors made in emergency departments (EDs), inpatient wards, and outpatient clinics. RESULTS In total, 143 WBIT errors were detected among 1,394,862 samples for an unadjusted aggregate WBIT proportion of 1.03/10,000 samples. Using a pooled random effects model, the WBIT proportion was estimated to be significantly higher in EDs (1.23/10,000 samples, 95% CI 0.62-2.43) than inpatient wards (0.71/10,000, 95% CI 0.44-1.14; p < .001) or outpatient clinics (0.24/10,000, 95% CI 0.08-0.65; p < .001) and significantly higher in inpatient wards than outpatient clinics (p = .043). The use of electronic positive patient identification (ePPID) systems was associated with a significantly lower WBIT proportion in the ED (odds ratio, OR: 0.32, 95% CI: 0.11-0.96, p = .041), but not in inpatient wards (OR: 0.45, 95% CI: 0.20-1.01, p = .054) or outpatient clinics (OR: 1.95, 95% CI: 0.39-9.74, p = .415). DISCUSSION Normalized for the number of samples drawn per location, the WBIT proportion in EDs was 1.7 times higher than inpatient wards and 5.1 times higher than outpatient clinics. EDs represent higher-risk clinical locations for WBIT errors, and electronic positive patient identification (ePPID) may provide a greater impact on safety in EDs relative to other clinical areas.
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Affiliation(s)
- Nancy M Dunbar
- Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
| | - Meghan Delaney
- Division Pathology & Laboratory Medicine, Children's National Hospital and Department of Pathology and Pediatrics, The George Washington University, Washington, District of Columbia, USA
| | - Michael F Murphy
- NHS Blood & Transplant, and Oxford Biomedical Research Centre, Oxford, UK
| | - Monica B Pagano
- Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
| | - Nabiha Huq Saifee
- Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.,Bloodworks Northwest, Seattle, Washington, USA
| | - Jansen Seheult
- Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,Vitalant, Pittsburgh, Pennsylvania, USA
| | - Mark Yazer
- Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,Vitalant, Pittsburgh, Pennsylvania, USA
| | - Richard M Kaufman
- Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA
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22
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Lancaster E, Rhodus E, Duke M, Harris A. Blood Transfusion Errors Within a Health System: A Review of Root Cause Analyses. PATIENT SAFETY 2021. [DOI: 10.33940/med/2021.6.6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022] Open
Abstract
Introduction: Blood transfusions are lifesaving treatments which require critical attention to processes and details. If processes are not followed, grievous errors can lead to sentinel events. A review of investigations completed due to reported events will show the error trends associated with systems used throughout the blood transfusion process.
Methods: This study employed root cause analyses (RCAs) within the Veterans Health Administration (VHA) to review the events leading to blood transfusion errors. Data was pulled from the RCA databases within the VA National Center for Patient Safety. The time frame was October 2014 to August 2019. A total of 53 RCAs and aggregated reviews were included in the study. These were reviewed for common themes and gaps present within processes.
Results: The most common events fell within the categories of incorrect or delayed blood orders, incorrect or lack of patient identification, and wrong blood given. The RCA for each event was reviewed and studied. The RCAs had a crossover of multiple causes; lack of a formal process, communication barriers, and technology barriers were the most frequent.
Conclusion: These RCAs express great variation between VHA facilities, such as process created, number of staff reports, and number of RCAs completed. Lack of standard practices nationwide, training barriers, and technology barriers may explain the variation of transfusion errors throughout the VHA. This study brings to light questions about standardization of transfusion protocols. Future study regarding such standardization is necessary to determine its plausibility.
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Affiliation(s)
| | | | - Mary Duke
- Lexington Veterans Affairs Health Care System
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23
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Affiliation(s)
- Barry Hill
- Director of Education (Employability), Nursing, Midwifery and Health, Northumbria University
| | - Julie Derbyshire
- Director of Education (Apprenticeships), Nursing, Midwifery and Health, Northumbria University, Newcastle upon Tyne
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24
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Haroun A, AL- Ruzzieh MA, Hussien N, Masa’ad A, Hassoneh R, Abu Alrub G, Ayaad O. Using Failure Mode and Effects Analysis in Improving Nursing Blood Sampling at an International Specialized Cancer Center. Asian Pac J Cancer Prev 2021; 22:1247-1254. [PMID: 33906319 PMCID: PMC8325149 DOI: 10.31557/apjcp.2021.22.4.1247] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/17/2021] [Accepted: 04/17/2021] [Indexed: 01/05/2023] Open
Abstract
BACKGROUND The process of blood sampling is considered one of the primary and most common nursing invasive procedures carried out daily. Any failure at any point could have a severe negative impact on patient outcomes. PURPOSE This project aimed to assess and improve the nursing blood sampling process in a specialized cancer center using failure mode and effect analysis (FMEA). METHODS An observational analytical design of the nursing blood sampling process using FMEA was conducted in King Hussein Cancer Center in Amman, Jordan. Seven steps were conducted, including a review of the blood sampling process, brainstorming potential failures, listing potential effects of each failure mode, assigning a severity rating for each potential effect, assigning a frequency/occurrence rating for each failure mode, assigning a detection rating scale for each failure mode, and calculating the Risk Priority Number (RPN) for each effect. RESULTS Eight (out of 28) main critical failure modes with more than 200 RPN were identified in the blood sampling process. Accordingly, five themes were developed to guide the corrective actions. These themes included: process and responsibility modifications, resource and information technology utilization, patients and family engagement, safety culture, and education and training after implementation of the corrective actions. This resulted in a 58 % reduction in the RPN of major failure modes. CONCLUSION Many factors lead to blood sampling errors. A critical focus should be conducted on the preparation phase due to the possible errors that may occur. Proper identification of patients and blood sample tests are the keys to a significant decrease in blood sampling errors. .
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Affiliation(s)
| | | | | | | | | | | | - Omar Ayaad
- King Hussein Cancer Center, Al-Jubeiha Amman, Jordan.
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25
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Lam C, Meinert E, Yang A, Cui Z. Comparison between centralized and decentralized supply chains of autologous chimeric antigen receptor T-cell therapies: a UK case study based on discrete event simulation. Cytotherapy 2021; 23:433-451. [PMID: 33674239 DOI: 10.1016/j.jcyt.2020.08.007] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2020] [Revised: 07/21/2020] [Accepted: 08/16/2020] [Indexed: 11/25/2022]
Abstract
BACKGROUND AIMS Decentralized, or distributed, manufacturing that takes place close to the point of care has been a manufacturing paradigm of heightened interest within the cell therapy domain because of the product's being living cell material as well as the need for a highly monitored and temperature-controlled supply chain that has the potential to benefit from close proximity between manufacturing and application. METHODS To compare the operational feasibility and cost implications of manufacturing autologous chimeric antigen receptor T (CAR T)-cell products between centralized and decentralized schemes, a discrete event simulation model was built using ExtendSIM 9 for simulating the patient-to-patient supply chain, from the collection of patient cells to the final administration of CAR T therapy in hospitals. Simulations were carried out for hypothetical systems in the UK using three demand levels-low (100 patients per annum), anticipated (200 patients per annum) and high (500 patients per annum)-to assess resource allocation, cost per treatment and system resilience to demand changes and to quantify the risks of mix-ups within the supply chain for the delivery of CAR T treatments. RESULTS The simulation results show that although centralized manufacturing offers better economies of scale, individual facilities in a decentralized system can spread facility costs across a greater number of treatments and better utilize resources at high demand levels (annual demand of 500 patients), allowing for an overall more comparable cost per treatment. In general, raw material and consumable costs have been shown to be one of the greatest cost drivers, and genetic modification-associated costs have been shown to account for over one third of raw material and consumable costs. Turnaround time per treatment for the decentralized scheme is shown to be consistently lower than its centralized counterpart, as there is no need for product freeze-thaw, packaging and transportation, although the time savings is shown to be insignificant in the UK case study because of its rather compact geographical setting with well-established transportation networks. In both schemes, sterility testing lies on the critical path for treatment delivery and is shown to be critical for treatment turnaround time reduction. CONCLUSIONS Considering both cost and treatment turnaround time, point-of-care manufacturing within the UK does not show great advantages over centralized manufacturing. However, further simulations using this model can be used to understand the feasibility of decentralized manufacturing in a larger geographical setting.
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Affiliation(s)
- Ching Lam
- Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK
| | - Edward Meinert
- Department of Paediatrics, University of Oxford, Oxford, UK
| | - Aidong Yang
- Department of Engineering Science, University of Oxford, Oxford, UK
| | - Zhanfeng Cui
- Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
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26
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Nakamura Y, Furuta Y, Tokida M, Ichikawa K, Shirahata M, Uzawa K, Takizawa M, Okubo M, Ohsaka A. A survey of nurses to assess transfusion practice at the bedside using an electronic identification system: Experience at a university hospital. Transfus Med 2021; 31:5-10. [PMID: 33398917 DOI: 10.1111/tme.12758] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/24/2020] [Revised: 10/05/2020] [Accepted: 12/27/2020] [Indexed: 11/30/2022]
Abstract
OBJECTIVES The objective of this study was to assess the performance and recognition of transfusion practice at the bedside by nurses in our hospital, where a barcode-based electronic identification system (EIS) has been used since 2002. BACKGROUND More than half of the steps in the transfusion chain are dependent on nurses' awareness and skills. METHODS Our transfusion policy at the bedside includes two-person checking of the patient and two-person signing of the label at the time of collecting blood samples for pre-transfusion testing and two-person blood administration, which generally involved a doctor-nurse pair but sometimes involved two nurses. Anonymous, paper-based questionnaires were sent in January 2018 to 1051 nurses who were working in Juntendo University Hospital, Tokyo, Japan. The questionnaire consisted of three parts: (a) background of respondents, (b) performance of collection of blood samples for pre-transfusion testing and (c) performance of pre-transfusion check procedures at the bedside using an EIS based on a total of 20 questions. RESULTS There was a good response rate of individual nurses (1006/1051, 96%). Most nurses (>90%) performed two-person checking of the patient and two-person signing of the label at the time of collecting blood samples. Most nurses (>90%) performed two-person blood administration involving a doctor-nurse pair and electronic pre-transfusion check using an EIS before blood administration. CONCLUSIONS The survey revealed that most nurses complied with our transfusion policy at the bedside, but some nurses did not. Further education/training and continuous support by the transfusion service may be needed for all nurses.
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Affiliation(s)
- Yuki Nakamura
- Department of Transfusion Service, Juntendo University Hospital, Tokyo, Japan
| | - Yoshiaki Furuta
- Department of Transfusion Service, Juntendo University Hospital, Tokyo, Japan
| | - Miho Tokida
- Department of Transfusion Service, Juntendo University Hospital, Tokyo, Japan
| | - Kayoko Ichikawa
- Department of Transfusion Service, Juntendo University Hospital, Tokyo, Japan
| | - Mineko Shirahata
- Department of Nursing, Juntendo University Hospital, Tokyo, Japan
| | - Kumiko Uzawa
- Department of Nursing, Juntendo University Hospital, Tokyo, Japan
| | - Makiko Takizawa
- Department of Nursing, Juntendo University Hospital, Tokyo, Japan
| | - Mitsuo Okubo
- Department of Transfusion Service, Juntendo University Urayasu Hospital, Chiba, Japan.,Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Graduate School of Medicine, Tokyo, Japan
| | - Akimichi Ohsaka
- Department of Transfusion Service, Juntendo University Hospital, Tokyo, Japan.,Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Graduate School of Medicine, Tokyo, Japan
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27
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O'Herlihy N, Griffin S, Henn P, Gaffney R, Cahill MR, Gallagher AG. Validation of phlebotomy performance metrics developed as part of a proficiency-based progression initiative to mitigate wrong blood in tube. Postgrad Med J 2020; 97:363-367. [PMID: 32817581 DOI: 10.1136/postgradmedj-2019-137254] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/13/2020] [Indexed: 01/22/2023]
Abstract
AIMS The purpose of this study was to (1) characterise the procedure of phlebotomy, deconstruct it into its constituent parts and develop a performance metric for the purpose of training healthcare professionals in a large teaching hospital and to (2) evaluate the construct validity of the phlebotomy metric and establish a proficiency benchmark. METHOD By engaging with a multidisciplinary team with a wide range of experience of preanalytical errors in phlebotomy and observing video recordings of the procedure performed in the actual working environment, we defined a performance metric. This was brought to a modified Delphi meeting, where consensus was reached by an expert panel. To demonstrate construct validity, we used the metric to objectively assess the performance of novices and expert practitioners. RESULTS A phlebotomy metric consisting of 11 phases and 77 steps was developed. The mean inter-rater reliability was 0.91 (min 0.83, max 0.95). The expert group completed more steps of the procedure (72 vs 69), made fewer errors (19 vs 13, p=0.014) and fewer critical errors (1 Vs 4, p=0.002) than the novice group. CONCLUSIONS The metrics demonstrated construct validity and the proficiency benchmark was established with a minimum observation of 69 steps, with no critical errors and no more than 13 errors in total.
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Affiliation(s)
| | | | - Patrick Henn
- School of Medicine, University College Cork, Cork, Ireland
| | - Robert Gaffney
- School of Medicine, University College Cork, Cork, Ireland
| | - Mary Rose Cahill
- School of Medicine, University College Cork, Cork, Ireland.,Haematology Department, Cork University Hospital Group, Cork, Ireland
| | - Anthony G Gallagher
- Faculty of Life and Health Sciences, University of Ulster - Magee Campus, Londonderry, UK
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28
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Documentation errors in transfusion chain: Challenges and interventions. Transfus Apher Sci 2020; 59:102812. [DOI: 10.1016/j.transci.2020.102812] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/03/2020] [Revised: 04/08/2020] [Accepted: 04/19/2020] [Indexed: 11/20/2022]
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29
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The best blood product and its best use for each patient: An evolving role for hemovigilance? Transfus Clin Biol 2019; 26:188-191. [DOI: 10.1016/j.tracli.2019.04.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/27/2019] [Accepted: 04/30/2019] [Indexed: 11/20/2022]
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30
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Stellungnahme Fehlanwendungen von Blutkomponenten. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019; 62:1140-1143. [PMID: 31463651 DOI: 10.1007/s00103-019-02989-9] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/15/2022]
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31
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Chou SS, Chen YJ, Shen YT, Yen HF, Kuo SC. Implementation and Effectiveness of a Bar Code-Based Transfusion Management System for Transfusion Safety in a Tertiary Hospital: Retrospective Quality Improvement Study. JMIR Med Inform 2019; 7:e14192. [PMID: 31452517 PMCID: PMC6732972 DOI: 10.2196/14192] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/07/2019] [Revised: 07/02/2019] [Accepted: 08/07/2019] [Indexed: 12/17/2022] Open
Abstract
Background Large-scale and long-term studies are not sufficient to determine the efficiency that IT solutions can bring to transfusion safety. Objective This quality-improvement report describes our continuous efforts to implement and upgrade a bar code–based transfusion management (BCTM) system since 2011 and examines its effectiveness and sustainability in reducing blood transfusion errors, in a 3000-bed tertiary hospital, where more than 60,000 prescriptions of blood transfusion are covered by 2500 nurses each year. Methods The BCTM system uses barcodes for patient identification, onsite labeling, and blood product verification, through wireless connection to the hospital information systems. Plan-Do-Study-Act (PDSA) cycles were used to improve the process. Process maps before and after implementation of the BCTM system in 2011 were drawn to highlight the changes. The numbers of incorrect labeling or wrong blood in tube incidents that occurred quarterly were plotted on a run chart to monitor the quality changes of each intervention introduced. The annual occurrences of error events from 2011 to 2017 were compared with the mean occurrence of 2008-2010 to determine whether implementation of the BCTM system could effectively reduce the number of errors in 2016 and whether this reduction could persist in 2017. Results The error rate decreased from 0.03% in 2008-2010 to 0.002% in 2016 (P<.001) and 0.001% in 2017 (P<.001) after implementation of the BTCM system. Only one incorrect labeling incident was noted among the 68,324 samples for blood typing, and no incorrect transfusions occurred among 67,423 transfusion orders in 2017. Conclusions This report demonstrates that continuous efforts to upgrade the existing process is critical to reduce errors in transfusion therapy, with support from information technology.
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Affiliation(s)
- Shin-Shang Chou
- Department of Nursing, Taipei Veterans General Hospital, Taipei City, Taiwan.,School of Nursing, National Yang-Ming University, Taipei, Taiwan.,School of Nursing, Taipei Medical University, Taipei, Taiwan
| | - Ying-Ju Chen
- Section of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
| | - Yu-Te Shen
- Department of Information Management, Taipei Veterans General Hospital, Taipei, Taiwan
| | - Hsiu-Fang Yen
- Department of Nursing, Taipei Veterans General Hospital, Taipei City, Taiwan
| | - Shu-Chen Kuo
- Department of Nursing, Taipei Veterans General Hospital, Taipei City, Taiwan.,School of Nursing, National Yang-Ming University, Taipei, Taiwan
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Affiliation(s)
- Sandhya R Panch
- From the Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health Clinical Center, Bethesda, MD
| | - Celina Montemayor-Garcia
- From the Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health Clinical Center, Bethesda, MD
| | - Harvey G Klein
- From the Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health Clinical Center, Bethesda, MD
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De la Salle B. Pre‐ and postanalytical errors in haematology. Int J Lab Hematol 2019; 41 Suppl 1:170-176. [DOI: 10.1111/ijlh.13007] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/04/2019] [Revised: 02/17/2019] [Accepted: 02/19/2019] [Indexed: 12/23/2022]
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Wood EM, Ang AL, Bisht A, Bolton-Maggs PH, Bokhorst AG, Flesland O, Land K, Wiersum-Osselton JC, Schipperus MR, Tiberghien P, Whitaker BI. International haemovigilance: what have we learned and what do we need to do next? Transfus Med 2019; 29:221-230. [PMID: 30729612 DOI: 10.1111/tme.12582] [Citation(s) in RCA: 29] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2018] [Revised: 11/05/2018] [Accepted: 01/12/2019] [Indexed: 02/06/2023]
Abstract
The International Haemovigilance Network (IHN) defines haemovigilance as 'a set of surveillance procedures covering the whole transfusion chain (from the collection of blood and its components to the follow-up of recipients), intended to collect and assess information on unexpected or undesirable effects resulting from the therapeutic use of labile blood products, and to prevent their occurrence or recurrence'. IHN, the International Society of Blood Transfusion and World Health Organization work together to support both developing and established haemovigilance systems. Haemovigilance systems provide valuable data on a range of adverse events related to blood donation and clinical transfusion, from donor syncopal events to transfusion-transmitted infections, immunological complications and the impact of human errors. Harmonised definitions for most adverse reactions have been developed and validated internationally. Definitions of pulmonary complications are again under review. Haemovigilance data have resulted in changes in policy, products and practice, and can complement and inform clinical audit and research, leading to improved blood donor safety, optimised product use and better clinical outcomes after transfusion. However, more work is needed. Not all countries have haemovigilance systems in place. More robust data and careful analysis are required to improve the understanding of the causes, occurrence and clinical outcomes of these events. Wider dissemination of results will facilitate health policy development internationally, and implementation of haemovigilance recommendations will support further important progress in blood safety.
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Affiliation(s)
- E M Wood
- Transfusion Research Unit, Monash University, Melbourne, Victoria, Australia.,Department of Clinical Haematology, Monash Health, Melbourne, Victoria, Australia
| | - A L Ang
- Blood Services Group, Health Sciences Authority, Singapore.,Department of Haematology, Singapore General Hospital, Singapore
| | - A Bisht
- Haemovigilance Programme of India, National Institute of Biologicals, Ministry of Health & Family Welfare, Noida, India
| | - P H Bolton-Maggs
- Serious Hazards of Transfusion, Manchester, UK.,University of Manchester, Manchester, UK
| | - A G Bokhorst
- Transfusion and Transplantation Reactions in Patients (TRIP), National Haemovigilance and Biovigilance Office, Leiden, The Netherlands
| | - O Flesland
- Norwegian Directorate of Health, Oslo, Norway
| | - K Land
- Blood Systems Inc., Tempe, Arizona, USA.,Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA
| | - J C Wiersum-Osselton
- Transfusion and Transplantation Reactions in Patients (TRIP), National Haemovigilance and Biovigilance Office, Leiden, The Netherlands
| | - M R Schipperus
- Transfusion and Transplantation Reactions in Patients (TRIP), National Haemovigilance and Biovigilance Office, Leiden, The Netherlands.,Department of Haematology, Haga Teaching Hospital, The Hague, The Netherlands
| | - P Tiberghien
- Etablissement Français du Sang, La Plaine St Denis, France.,Université de Franche-Comté, Inserm, EFS, UMR 1098, Besançon, France
| | - B I Whitaker
- Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Review US Food & Drug Administration, Silver Spring, Maryland, USA
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Kaufman RM, Dinh A, Cohn CS, Fung MK, Gorlin J, Melanson S, Murphy MF, Ziman A, Elahie AL, Chasse D, Degree L, Dunbar NM, Dzik WH, Flanagan P, Gabert K, Ipe TS, Jackson B, Lane D, Raspollini E, Ray C, Sharon Y, Ellis M, Selleng K, Staves J, Yu P, Zeller M, Yazer M. Electronic patient identification for sample labeling reduces wrong blood in tube errors. Transfusion 2018; 59:972-980. [DOI: 10.1111/trf.15102] [Citation(s) in RCA: 19] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2018] [Revised: 11/07/2018] [Accepted: 11/11/2018] [Indexed: 11/30/2022]
Affiliation(s)
| | - Anh Dinh
- Department of Pathology and Laboratory MedicineChildren's Hospital of Philadelphia Philadelphia PA
| | - Claudia S. Cohn
- Department of Laboratory Medicine and PathologyUniversity of Minnesota Minneapolis MN
| | - Mark K. Fung
- Department of PathologyUniversity of Vermont Burlington VT
| | | | - Stacy Melanson
- Department of PathologyBrigham and Women's Hospital Boston MA
| | | | - Alyssa Ziman
- Department of Pathology and Laboratory MedicineUCLA Health Los Angeles CA
| | | | - Danielle Chasse
- Dartmouth‐Hitchcock Medical Center, Department of Pathology and Laboratory Medicine Lebanon NH
| | - Lynsi Degree
- Department of PathologyUniversity of Vermont Burlington VT
| | - Nancy M. Dunbar
- Dartmouth‐Hitchcock Medical Center, Department of Pathology and Laboratory Medicine Lebanon NH
| | - Walter H. Dzik
- Department of PathologyMassachusetts General Hospital Boston MA
| | | | - Kimberly Gabert
- Department of Pathology and the Institute for Transfusion MedicineUniversity of Pittsburgh Pittsburgh PA
| | - Tina S. Ipe
- Department of Pathology and Genomic MedicineHouston Methodist Hospital Houston TX
| | - Bryon Jackson
- Department of Pathology and Laboratory MedicineEmory University School of Medicine Atlanta GA
| | | | | | - Charles Ray
- Dartmouth‐Hitchcock Medical Center, Department of Pathology and Laboratory Medicine Lebanon NH
| | | | | | - Kathleen Selleng
- University Medicine Greifswald, Institute for Immunology and Transfusion Medicine Greifswald Germany
| | - Julie Staves
- Oxford University Hospitals Foundation Trust Oxford United Kingdom
| | - Philip Yu
- St. Paul's Hospital Vancouver Canada
| | | | - Mark Yazer
- Department of Pathology and the Institute for Transfusion MedicineUniversity of Pittsburgh Pittsburgh PA
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Rosenbaum MW, Baron JM. Using Machine Learning-Based Multianalyte Delta Checks to Detect Wrong Blood in Tube Errors. Am J Clin Pathol 2018; 150:555-566. [PMID: 30169595 DOI: 10.1093/ajcp/aqy085] [Citation(s) in RCA: 37] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/14/2022] Open
Abstract
OBJECTIVES An unfortunate reality of laboratory medicine is that blood specimens collected from one patient occasionally get mislabeled with identifiers from a different patient, resulting in so-called "wrong blood in tube" (WBIT) errors and potential patient harm. Here, we sought to develop a machine learning-based, multianalyte delta check algorithm to detect WBIT errors and mitigate patient harm. METHODS We simulated WBIT errors within sets of routine inpatient chemistry test results to develop, train, and evaluate five machine learning-based WBIT detection algorithms. RESULTS The best-performing WBIT detection algorithm we developed was based on a support vector machine and incorporated changes in test results between consecutive collections across 11 analytes. This algorithm achieved an area under the curve of 0.97 and considerably outperformed traditional single-analyte delta checks. CONCLUSIONS Machine learning-based multianalyte delta checks may offer a practical strategy to identify WBIT errors prior to test reporting and improve patient safety.
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Affiliation(s)
- Matthew W Rosenbaum
- Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston
| | - Jason M Baron
- Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston
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Plebani M. Harmonization in laboratory medicine: more than clinical chemistry? Clin Chem Lab Med 2018; 56:1579-1586. [DOI: 10.1515/cclm-2017-0865] [Citation(s) in RCA: 30] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/02/2023]
Abstract
Abstract
The goal of harmonizing laboratory information is to contribute to quality in patient care, ultimately improving upon patient outcomes and safety. The main focus of harmonization and standardization initiatives has been on analytical processes within the laboratory walls, clinical chemistry tests in particular. However, two major evidences obtained in recent years show that harmonization should be promoted not only in the analytical phase but also in all steps of the testing process, encompassing the entire field of laboratory medicine, including innovative areas (e.g. “omics”) rather than just conventional clinical chemistry tests. A large body of evidence demonstrates the vulnerability of the extra-analytical phases of the testing cycle. Because only “good biological samples” can assure good analytical quality, a closer interconnection between the different phases of the cycle is needed. In order to provide reliable and accurate laboratory information, harmonization activities should cover all steps of the cycle from the “pre-pre-analytical” phase (right choice of test at right time for right patient) through the analytical steps (right results with right report) to the “post-post-analytical” steps (right and timely acknowledgment of laboratory information, right interpretation and utilization with any necessary advice as to what to do next with the information provided). In addition, modern clinical laboratories are performing a broad menu of hundreds of tests, covering both traditional and innovative subspecialties of the discipline. In addition, according to a centered viewpoint, harmonization initiatives should not be addressed exclusively to clinical chemistry tests but should also include all areas of laboratory medicine.
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Affiliation(s)
- Mario Plebani
- Department of Laboratory Medicine , University-Hospital of Padova , Via Nicolo Giustiniani 2 , 35128 Padova , Italy
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Burns KE, Haysom HE, Higgins AM, Waters N, Tahiri R, Rushford K, Dunstan T, Saxby K, Kaplan Z, Chunilal S, McQuilten ZK, Wood EM. A time-driven, activity-based costing methodology for determining the costs of red blood cell transfusion in patients with beta thalassaemia major. Transfus Med 2018; 29:33-40. [PMID: 29637650 DOI: 10.1111/tme.12523] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/25/2017] [Revised: 02/22/2018] [Accepted: 03/02/2018] [Indexed: 12/31/2022]
Abstract
OBJECTIVES To describe the methodology to estimate the total cost of administration of a single unit of red blood cells (RBC) in adults with beta thalassaemia major in an Australian specialist haemoglobinopathy centre. BACKGROUND Beta thalassaemia major is a genetic disorder of haemoglobin associated with multiple end-organ complications and typically requiring lifelong RBC transfusion therapy. New therapeutic agents are becoming available based on advances in understanding of the disorder and its consequences. Assessment of the true total cost of transfusion, incorporating both product and activity costs, is required in order to evaluate the benefits and costs of these new therapies. METHODS We describe the bottom-up, time-driven, activity-based costing methodology used to develop process maps to provide a step-by-step outline of the entire transfusion pathway. Detailed flowcharts for each process are described. Direct observations and timing of the process maps document all activities, resources, staff, equipment and consumables in detail. The analysis will include costs associated with performing these processes, including resources and consumables. Sensitivity analyses will be performed to determine the impact of different staffing levels, timings and probabilities associated with performing different tasks. RESULTS Thirty-one process maps have been developed, with over 600 individual activities requiring multiple timings. These will be used for future detailed cost analyses. CONCLUSIONS Detailed process maps using bottom-up, time-driven, activity-based costing for determining the cost of RBC transfusion in thalassaemia major have been developed. These could be adapted for wider use to understand and compare the costs and complexities of transfusion in other settings.
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Affiliation(s)
- K E Burns
- Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
| | - H E Haysom
- Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
| | - A M Higgins
- Centre for Research Excellence in Patient Blood Management in Critical Illness and Trauma, Monash University, Melbourne, Victoria, Australia
| | - N Waters
- Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
| | - R Tahiri
- Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
| | - K Rushford
- Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia
| | - T Dunstan
- Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia
| | - K Saxby
- Centre for Health Economics, Monash University, Melbourne, Victoria, Australia
| | - Z Kaplan
- Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia
| | - S Chunilal
- Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia
| | - Z K McQuilten
- Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.,Centre for Research Excellence in Patient Blood Management in Critical Illness and Trauma, Monash University, Melbourne, Victoria, Australia.,Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia
| | - E M Wood
- Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.,Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia
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Dubois H, Schmidt PT, Creutzfeldt J, Bergenmar M. Person-centered endoscopy safety checklist: Development, implementation, and evaluation. World J Gastroenterol 2017; 23:8605-8614. [PMID: 29358869 PMCID: PMC5752721 DOI: 10.3748/wjg.v23.i48.8605] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/30/2017] [Revised: 09/27/2017] [Accepted: 10/17/2017] [Indexed: 02/06/2023] Open
Abstract
AIM To describe the development and implementation of a person-centered endoscopy safety checklist and to evaluate the effects of a “checklist intervention”.
METHODS The checklist, based on previously published safety checklists, was developed and locally adapted, taking patient safety aspects into consideration and using a person-centered approach. This novel checklist was introduced to the staff of an endoscopy unit at a Stockholm University Hospital during half-day seminars and team training sessions. Structured observations of the endoscopy team’s performance were conducted before and after the introduction of the checklist. In addition, questionnaires focusing on patient participation, collaboration climate, and patient safety issues were collected from patients and staff.
RESULTS A person-centered safety checklist was developed and introduced by a multi-professional group in the endoscopy unit. A statistically significant increase in accurate patient identity verification by the physicians was noted (from 0% at baseline to 87% after 10 mo, P < 0.001), and remained high among nurses (93% at baseline vs 96% after 10 mo, P = nonsignificant). Observations indicated that the professional staff made frequent attempts to use the checklist, but compliance was suboptimal: All items in the observed nurse-led “summaries” were included in 56% of these interactions, and physicians participated by directly facing the patient in 50% of the interactions. On the questionnaires administered to the staff, items regarding collaboration and the importance of patient participation were rated more highly after the introduction of the checklist, but this did not result in statistical significance (P = 0.07/P = 0.08). The patients rated almost all items as very high both before and after the introduction of the checklist; hence, no statistical difference was noted.
CONCLUSION The intervention led to increased patient identity verification by physicians - a patient safety improvement. Clear evidence of enhanced person-centeredness or team work was not found.
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Affiliation(s)
- Hanna Dubois
- Center for Digestive Diseases, Karolinska University Hospital, Stockholm 14186, Sweden
- Center for Advanced Medical Simulation and Training, Karolinska University Hospital, Stockholm 14186, Sweden
| | - Peter T Schmidt
- Center for Digestive Diseases, Karolinska University Hospital, Stockholm 14186, Sweden
- Center for Advanced Medical Simulation and Training, Karolinska University Hospital, Stockholm 14186, Sweden
- Department of Medicine, Karolinska Institutet, Stockholm 17177, Sweden
| | - Johan Creutzfeldt
- Center for Advanced Medical Simulation and Training, Karolinska University Hospital, Stockholm 14186, Sweden
- Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm 14186, Sweden
- Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm 17177, Sweden
| | - Mia Bergenmar
- Center for Digestive Diseases, Karolinska University Hospital, Stockholm 14186, Sweden
- Department of Oncology-Pathology, Karolinska Institutet, Stockholm 17176, Sweden
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Frietsch T, Thomas D, Schöler M, Fleiter B, Schipplick M, Spannagl M, Knels R, Nguyen X. Administration Safety of Blood Products - Lessons Learned from a National Registry for Transfusion and Hemotherapy Practice. Transfus Med Hemother 2017; 44:240-254. [PMID: 28924429 DOI: 10.1159/000453320] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/20/2016] [Accepted: 10/28/2016] [Indexed: 12/19/2022] Open
Abstract
BACKGROUND Compared to blood component safety, the administration of blood may not be as safe as intended. The German Interdisciplinary Task Force for Clinical Hemotherapy (IAKH) specialized registry for administration errors of blood products was chosen for a detailed analysis of reports. METHODS Voluntarily submitted critical incident reports (n = 138) from 2009 to 2013 were analyzed. RESULTS Incidents occurred in the operation room (34.1%), in the ICU (25.2%), and in the peripheral ward (18.5%). Procedural steps with errors were administration to the patient (27.2%), indication and blood order (17.1%), patient identification (17.1%), and blood sample withdrawal and tube labeling (18.0%). Bedside testing (BST) of blood groups avoided errors in only 2.6%. Associated factors were routine work conditions (66%), communication error (36%), emergency case (26%), night or weekend team (39%), untrained personnel (19%). Recommendations addressed process and quality (n = 479) as well as structure quality (n = 314). In 189 instances, an IT solution would have helped to avoid the error. CONCLUSIONS The administration process is prone to errors at the patient assessment for the need to transfuse and the application of blood products to patients. BST is only detecting a minority of handling errors. According to the expert recommendations for practice improvement, the potential to improve transfusion safety by a technical solution is considerable.
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Affiliation(s)
- Thomas Frietsch
- Department of Anesthesiology and Critical Care Medicine, Diakonissenkrankenhaus Mannheim, Teaching Hospital of the University Medicine Mannheim, University of Heidelberg, Mannheim, Germany
| | - Daffyd Thomas
- Department of Anaesthesia and Critical Care, Morriston Hospital, Swansea, Wales, UK
| | - Michael Schöler
- Department of Anesthesiology and Surgical Intensive Care Medicine, University Medical Center Mannheim, Mannheim, Germany
| | | | - Martin Schipplick
- Department of Anesthesiology and Critical Care Medicine, Krankenhaus Leonberg, Leonberg, Germany
| | - Michael Spannagl
- Department of Hemostasis and Transfusion Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany
| | - Ralf Knels
- Medical Care Center Dresden, Labor Moebius, Dresden, Germany
| | - Xuan Nguyen
- Duc's Laboratories, Amita Monestry, Mannheim, Germany
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Abstract
A body of evidence collected in the last few decades demonstrates that the pre- and post-analytical phases of the testing cycle are more error-prone than the analytical phase. However, the paradigm of errors and quality in laboratory medicine has been questioned, analytical mistakes continuing to be a major cause of adverse clinical outcomes and patient harm. Although the brain-to-brain concept is widely recognized in the community of laboratory professionals, there is lack of clarity concerning the inter-relationship between the different phases of the cycle, interdependence between the pre-analytical phase and analytical quality, and the effect of the post-analytical steps on the quality of ultimate laboratory information. Analytical quality remains the "core business" of clinical laboratories, but laboratory professionals and clinicians alike should never lose sight of the fact that pre-analytical variables are often responsible for erroneous test results and that quality biospecimens are pre-requisites for a reliable analytical phase. In addition, the pressure for expert advice on test selection and interpretation of results has increased hand in hand with the ever-increasing complexity of tests and diagnostic fields. Finally, the data on diagnostic errors and inappropriate clinical decisions made due to delay or misinterpretation of laboratory data underscore the current need for greater collaboration at the clinical-laboratory interface.
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Forest SK, Shirazi M, Wu-Gall C, Stotler BA. The Impact of an Electronic Ordering System on Blood Bank Specimen Rejection Rates. Am J Clin Pathol 2017; 147:105-109. [PMID: 28158445 DOI: 10.1093/ajcp/aqw204] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/14/2022] Open
Abstract
OBJECTIVES To evaluate the impact that an electronic ordering system has on the rate of rejection of blood type and screen testing samples and the impact on the number of ABO blood-type discrepancies over a 4-year period. METHODS An electronic ordering system was implemented in May 2011. Rejection rates along with reasons for rejection were tracked between January 2010 and December 2013. RESULTS A total of 40,104 blood samples were received during this period, of which 706 (1.8%) were rejected for the following reasons: 382 (54.0%) unsigned samples, 235 (33.0%) mislabeled samples, 57 (8.0%) unsigned requisitions, 18 (2.5%) incorrect tubes, and 14 (1.9%) ABO discrepancies. Of the samples, 2.5% were rejected in the year prior to implementing the electronic ordering system compared with 1.2% in the year following implementation ( P < .0001). CONCLUSIONS Our data demonstrate that implementation of an electronic ordering system significantly decreased the rate of blood sample rejection.
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Affiliation(s)
- Stefanie K Forest
- From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY
- NewYork-Presbyterian Hospital, New York, NY
| | - Maryam Shirazi
- From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY
- NewYork-Presbyterian Hospital, New York, NY
| | | | - Brie A Stotler
- From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY
- NewYork-Presbyterian Hospital, New York, NY
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Reduction in Hospital-Wide Clinical Laboratory Specimen Identification Errors following Process Interventions: A 10-Year Retrospective Observational Study. PLoS One 2016; 11:e0160821. [PMID: 27494020 PMCID: PMC4975414 DOI: 10.1371/journal.pone.0160821] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/11/2016] [Accepted: 07/26/2016] [Indexed: 11/19/2022] Open
Abstract
Background Accurate patient identification and specimen labeling at the time of collection are crucial steps in the prevention of medical errors, thereby improving patient safety. Methods All patient specimen identification errors that occurred in the outpatient department (OPD), emergency department (ED), and inpatient department (IPD) of a 3,800-bed academic medical center in Taiwan were documented and analyzed retrospectively from 2005 to 2014. To reduce such errors, the following series of strategies were implemented: a restrictive specimen acceptance policy for the ED and IPD in 2006; a computer-assisted barcode positive patient identification system for the ED and IPD in 2007 and 2010, and automated sample labeling combined with electronic identification systems introduced to the OPD in 2009. Results Of the 2000345 specimens collected in 2005, 1023 (0.0511%) were identified as having patient identification errors, compared with 58 errors (0.0015%) among 3761238 specimens collected in 2014, after serial interventions; this represents a 97% relative reduction. The total number (rate) of institutional identification errors contributed from the ED, IPD, and OPD over a 10-year period were 423 (0.1058%), 556 (0.0587%), and 44 (0.0067%) errors before the interventions, and 3 (0.0007%), 52 (0.0045%) and 3 (0.0001%) after interventions, representing relative 99%, 92% and 98% reductions, respectively. Conclusions Accurate patient identification is a challenge of patient safety in different health settings. The data collected in our study indicate that a restrictive specimen acceptance policy, computer-generated positive identification systems, and interdisciplinary cooperation can significantly reduce patient identification errors.
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Abstract
Positive patient identification is pivotal to several steps of the transfusion process; it is integral to ensuring that the correct blood is given to the correct patient. If patient misidentification occurs, this has potentially fatal consequences for patients. Historically patient involvement in healthcare has focused on clinical decision making, where the patient, having been provided with medical information, is encouraged to become involved in the decisions related to their individualised treatment. This article explores the aspects of patient contribution to patient safety relating to positive patient identification in transfusion. When involving patients in their care, however, clinicians must recognise the diversity of patients and the capacity of the patient to be involved. It must not be assumed that all patients will be willing or indeed able to participate. Additionally, clinicians' attitudes to patient involvement in patient safety can determine whether cultural change is successful.
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Affiliation(s)
- Lynn Stout
- Transfusion Practitioner, NHS National Services Scotland, Aberdeen and North East Scotland Blood Transfusion Centre, Aberdeen
| | - Sundari Joseph
- Senior Lecturer/Research Degrees Coordinator, School of Nursing and Midwifery, Robert Gordon University, Aberdeen
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45
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Piva E, Tosato F, Plebani M. Pre-analytical phase: The automated ProTube device supports quality assurance in the phlebotomy process. Clin Chim Acta 2015; 451:287-91. [DOI: 10.1016/j.cca.2015.10.010] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/21/2015] [Revised: 10/09/2015] [Accepted: 10/11/2015] [Indexed: 02/06/2023]
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