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Gultekin SC, Karadibak D, Cakir AB, Guc ZG, Yavuzsen T. Self-administered versus lymphedema therapist-administered complex decongestive therapy protocol in breast cancer-related lymphedema: a non-inferiority randomized controlled trial with three-month follow-up. Breast Cancer Res Treat 2025; 212:123-138. [PMID: 40329151 PMCID: PMC12086114 DOI: 10.1007/s10549-025-07709-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/25/2025] [Accepted: 04/22/2025] [Indexed: 05/08/2025]
Abstract
PURPOSE The aim of this study was to demonstrate that a self-administered complex decongestive therapy (CDT) protocol is not inferior to certified lymphedema therapist (CLT)-administered CDT in the management of lymphedema and health-related outcomes in patients with breast cancer-related lymphedema (BCRL). METHODS Fifty patients with BCRL were randomly assigned to two experimental groups: (1) a CLT-administered CDT group (n = 25) or a self-administered CDT group (n = 25). CDT was a multimodal approach in two experimental conditions consisting of patient education, manual lymph drainage, multi-layer bandaging, therapeutic exercises and skin/nail care. Lymphedema severity was assessed using circumference measurement, and BCRL-related symptoms were assessed using a numerical rating scale. The following measurement methods were used to assess health-related outcomes: universal goniometer for range of motion (ROMs), hand grip dynamometer for peripheral muscle strength, disabilities of the arm, shoulder and hand (DASH) questionnaire for disability level, International Physical Activity Questionnaire-Short Form (IPAQ-SF) for physical activity level, the checklist for individual strength (CIS) for fatigue and upper limb lymphedema quality of life questionnaire (ULL-27) for quality of life. RESULTS Following CDT, there was a significant decrease in lymphedema severity and lymphedema-related symptoms in both groups (p < 0.001). There was no significant difference between the groups regarding the mean difference in health-related outcomes following CDT (post-treatment-baseline) (p < 0.05). Lymphedema severity and symptoms remained stable during the 3-month follow-up periods in the CLT-administered CDT group (p > 0.05). There was a decrease in the severity of lymphedema, stiffness, heaviness and fatigue in the self-administered CDT group at 3-month follow-up (p < 0.05), while pain and tingling remained unchanged (p > 0.05). CONCLUSION The present findings demonstrated self-administered CDT protocol is not inferior to CLT-administered CDT in the management of lymphedema and reduction of lymphedema-related disabilities.
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Affiliation(s)
- Sukriye Cansu Gultekin
- Faculty of Physiotherapy and Rehabilitation, Graduate School of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
| | - Didem Karadibak
- Faculty of Physiotherapy and Rehabilitation, Department of Physiotherapy and Rehabilitation, Division of Cardiopulmonary Physiotherapy-Rehabilitation, Dokuz Eylul University, Izmir, Turkey
| | - Ahmet Burak Cakir
- Faculty of Physiotherapy and Rehabilitation, Graduate School of Health Sciences, Dokuz Eylul University, Izmir, Turkey
| | - Zeynep Gulsum Guc
- Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey
| | - Tugba Yavuzsen
- Faculty of Medicine, Department of Internal Medicine, Division of Oncology, Dokuz Eylul University, Izmir, Turkey
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An S, Gunathilake M, Kim J. Dairy consumption is associated with breast cancer risk: a comprehensive meta-analysis stratified by hormone receptor and menopausal status, and age. Nutr Res 2025; 138:68-75. [PMID: 40311535 DOI: 10.1016/j.nutres.2025.02.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/14/2024] [Revised: 02/23/2025] [Accepted: 02/24/2025] [Indexed: 05/03/2025]
Abstract
Breast cancer (BC) is a prevalent global health concern, with various risk factors contributing to its heterogeneity. This comprehensive meta-analysis aims to explore the association between dairy consumption and BC risk, stratified by hormone receptor, menopausal status, and age. To assess the association between dairy consumption and BC risk, a systematic literature review based on studies published until December 2024 retrieved from PubMed, SCOPUS, Web of Science, and Cochrane Library. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated and then aggregated using random-effects models. Summary RR from 51 studies with 62,602 BC cases showed that overall dairy consumption is inversely associated with BC risk (RR = 0.91, 95% CI: 0.84-0.98, I2 = 75%), particularly among individuals aged over 45 (RR = 0.81, 95% CI: 0.68-0.98, I2 = 0%). Notably, higher intake of low-fat dairy products showed potential protective effects (RR = 0.91, 95% CI: 0.84-0.98, I2 = 56%), especially in premenopausal women (skimmed milk, RR = 0.86, 95% CI: 0.76-0.97, I2 = 0%). Fermented dairy products, including yogurt, exhibited a decreased BC risk, particularly in postmenopausal women (RR = 0.91, 95% CI: 0.87-0.96, I2 = 0%). However, a positive association was observed between total milk intake and the risk of estrogen receptor-negative BC (RR = 1.31, 95% CI: 1.08-1.59, I2 = 0%). This meta-analysis provides comprehensive insights into the association between specific dairy product consumption and BC risk. The findings highlight the protective impact of specific dairy products on different subtypes, offering valuable insights for BC prevention.
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Affiliation(s)
- Seokyung An
- Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-Si, South Korea
| | - Madhawa Gunathilake
- Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-Si, South Korea
| | - Jeongseon Kim
- Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-Si, South Korea.
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Tucker AC, Raber M, Ammerman AS, Wolfson JA. Application of Behavioral Theory in Cooking Interventions Targeting Dietary Intake in Adults: A Systematic Review. JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR 2025; 57:508-521. [PMID: 40186611 PMCID: PMC12146092 DOI: 10.1016/j.jneb.2025.02.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 02/20/2024] [Revised: 02/03/2025] [Accepted: 02/03/2025] [Indexed: 04/07/2025]
Abstract
OBJECTIVE Studies of cooking interventions often state that behavioral theory was used to inform intervention development. However, to understand why interventions impact behavior change, it is crucial to understand how theory is used in the development, evaluation, and interpretation of interventions. DESIGN We conducted a systematic review by searching PubMed, Scopus, and CINAHL for articles published between January, 2000 and March, 2023. PARTICIPANTS We considered studies involving adults aged > 18 years. VARIABLES MEASURED Dietary intake was the primary outcome, and cooking behavior was the secondary outcome. ANALYSIS We used the Theory Coding Scheme to assess theory use. We used descriptive statistics to summarize study characteristics and outcomes of interest. RESULTS We identified 7,846 unique articles; 31 met the inclusion criteria. On average, studies met less than 6 of 17 criteria from the Theory Coding Scheme. The majority (65%) of interventions had a positive impact on at least 1 measure of dietary intake. However, more than half (55%) measured cooking behavior and only 41% of these reported a positive impact on cooking behavior. CONCLUSIONS AND IMPLICATIONS These findings support the need for future studies to link intervention techniques with theoretical constructs and evaluate whether changes in constructs mediate improvements in dietary intake and cooking behavior.
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Affiliation(s)
- Anna C Tucker
- Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
| | - Margaret Raber
- Department of Health Disparities Research, University of Texas MD Anderson Cancer Center, Houston, TX
| | - Alice S Ammerman
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC; Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, NC
| | - Julia A Wolfson
- Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
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Yin Y, Zhang X. Analysis of trends in the burden of colorectal cancer in China and globally from 1990 to 2021 with projections for the next 15 years: a cross-sectional study based on the GBD database. Front Public Health 2025; 13:1518536. [PMID: 40492005 PMCID: PMC12146330 DOI: 10.3389/fpubh.2025.1518536] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Accepted: 03/04/2025] [Indexed: 06/11/2025] Open
Abstract
Objective To analyze the changes in the burden of colorectal cancer in China and globally from 1990 to 2021, and to explore the disease burden across different age groups and sexes by integrating projected data from 2022 to 2036. This study aims to provide a scientific foundation for formulating targeted prevention and control strategies. Materials and methods This study utilized colorectal cancer data from the Global Burden of Disease (GBD) database for the period 1990-2021. Trend analysis was conducted using Joinpoint regression, and future burden projections from 2022 to 2036 were made with an Auto-Regressive Integrated Moving Average (ARIMA) model. Key indicators analyzed included the Age-Standardized Incidence Rate (ASIR), Age-Standardized Prevalence Rate (ASPR), Age-Standardized Mortality Rate (ASMR), and Disability-Adjusted Life Years (DALYs). Results Between 1990 and 2021, the burden of colorectal cancer increased both in China and globally, although notable differences were observed across gender and regions. In Chinese men, the ASIR and ASMR have shown a continuous rise, reaching approximately 50 and 300 per 100,000, respectively, by 2021. Projections indicate that these rates will continue to increase through at least 2036. The ASIR in Chinese women also exhibits an upward trend, whereas the global ASIR for women has declined. From 1990 to 2021, both China and the world experienced a steady rise in ASPR, with minimal fluctuations. In contrast, while the ASDR has decreased in both China and globally, the volatility in China's ASDR is notably more pronounced than that observed worldwide. Conclusion The burden of colorectal cancer in China is projected to increase significantly in the coming years, particularly among males and the older adult population. This study provides critical scientific insights for the development of targeted prevention strategies and resource allocation, underscoring the urgent need to enhance early screening initiatives and health education efforts in China.
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Affiliation(s)
- Yulai Yin
- Nankai University School of Medicine, Nankai University, Tianjin, China
- Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China
- Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
- Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China
| | - Xiaoyu Zhang
- Department of Thyroid and Breast Surgery, Cangzhou Central Hospital, Cangzhou, China
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McLeod D, Martins I, Tinker AV, Selk A, Brezden-Masley C, LeVasseur N, Altman AD. Changes in female cancer diagnostic billing rates over the COVID-19 period in the Ontario Health Insurance Plan. Ther Adv Med Oncol 2025; 17:17588359251339919. [PMID: 40433105 PMCID: PMC12106997 DOI: 10.1177/17588359251339919] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2024] [Accepted: 04/18/2025] [Indexed: 05/29/2025] Open
Abstract
Background The initial response to coronavirus disease 2019 (COVID-19) in Ontario included suspension of cancer screening programs and deferral of diagnostic procedures and many treatments. Although the short-term impact of these measures on female cancers is well documented, few studies have assessed the mid- to long-term impacts. Objectives To compare annual billing prevalence and incidence rates of female cancers during the COVID-19 period (2020-2022) to pre-COVID-19 levels (2015-2019). Design Retrospective analysis of aggregated claims data for female cancer diagnostic codes from the Ontario Health Insurance Plan (OHIP). Methods Linear regression analysis was used to fit pre-COVID-19 (2015-2019) data for each OHIP billing code and extrapolate counterfactual values for the years of 2020-2022. Excess billing rates were calculated as the difference between projected and actual rates for each year. Results In 2020, OHIP billing prevalence rates for cervical, breast, uterine, and ovarian cancers decreased relative to projected values for that year by -50.7/100k, -13.9/100k, -3.5/100k, and -3.8/100k, respectively. The reverse was observed in 2021 with rate increases of 47.8/100k, 59.1/100k, 2.5/100k, and 3.7/100k, respectively. In 2022, the excesses were further amplified, especially for cervical and breast cancers (111.2/100k and 78.67/100k, respectively). The net excess patient billing rate for 2020-2022 was largely positive for all female cancer types (108.3/100k, 123.7/100k, 5.2/100k, and 1.8/100k, respectively). Analysis of billing incidence rates showed similar trends. Conclusion The expected female cancer billing rate decreases in 2020 were followed by large increases in 2021 and 2022, resulting in a cumulative excess during the COVID-19 period. Further research is required to assess the nature of these changes.
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Affiliation(s)
| | | | - Anna V. Tinker
- BC Cancer Agency, BC Cancer—Vancouver Centre, University of British Columbia, 600 West 10th Avenue, 4th Floor, Vancouver, BC V5Z 4E6, Canada
| | - Amanda Selk
- Women’s College Hospital, Toronto, ON, Canada
| | | | - Nathalie LeVasseur
- BC Cancer—Vancouver Centre, University of British Columbia, Vancouver, BC, Canada
| | - Alon D. Altman
- CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
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Cerrai S, Lachi A, Franchini M, Pieroni S, Anastasi G, Scalese M, Odone A, Gallus S, Smits L, Molinaro S. Alcohol consumption and breast lesions: targets for risk-based screening in high-risk Italian women. Breast Cancer 2025:10.1007/s12282-025-01720-8. [PMID: 40380018 DOI: 10.1007/s12282-025-01720-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2024] [Accepted: 05/06/2025] [Indexed: 05/19/2025]
Abstract
BACKGROUND Breast cancer in Italy is still the most frequent cancer among women, and alcohol consumption is recognized as a risk factor for its development. Overall, in 2020, approximately 10% of all breast cancer-related deaths were attributable to alcohol consumption. Despite advancements in diagnostics and therapeutic options reducing mortality trends, the incidence of breast cancer is projected to rise in Italy. This study aims to assess how alcohol consumption influences the timing of breast lesion diagnosis. Understanding these associations can enhance primary prevention strategies and support the adoption of a risk-based prevention approach, integrating lifestyle factors into personalized screening programs. METHODS P.I.N.K. (Prevention, Imaging, Network and Knowledge) study collected data on a prospective dynamic cohort of women who voluntarily underwent breast cancer screening at breast centers throughout Italy, between 2018 and 2023, outside the free national screening program. The occurrence of breast lesion diagnosis and baseline information were collected through clinical visits and an auto-administered questionnaire, including data on absent, moderate or high alcohol consumption during the last 12 months and smoking. 3774 women (mean age 58.9 ± 10.0, range 40-98 years) were included in the present analysis, encompassing women with a suspected or confirmed diagnosis of benign or malignant tumor and healthy women that contributed at least 4 years to the study. An Event History Analysis was carried out to evaluate the effect of alcohol consumption on the timing to event. The event was represented by the transition of the health status, from not diagnosed to diagnosed with breast lesion. The Accelerated Failure Time parameterization was used to directly interpret how the covariates influence the time to the event. The model was adjusted by familiality of breast/ovarian cancer, marital status, level of education, and type of access to health care. RESULTS High alcohol consumption exhibited an accelerating effect on the transition to the diagnosed state, indicating a significantly shortened time to event: β coefficient - 0.33 (p-value 0.010) in the adjusted model, indicating an anticipation of about 4 months. The effect of moderate alcohol consumption did not reach statistical significance, neither in the unadjusted model nor in the adjusted model. Adjustment for smoking status led to a further increase of the β coefficient for high alcohol consumption (- 0.40; p value 0.003) and brought moderate alcohol consumption closer to statistical significance (β - 0.15; p-value 0.087). Familiality of breast or ovarian cancer showed a statistically non-significant accelerating effect, while marital status different from maiden, high education, and private access to health care showed decelerating effects. CONCLUSIONS High alcohol consumption was confirmed as an accelerating factor in breast lesions diagnosis, while the effect of moderate consumption did not reach statistical significance. These results help identifying actionable targets for high-risk populations, emphasizing personalized risk-based screening programs and gender-sensitive interventions.
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Affiliation(s)
- Sonia Cerrai
- Epidemiology and Health Research Lab, Institute of Clinical Physiology of the National Research Council of Italy (IFC-CNR), Pisa, Italy
- Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
| | - Alessio Lachi
- Saint Camillus International University of Health and Medical Sciences, Rome, Italy
| | - Michela Franchini
- Epidemiology and Health Research Lab, Institute of Clinical Physiology of the National Research Council of Italy (IFC-CNR), Pisa, Italy.
| | - Stefania Pieroni
- Epidemiology and Health Research Lab, Institute of Clinical Physiology of the National Research Council of Italy (IFC-CNR), Pisa, Italy
| | - Giada Anastasi
- Epidemiology and Health Research Lab, Institute of Clinical Physiology of the National Research Council of Italy (IFC-CNR), Pisa, Italy
- Institute of Computer Science, University of Pisa, Pisa, Italy
| | - Marco Scalese
- Epidemiology and Health Research Lab, Institute of Clinical Physiology of the National Research Council of Italy (IFC-CNR), Pisa, Italy
| | - Anna Odone
- Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy
| | - Silvano Gallus
- Department of Medical Epidemiology, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
| | - Luc Smits
- Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
| | - Sabrina Molinaro
- Epidemiology and Health Research Lab, Institute of Clinical Physiology of the National Research Council of Italy (IFC-CNR), Pisa, Italy
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Ortega-Guzmán A, Parra-Soto S, Vega-Salas MJ, Rodríguez-Osiac L, López-Arana S. Assessing the Alignment of Chilean Food-Based Dietary Guidelines on Cancer Prevention: A Content Analysis. Healthcare (Basel) 2025; 13:1133. [PMID: 40427969 PMCID: PMC12111562 DOI: 10.3390/healthcare13101133] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/31/2024] [Revised: 03/27/2025] [Accepted: 04/12/2025] [Indexed: 05/29/2025] Open
Abstract
Background/Objectives: Cancer is a multifactorial disease. Evidence suggests that 30% to 50% of cancer incidence is linked to unhealthy behaviors. It is therefore important that dietary recommendations, including population-based dietary guidelines, and public policies be designed to support and facilitate healthier choices. We evaluated the alignment between the updated Chilean Food-Based Dietary Guidelines (FBDGs) and cancer prevention recommendations from the World Cancer Research Fund (WCRF/AICR) and the Latin America and the Caribbean Code Against Cancer (LAC-Code). Methods: A qualitative content analysis was performed based on the dissemination and technical documents from the updated Chilean FBDGs (2023), the WCRF/AICR and the LAC Code. A first set of codes was developed to evaluate the relevance of the messages with cancer prevention recommendations, and a second one aimed to characterize the food and diet recommendations included in cancer prevention recommendations and the Chilean FBDGs. Furthermore, we compared the 10 Chilean FBDG messages with the WCRF/AICR and the LAC Code recommendations. Results: The updated Chilean FBDG messages met most of the categories included. Four out of ten of the Chilean FBDG messages were directly aligned with LAC Code and the WCRF/AICR recommendations, five had an indirect relationship, and one was not related to any cancer recommendation. Conclusions: Our study suggests that the updated Chilean FBDG messages are most often indirectly aligned with the worldwide and the Latin American region cancer prevention recommendations over the role of diet, nutrition and physical activity in cancer risk among the general population.
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Affiliation(s)
- Alejandra Ortega-Guzmán
- Centro para la Transversalización de Género en I+D+i+e, Vicerrectoría de Investigación y Doctorados, Universidad Autónoma de Chile, Santiago 7500912, Chile;
| | - Solange Parra-Soto
- Department of Nutrition and Public Health, Faculty of Health and Food Science, Universidad del Bío-Bío, Chillan 4051381, Chile;
- Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile; (M.J.V.-S.); (L.R.-O.)
| | - María Jesús Vega-Salas
- Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile; (M.J.V.-S.); (L.R.-O.)
- Departamento de Nutrición y Dietética, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
| | - Lorena Rodríguez-Osiac
- Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile; (M.J.V.-S.); (L.R.-O.)
- Escuela de Salud Pública Dr. Salvador Allende, Universidad de Chile, Santiago 8380453, Chile
| | - Sandra López-Arana
- Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile; (M.J.V.-S.); (L.R.-O.)
- Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Finis Terrae, Providencia 7501014, Chile
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Kim YN, Kim CY. Exploration of the relationship between gastric cancer and nutritional risk factors: insights from the Korea National Health Insurance Database. Front Nutr 2025; 12:1538133. [PMID: 40432962 PMCID: PMC12106021 DOI: 10.3389/fnut.2025.1538133] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2024] [Accepted: 04/15/2025] [Indexed: 05/29/2025] Open
Abstract
Background/Objectives Gastric cancer is the third most common cause of cancer-related deaths. Gastric cancer rates vary across regions, which may be attributable to factors such as Helicobacter pylori infection, environmental factors, and genetic predispositions. We examined the association between gastric cancer, nutrient intake, and lifestyle parameters in Korean adults. Methods This study utilized the KNHANES dataset (2012-2016) to explore the nutritional risk factors associated with gastric cancer. Multivariable analysis was conducted to confirm the association between micronutrients and specific food items using questionnaires designed to collect data on individuals' consumption frequency and nutrient intake. Results This study enrolled 18,894 participants, including 229 diagnosed with gastric cancer. Factors associated with gastric cancer included male sex, older age, low body-mass index, and frequent consumption of food outside the home. Multivariate analysis indicated that a lower intake of protein (odds ratio [OR] 0.98, 95% confidence interval [CI] 0.97-0.99, p < 0.001), fat (OR 0.99, 95% CI 0.98-0.99, p < 0.004), and thiamine (OR 0.59, 95% CI 0.45-0.76, p < 0.001) and a higher intake of niacin (OR 1.05, 95% CI 1.02-1.08, p < 0.001) were correlated with an increased risk of gastric cancer. Additionally, specific dietary items, such as tteok (rice cake) and soju, contributed to an elevated gastric cancer risk (OR 1.21, 95% CI, 1.01-1.40; OR 1.14, 95% CI, 1.03-1.25; p < 0.001). Conclusion We found an association between gastric cancer and various nutritional and lifestyle parameters. Nutrient intake and lifestyle-related factors significantly influence the prevalence of gastric cancer, suggesting that tailored interventions could mitigate this risk in specific populations.
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Affiliation(s)
- You Na Kim
- Department of General Surgery, Ewha Mokdong Hospital, Ewha Womens University School of Medicine, Seoul, Republic of Korea
| | - Chi Young Kim
- Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
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Sun R, Xing L, Wang W, Cui X, Guo Y, Gao F, Geng B, Cheng H, Liang H. A study on the microbiome within oropharyngeal cancer tissues. Discov Oncol 2025; 16:701. [PMID: 40342038 PMCID: PMC12061805 DOI: 10.1007/s12672-025-02534-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/23/2025] [Accepted: 04/29/2025] [Indexed: 05/11/2025] Open
Abstract
Oropharyngeal cancer (OPC), a prevalent head and neck malignancy, is witnessing a rise in incidence and mortality rates annually. Our study aimed to understand the microbial composition within OPC tissue, utilizing the 2bRAD-M technique to analyze microbiome characteristics of tissue samples from 46 OPC patients and 31 with tonsillitis, followed by bioinformatics analysis. We identified higher relative abundances of Selenomonas sputigena, Nocardia farcinica, and other species in the OPC group compared to the tonsillitis group. KEGG functional prediction revealed enrichment in bile secretion, type II polyketide backbone biosynthesis, staurosporine biosynthesis, and cGMP-PKG signaling pathways. HPV-positive OPC patients showed greater abundances of Pseudomonas and other species, with differential gene enrichment in "ATP-binding cassette" and "ACSL" processes. These microbial disparities may offer potential biomarkers for OPC prediction and insight into its progression, informing treatment strategies for HPV-positive and HPV-negative patients.
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Affiliation(s)
- Ran Sun
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
- Department of Otorhinolaryngology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, 250000, Shandong, China
| | - Lu Xing
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
- Department of Otorhinolaryngology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, 250000, Shandong, China
| | - Wenqing Wang
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
- Department of Otorhinolaryngology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, 250000, Shandong, China
| | - Xinhua Cui
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
| | - Ying Guo
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
| | - Fangfang Gao
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
| | - Bo Geng
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China
| | - Hongxia Cheng
- Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
| | - Hui Liang
- Department of Otorhinolaryngology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Ji'nan, 250014, Shandong, China.
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Uzel K, Bilir F, Tosun M, Topbas Selcuki NF, Eren Keskin S, Gokbayrak M, Demir G, Cine N, Ulug P, Iyibozkurt AC, Savlı H. The Role of Ultrasonography in Predicting Genetic Characteristics of Endometrial Cancers. J Clin Med 2025; 14:3216. [PMID: 40364249 PMCID: PMC12072879 DOI: 10.3390/jcm14093216] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/01/2025] [Revised: 04/28/2025] [Accepted: 04/30/2025] [Indexed: 05/15/2025] Open
Abstract
Background/Objectives: To evaluate the association between endometrial tissue stiffness, as measured by shear wave elastography (SWE), and the presence of specific gene mutations in patients diagnosed with endometrial cancer. Methods: Peripheral blood samples were collected for DNA extraction and next-generation sequencing (NGS) to identify gene mutations. Preoperative SWE was performed to measure endometrial stiffness, with values expressed in kilopascals (kPa). Statistical analyses were conducted to assess the correlation between SWE measurements and genetic findings. Results: Genetic mutations were detected in 66% (n = 31) of cases, with TTN, PLEC, and PRSS1 being the most frequently mutated genes. The median SWE measurement was 36.5 kPa (range: 19.1-70.4 kPa). No statistically significant correlation was found between SWE values and the presence of gene mutations (p > 0.05). Cases with metastasis exhibited higher median SWE values (40.1 kPa) compared to non-metastatic cases (34.7 kPa), though this difference was not statistically significant. Conclusions: While no significant association was observed between endometrial stiffness and specific gene mutations, higher SWE values in metastatic cases suggest that increased tissue stiffness may be linked to tumor aggressiveness. Further large-scale studies are warranted to validate these findings and explore the potential of SWE as a non-invasive tool in assessing endometrial cancer characteristics.
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Affiliation(s)
- Kemine Uzel
- Department of Obstetrics and Gynecology, Demiroglu Science University, 41100 Istanbul, Turkey;
| | - Filiz Bilir
- Department of Obstetrics and Gynecology, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey;
| | - Mesude Tosun
- Department of Radiology, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey;
| | - Nura Fitnat Topbas Selcuki
- Department of Obstetrics and Gynecology, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences Turkey, 34000 Istanbul, Turkey;
| | - Seda Eren Keskin
- Department of Genetics, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey; (S.E.K.); (M.G.); (G.D.); (N.C.); (H.S.)
| | - Merve Gokbayrak
- Department of Genetics, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey; (S.E.K.); (M.G.); (G.D.); (N.C.); (H.S.)
| | - Gulhan Demir
- Department of Genetics, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey; (S.E.K.); (M.G.); (G.D.); (N.C.); (H.S.)
| | - Naci Cine
- Department of Genetics, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey; (S.E.K.); (M.G.); (G.D.); (N.C.); (H.S.)
| | - Pasa Ulug
- Department of Obstetrics and Gynecology, Istanbul Haseki Training and Research Hospital, 34096 Istanbul, Turkey;
| | - Ahmet Cem Iyibozkurt
- Department of Obstetrics and Gynecology, Demiroglu Science University, 41100 Istanbul, Turkey;
| | - Hakan Savlı
- Department of Genetics, Faculty of Medicine, Kocaeli University, 41001 Kocaeli, Turkey; (S.E.K.); (M.G.); (G.D.); (N.C.); (H.S.)
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Abbasi MM, Babaahmadi P, Nozari F, Khosravi F, Golkar Z, Tavasoli Z, Alizadeh V, Nouriani M, Jafari M, Shabani N, Nezhad HH, Soltaninejad H, Rahmanian M. Association between adhering to a dietary approach to stop hypertension and risk of colorectal cancer: a systematic review and meta-analysis. BMC Gastroenterol 2025; 25:335. [PMID: 40329201 PMCID: PMC12054039 DOI: 10.1186/s12876-025-03859-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/26/2024] [Accepted: 04/07/2025] [Indexed: 05/08/2025] Open
Abstract
BACKGROUND Colorectal cancer (CRC) is a high incidence cancer and health problem influenced by many factors emphasizes on the importance of identifying risk factors which can be modified. A dietary approach to stop hypertension (DASH) style promotes a balanced nutrition approach that might have effects on CRC. The aim of this study was to analyze existing evidence on the DASH diet's association with CRC. METHODS Databases, including Scopus, Web of Science, and PubMed, were searched to identify eligible studies up to March 2025. Observational studies investigating the association between adherence to the DASH diet and CRC were included. Effect sizes (ESs) and their confidence intervals (CIs) from fully adjusted models were extracted for the meta-analysis. A random-effects model was employed to calculate the combined ES and assess the relationship between the DASH diet and CRC. The publication bias was assessed using Egger's test and heterogeneity between studies was examined using the I2 statistic. RESULTS Fourteen studies were included in this study. Adherence to DASH diet reduced CRC risk (RR = 0.81, 95% CI: 0.73-0.89). Subgroup analyses found consistent effects across cohorts and various factors, with no publication bias. For rectal cancer (RC), adherence to DASH dietary pattern reduced risk of RC (RR = 0.75, 95% CI: 0.66-0.86), particularly in males and cohort studies. Colon cancer risk was also reduced (RR = 0.83, 95% CI: 0.79-0.88), with stronger effects in males and cohort studies. For colorectal adenoma, DASH showed a significant risk reduction (RR = 0.42, 95% CI: 0.22-0.80). CONCLUSIONS Our results highlight that following the DASH diet has a significant effect on lowering the risk of CRC which aligns with previous research. These findings support recommendation of following the DASH diet pattern reduces the burden of CRC. PROSPERO, registration ID: CRD42024569140.
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Affiliation(s)
- Mohammad Mehdi Abbasi
- Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| | - Paria Babaahmadi
- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Fateme Nozari
- Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran
| | - Farbod Khosravi
- Shahid Beheshti University of Medical Sciences, Tehran, Iran
| | - Zahra Golkar
- Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Zahra Tavasoli
- Student Research Committee, School of Dentistry, Islamic Azad University, IAU (Khorasgan Branch), Isfahan, Iran
| | - Venus Alizadeh
- Shahid Beheshti University of Medical Sciences, Tehran, Iran
| | | | | | - Niloufar Shabani
- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| | - Hadis Hashemi Nezhad
- Student Research Committee, Jondishapoor University of Medical Science, Ahvaz, Iran
| | - Hossein Soltaninejad
- Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran.
| | - Mohammad Rahmanian
- Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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12
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Sanchez-Lastra MA, Del Pozo Cruz B, Ekelund U, Tarp J, Ding D. Physical Activity and Life Expectancy Free of Cancer: Prospective Evidence From the UK Biobank Study. J Phys Act Health 2025; 22:636-639. [PMID: 39837315 DOI: 10.1123/jpah.2024-0390] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/29/2024] [Revised: 11/14/2024] [Accepted: 11/30/2024] [Indexed: 01/23/2025]
Abstract
BACKGROUND Life expectancy free of cancer (LEFC) is a novel measure that considers both morbidity and mortality and could be a useful metric for disease surveillance and risk communication. We aimed to examine the association between physical activity and LEFC in British adults. METHODS This was a prospective cohort study of 292,559 apparently healthy UK Biobank participants (mean [SD] age, 56.0 [8.1] y, 51% women). Participants were categorized based on self-reported physical activity as "no activity" (0 min/wk), "insufficiently active" (10-599 metabolic equivalent-min/wk), "active" (600-1199 metabolic equivalent-min/wk), and "very active" (>1200 metabolic equivalent-min/wk). Hazard ratios from multistate models for transitions between 3 states (cancer-free, cancer diagnosis, and all-cause mortality) were used to calculate differences in predicted remaining LEFC across physical activity levels for men and women at ages 45 and 65 years. RESULTS During a median follow-up of 11.0 years, we recorded 13,143 cancer cases for men and 10,255 for women, and 6488 deaths for men and 3739 for women. At age 45, "insufficiently active," "active," and "very active" had a higher LEFC by 2.35, 2.46, and 2.76 years compared with "no activity," and by 1.44, 1.62, and 1.84 years at age 65. In women, the "insufficiently active," "active," and "very active" had a higher LEFC by 1.09, 1.42, and 1.59 years at age 45, and by 1.25, 1.54, and 1.71 years at age 65. CONCLUSIONS Engaging in physical activity, even below recommended levels, appears to extend cancer-free years of life. Promoting physical activity is an important strategy for cancer prevention.
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Affiliation(s)
- Miguel Adriano Sanchez-Lastra
- Department of Special Didactics, Faculty of Education and Sports Sciences, University of Vigo, Pontevedra, Spain
- Well-Move Research Group, Galicia-Sur Health Research Institute (SERGAS-UVIGO), Vigo, Spain
- Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
| | - Borja Del Pozo Cruz
- Faculty of Sport Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain
- Center for Active and Healthy Aging, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
| | - Ulf Ekelund
- Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
- Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway
| | - Jakob Tarp
- Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
| | - Ding Ding
- Prevention Research Collaboration, Sydney School of Public Health, The University of Sydney, Camperdown, NSW, Australia
- Charles Perkins Center, The University of Sydney, Camperdown, NSW, Australia
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Oh J, Kim S, Kim MS, Abate YH, Abd ElHafeez S, Abdelkader A, Abdi P, Abdulah DM, Aboagye RG, Abolhassani H, Abtahi D, Abualruz H, Abu-Gharbieh E, Aburuz S, Adane MM, Addo IY, Adeleke OT, Aden B, Adnani QES, Adra S, Afzal MS, Ahmad S, Ahmad T, Ahmadi A, Ahmed SA, Al Awaidy S, Al Bakour MA, Alam K, Albashtawy M, Al-Eyadhy A, Al-Gheethi AAS, Alhalaiqa FN, Ali SS, Ali W, Alif SM, Al-Jabi SW, Alqahtani JS, AlQudah M, Alrawashdeh A, Alshahrani NZ, Altaany Z, Altaf A, Al-Tammemi AB, Altirkawi KA, Alvis-Guzman N, Alwafi H, Al-Wardat M, Al-Worafi YM, Aly H, Alyahya MSI, Alzoubi KH, Amusa GA, Ansar A, Anuoluwa BS, Anuoluwa IA, Anyasodor AE, Arabloo J, Aravkin AY, Areda D, Asghari-Jafarabadi M, Ashraf T, Athari SS, Aujayeb A, Ayana LAA, Aziz S, Azzam AY, Barqawi HJ, Barrow A, Bastan MM, Batra K, Behera P, Behzadi P, Bell ML, Beneke AA, Berhie AY, Beyene KA, Bhattacharjee P, Bhatti JS, Bolarinwa OA, Bouaoud S, Bustanji Y, Butt NS, Camargos P, Cámera LA, Carugno A, Cenderadewi M, Cerrai S, Chakraborty S, Chan JSK, Chandika RM, Chattu VK, Chaudhary AA, Cheng ETW, Chichagi F, Chimoriya R, Ching PR, Chirinos-Caceres JL, Chong YY, Chopra H, Chu DT, et alOh J, Kim S, Kim MS, Abate YH, Abd ElHafeez S, Abdelkader A, Abdi P, Abdulah DM, Aboagye RG, Abolhassani H, Abtahi D, Abualruz H, Abu-Gharbieh E, Aburuz S, Adane MM, Addo IY, Adeleke OT, Aden B, Adnani QES, Adra S, Afzal MS, Ahmad S, Ahmad T, Ahmadi A, Ahmed SA, Al Awaidy S, Al Bakour MA, Alam K, Albashtawy M, Al-Eyadhy A, Al-Gheethi AAS, Alhalaiqa FN, Ali SS, Ali W, Alif SM, Al-Jabi SW, Alqahtani JS, AlQudah M, Alrawashdeh A, Alshahrani NZ, Altaany Z, Altaf A, Al-Tammemi AB, Altirkawi KA, Alvis-Guzman N, Alwafi H, Al-Wardat M, Al-Worafi YM, Aly H, Alyahya MSI, Alzoubi KH, Amusa GA, Ansar A, Anuoluwa BS, Anuoluwa IA, Anyasodor AE, Arabloo J, Aravkin AY, Areda D, Asghari-Jafarabadi M, Ashraf T, Athari SS, Aujayeb A, Ayana LAA, Aziz S, Azzam AY, Barqawi HJ, Barrow A, Bastan MM, Batra K, Behera P, Behzadi P, Bell ML, Beneke AA, Berhie AY, Beyene KA, Bhattacharjee P, Bhatti JS, Bolarinwa OA, Bouaoud S, Bustanji Y, Butt NS, Camargos P, Cámera LA, Carugno A, Cenderadewi M, Cerrai S, Chakraborty S, Chan JSK, Chandika RM, Chattu VK, Chaudhary AA, Cheng ETW, Chichagi F, Chimoriya R, Ching PR, Chirinos-Caceres JL, Chong YY, Chopra H, Chu DT, Corlateanu A, Cruz-Martins N, da Silva AG, Dababo N, Dadras O, Dai X, Damiani G, Dandona L, Dandona R, Dellavalle RP, Devanbu VGC, Dhane AS, Dharmaratne SD, Dhulipala VR, Di Pumpo M, Diaz MJ, Dima A, Ding DD, Do TC, Do THP, Doshi OP, Drucker AM, Durojaiye OC, E'mar AR, Efendi D, Ekholuenetale M, Ekundayo TC, El Arab RA, El Bayoumy IF, El Meligy OAA, Elagali AEM, Elhadi M, Elsohaby I, Emeto TI, Fagbamigbe AF, Fahim A, Faiz R, Fakhradiyev IR, Fatehizadeh A, Fazeli P, Fazylov T, Feizkhah A, Ferreira N, Fetensa G, Fischer F, Fonzo M, Foroutan B, Fukumoto T, Gaipov A, Gandhi AP, Gautam RK, Gebregergis MW, Gebrehiwot M, Gebremeskel TG, Getahun GK, Ghadirian F, Ghamari SH, Gholamalizadeh M, Gillum RF, Girmay AA, Gohari K, Goleij P, Guan SY, Gunawardane DA, Gupta S, Hadi NR, Haghmorad D, Halwani R, Hamoudi R, Has EMM, Hasaballah AI, Hasani H, Hasnain MS, Hassan N, Hay SI, Heibati B, Heidari M, Heydari M, Holla R, Horita N, Hosseinzadeh H, Hosseinzadeh M, Hundie TG, Hwang BF, Ikiroma A, Ilesanmi OS, Ilic IM, Imam MT, Inbaraj LR, Islam MR, Islam SMS, Ismail NE, Ispayeva ZB, Iyasu AN, J V, Jafarzadeh A, Jain A, Jain N, Jairoun AA, Jalilzadeh Yengejeh R, Janodia MD, Javidnia J, Jayaram S, Jonas JB, Joseph N, Joshua CE, Jozwiak JJ, K V, Kadashetti V, Kaliyadan F, Kanmiki EW, Kant S, Kasraei H, Kaur H, Keykhaei M, Khajuria H, Khamesipour F, Khan M, Khan MAB, Khatatbeh MM, Kheirallah KA, Khidri FF, Khosravi S, Khubchandani J, Kim YJ, Kisa A, Kisa S, KM S, Kompani F, Korzh O, Kuddus M, Kuehni CE, Kuitunen I, Kulimbet M, Kulkarni V, Kumar D, Kumar GA, Kumar P, Kumar R, Kumar V, Kuttikkattu A, Lahariya C, Latief K, Lauriola P, Lawal BK, Le TTT, Le TDT, Ledda C, Lee SW, Lee SW, Lee YH, Li MC, Li W, Ligade VS, Lim SS, Lin Q, Liu G, Liu W, Liu X, López-Gil JF, Mahalleh M, Maharaj SB, Mahmoudvand G, Majeed A, Malik AA, Malik I, Marzo RR, Matei CN, Mathioudakis AG, Mathur N, Matthew IL, Maugeri A, McPhail SM, Mehmood A, Mekene Meto T, Meles HN, Menezes RG, Mensah GA, Mestrovic T, Mettananda S, Minervini G, Mirrakhimov EM, Misganaw A, Mohamed NS, Mohammadian-Hafshejani A, Mohammed S, Mojiri-Forushani H, Mokdad AH, Monasta L, Moodi Ghalibaf A, Mougin V, Mukherjee S, Mulita A, Munjal K, Murillo-Zamora E, Murray CJL, Musaigwa F, Mustafa G, Naik GR, Najdaghi S, Nangia V, Narimani Davani D, Nascimento GG, Natto ZS, Nauman J, Nayak BP, Nematollahi MH, Nguyen NNY, Nguyen VT, Niazi RK, Nikpoor AR, Noor STA, Nri-Ezedi CA, Nugen F, Nunemo MH, Nuñez-Samudio V, Nurrika D, Nzoputam OJ, Oancea B, Odetokun IA, Okati-Aliabad H, Okwute PG, Olagunju AT, Ordak M, Ouyahia A, P A M, Padubidri JR, Pandey A, Pandey A, Pandi-Perumal SR, Pantazopoulos I, Pardhan S, Park EK, Parthasarathi A, Patel J, Pathan AR, Patil S, Peprah P, Pereira G, Pereira MO, Perianayagam A, Perna S, Poddighe D, Poluru R, Pourbabaki R, Pourshams A, Prabhu D, Pradhan J, Prates EJS, Qattea I, Rahman MHU, Rahman M, Rahman MA, Rahmani AM, Rahmani S, Rahmati M, Rajizadeh MA, Rajput P, Rancic N, Rao M, Rasali DP, Rashedi S, Rasouli-Saravani A, Rathish D, Rawaf DL, Rawaf S, Redwan EM, Rezaei N, Rezaei N, Rezaeian M, Rodrigues M, Rodriguez JAB, Roever L, Rokni M, Ronfani L, Root KT, Ross AG, Rout HS, Roy S, Saad AMA, Saadeddin A, Saber-Ayad MM, Sabet CJ, Saddik BA, Saeb MR, Saeed U, Saheb Sharif-Askari F, Saheb Sharif-Askari N, Sahebkar A, Sajid MR, Salami AA, Salciccioli JD, Saleh MA, Samargandy S, Samodra YL, Samuel VP, Samy AM, Saravanan A, Sathian B, Sawhney M, Saxena S, Schumacher AE, Sendekie AK, Senthilkumaran S, Sethi Y, Shahid W, Shahwan MJ, Shaikh MA, Sham S, Shamim MA, Shamsutdinova A, Shanawaz M, Shannawaz M, Sharfaei S, Sharifan A, Sharifi Rad J, Sharma A, Sharma M, Sheidaei A, Sheikh A, Shekouhi R, Shenoy MM, Shenoy RR, Shetty PH, Shetty PK, Shittu A, Shorofi SA, Si Y, Siddig EE, Singh A, Singh H, Singh JA, Singh P, Singh V, Skryabina AA, Sobia F, Solanki S, Sood A, Soraneh S, Soriano JB, Srinivasamurthy SK, Stockfelt L, Swain CK, Szarpak L, Szeto MD, Tabatabaei SM, Tabish M, Taha ZMA, Taiba J, Talaat IM, Tampa M, Tamuzi JL, Tan KK, Tanwar M, Tat NY, Temsah MH, Thangaraju P, Thayakaran R, Thayumana Sundaram M, Ticoalu JHV, Tomo S, Topor-Madry R, Tran JT, Tran NH, Tran TH, Tran Minh Duc N, Tsatsakis A, Tualeka AR, Tumurkhuu M, Umar M, Upadhyay E, Valenti M, Van den Eynde J, Vasankari TJ, Verras GI, Vieira RJ, Vinayak M, Violante FS, Wada HT, Werdecker A, Wickramasinghe ND, Yadav L, Yadav MK, Yismaw Y, Yonemoto N, Yu C, Zaki N, Zastrozhin M, Zhang ZJ, Zhao H, Zia H, Zielinska M, Shin JI, Yon DK. Global, regional, and national burden of asthma and atopic dermatitis, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. THE LANCET. RESPIRATORY MEDICINE 2025; 13:425-446. [PMID: 40147466 DOI: 10.1016/s2213-2600(25)00003-7] [Show More Authors] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Revised: 12/18/2024] [Accepted: 01/07/2025] [Indexed: 03/29/2025]
Abstract
BACKGROUND Asthma and atopic dermatitis are common allergic conditions that contribute to substantial health loss, economic burden, and pain across individuals of all ages worldwide. Therefore, as a component of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, we present updated estimates of the prevalence, disability-adjusted life-years (DALYs), incidence, and deaths due to asthma and atopic dermatitis and the burden attributable to modifiable risk factors, with forecasted prevalence up to 2050. METHODS Asthma and atopic dermatitis prevalence, incidence, DALYs, and mortality, with corresponding 95% uncertainty intervals (UIs), were estimated for 204 countries and territories from 1990 to 2021. A systematic review identified data from 389 sources for asthma and 316 for atopic dermatitis, which were further pooled using the Bayesian meta-regression tool. We also described the age-standardised DALY rates of asthma attributable to four modifiable risk factors: high BMI, occupational asthmagens, smoking, and nitrogen dioxide pollution. Furthermore, as a secondary analysis, prevalence was forecasted to 2050 using the Socio-demographic Index (SDI), air pollution, and smoking as predictors for asthma and atopic dermatitis. To assess trends in the burden of asthma and atopic dermatitis before (2010-19) and during (2019-21) the COVID-19 pandemic, we compared their average annual percentage changes (AAPCs). FINDINGS In 2021, there were an estimated 260 million (95% UI 227-298) individuals with asthma and 129 million (124-134) individuals with atopic dermatitis worldwide. Asthma cases declined from 287 million (250-331) in 1990 to 238 million (209-272) in 2005 but increased to 260 million in 2021. Atopic dermatitis cases consistently rose from 107 million (103-112) in 1990 to 129 million (124-134) in 2021. However, age-standardised prevalence rates decreased-by 40·0% (from 5568·3 per 100 000 to 3340·1 per 100 000) for asthma and 8·3% (from 1885·4 per 100 000 to 1728·5 per 100 000) for atopic dermatitis. In 2021, there were substantial variations in the burden of asthma and atopic dermatitis across different SDI groups, with the highest age-standardised DALY rate found in south Asia for asthma (465·0 [357·2-648·9] per 100 000) and the high-income super-region for atopic dermatitis (3552·5 [3407·2-3706·1] per 100 000). During the COVID-19 pandemic, the decline in asthma prevalence had stagnated (AAPC pre-pandemic -1·39% [-2·07 to -0·71] and during the pandemic 0·47% [-1·86 to 2·79]; p=0·020); however, there was no significant difference in atopic dermatitis prevalence in the same period (pre-pandemic -0·28% [-0·33 to -0·22] and during the pandemic -0·35% [-0·78 to 0·08]; p=0·20). Modifiable risk factors were responsible for 29·9% of the global asthma DALY burden; among them, high BMI was the greatest contributor (39·4 [19·6-60·2] per 100 000), followed by occupational asthmagens (20·8 [16·7-26·5] per 100 000) across all regions. The age-standardised DALY rate of asthma attributable to high BMI was highest in high-SDI settings, whereas the contribution of occupational asthmagens was highest in low-SDI settings. According to our forecasting models, we expect 275 million (224-330) asthma cases and 148 million (140-158) atopic dermatitis cases in 2050, with population growth driving this increase. However, age-standardised prevalence rates are expected to remain stable (-23·2% [-44·4 to 5·3] for asthma and -1·4% [-9·1 to 7·0] for atopic dermatitis) from 2021 to 2050. INTERPRETATION Although the increases in the total number of asthma and atopic dermatitis cases will probably continue until 2050, age-standardised prevalence rates are expected to remain stable. A considerable portion of the global burden could be managed through efforts to address modifiable risk factors. Additionally, the contribution of risk factors to the burden substantially varied by SDI, which suggests the need for tailored initiatives for specific SDI settings. The growing number of individuals expected to be affected by asthma and atopic dermatitis in the future suggests that it is essential to improve our understanding of risk factors for asthma and atopic dermatitis and collect disease prevalence data that are globally generalisable. FUNDING Gates Foundation.
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Wilson OWA, Wojcik KM, Jayasekera J, Rogers LQ, Demark-Wahnefried W, Farrell D, Butera G, Matthews CE, Street RL. Exercise Communication for Breast Cancer Survivors: A Systematic Scoping Review. JAMA Netw Open 2025; 8:e258862. [PMID: 40377942 DOI: 10.1001/jamanetworkopen.2025.8862] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 05/18/2025] Open
Abstract
Importance Exercise may offer various clinical benefits to breast cancer survivors. However, exercise participation among survivors is low. Discussions about exercise can increase participation, but details regarding implementation of exercise communication for breast cancer survivors are unclear. Objective To examine the development and implementation of explicitly reported exercise communication for breast cancer survivors. Evidence Review The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews was used. Six databases (PubMed/MEDLINE, Cochrane Library, Embase, Web of Science, Communication and Mass Media Complete, and PsycINFO) were searched for articles describing exercise communication for female breast cancer survivors in any geographical location or setting published up to April 2024. Information about study and participant characteristics, exercise communication, and intervention components and effects were extracted. Findings Thirty-nine studies were included. Information consistent with exercise guidelines was communicated in 32 studies for aerobic exercise (82.1%) and 7 studies for muscle-strengthening exercise (17.9%). More studies communicated information about exercise benefits (20 [51.3%]) compared with exercise safety (3 [7.7%]). Studies included breast cancer survivors who were predominantly White (median [range], 85.5% [47.4%-98.7%]). Most included breast cancer survivors were educated (median percentage, 50.7% were college graduates) and had completed primary treatment (eg, median percentage, 66.7% had completed chemotherapy). Seventeen individualized (ie, tailored) information based on demographic or clinical characteristics (43.6%), and 5 considered contextual factors, such as the environment (12.8%). Most interventions reported an increase in exercise (19 of 21 [90.4%]). Heterogeneity in intervention design (eg, dietary advice or exercise trackers in addition to exercise information) and evaluation (eg, intervention length and outcomes) prevented quantitative synthesis of intervention effects. Conclusions and Relevance In this systematic scoping review of exercise communication for breast cancer survivors, interventions including exercise communication appeared to show a favorable effect. However, data were limited about the development and implementation of these interventions among underrepresented breast cancer survivors. Interest in research involving exercise communication for breast cancer survivors in clinical settings remains strong.
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Affiliation(s)
- Oliver W A Wilson
- Division of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland
| | - Kaitlyn M Wojcik
- Division of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland
| | - Jinani Jayasekera
- Division of Intramural Research at the National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland
| | - Laura Q Rogers
- Division of Preventive Medicine, Department of Medicine at University of Alabama at Birmingham
| | | | | | - Gisela Butera
- Office of Research Services, National Institutes of Health Library, Bethesda, Maryland
| | - Charles E Matthews
- Metabolic Epidemiology Branch at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland
| | - Richard L Street
- Department of Communication and Journalism at Texas A & M University, College Station
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15
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Zheng S, Yan J, Wang J, Wang X, Kang YE, Koo BS, Shan Y, Liu L. Unveiling the Effects of Cruciferous Vegetable Intake on Different Cancers: A Systematic Review and Dose-Response Meta-analysis. Nutr Rev 2025; 83:842-858. [PMID: 39348271 DOI: 10.1093/nutrit/nuae131] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/02/2024] Open
Abstract
CONTEXT Epidemiological studies indicated that cruciferous vegetable intake is associated with positive health outcomes. However, the role of cruciferous vegetables may have differential impacts on various cancers. OBJECTIVE This meta-analysis aims to review recent epidemiological studies on the link between cruciferous vegetables and various cancers. It seeks to identify the optimal intake dose and timing of cruciferous vegetables influencing their association with cancer risk. DATA SOURCES Studies on cruciferous vegetables and cancer were searched in PubMed, NCBI, Web of Science, and Elsevier databases from 1978 to June 2023. DATA EXTRACTION Extracted data from 226 relevant case-control and cohort studies were expressed by standardized mean difference and 95% CI, followed by the subgroup analysis to eliminate heterogeneity. RESULTS Intake of cruciferous vegetables can prevent cancers, with an odds ratio of 0.77 and risk ratio (RR) of 0.96. The intake levels of cruciferous vegetables associated with the risk of colorectal cancer, lung cancer, upper gastrointestinal cancer, gynecological cancer (ovarian cancer and endometrial cancer), bladder cancer, renal cancer, and prostate cancer were found to be 5.41 servings/week, 5.41 servings/week, 5.5 servings/week, 7.4 servings/week, 5.5 servings/week, 4.85 servings/week, and 3 servings/week, respectively. In a cohort followed for 2 to 15 years, limited consumption of cruciferous vegetables was correlated with a higher cancer RR. In the Asian population, cruciferous vegetables had a significant relationship with lung cancer, head and neck squamous cell carcinoma, and esophageal cancer. Conversely, cruciferous vegetables are predominantly associated with colorectal, renal, gynecological, and prostate cancer in the American population. CONCLUSION This study highlights the complex link between cruciferous vegetables and cancer, influenced by factors such as cancer type, region, intake level, and follow-up duration.
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Affiliation(s)
- Sicong Zheng
- Department of Nutrition, Public Health and Management College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
- Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
| | - Jielin Yan
- Department of Nutrition, Public Health and Management College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
| | - Jiaxin Wang
- Department of Nutrition, Public Health and Management College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
- Southern Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, Wenzhou, Zhejiang 325809, China
| | - Xinyi Wang
- Department of Nutrition, Public Health and Management College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
- Southern Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, Wenzhou, Zhejiang 325809, China
| | - Yea Eun Kang
- Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
| | - Bon Seok Koo
- Department of Otolaryngology-Head and Neck Surgery, Research Institute for Medical Science, Chungnam National University, School of Medicine, Daejeon 35015, Republic of Korea
| | - Yujuan Shan
- Department of Nutrition, Public Health and Management College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
- Southern Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, Wenzhou, Zhejiang 325809, China
| | - Lihua Liu
- Department of Nutrition, Public Health and Management College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
- Southern Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, Wenzhou, Zhejiang 325809, China
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16
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Pernaton L, Cellier D, Buono R, Pierre A, Sauzet M, Blay JY, Pérol O, Fervers B. [Cancer and nutritional management of overweight and obesity: Practice evaluation]. Bull Cancer 2025; 112:478-494. [PMID: 39863506 DOI: 10.1016/j.bulcan.2024.10.011] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/10/2024] [Revised: 10/27/2024] [Accepted: 10/30/2024] [Indexed: 01/27/2025]
Abstract
CONTEXT The aim of this practice evaluation was to assess weight trends during and after a nutritional intervention in cancer patients and survivors. METHODS This retrospective study was conducted between January 2014 and October 2020 in adults with different cancer types managed at the Léon-Bérard Cancer Center, undergoing treatment or during post-treatment follow-up, with a BMI≥25kg/m2 and who had at least 3 consultations with a nutrition physician. Nutritional management focused on behavioral, metabolic and nutritional aspects. Anthropometrics measurements, i.e., waist circumference, weight and BMI, were monitored prospectively during the nutritional consultation. The aim of this study was to evaluate the impact of the nutritional intervention on the anthropometrics measurements. RESULTS Overall, 247 patients were included in the analysis. The median duration of the nutritional intervention was 7.2months. Between the first and the last nutrition consultation, waist circumference was reduced in 97.2% of the patients, with a median loss of 10cm; weight and BMI were reduced in 85.0% and 83.8% of the patients respectively. Six months after the end of the nutritional intervention, 53.7% of patients had stable or continued reduced weight. CONCLUSION This analysis of practice shows the positive impact of a nutritional intervention during cancer treatments on anthropometric parameters, and maintenance or continued weight loss at distance from the intervention in half of the patients.
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Affiliation(s)
- Léo Pernaton
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France; Université Claude-Bernard, Lyon, France
| | - Dominique Cellier
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France.
| | - Romain Buono
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France
| | - Antoine Pierre
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France
| | - Marine Sauzet
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France
| | - Jean-Yves Blay
- Département d'oncologie médicale, centre Léon-Bérard, 69008 Lyon, France; Université Claude-Bernard, Lyon, France
| | - Olivia Pérol
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France; Inserm U1296 rayonnements : défense, santé, environnement, centre Léon-Bérard, 69008 Lyon, France
| | - Béatrice Fervers
- Département prévention cancer environnement, centre Léon-Bérard, 69008 Lyon, France; Inserm U1296 rayonnements : défense, santé, environnement, centre Léon-Bérard, 69008 Lyon, France
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17
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Malathi N, Rajan ST, Warnakulasuriya S. Natural products and diet for the prevention of oral cancer: Research from south and southeast Asia. Oral Dis 2025; 31:1503-1516. [PMID: 38804557 DOI: 10.1111/odi.15002] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2024] [Revised: 04/19/2024] [Accepted: 05/06/2024] [Indexed: 05/29/2024]
Abstract
Medicinal plants are of prime importance in the discovery of drugs. They are an inherent source of naturally available phytochemicals that can help in the prevention and treatment of several diseases including cancer. This article reviews the experimental and clinical evidence of phytochemicals available in natural dietary products that are used in everyday life across South Asia and South-East Asia for their perceived effectiveness in the management of Potentially Malignant Disorders and prevention of Oral Cancer. The review also highlights the active phytometabolites, their in vitro anti-proliferative properties and targeted signalling pathways, biological activities in in vivo models and translative potential for clinical trials in humans.
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Affiliation(s)
- N Malathi
- Department of Oral Pathology, Sri Ramachandra Dental College & Hospital, Sri Ramachandra Institute of Higher Education & Research, Chennai, Tamil Nadu, India
| | - Sharada T Rajan
- Department of Oral Pathology, Sri Ramachandra Dental College & Hospital, Sri Ramachandra Institute of Higher Education & Research, Chennai, Tamil Nadu, India
| | - Saman Warnakulasuriya
- Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK
- WHO Collaborating Centre for Oral Cancer, London, UK
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18
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Gonçalves E, Fontes F, Rodrigues JR, Calisto R, Bento MJ, Lunet N, Morais S. Risk and survival of third primary cancers in a population-based cohort of patients with a cervical, endometrial, or ovarian cancer. J Obstet Gynaecol Res 2025; 51:e16297. [PMID: 40302142 DOI: 10.1111/jog.16297] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2024] [Accepted: 04/08/2025] [Indexed: 05/01/2025]
Abstract
PURPOSE Multiple primary cancers are relevant outcomes among survivors of gynecological cancers, contributing to the overall cancer burden and having a potential impact on the management of each primary cancer. This study aimed to estimate the risk and survival of third primary cancers (TPCs) among females with a cervical, endometrial, or ovarian first primary cancer (FPC). METHODS Patients with a cervical, endometrial, or ovarian FPC from the Portuguese North Region Cancer Registry, diagnosed between 2000 and 2010 (n = 5846), were followed for a TPC (December 31, 2015) and death from any cause (December 31, 2023). The cumulative incidence of TPCs and mortality was estimated. Patients with a TPC were matched (1:1) to patients without a TPC (FPC + second primary cancer [SPC] only) to compare survival. RESULTS Overall, 29 (0.5% of FPCs and 5.4% of SPCs) TPCs were diagnosed. The most common sites were digestive organs (n = 9) followed by breast and urinary tract cancers (n = 4 each). Among all FPCs, the 10-year cumulative incidence (95% confidence interval [CI]) of a TPC was 0.5% (0.3%-0.7%) and among SPCs, it was 5.8% (3.3%-8.2%). For TPCs, compared to matched patients, the age-adjusted hazard ratio (95% CI) for death was 3.0 (1.39-6.50). The 10-year cumulative mortality of TPCs and matched patients was 75.7% and 42.0%, respectively. CONCLUSIONS In Northern Portugal, TPCs occurred mainly in digestive organs, followed by the breast and urinary tract, with a 10-year cumulative incidence of 0.5% among all FPCs. TPCs had a worse long-term survival compared to patients with an SPC only.
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Affiliation(s)
- Elisabete Gonçalves
- EPIUnit ITR, Instituto de Saúde Pública da Universidade do Porto, Universidade do Porto, Porto, Portugal
- Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
| | - Filipa Fontes
- Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
- Grupo de Abordagem de Lesões Precursoras e Cancro Precoce - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde), Instituto Português de Oncologia do Porto FG, Porto, Portugal
| | - Jéssica Rocha Rodrigues
- Grupo de Investigação em Epidemiologia, Resultados, Economia e Gestão em Oncologia - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde), Instituto Português de Oncologia do Porto FG, EPE (IPO-Porto), Porto, Portugal
- Serviço de Epidemiologia, Instituto Português de Oncologia do Porto FG, EPE - Porto, Porto, Portugal
| | - Rita Calisto
- Grupo de Investigação em Epidemiologia, Resultados, Economia e Gestão em Oncologia - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde), Instituto Português de Oncologia do Porto FG, EPE (IPO-Porto), Porto, Portugal
- Serviço de Epidemiologia, Instituto Português de Oncologia do Porto FG, EPE - Porto, Porto, Portugal
| | - Maria José Bento
- Grupo de Investigação em Epidemiologia, Resultados, Economia e Gestão em Oncologia - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde), Instituto Português de Oncologia do Porto FG, EPE (IPO-Porto), Porto, Portugal
- Serviço de Epidemiologia, Instituto Português de Oncologia do Porto FG, EPE - Porto, Porto, Portugal
- Departamento Estudos de Populações, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
| | - Nuno Lunet
- EPIUnit ITR, Instituto de Saúde Pública da Universidade do Porto, Universidade do Porto, Porto, Portugal
- Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
| | - Samantha Morais
- EPIUnit ITR, Instituto de Saúde Pública da Universidade do Porto, Universidade do Porto, Porto, Portugal
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Normann AJ, Wilson RL, Matarese E, Lu C, Ranieri BP, Gardiner JR, Marinac CR, Dieli-Conwright CM. Racial Health Disparity and Risk of Multiple Myeloma: Implications for Energy Balance Interventions. Cancer Prev Res (Phila) 2025; 18:261-269. [PMID: 40308084 DOI: 10.1158/1940-6207.capr-24-0199] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2024] [Revised: 09/04/2024] [Accepted: 02/25/2025] [Indexed: 05/02/2025]
Abstract
Established risk factors for multiple myeloma, including obesity and sedentary lifestyles, are associated with well-known racial/ethnic disparities in disease risk. This review examines established risk determinants for multiple myeloma in Black adults, summarizes evidence linking lifestyle factors, including obesity, physical inactivity, and diet, to disease risk, and discusses energy balance interventions, including cultural tailoring, to mitigate multiple myeloma risk. We summarize current evidence for racial/ethnic disparities in risk factors for multiple myeloma, including unmodifiable heritable factors, modifiable contributors to obesity, including diet and physical activity, and barriers to meeting physical activity and healthful diet guidelines. With this evidence, we present considerations to research lifestyle interventions directed toward risk factors for multiple myeloma. Current foundational scientific evidence in energy balance interventions for cancer risk management is primarily supported in non-Hispanic White populations. Evidence for preventative exercise, diet, or lifestyle interventions for multiple myeloma among underrepresented populations is scarce. Research considerations are proposed to provide strategies utilizing community engagement, primary care education, and importantly, availability of exercise and dietary resources. The importance of tailoring exercise and dietary interventions is also underscored, in addition to generating clinical trial-based evidence to be equitable and beneficial for all populations.
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Affiliation(s)
- Amber J Normann
- Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
- Department of Health Sciences, Boston University, Boston, Massachusetts
| | - Rebekah L Wilson
- Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
- Harvard Medical School, Boston, Massachusetts
| | - Ellaney Matarese
- Department of Neuroscience, Harvard University, Boston, Massachusetts
| | - Chuan Lu
- Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
| | - Brett P Ranieri
- Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts
| | - John R Gardiner
- Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
| | - Catherine R Marinac
- Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
- Harvard Medical School, Boston, Massachusetts
| | - Christina M Dieli-Conwright
- Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts
- Harvard Medical School, Boston, Massachusetts
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20
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Zhan Z, Chen B, Lin W, Chen X, Huang R, Yang C, Guo Z. Rising Burden of Colon and Rectum Cancer in China: An Analysis of Trends, Gender Disparities, and Projections to 2030. Ann Surg Oncol 2025; 32:3361-3371. [PMID: 39836276 DOI: 10.1245/s10434-025-16905-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/19/2024] [Accepted: 01/06/2025] [Indexed: 01/22/2025]
Abstract
BACKGROUND Colon and rectum cancer (CRC) is a major health burden in China, with notable gender disparities. This study was designed to analyze trends in CRC incidence, prevalence, and mortality from 1990 to 2021 and to project future trends. METHODS Using data from the Global Burden of Disease (GBD) Study 2021, we examined CRC burden in China, including incidence, prevalence, mortality, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs). Joinpoint regression, Bayesian age-period-cohort (BAPC) models, and age-period-cohort (APC) analysis identified trends and projected incidence up to 2030. RESULTS In 2021, CRC incidence was 658,321 cases, disproportionately affecting males, with an age-standardized incidence rate of 42.24 per 100,000 in males and 21.87 per 100,000 in females. The CRC-related deaths reached 275,129, with higher mortality in males (18.95 per 100,000) than females (9.34 per 100,000). The DALYs totaled 6,848,390 and largely impacted males. Joinpoint analysis showed a persistent increase in incidence and prevalence, especially in younger cohorts, whereas mortality declined slightly but began rising again after 2015. The BAPC analysis projected further incidence growth, particularly in males, through 2030. The APC analysis revealed higher CRC risk among younger cohorts, suggesting increasing early-onset CRC linked to lifestyle risk factors, such as smoking, high alcohol consumption, and diets low in fiber and calcium, with a stronger effect on males. CONCLUSIONS The increase of CRC incidence and prevalence in China, particularly among males, underscores the need for targeted prevention and early detection. Future research should address gender disparities and modifiable lifestyle risks through public health interventions.
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Affiliation(s)
- Zhouwei Zhan
- Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China
| | - Bijuan Chen
- Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China
| | - Wei Lin
- Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China
| | - Xiamei Chen
- Department of Operation, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China
| | - Rui Huang
- Digestive Endoscopy Center, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China
| | - Chunkang Yang
- Department of Gastrointestinal Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
| | - Zengqing Guo
- Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
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21
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Gong H, Gao M, Zeng Z. The association between life's crucial 9 and all-cause, cancer-specific and cardiovascular mortality in US cancer survivors: a cohort study of NHANES. BMC Cancer 2025; 25:805. [PMID: 40307773 PMCID: PMC12042308 DOI: 10.1186/s12885-025-14229-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2024] [Accepted: 04/25/2025] [Indexed: 05/02/2025] Open
Abstract
BACKGROUND Life's Crucial 9 (LC9) is a recently proposed cardiovascular health (CVH) scoring system that integrates psychological well-being with Life's Essential 8 (LE8). However, its prognostic value remains unclear. This study aims to investigate the association between LC9 and outcomes among cancer survivors. METHODS A total of 2,558 cancer survivors from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 were included in this study. LC9, representing a dimension of psychological health, was calculated as the average of the LE8 score and the depression score. Cox proportional hazards regression, restricted cubic spline (RCS) analysis, subgroup analysis, and Kaplan-Meier survival curves were employed to evaluate the association between LC9 and mortality risk, with adjustments for potential confounders. RESULTS During an average follow-up period of 80 months, 640 deaths occurred, including 205 from cancer and 128 from cardiovascular disease. After adjusting for all covariates using Cox regression, a 10-point increase in the LC9 score was associated with a 24% reduction in all-cause mortality (HR: 0.76; 95% CI: 0.68-0.84), a 19% reduction in cancer-specific mortality (HR: 0.81; 95% CI: 0.68-0.97), and a 28% reduction in cardiovascular mortality (HR: 0.72; 95% CI: 0.58-0.90). Kaplan-Meier survival curves indicated lower rates of all-cause, cancer-specific, and cardiovascular mortality among participants with higher LC9 scores. RCS analysis revealed a linear inverse association between LC9 and all-cause and cancer-specific mortality and a nonlinear inverse association with cardiovascular mortality. CONCLUSION Among cancer survivors in the United States, higher LC9 scores were independently associated with lower risks of all-cause, cancer-specific, and cardiovascular mortality. This finding highlights the potential link between cardiovascular health and survival outcomes in cancer survivors, suggesting that improving cardiovascular health may serve as an important preventive strategy to enhance survival rates in this population.
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Affiliation(s)
- Hongyang Gong
- Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of Korea
| | - Ming Gao
- Department of Gastroenterology, The First Hospital of Jilin University, Changchun, Jilin, China
| | - Zhiwen Zeng
- Department of Oncology, NANCHANG PEOPLE'S HOSPITAL, Nanchang, Jiangxi, China.
- Department of Oncology, NANCHANG PEOPLE'S HOSPITAL, No. 2, Xiangshan South Road, Nanchang, 330009, China.
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Chen X, Zhu D, Li C, Lin Y, Lv L, Ai F, Chen Z, Shen R, Shen X, You G, Jiang Z, Zhong W, Lin T. Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study. J Transl Med 2025; 23:486. [PMID: 40301980 PMCID: PMC12042550 DOI: 10.1186/s12967-025-06372-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/29/2025] [Accepted: 03/08/2025] [Indexed: 05/01/2025] Open
Abstract
BACKGROUND Modifiable factors affect cancer's survival but literature did not differentiate prior to versus after cancer diagnosis. It is essential to provide references for the intervention prioritized at different stages. METHODS In this prospective cohort study, we analyzed national data from the UK Biobank, including 121,399 participants, to assess the association of modifiable factors with cancer-specific survival (CSS) in two independent cohorts: a pre-cancer cohort (n = 78,027) and a post-cancer cohort (n = 43,372). Additionally, a weighted standardized score was derived to evaluate the joint effects across different domains. Interactions between the six domains and age at diagnosis, sex, and cancer site were evaluated using likelihood ratio tests. Subgroup analyses were then performed for factors showing significant effect modification. Population-attributable fractions (PAF) of different domains on 5-year cancer-specific death were calculated. RESULTS Our study comprehensively presented the differential patterns of modifiable factors' impact on CSS among pre-cancer and post-cancer cohorts, sexes and different cancer sites. In the pre-cancer cohort, CSS were predominantly attributable to smoking/alcohol consumption (PAF 9·2%) and daily activity (PAF 10·6%). Men exhibited a higher risk than women for dietary habits (HR:1·25 versus 1·18), daily activity (HR:1·50 versus 1·29) and living environment (HR:1·13 versus 1·03). The impact of modifiable factors, including daily activity, smoking/alcohol consumption, and physical measures, on CSS varied across different cancer sites. In the post-cancer cohort, 18·6% of 5-year cancer-specific deaths were attributable to unfavourable mental health. In subgroup analysis, the risk of CSS in the domain of smoking/alcohol consumption was higher in men than that in women (HR: 1·58 versus 1·34). The impact of modifiable factors, including smoking/alcohol consumption, mental health and physical measures, on CSS varied across different cancer sites. CONCLUSIONS Our findings suggested that targeted prevention and early intervention strategies should be implemented to reduce the risk of cancer-related deaths.
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Affiliation(s)
- Xiong Chen
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, PR China
| | - Dongxi Zhu
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, PR China
| | - Chenchen Li
- Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China
| | - Yi Lin
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, PR China
| | - Lin Lv
- School of Medicine, Sun Yat-sen University, Guangzhou, PR China
| | - Feiling Ai
- Faculty of Medicine, Ludwig Maximilian University of Munich, Munich, Germany
| | - Zhijian Chen
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
- Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, PR China
| | - Runnan Shen
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China
| | - Xuwen Shen
- School of Medicine, Sun Yat-sen University, Guangzhou, PR China
| | - Guochang You
- School of Medicine, Sun Yat-sen University, Guangzhou, PR China
| | - Zhige Jiang
- School of Medicine, Sun Yat-sen University, Guangzhou, PR China
| | - Wenlong Zhong
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China.
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China.
- Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, PR China.
| | - Tianxin Lin
- Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China.
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China.
- Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou, PR China.
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Abrignani MG, Lucà F, Abrignani V, Nucara M, Grosseto D, Lestuzzi C, Mistrangelo M, Passaretti B, Rao CM, Parrini I. Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation. J Clin Med 2025; 14:3083. [PMID: 40364115 PMCID: PMC12072322 DOI: 10.3390/jcm14093083] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2025] [Revised: 03/30/2025] [Accepted: 04/09/2025] [Indexed: 05/15/2025] Open
Abstract
Cardiovascular diseases and cancer are the two primary causes of mortality worldwide. Although traditionally regarded as distinct pathologies, they share numerous pathophysiological mechanisms and risk factors, including chronic inflammation, insulin resistance, obesity, and metabolic dysregulation. Notably, several cancers have been identified as closely linked to cardiovascular diseases, including lung, breast, prostate, and colorectal cancers, as well as hematological malignancies, such as leukemia and lymphoma. Additionally, renal and pancreatic cancers exhibit a significant association with cardiovascular complications, partly due to shared risk factors and the cardiotoxic effects of cancer therapies. Addressing the overlapping risk factors through lifestyle modifications-such as regular physical activity, a balanced diet, and cessation of smoking and alcohol-has proven effective in reducing both CV and oncological morbidity and mortality. Furthermore, even in patients with established cancer, structured interventions targeting physical activity, nutritional optimization, and smoking cessation have been associated with improved outcomes. Beyond lifestyle modifications, pharmacological strategies play a crucial role in the prevention of both diseases. Several cardiovascular medications, including statins, aspirin, beta-blockers, and metformin, exhibit pleiotropic effects that extend beyond their primary indications, demonstrating potential anti-neoplastic properties in preclinical and observational studies. Recently, novel therapeutic agents have garnered attention for their possible cardioprotective and metabolic benefits. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is), initially developed for managing type 2 diabetes, have shown CV and renal protective effects, alongside emerging evidence of their role in modulating cancer-related metabolic pathways. Inclisiran, a small interfering RNA targeting PCSK9, effectively lowers LDL cholesterol and may contribute to reducing CV risk, with potential implications for tumor biology. Additionally, sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor, has revolutionized heart failure management by improving hemodynamic parameters and exerting anti-inflammatory effects that may have broader implications for chronic disease prevention. Given the intricate interplay between CVD and cancer, further research is essential to clarify the exact mechanisms linking these conditions and assessing the potential of CV therapies in cancer prevention. This review aims to examine shared risk factors, consider the role of pharmacological and lifestyle interventions, and emphasize crucial epidemiological and mechanistic insights into the intersection of CV and oncological health.
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Affiliation(s)
| | - Fabiana Lucà
- O.U. Interventional Cardiology-ICCU, A.O. Bianchi Melacrino Morelli, 89128 Reggio Calabria, Italy;
| | - Vincenzo Abrignani
- Internal Medicine and Stroke Care Ward, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90133 Palermo, Italy;
| | - Mariacarmela Nucara
- O.U. Interventional Cardiology-ICCU, A.O. Bianchi Melacrino Morelli, 89128 Reggio Calabria, Italy;
| | | | | | - Marinella Mistrangelo
- Department Rete Oncologica Piemonte e Valle d’Aosta, Città della Salute e della Scienza, 10126 Turin, Italy;
| | - Bruno Passaretti
- Cardiology Unit, Homanitas, Gavazzeni-Castelli, 24125 Bergamo, Italy;
| | | | - Iris Parrini
- Cardiology Department, Ospedale Mauriziano Umberto I, 10128 Turin, Italy;
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Shi W, Zhang J, Wei S, Wang X, Cao H, Ye D, Fang X. Assessing the impact of gout on cancer risk and the role of healthy lifestyles. Front Oncol 2025; 15:1557175. [PMID: 40356762 PMCID: PMC12066266 DOI: 10.3389/fonc.2025.1557175] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2025] [Accepted: 04/09/2025] [Indexed: 05/15/2025] Open
Abstract
Background Conflicting evidence exists on the link between gout and cancer risk, with limited clarity on the impact of healthy lifestyle factors. Methods In the UK Biobank, 7,169 gout patients were matched with 21,507 non-gout controls (1:3 ratio) using propensity scores. Cox regression models assessed cancer risk associated with gout. Among 6,105 gout patients, cancer risk was further evaluated using an eight-factor Healthy Lifestyle Score (HLS) and a weighted HLS. Results Gout was linked to a higher cancer incidence [HR (95% CI) = 1.075 (1.013-1.140)]. High HLS in gout patients correlated with a lower cancer risk [HR (95% CI) = 0.825 (0.717-0.948)], with the strongest protective effect observed in those aged ≥60. Sensitivity analyses confirmed these findings. Conclusion Gout patients have a higher risk of developing cancer, but a healthy lifestyle, particularly in those aged 60 and older, significantly reduces this risk. These findings highlight the importance of lifestyle interventions for cancer prevention in patients with gout.
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Affiliation(s)
- Wenru Shi
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
| | - Jie Zhang
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
- School of Public Health, Anhui University of Science and Technology, Hefei, Anhui, China
| | - Sitong Wei
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
| | - Xiang Wang
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
| | - Hongfei Cao
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
| | - Dongqing Ye
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
- School of Public Health, Anhui University of Science and Technology, Hefei, Anhui, China
| | - Xinyu Fang
- Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China
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Guo L, Li X. Nurse night shift work and risk of gastrointestinal cancers. Front Public Health 2025; 13:1532623. [PMID: 40356833 PMCID: PMC12066619 DOI: 10.3389/fpubh.2025.1532623] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/22/2024] [Accepted: 04/07/2025] [Indexed: 05/15/2025] Open
Abstract
The prevalence of night-shift employment is on the rise among full-time and part-time workers globally. Those engaged in night-shift work encounter various biological challenges, including exposure to artificial light during nighttime and disruptions to their circadian rhythms. These factors, along with changes in daily routines and activities, may pose significant risks to the health of night workers. Notably, the number of individuals working overtime or on night shifts has increased across various sectors, particularly in transportation, healthcare, and manufacturing. The International Agency for Research on Cancer (IARC) has classified night-shift work as probably carcinogenic to humans (IARC Group 2A). Subsequent research has identified several potential mechanisms through which night-shift work may contribute to carcinogenicity: (1) disruption of circadian rhythms, (2) suppression of melatonin levels due to nighttime light exposure, (3) physiological alterations, (4) lifestyle changes, and (5) reduced vitamin D levels resulting from inadequate sunlight exposure. Colorectal cancer (CRC) poses a significant public health challenge, ranking as the second leading cause of cancer-related death worldwide in 2020. Other than CRC, other gastrointestinal cancers are also creating a great global health issue because of their morbidity and mortality rates. In this review, we highlight the role of night shifts in disturbing circadian rhythm and how this action leads to carcinogenesis in the GI tract.
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Affiliation(s)
- Lin Guo
- Medical Simulated Center, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
| | - Xiaojun Li
- School of Nursing, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
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Hoe ZQ, Joseph R, Dick N, Thio CSH, Wallen M, Chua LD, Miller C, Lee J, Chan RJ, Han CY. Nutrition and Exercise Knowledge, Attitude, and Practice: A Scoping Review of Assessment Questionnaires in Cancer Survivorship. Nutrients 2025; 17:1412. [PMID: 40362721 PMCID: PMC12073881 DOI: 10.3390/nu17091412] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2025] [Revised: 04/16/2025] [Accepted: 04/22/2025] [Indexed: 05/15/2025] Open
Abstract
Cancer survivors are encouraged to maintain a healthy diet and engage in regular exercise to improve overall physical and psychosocial health, and to reduce the likelihood of cancer recurrence and related mortality. Consequently, nutrition and exercise (the structured component of physical activity) knowledge, attitude, and practice (NE-KAP) are frequently evaluated in research studies involving cancer survivors and are associated with various health outcomes. The aims of this scoping review were to (1) systematically map the types of NE-KAP assessment questionnaires used in cancer survivorship research (i.e., trend or use over the past five years), (2) provide a directory of questionnaires, and (3) identify the most frequently reported health outcomes that have been associated with them. A systematic search was conducted across four databases-Medline, Emcare, CINAHL, and Scopus-from 1 January 2019 to 9 May 2024, for studies addressing one or more aspects of NE-KAP (e.g., food frequency questionnaire for nutrition practice, attitude towards exercise scale for exercise attitude). Eligible studies were extracted, assessed, and reviewed by two independent authors, and data were summarized descriptively. Of the initial 5452 records screened, 1122 articles were screened for full text, and 852 were deemed eligible, with 262 studies included. There was an overall increasing trend in NE-KAP research in cancer survivorship research from 2019 to 2023. Of the 200 unique questionnaires aligning with at least one NE-KAP domain, 45 were untitled and created/adapted specifically for their respective studies, with limited information about their psychometric properties. Out of the 262 included studies, the most utilized questionnaires were those measuring nutrition or physical activity practices, such as study-specific food frequency questionnaires (n = 26, 10%) and the Godin-Shephard Leisure-Time Physical Activity questionnaire (n = 52, 20%). Out of studies that had reported health outcomes (nutrition, n = 23; exercise, n = 40), health-related quality of life was most commonly associated with nutrition (n = 12, 53%) and exercise (n = 9, 23%), and from cross-sectional studies (nutrition, n = 13; exercise, n = 23). An emphasis was placed on assessing nutrition and exercise practices, with limited attention towards the knowledge and attitude domains. Psychometric evaluation of questionnaires was also lacking.
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Affiliation(s)
- Zhi Qi Hoe
- Department of Dietetics, National University Hospital, National University Health System, Singapore 119074, Singapore;
| | - Ria Joseph
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
| | - Narayanee Dick
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
| | - Christina Syu Hong Thio
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
| | - Matthew Wallen
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
| | - Ling Di Chua
- Department of Nutrition and Dietetics, Tan Tock Seng Hospital, National Healthcare Group, Singapore 308433, Singapore;
| | - Claire Miller
- Healthy Lifestyles Australia, Lowood, QLD 4311, Australia;
| | - Jane Lee
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
| | - Raymond Javan Chan
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
| | - Chad Yixian Han
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia; (R.J.); (N.D.). (M.W.); (J.L.); (R.J.C.)
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Souni F, Mansouri F, Jafari F, Sharifi R, PourvatanDoust S, Shateri Z, Nouri M, Rashidkhani B. The association between plant-based diet indices and the risk of breast cancer: a case-control study. JOURNAL OF HEALTH, POPULATION, AND NUTRITION 2025; 44:127. [PMID: 40253371 PMCID: PMC12008985 DOI: 10.1186/s41043-025-00879-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/18/2024] [Accepted: 04/11/2025] [Indexed: 04/21/2025]
Abstract
BACKGROUND Previous studies examining the relationship between plant-based diets and breast cancer (BrC) have provided conflicting evidence. To address these inconsistencies, we aimed to evaluate the association between the plant-based diet index (PDI), healthful PDI (hPDI), and unhealthy PDI (uPDI) with the odds of BrC in Iranian women. METHODS The current case-control research was performed on 133 Iranian women with BrC and 265 controls. The study subjects were selected from hospitals in Tehran. PDI, hPDI, and uPDI were categorized into eighteen food groups based on nutrient composition similarity. The relationship between PDIs and BrC was assessed using logistic regression. RESULTS After adjusting for confounding factors, the chance of developing BrC was lower in the highest tertile of hPDI compared to the lowest tertile (odds ratio (OR) = 0.495; 95% confidence interval (CI): 0.274-0.891; P = 0.019). In addition, postmenopausal women in the second and last tertiles of hPDI had lower odds of BrC than those in the first tertile (T) (T2: OR = 0.342; 95% CI: 0.141-0.828; P = 0.017- T3: OR = 0.262; 95% CI: 0.107-0.639; P = 0.003) in the adjusted model. Furthermore, in premenopausal women in the highest tertile of uPDI, the odds of BrC were increased compared to the lowest tertile (OR = 2.546; 95% CI: 1.051-6.167; P = 0.038) in the adjusted model. CONCLUSIONS Adherence to a healthy plant-based dietary pattern, including vegetables, fruits, whole grains, nuts, and legumes, seems to be beneficial for BrC prevention, particularly in postmenopausal women. Future prospective cohort studies that consider menopausal status and the type of BrC are needed to support these findings.
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Affiliation(s)
- Fateme Souni
- Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Fatemeh Mansouri
- Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Fatemeh Jafari
- Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
| | - Reza Sharifi
- Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
| | - Sepideh PourvatanDoust
- Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
| | - Zainab Shateri
- Department of Nutrition and Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
| | - Mehran Nouri
- Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical sciences, Babol, Iran.
| | - Bahram Rashidkhani
- Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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QUAN JINGDAN, WAN ZIXIN, WU WEI, CAO XINYUAN, QIU JIAYUAN, LIU XIAOYE, ZHANG ZHIWEI. Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer. Oncol Res 2025; 33:1069-1089. [PMID: 40296904 PMCID: PMC12034007 DOI: 10.32604/or.2025.063005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/01/2025] [Accepted: 03/17/2025] [Indexed: 04/30/2025] Open
Abstract
One of the most prevalent malignant tumors worldwide, stomach cancer still has a high incidence and fatality rate in China, and the number of young people developing early-onset gastric cancer is steadily increasing. The 5-year survival rate of stomach cancer is typically 30%-35%, the prognosis is bad, the patients' quality of life is low, and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery, chemotherapy, and other medicines. We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate, extend patient survival, and improve patient quality of life. The initial diagnosis of gastric cancer primarily depends on gastroscopy and biopsy, and invasive procedures cause significant discomfort to patients. Similar to this, treating advanced and metastatic stomach cancer is a pressing issue that requires attention. More and more immune checkpoint molecules have been discovered, and corresponding inhibitors are gradually being applied to clinical diagnosis and treatment. Recently, some non-coding RNAs have begun to be used as new targets for the treatment of gastric cancer. Some non-coding RNAs are highly present in the serum or urine of gastric cancer patients and can be used as diagnostic markers or prognostic indicators. Many clinical trials targeting non-coding RNAs have also shown good therapeutic effects. In general, targeting non-coding RNAs has shown good therapeutic effects. The biomarkers for gastric cancer detection and treatment are reviewed in this article, focusing on the new non-coding RNAs used in diagnosis, prognosis, and treatment. Patients with stomach cancer should have access to more precise and efficient diagnosis and treatment choices as a result of ongoing technological advancements and thorough research.
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Affiliation(s)
- JINGDAN QUAN
- Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, 421001, China
| | - ZIXIN WAN
- Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, 421001, China
| | - WEI WU
- Hengyang Medical College, University of South China, Hengyang, 421001, China
| | - XINYUAN CAO
- Hengyang Medical College, University of South China, Hengyang, 421001, China
| | - JIAYUAN QIU
- Hengyang Medical College, University of South China, Hengyang, 421001, China
| | - XIAOYE LIU
- Hengyang Medical College, University of South China, Hengyang, 421001, China
| | - ZHIWEI ZHANG
- Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, 421001, China
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Xin B, Zhao Q, Chen D, Ma D, Su H, Jiang W. Development and validation of an information-motivation-behavioral skills questionnaire for colorectal cancer prevention in a high-risk population. BMC Psychol 2025; 13:375. [PMID: 40221770 PMCID: PMC11994010 DOI: 10.1186/s40359-025-02700-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2024] [Accepted: 04/04/2025] [Indexed: 04/14/2025] Open
Abstract
BACKGROUND Colorectal cancer (CRC) is one of the most prevalent cancers, and the risk of CRC is substantially greater in a high-risk population than in the general population. However, no existing assessment instruments have been specifically designed to evaluate CRC prevention behaviors in a high-risk population. The aim of this study was to develop and psychometrically validate an information-motivation-behavioral skills (IMB) questionnaire tailored for the population at high risk for CRC (IMB-CRC) to assess the factors influencing prevention behaviors. METHODS This cross-sectional study was conducted in northeastern China. The initial questionnaire items were derived from a comprehensive literature review, semistructured interviews analyzed via content analysis, and expert focus group discussions. Content validity was assessed through expert consultation using the Delphi method, and face validity was evaluated in the high-risk population for CRC. Explanatory factor analysis (EFA) was performed on Sample 1 (N = 287) to identify underlying factors, and confirmatory factor analysis (CFA) was performed on Sample 2 (N = 224) to validate the model. Internal consistency and test-retest reliability were also examined to ensure the stability and consistency of the questionnaire. RESULTS The final IMB-CRC comprises 21 items distributed across four dimensions: prevention information (7 items), objective skills (5 items), self-efficacy (5 items), and motivation (4 items), collectively accounting for 61.99% of the variance. CFA indicated that the proposed model fit the data well (χ2/df = 1.779, RMSEA = 0.059, AGFI = 0.852, GFI = 0.883, CFI = 0.950, IFI = 0.951, TLI = 0.943, and NFI = 0.894). The item content validity index (I-CVI) for individual items ranged from 0.905 to 1, and the scale content validity index (S-CVI) was 0.952, suggesting good content validity. The IMB-CRC demonstrated high reliability, with a Cronbach's alpha of 0.937, McDonald's omega of 0.939, and test-retest reliability of 0.919. Significant positive correlations were observed between the IMB-CRC and each of its four dimensions, indicating that higher IMB-CRC scores were associated with greater engagement in cancer prevention behaviors among the high-risk population. CONCLUSION The IMB-CRC exhibited appropriate validity and reliability, indicating that this questionnaire is a robust tool for assessing behavioral components essential for CRC prevention in the high-risk population. Health care professionals and policymakers can use the IMB-CRC to develop targeted CRC risk communication and behavioral education strategies, thereby improving the preventive abilities of a high-risk population.
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Affiliation(s)
- Bo Xin
- Health Science Center, Xi'an Jiaotong University, Yanta West Road 76#, Xi'an, 710061, China
| | - Qiuli Zhao
- The Second Affiliated Hospital of Harbin Medical University, Harbin, China
| | - Dong Chen
- Department of Nursing, Heilongjiang Nursing College, Harbin, China
| | - Dexin Ma
- Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
| | - Han Su
- The Second Affiliated Hospital of Harbin Medical University, Harbin, China
| | - Wenhui Jiang
- Health Science Center, Xi'an Jiaotong University, Yanta West Road 76#, Xi'an, 710061, China.
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Abebe Z, Wassie MM, Reynolds AC, Melaku YA. Burden and Trends of Diet-Related Colorectal Cancer in OECD Countries: Systematic Analysis Based on Global Burden of Disease Study 1990-2021 with Projections to 2050. Nutrients 2025; 17:1320. [PMID: 40284185 PMCID: PMC12029645 DOI: 10.3390/nu17081320] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/20/2025] [Revised: 04/07/2025] [Accepted: 04/08/2025] [Indexed: 04/29/2025] Open
Abstract
Background: An unhealthy diet is a major risk factor for colorectal cancer (CRC). This study assessed the diet-related CRC burden from 1990 to 2021 in Organisation for Economic Co-operation and Development (OECD) nations and estimated the burden until 2050. Methods: Data for OECD countries on diet-related CRC disability-adjusted life years (DALYs) and deaths were obtained from the Global Burden of Disease 2021 study. The estimated annual percent change (EAPC) was calculated to analyse the CRC burden attributable to dietary factors. A generalised additive model with a negative binomial distribution was used to predict the future burden of CRC attributable to dietary factors from 2021 to 2050. Results: In 2021, the age-standardised percentages of diet-related CRC DALYs and deaths were 39.1% (95% uncertainty interval (UI): 9.3, 61.3) and 39.0% (95% UI: 9.7, 60.9), respectively, in the OECD countries. Between 1990 and 2021, the age-standardised DALYs decreased from 185 to 129 per 100,000, and deaths decreased from 8 to 6 per 100,000 population for OECD countries. Similarly, the EAPC in the rates showed a downward trend (EAPCdeaths = -1.26 and EAPCDALYs = -1.20). The estimated diet-related CRC DALYs and deaths are projected to increase to 4.1 million DALYs and 0.2 million deaths by 2050. There is a downward trend in CRC deaths (EAPC = 1.33 for both sexes) and in DALYs (-0.90 for males and -1.0 for females) from 1990 to 2050. Conclusions: The diet-related CRC burden remains significant. Implementing nutrition intervention programmes is necessary to promote access to affordable and nutritious foods and raise awareness about the importance of a healthy diet in reducing CRC risk.
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Affiliation(s)
- Zegeye Abebe
- Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia; (M.M.W.); (A.C.R.); (Y.A.M.)
- Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar P.O. Box 196, Ethiopia
| | - Molla Mesele Wassie
- Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia; (M.M.W.); (A.C.R.); (Y.A.M.)
| | - Amy C. Reynolds
- Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia; (M.M.W.); (A.C.R.); (Y.A.M.)
| | - Yohannes Adama Melaku
- Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia; (M.M.W.); (A.C.R.); (Y.A.M.)
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Sharma R, Kumar S, Komal K, Ghosh R, Thakur S, Pal RR, Kumar M. Comprehensive insights into pancreatic cancer treatment approaches and cutting-edge nanocarrier solutions: from pathology to nanomedicine. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY 2025:10.1007/s00210-025-04094-y. [PMID: 40202672 DOI: 10.1007/s00210-025-04094-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/07/2025] [Accepted: 03/21/2025] [Indexed: 04/10/2025]
Abstract
Pancreatic cancer is one of the most lethal malignancies worldwide. It is characterized by poor prognosis, high mortality, and recurrence rates. Various modifiable and non-modifiable risk factors are associated with pancreatic cancer incidence. Available treatments for pancreatic cancer include surgery, chemotherapy, radiotherapy, photodynamic therapy, supportive care, targeted therapy, and immunotherapy. However, the survival rates for PC are very low. Regrettably, despite efforts to enhance prognosis, the survival rate of pancreatic cancer remains relatively low. Therefore, it is essential to investigate new approaches to improve pancreatic cancer treatment. By synthesizing current knowledge and identifying existing gaps, this article provides a comprehensive overview of risk factors, pathology, conventional treatments, targeted therapies, and recent advancements in nanocarriers for its treatment, along with various clinical trials and patents that justify the safety and efficacy of innovative carriers for drug delivery systems. Ultimately, this review underscores the potential of these innovative formulations to improve outcomes and contribute significantly to the advancement of Pancreatic Cancer treatment. Together, these insights highlight nano-formulations as a promising frontier for effectively treating Pancreatic Cancer.
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Affiliation(s)
- Rohit Sharma
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India
| | - Sourabh Kumar
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India
| | - Kumari Komal
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India
| | - Rashmi Ghosh
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India
| | - Shubham Thakur
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India
| | - Ravi Raj Pal
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India
| | - Manish Kumar
- Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga, 142001, Punjab, India.
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Li M, Meng L, Gu H, Tian Y, Qu B, Ao Y, Chen X, Song Y, Cui W. B vitamins and colorectal cancer: exploring research hotspots and frontiers from a bibliometric and visual analysis (1994-2024). Carcinogenesis 2025; 46:bgaf021. [PMID: 40243145 DOI: 10.1093/carcin/bgaf021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2025] [Revised: 03/24/2025] [Accepted: 04/10/2025] [Indexed: 04/18/2025] Open
Abstract
Most studies suggest that B vitamins can reduce the risk of colorectal cancer (CRC), and research in this field has been growing. Focusing on 2617 articles in the field, this study used CiteSpace and VOSviewer software to evaluate the contributions of various countries/regions, institutions, authors, and journals. The United States and Harvard University were identified as the most productive nation and institution, respectively, with Edward L. Giovannucci (Harvard) being the top contributor. Cancer Epidemiology Biomarkers & Prevention was recognized as the leading journal. Through the analysis of keywords and citations, we found that the potential of B vitamins (B1, B2, B6, B9, and B12) in the prevention and treatment of CRC and their mechanisms including regulation of gene expression, anti-inflammatory and antioxidant, and modulation of gut microenvironment are hot topics of research in this field. Burst detection analysis further revealed that the application of nanoparticle-based targeted drug delivery systems (such as folate-conjugated nanocarriers) in the treatment of CRC represents both a current hotspot and a future trend. This study offers a comprehensive overview of the field, highlights research hotspots and trends, and offers valuable information for researchers to further grasp the research direction.
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Affiliation(s)
- Meichen Li
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
| | - Lingshi Meng
- Department of Cardiology, Jilin Province People's Hospital, Changchun, China
| | - Hong Gu
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
| | - Yuan Tian
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
| | - Boyang Qu
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
| | - Yanrong Ao
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
| | - Xingyang Chen
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
| | - Yuan Song
- Department of Gastroenterology, Jilin Province People's Hospital, Changchun, China
| | - Weiwei Cui
- Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China
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de Melo LRS, Dos Santos Pereira J, Melo MS, Andrade LA, Bezerra-Santos M, Lima CA, Dos Santos AD. Spatial and temporal dynamic of colorectal cancer mortality in Brazil: A nationwide population-based study of four decades (1980-2021). Cancer Epidemiol 2025; 95:102766. [PMID: 39923291 DOI: 10.1016/j.canep.2025.102766] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2024] [Revised: 01/19/2025] [Accepted: 02/04/2025] [Indexed: 02/11/2025]
Abstract
BACKGROUND Regardless of being preventable through screening strategies and prompt diagnosis, deaths from colorectal cancer (CRC) still represent a serious public health concern in Brazil, with more than 20 thousand deaths annually. Herein, we aimed to assess the temporal trends and spatiotemporal patterns of CRC mortality in all Brazilian states. METHODS An ecological study using temporal and spatial analysis techniques on deaths due to CRC as the underlying cause in Brazil from 1980 to 2021 was conducted. Death certificate and population data were provided by the Department of Informatics of the Unified Health System (DATASUS) and by the Brazilian Institute of Geography and Statistics (IBGE), respectively. RESULTS A total of 395,782 deaths from CRC were recorded in this period and most of them were in female (205,479; 51.92 %), ≥ 65 years old (233,059; 58.89 %), diagnosed with malignant neoplasm of the colon (212,277; 53.63 %), with 1-7 years of education (157.564; 39.81 %), married (192.276; 48.58 %), hospital as place of death (331.393; 83.73 %) and white (212.666; 65.07 %). Moreover, there was an increasing temporal trend in the Northeast region (APC: 2.6; p < 0.05), men (APC: 1.5; p < 0.05) and 45-64 years old (APC: 1.2; p < 0.05). Also, the spatial analysis showed positive spatial autocorrelation in all periods, with the South and Southeast regions presenting the highest concentration of high-risk clusters CRC deaths. Nevertheless, high-risk clusters were also observed in capitals and municipalities in metropolitan regions in the Northeast region. CONCLUSIONS In general, a temporal and spatial expansion of CRC mortality has been observed in Brazil over the last few decades.
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Affiliation(s)
- Luís Ricardo Santos de Melo
- Nursing Graduate Program, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Center for Research in Public Health, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
| | - Júlio Dos Santos Pereira
- Center for Research in Public Health, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Department of Pharmacy, Federal University of Sergipe, Lagarto, Sergipe, Brazil
| | - Matheus Santos Melo
- Center for Research in Public Health, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Department of Health and Environmental Surveillance, Ministry of Health, Distrito Federal, Brasília, Brazil
| | - Lucas Almeida Andrade
- Center for Research in Public Health, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Health Sciences Graduate Program, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil
| | - Márcio Bezerra-Santos
- Center for Research in Public Health, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Health Sciences Graduate Program, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Health Sciences Graduate Program, Federal University of Alagoas, Maceió, Alagoas, Brazil; Medical and Nursing Science Complex Federal University of Alagoas, Maceió, Alagoas, Brazil
| | - Carlos Anselmo Lima
- University Hospital, Federal University of Sergipe, Aracaju, Sergipe, Brazil; Aracaju Cancer Registry, Aracaju, Sergipe, Brazil
| | - Allan Dantas Dos Santos
- Nursing Graduate Program, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Center for Research in Public Health, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil; Department of Nursing, Federal University of Sergipe, Lagarto, Sergipe, Brazil
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Cole AP, Qian Z, Gupta N, Leapman M, Zurl H, Trinh QD, Sherman JD, Loeb S, Iyer HS. Urology on a changing planet: links between climate change and urological disease. Nat Rev Urol 2025; 22:208-222. [PMID: 39875561 DOI: 10.1038/s41585-024-00979-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/27/2024] [Indexed: 01/30/2025]
Abstract
Urological diseases and their varied forms of management warrant special attention in the setting of climate change. Regarding urological cancers, climate change will probably increase the incidence and severity of cancer diagnoses through exposures to certain environmental risk factors, while simultaneously disrupting cancer care delivery and downstream outcomes. Regarding benign urological diseases, a burgeoning body of work exists on climate-related heat waves, dehydration, urolithiasis, renal injury and infectious and vector-borne diseases. Adding to the potential effect on disease pathogenesis, many patients with urological diseases undergo high-tech, resource-intensive interventions, such as robotic surgery, and entail intensive longitudinal assessments over many years. These features incur a considerable carbon footprint, generate substantial waste, and can introduce vulnerabilities to climate-related weather events. Links exist between planetary health (the health of humans and the natural systems that support our health), climate change and urological disease and urological care providers face many challenges in the era of anthropogenic climate change. The next steps and priorities for research, management, and health care delivery include identification and prioritization of health care delivery strategies to minimize waste and carbon emissions, while supporting climate resilience. Examples include supporting telemedicine, limiting low-value care, and building resilience to minimize impacts of climate-related disasters to prepare for the challenges ahead.
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Affiliation(s)
- Alexander P Cole
- Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
- Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
| | - Zhiyu Qian
- Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
| | - Natasha Gupta
- Department of Urology, New York University Langone Health, New York, NY, USA
- Department of Population Health, New York University Langone Health, New York, NY, USA
- Department of Surgery/Urology, Manhattan Veterans Affairs, New York, NY, USA
| | - Michael Leapman
- Department of Urology, Yale School of Medicine, New Haven, CT, USA
| | - Hanna Zurl
- Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Department of Urology, Medical University of Graz, Graz, Austria
| | - Quoc-Dien Trinh
- Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
- Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
| | - Jodi D Sherman
- Department of Anaesthesiology, Yale School of Medicine; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA
| | - Stacy Loeb
- Department of Urology, New York University Langone Health, New York, NY, USA
- Department of Population Health, New York University Langone Health, New York, NY, USA
- Department of Surgery/Urology, Manhattan Veterans Affairs, New York, NY, USA
| | - Hari S Iyer
- Section of Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute, New Brunswick, NJ, USA
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Sharma R, Ghosh R, Kumar S, Komal K, Kumar M. Decoding pancreatic cancer: key risk factors across genetics and lifestyle. Expert Rev Mol Diagn 2025; 25:95-99. [PMID: 39918844 DOI: 10.1080/14737159.2025.2464563] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/21/2024] [Accepted: 02/05/2025] [Indexed: 02/09/2025]
Affiliation(s)
- Rohit Sharma
- Department of Pharmaceutics, ISF College Pharmacy, Moga, India
| | - Rashmi Ghosh
- Department of Pharmaceutics, ISF College Pharmacy, Moga, India
| | - Sourabh Kumar
- Department of Pharmaceutics, ISF College Pharmacy, Moga, India
| | - Kumari Komal
- Department of Pharmaceutics, ISF College Pharmacy, Moga, India
| | - Manish Kumar
- Department of Pharmaceutics, ISF College Pharmacy, Moga, India
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Anastasiou IA, Kounatidis D, Vallianou NG, Skourtis A, Dimitriou K, Tzivaki I, Tsioulos G, Rigatou A, Karampela I, Dalamaga M. Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer. Curr Oncol Rep 2025; 27:390-414. [PMID: 40014232 PMCID: PMC11976848 DOI: 10.1007/s11912-025-01654-6] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 02/11/2025] [Indexed: 02/28/2025]
Abstract
PURPOSEOF REVIEW Ultra-processed foods (UPFs) are becoming more and more important in daily diets around the world; in some cases, they can account for as much as 60% of daily energy intake. Epidemiological evidence suggests that this shift toward high levels of food processing may be partially responsible for the global obesity epidemic and the rise in the prevalence of chronic diseases. RECENT FINDINGS Few prospective studies have examined the relationship between UPF consumption and cancer outcomes. According to currently available information, UPFs may increase the risk of cancer due to their obesogenic properties and exposure to substances that can cause cancer, such as certain food additives and pollution from product processing. The complex relationship between obesity and cancer involves factors such as immune dysregulation, altered adipokine and sex hormone levels, abnormal fatty acid metabolism, extracellular matrix remodeling, and chronic inflammation. Addressing cancer risk associated with UPF consumption could involve a multifaceted approach, including consumer behavior modification programs and robust public health regulations aimed at enhancing food environments. Improved knowledge of the potential dual negative impacts of UPFs on the environment and cancer risk is one of the priority areas we identify for future research and policy implications. Various approaches could be used to prevent cancers associated with UPF consumption, such as consumer behavior change programs and stricter public health regulations needed to improve the food environment. This review examines for the first time the potential role of UPFs in cancer risk associated with obesity, exploring underlying biological mechanisms and identifying key areas for future research and policy action, including the dual environmental and health impact of UPFs.
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Affiliation(s)
- Ioanna A Anastasiou
- Diabetes CenterDepartment of Propaedeutic Internal MedicineMedical School, Laiko General Hospital, National and Kapodistrian University of Athens, FirstAthens, Greece
- Department of Pharmacology, National and Kapodistrian University of Athens, 11527, Athens, Greece
| | - Dimitris Kounatidis
- Diabetes CenterDepartment of Propaedeutic Internal MedicineMedical School, Laiko General Hospital, National and Kapodistrian University of Athens, FirstAthens, Greece
| | - Natalia G Vallianou
- First Department of Internal Medicine, Sismanogleio General Hospital, 15126, Athens, Greece
| | - Alexandros Skourtis
- Department of Internal Medicine, Evangelismos General Hospital, 10676, Athens, Greece
| | - Krystalia Dimitriou
- Second Department of Internal Medicine, Medical School, National &, Hippokratio General Hospital, Kapodistrian University of Athens, 11527, Athens, Greece
| | - Ilektra Tzivaki
- First Department of Internal Medicine, Sismanogleio General Hospital, 15126, Athens, Greece
| | - Georgios Tsioulos
- Fourth Department of Internal Medicine, Medical School, Attikon General University Hospital, National and Kapodistrian University of Athens, 12462, Athens, Greece
| | - Anastasia Rigatou
- First Department of Internal Medicine, Sismanogleio General Hospital, 15126, Athens, Greece
| | - Irene Karampela
- Second Department of Critical Care, Medical School, Attikon General University Hospital, National and Kapodistrian University of Athens, Athens, Greece
| | - Maria Dalamaga
- Department of Biological Chemistry, National and Kapodistrian University of Athens, 11527, Athens, Greece.
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Mahjourian M, Anjom-Shoae J, Mohammadi MA, Feinle-Bisset C, Sadeghi O. Associations of dietary fat types (MUFA, PUFA, SFA) and sources (animal, plant) with colorectal cancer risk: A comprehensive systematic review and dose-response meta-analysis of prospective cohort studies. Cancer Epidemiol 2025; 95:102768. [PMID: 39951860 DOI: 10.1016/j.canep.2025.102768] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/08/2024] [Revised: 01/25/2025] [Accepted: 02/05/2025] [Indexed: 02/17/2025]
Abstract
BACKGROUND AND OBJECTIVES While dietary fat intake has long been implicated as a risk factor for colorectal cancer, evidence from prospective cohort studies remains inconsistent. Moreover, previous meta-analyses examining the link between dietary fat intake and risk of colorectal cancer have not explored the dose-response relationships. Therefore, the current systematic review and meta-analysis was conducted to assess the dose-response associations of intakes of specific types (MUFA, PUFA and SFA) and sources (animal, plant) of dietary fat with the risk of colorectal, colon or rectal cancer. METHODS A comprehensive literature search of relevant online databases was performed to detect eligible studies until May 2023, identifying 21 prospective cohort studies with a total sample size of 2311,737 participants. The follow-up periods ranged from 7 to 19.4 years, during which 21,125 cases of colorectal, colon or rectal cancer were recorded. RESULTS Comparing extreme intake levels of total fat revealed the summary relative risk (RR) of 1.05 (95 % CI: 0.96-1.15) for colorectal cancer, 0.99 (95 % CI: 0.87-1.11) for colon cancer, and 1.09 (0.95 % CI: 0.93-1.13) for rectal cancer, indicating no significant association. Neither animal nor plant fat intake was associated with the risk of cancers. While no significant findings were also observed for MUFA or PUFA, the highest versus lowest comparison showed that a high intake of SFA was associated with a reduced risk of both colorectal 0.91 (95 % CI: 0.85-0.99) and colon cancer 0.86 (95 % CI: 0.75-0.98). However, in the non-linear dose-response analysis, the inverse association was seen within a certain range (<40 g/day). CONCLUSIONS These findings suggest that dietary SFA intake, less than 40 g/day, may have a protective effect against colorectal cancer. Further studies are needed to confirm our findings.
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Affiliation(s)
| | - Javad Anjom-Shoae
- Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia
| | | | - Christine Feinle-Bisset
- Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia
| | - Omid Sadeghi
- Nutrition and Food Security Research Centre and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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Yun A, Choi Y, Jung H, Kim B. Awareness and Practice of Global Cancer Prevention Dietary Guidelines among Koreans. J Cancer Prev 2025; 30:32-40. [PMID: 40201025 PMCID: PMC11973460 DOI: 10.15430/jcp.24.036] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2024] [Revised: 02/28/2025] [Accepted: 03/09/2025] [Indexed: 04/10/2025] Open
Abstract
Due to rapid westernization, Korean dietary habits have emerged as significant risk factors for chronic disease and cancer. Despite this transition, Korea's cancer prevention guidelines have remained consistent since their establishment about 18 years ago. This study aimed to investigate the degree of awareness and practice to global dietary guidelines among Korean adults and identify demographic and lifestyle factors associated with low practice. A cross-sectional survey conducted in 2023 included 4,000 adults and assessed their awareness and practice of four global recommendations: "Eat a diet rich in whole grains," "Limit consumption of processed meat," "Limit consumption of sugar-sweetened beverages," and "Limit consumption of fast and other processed foods." While more than half of the participants recognized the guidelines' importance for cancer prevention, implementation rates remained below 40%. Furthermore, over 80% of the respondents expressed a compelling requirement for updated and tailored dietary guidelines. Younger individuals, those who were physically inactive, individuals who had not received prior nutrition education, and participants with obesity were more likely to exhibit low practice, particularly to guidelines limiting processed foods and sugary beverages intake. These findings highlight the need to revise Korea's cancer prevention recommendations by incorporating global dietary practices and addressing the westernized eating patterns prevalent within the population. Efforts should focus on promoting these updated guidelines through targeted education and public health interventions that improve practice, especially in high-risk groups, and effectively mitigate the burden of diet-related cancers in Korea.
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Affiliation(s)
- Ahyoung Yun
- Division of Cancer Prevention, National Cancer Control Institute, Goyang, Korea
| | - Yoonjoo Choi
- Division of Cancer Prevention, National Cancer Control Institute, Goyang, Korea
| | - Hyein Jung
- Division of Cancer Prevention, National Cancer Control Institute, Goyang, Korea
| | - Byungmi Kim
- Division of Cancer Prevention, National Cancer Control Institute, Goyang, Korea
- Department of Public Health and AI, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea
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Lin F, Hu W, Yang C, Cheng B, Chen H, Li J, Zhu H, Zhang H, Yuan X, Ren X, Hong X, Tang X. Associations of combined lifestyle and metabolic risks with cancer incidence in the UK biobank study. BMC Cancer 2025; 25:547. [PMID: 40140964 PMCID: PMC11948676 DOI: 10.1186/s12885-025-13955-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2024] [Accepted: 03/17/2025] [Indexed: 03/28/2025] Open
Abstract
BACKGROUND Although metabolic syndrome (MetS) is associated with an increased risk of various cancers, the combined impact of MetS and healthy lifestyle factors (HLF) on cancer risk is unclear. This study aimed to investigate the independent and combined effects of MetS and HLF on the risk of 16 site-specific cancers in a large community-based cohort. METHODS A total of 289,557 participants in the UK Biobank were analyzed. MetS was defined using a combination of metabolic factors, while HLF scores were evaluated based on lifestyle behaviors, such as smoking, alcohol consumption, physical activity, and diet. Cox proportional hazard models were used to investigate the relationship between MetS or HLF and cancer risk, adjusting for age, sex, ethnicity, education level, family history of cancer, and the Townsend Deprivation Index (TDI). RESULTS During a median follow-up of 11.69 years, 11,190 individuals developed cancer. MetS was associated with an increased risk of 9 cancers in men and 7 cancers in women. Compared with participants with unfavorable lifestyles, regardless of metabolic status, HLF was significantly associated with decreased risk of overall cancer (without MetS: HR: 0.812; 95% CI: 0.745-0.886 for intermediate lifestyle and HR: 0.757; 95% CI: 0.669-0.855 for favorable lifestyle; with MetS: HR: 0.702; 95% CI: 0.572-0.862 for favorable lifestyle) and oesophagus, stomach, liver, lung, bronchus, trachea cancers in men and of lung, bronchus, trachea cancers in women. Our analysis demonstrated that the protective association between HLF and reduced cancer risk was confined to subgroups without MetS. Specifically, this association was observed for cancers of the lip, oral cavity, pharynx, colon, rectum, pancreas, kidney, bladder, and lymphoid leukemia in men, and for overall cancer in women(HR: 0.917; 95% CI: 0.862-0.975 for intermediate lifestyle and HR: 0.875; 95% CI: 0.817-0.938 for favorable lifestyle). CONCLUSION MetS elevates risks for multiple cancers, while adopting a healthy lifestyle reduces risks of oesophagus, stomach, and lung, bronchus, trachea cancers in men and lung, bronchus, trachea cancer in women, regardless of metabolic status. However, MetS counteracts lifestyle-mediated protection against specific cancers-including lip, oral cavity, pharynx, colon, rectum, pancreas, kidney, and bladder cancers in men, as well as pancreas and breast cancers in women. These findings underscore the necessity to develop metabolic status-stratified management strategies and implement proactive prevention of MetS.
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Affiliation(s)
- Feng Lin
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Wen Hu
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Chenfenglin Yang
- Department of Hepatobiliary Surgery, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Binglin Cheng
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Hongfan Chen
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Jiaxin Li
- Department of Obstetrics & Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
| | - Hanrui Zhu
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Haixiang Zhang
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Xiang Yuan
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
| | - Xianyue Ren
- Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China
| | - Xiaohong Hong
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China.
| | - Xinran Tang
- Department of Radiation Oncology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China.
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Nishida A, Andoh A. The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis. Cells 2025; 14:488. [PMID: 40214442 PMCID: PMC11987742 DOI: 10.3390/cells14070488] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2025] [Revised: 03/14/2025] [Accepted: 03/20/2025] [Indexed: 04/14/2025] Open
Abstract
Inflammation is an essential component of the immune response that protects the host against pathogens and facilitates tissue repair. Chronic inflammation is a critical factor in cancer development and progression. It affects every stage of tumor development, from initiation and promotion to invasion and metastasis. Tumors often create an inflammatory microenvironment that induces angiogenesis, immune suppression, and malignant growth. Immune cells within the tumor microenvironment interact actively with cancer cells, which drives progression through complex molecular mechanisms. Chronic inflammation is triggered by factors such as infections, obesity, and environmental toxins and is strongly linked to increased cancer risk. However, acute inflammatory responses can sometimes boost antitumor immunity; thus, inflammation presents both challenges and opportunities for therapeutic intervention. This review examines how inflammation contributes to tumor biology, emphasizing its dual role as a critical factor in tumorigenesis and as a potential therapeutic target.
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Affiliation(s)
- Atsushi Nishida
- Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Shiga, Japan;
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Sousa-Martins N, Azevedo L, Lopes LV, Barbieri-Figueiredo MDC. A phenomenological study of the cultural lived experiences among Angolan women with breast cancer. Eur J Oncol Nurs 2025; 76:102885. [PMID: 40174505 DOI: 10.1016/j.ejon.2025.102885] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2024] [Revised: 02/11/2025] [Accepted: 03/23/2025] [Indexed: 04/04/2025]
Abstract
PURPOSE This study aims to explore and describe the lived experiences of Angolan women with breast cancer, considering the socio-cultural context and health care challenges they face. METHOD Eighteen semi-structured interviews were conducted among Angolan women with breast cancer. Purposeful sampling was utilised to select participants with diverse age groups and ethnic backgrounds. We performed a qualitative study using Giorgi's descriptive phenomenological approach. RESULTS The present study found cultural views of breast cancer, family support, and religious-spiritual coping to be essential themes. The results offer significant insights into the cultural framework of health in Angolan society, encompassing the information, perceptions, and cognitions employed to describe, comprehend, and elucidate illness, as well as the pursuit of therapy that seldom aligns biological criteria. CONCLUSIONS The present study has implications for nursing, as it recognises that individuals have unique behaviours and thoughts related to their current understanding of the illness, their personal experience with the illness, and their specific beliefs about health and healing. The findings of this study provide essential insights into how Angolan women's cultural beliefs and practices shape their experiences with breast cancer, offering nurses a foundation to develop culturally competent care approaches.
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Affiliation(s)
- Naira Sousa-Martins
- Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal
| | - Luís Azevedo
- Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal; Centre for Health Technology and Services Research & Health Research Network Associate Laboratory (CINTESIS@RISE), University of Porto, Rua Dr. Plácido da Costa, 4200-450, Porto, Portugal
| | | | - Maria do Céu Barbieri-Figueiredo
- Centre for Health Technology and Services Research & Health Research Network Associate Laboratory (CINTESIS@RISE), University of Porto, Rua Dr. Plácido da Costa, 4200-450, Porto, Portugal; University of Huelva, Campus de El Carmen, 21071, Huelva, Spain; School of Medicine and Biomedical Sciences, ICBAS, R. Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portugal.
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Ryding HG, Rigby RR, Johnston EA, Kruger R, Mitchell LJ. Dietitians' practices and perspectives of the delivery of nutritional care to cancer survivors in the primary care setting. Support Care Cancer 2025; 33:290. [PMID: 40095197 PMCID: PMC11913905 DOI: 10.1007/s00520-025-09330-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/22/2024] [Accepted: 03/03/2025] [Indexed: 03/19/2025]
Abstract
PURPOSE The number of people living longer after a cancer diagnosis is increasing. Guidelines for cancer survivorship recommend a healthy diet and maintaining a healthy weight post-treatment. While cancer survivors often express the need for professional support for nutrition management, few report seeing a dietitian. This study aimed to explore primary care dietitians' experiences, practices, and perspectives in providing nutritional care to cancer survivors in Australia. METHODS This qualitative study used in-depth, semi-structured interviews with primary care dietitians working in private practice and community care. Interviews were recorded and transcribed. A qualitative descriptive methodological approach integrated with a working analytical framework was utilized for coding and data analysis. RESULTS Twenty-four dietitians working in primary care participated. Four themes and 13 sub-themes were identified: (1) diversity in dietetic practice and cancer-related care interactions; (2) accessing referral pathways and funding sources in a complex healthcare system; (3) the application of nutrition education, and upskilling in cancer care; (4) client barriers and dietitians' challenges and factors influencing confidence in cancer care. CONCLUSION Dietitians in this study highlighted the need for clear referral pathways to primary care particularly as a continuation of cancer-related care following the acute setting. There is a need for tailored support for dietitians supporting people diagnosed with cancer in the primary care setting, including opportunities to upskill in cancer care.
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Affiliation(s)
- Henriette G Ryding
- School of Health Sciences and Social Work, Griffith University, Gold Coast, QLD, Australia
| | - Roshan R Rigby
- School of Health Sciences and Social Work, Griffith University, Gold Coast, QLD, Australia
- Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia
| | - Elizabeth A Johnston
- Viertel Cancer Research Centre, Cancer Council Queensland, Fortitude Valley, QLD, Australia
- School of Exercise and Nutrition Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Population Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
| | - Rozanne Kruger
- School of Health Sciences and Social Work, Griffith University, Gold Coast, QLD, Australia
- School of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand
| | - Lana J Mitchell
- School of Health Sciences and Social Work, Griffith University, Gold Coast, QLD, Australia.
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Zhang YX, Wan H, Shan GY, Cheng JY, Liu YY, Shi WN, Li HJ. Pharmacological role of Herba Patriniae and Coix seed in colorectal cancer. World J Gastrointest Oncol 2025; 17:99673. [PMID: 40092956 PMCID: PMC11866235 DOI: 10.4251/wjgo.v17.i3.99673] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/27/2024] [Revised: 10/31/2024] [Accepted: 12/25/2024] [Indexed: 02/14/2025] Open
Abstract
Colorectal cancer (CRC) is the most prevalent cancer globally, and its traditional treatment modalities commonly encompass radiation therapy, chemotherapy, surgery and the administration of cytotoxic drugs. Currently, novel chemotherapy drugs that combine traditional Chinese medicine (TCM) with herbal extracts exhibit superior comprehensive benefits. Herein, we delved into an article authored by Wang et al, focusing specifically on the pharmacological effects of "Herba Patriniae and Coix seed (HC)" and their targeted mechanisms in combating CRC. From the perspective of TCM philosophy, damp-heat stagnation and toxicity are the cardinal pathogenic factors underlying CRC. HC, renowned for their abilities to antipyretic and enhance diuresis, have demonstrated promising efficacy in preliminary studies for the treatment of CRC. These findings offer potential insights in favor of fostering anti-cancer medications.
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Affiliation(s)
- Yu-Xin Zhang
- Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
| | - Hui Wan
- Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
| | - Guan-Yue Shan
- Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
| | - Jun-Ya Cheng
- Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130061, Jilin Province, China
| | - Yi-Ying Liu
- Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
| | - Wen-Na Shi
- Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
| | - Hai-Jun Li
- Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
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Brenes-Castillo F, Goodman W, Lally P, Fisher A, Beeken RJ. Perceived changes in health behaviours and body weight in response to a cancer diagnosis among individuals living with and beyond breast, prostate, and colorectal cancer in the UK: a cross-sectional study. Support Care Cancer 2025; 33:247. [PMID: 40038108 PMCID: PMC11880087 DOI: 10.1007/s00520-025-09305-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2024] [Accepted: 02/24/2025] [Indexed: 03/06/2025]
Abstract
PURPOSE This study explored perceived changes in health behaviours and body weight following a cancer diagnosis and investigated related sociodemographic and clinical characteristics. METHODS Individuals living with and beyond breast, prostate, or colorectal cancer (N = 5835) completed the 'Health and Lifestyle After Cancer Survey' which explored their perceptions of health behaviour change following a cancer diagnosis. Multinomial logistic regressions were conducted with perceived changes as dependent variables, and sociodemographic and clinical characteristics as independent variables. RESULTS Approximately half of the participants did not perceive changes in their physical activity, alcohol intake and body weight, and most did not perceive dietary changes. Less than a third of individuals perceived positive health behaviour changes (11.7% increased physical activity, 24.3% healthier diet, and 31.3% decreased alcohol intake), 35.9% perceived decreases in physical activity, and 27.0% perceived increases in body weight, whereas 19.2% perceived decreases in body weight. Individuals with no education, who were unmarried, and with anxiety/depression and pain/discomfort, were more likely to perceive changes in physical activity, body weight, and diet, but in different directions. Participants of younger age were more likely to perceive increases in their physical activity, a healthier diet, and increases in body weight. CONCLUSION Following a diagnosis of cancer, a large proportion of individuals perceived that their health behaviours were unchanged. However, some groups of individuals were more likely to perceive positive changes, whereas others were more likely to perceive negative changes, with differences also observed according to the type of health behaviour. IMPLICATIONS FOR CANCER SURVIVORS Participants with no education, who were unmarried, with anxiety/depression and pain/discomfort, may be more at risk of experiencing negative health behaviour changes post-diagnosis. Clinicians should consider targeting health behaviour support to prevent worse outcomes in the long term.
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Affiliation(s)
- Francisco Brenes-Castillo
- Research Department of Behavioural Science and Health, University College London, Gower Street, London, WC1E 6BT, UK
- Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AB, UK
| | - William Goodman
- Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK
| | - Phillippa Lally
- School of Psychology, University of Surrey, Guildford, Surrey, GU2 7XH, UK
| | - Abi Fisher
- Research Department of Behavioural Science and Health, University College London, Gower Street, London, WC1E 6BT, UK
| | - Rebecca J Beeken
- Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
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Luo MZ, Shu L, Ye XS. Association between priori and posteriori dietary patterns and gastric cancer risk: an updated systematic review and meta-analysis of observational studies. Eur J Cancer Prev 2025; 34:157-172. [PMID: 38884362 PMCID: PMC11781554 DOI: 10.1097/cej.0000000000000900] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/19/2024] [Accepted: 05/13/2024] [Indexed: 06/18/2024]
Abstract
An increasing number of epidemiological studies have explored the relationship between the risk of gastric cancer and specific dietary patterns, but the findings remain inconclusive. We, therefore, performed this comprehensive systematic review and meta-analysis to analyze the available evidence regarding the associations between a priori and a posteriori dietary patterns and the risk of gastric cancer. A systematic search of six electronic databases, including PubMed , Web of Science , EBSCO , Scopus , China National Knowledge Infrastructure ( CNKI ), and Wanfang Data , was carried out to retrieve the relevant articles published up to March 2024. Thirty-six studies (10 cohort and 26 case-control studies) with a total of 2 181 762 participants were included in the final analyses. Combining 15 effect sizes extracted from 12 articles, we observed a reduced risk of gastric cancer in the highest versus the lowest categories of the Mediterranean diet [relative risk (RR), 0.72; 95% confidence interval (CI), 0.61-0.85; P < 0.001]. Combining 11 effect sizes from 10 articles (involving 694 240 participants), we found that the highest Dietary Inflammatory Index scores were significantly associated with an increased risk of gastric cancer (RR, 1.32; 95% CI, 1.11-1.57; P < 0.001). A reduced risk of gastric cancer was shown for the highest compared with the lowest categories of healthy dietary pattern (RR, 0.78; 95% CI, 0.67-0.91; P = 0.002). Conversely, the highest adherence to the Western dietary pattern was associated with an increased risk of gastric cancer (RR, 1.33; 95% CI, 1.19-1.49; P < 0.001). Our study demonstrated that the Mediterranean diet and a healthy dietary pattern were associated with a decreased risk of gastric cancer. Conversely, the Dietary Inflammatory Index and Western dietary pattern were associated with an increased risk of gastric cancer.
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Affiliation(s)
| | - Long Shu
- Nutrition, Zhejiang Hospital, Hangzhou, China
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Shan Y, Bertrand KA, Petrick JL, Sheehy S, Palmer JR. Planetary Health Diet Index in relation to mortality in a prospective cohort study of United States Black females. Am J Clin Nutr 2025; 121:589-596. [PMID: 39863116 PMCID: PMC11923421 DOI: 10.1016/j.ajcnut.2025.01.023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/14/2024] [Revised: 12/24/2024] [Accepted: 01/21/2025] [Indexed: 01/27/2025] Open
Abstract
BACKGROUND To improve both human health and the health of our planet, the EAT-Lancet Commission proposed the planetary health diet (PHD). OBJECTIVES We aimed to evaluate associations of PHD with all-cause, cardiovascular disease (CVD), and cancer-specific mortality among United States Black females. METHODS The Black Women's Health Study is a prospective study of self-identified United States Black females. In 2001, 33,824 participants free of cancer and CVD completed a validated food frequency questionnaire. PHD Index (PHDI) was calculated based on reported consumption of 15 food groups, such as whole grains, nonstarchy vegetables, legumes, soy foods, added fat and trans fat, and red/processed meats. Deaths were identified through linkage to the National Death Index. Cox proportional hazards regression, stratified by age and adjusted for smoking status, body mass index, and other CVD risk factors, was used to calculate hazard ratios (HRs) for quintiles of PHDI in relation to all-cause, CVD-, and cancer-specific mortality. RESULTS During 18 years of follow-up, we identified 3537 deaths, including 779 from CVD and 1625 from cancer. Females in the quintile representing the highest adherence to PHD were estimated to have an 18% reduction in risk of all-cause mortality [HR = 0.82, 95% confidence interval (CI): 0.71, 0.94] and 26% reduction in CVD-specific mortality (HR = 0.74, 95% CI: 0.55, 0.98), compared with those in the lowest quintile, with similar reductions observed for quintiles 2, 3, and 4. Among individuals under age 55, there was a significant trend of lower CVD mortality risk with a higher level of adherence to PHD (Ptrend = 0.004), and the HR for the highest compared with the lowest quintile was 0.43 (95% CI: 0.21, 0.87). PHDI was not associated with cancer-specific mortality. CONCLUSIONS Adherence to a diet that has been shown to benefit the planet was associated with a lower risk of mortality among Black females, primarily driven by a reduction in CVD-specific mortality risk.
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Affiliation(s)
- Yifei Shan
- Slone Epidemiology Center at Boston University, Boston, MA, United States; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States
| | - Kimberly A Bertrand
- Slone Epidemiology Center at Boston University, Boston, MA, United States; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States
| | - Jessica L Petrick
- Slone Epidemiology Center at Boston University, Boston, MA, United States; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States
| | - Shanshan Sheehy
- Slone Epidemiology Center at Boston University, Boston, MA, United States; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States
| | - Julie R Palmer
- Slone Epidemiology Center at Boston University, Boston, MA, United States; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
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Lu X, Lin W, Zheng J, Huang W, Yu S, Chen H, Wang H, Zhang Y. Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis. Br J Cancer 2025; 132:340-353. [PMID: 39799274 PMCID: PMC11833070 DOI: 10.1038/s41416-024-02923-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Revised: 11/21/2024] [Accepted: 11/28/2024] [Indexed: 01/15/2025] Open
Abstract
BACKGROUND Tongue squamous cell carcinoma (TSCC) is a malignant oral cancer with unclear pathogenesis that shows a tendency for early-stage lymphatic metastasis. This results in a poor prognosis, with a low 5-year survival rate. Dietary sodium nitrite (NaNO2) has proposed associations with disease, including cancer. However, a direct relationship between NaNO2 and TSCC has not been established. METHODS In vitro and in vivo assays were used to investigate the role of NaNO2 in TSCC. Protein expression in TSCC specimens was detected by immunohistochemistry and immunofluorescence. The molecular mechanism was determined using RT-qPCR, western blot, RNA-seq, luciferase reporter assays, migration assays, and FACS analysis. More detail of methods can be found in the Materials and methods section. RESULTS The data in this study showed that NaNO2 did not initiate carcinogenesis in the tongue but improved the lymphatic metastatic potential of TSCC cells in the specified experimental period. During metastasis to lymph nodes, monocyte-macrophage markers were upregulated in TSCC cells, whereas keratin markers were downregulated. Specifically, expression of the CD68 gene was high in TSCC cells following NaNO2-induced TSCC phenotypic switching. These phenotypic changes were associated with activation of transcription factor cyclic-AMP response binding protein (CREB1), which directly targets CD68 transcription. Furthermore, blocking CREB1 activity either through gene knockout or specific inhibitor treatment decreased the migration ability of TSCC cells and suppressed CD68 expression. CONCLUSIONS Our findings highlight the role of NaNO2 in enabling macrophage mimicry in TSCC cells through the CREB1-CD68 signaling pathway, which promotes lymphatic metastasis. Shedding light on drivers of lymphatic metastasis in TSCC and providing a new perspective on dietary strategies to improve outcomes of patients with TSCC.
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Affiliation(s)
- Xiangwan Lu
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China
| | - Weifan Lin
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China
| | - Junheng Zheng
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China
| | - Wuheng Huang
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China
| | - Shuyi Yu
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China
| | - Haoxiang Chen
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China
| | - Hua Wang
- Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
| | - Yan Zhang
- MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
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Filis P, Markozannes G, Chan DS, Mauri D, Foukakis T, Matikas A, Droufakou S, Pentheroudakis G, Tsilidis K. Grading the evidence for physical activity and any outcome in cancer survivors: An Umbrella review of 740 meta-analytic associations. Crit Rev Oncol Hematol 2025; 207:104602. [PMID: 39730034 DOI: 10.1016/j.critrevonc.2024.104602] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2024] [Revised: 12/17/2024] [Accepted: 12/18/2024] [Indexed: 12/29/2024] Open
Abstract
BACKGROUND To contribute to the refinement of future physical activity (PA) guidelines, which have remained mostly generic until now, we performed an umbrella review of meta-analyses for PA in cancer survivors. METHODS Medline and Scopus databases were searched in January 2024 for systematic reviews and meta-analyses on the association/effect of any type of PA in every cancer type and for any studied outcome. Statistically significant meta-analyses were categorized into four evidence groups (strong, highly suggestive, suggestive, weak) using pre-established grading criteria. RESULTS A total of 102 publications reporting 740 meta-analytic associations were identified, including breast (n = 427), prostate (n = 104), hematological (n = 58), colorectal (n = 79) and lung (n = 54) cancer survivors. Overall, 401 (54 %) associations were nominally statistically significant, of which 16 were categorised as strong, 10 as highly suggestive, and 93 as suggestive evidence. In breast cancer, there was strong or highly suggestive evidence that post-diagnosis PA is associated with lower all-cause mortality, recurrence, cancer-related fatigue, depression, and higher mental health, body strength, aerobic capacity, and weight loss. In prostate cancer, strong evidence was identified for the positive association of PA with cardiovascular fitness, quality of life and fatigue amelioration. In colorectal cancer, strong and highly suggestive evidence supported the association of PA with lower all-cause mortality. In lung cancer, strong evidence supported the association of preoperative combination of breathing exercise and PA with reduced length of hospital stay. CONCLUSION This grading of the entirety of the available evidence can facilitate robust introduction of targeted exercise prescription in oncology care as standard practice.
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Affiliation(s)
- Panagiotis Filis
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece; Department of Medical Oncology, University of Ioannina, Ioannina 45110, Greece.
| | - Georgios Markozannes
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W12 0BZ, UK.
| | - Doris Sm Chan
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W12 0BZ, UK.
| | - Davide Mauri
- Department of Medical Oncology, University of Ioannina, Ioannina 45110, Greece.
| | - Theodoros Foukakis
- Department of Oncology/Pathology, Karolinska Institutet, Stockholm 17164, Sweden; Breast Center, Karolinska Comprehensive Cancer Center and Karolinska University Hospital, Stockholm 17164, Sweden.
| | - Alexios Matikas
- Department of Oncology/Pathology, Karolinska Institutet, Stockholm 17164, Sweden; Breast Center, Karolinska Comprehensive Cancer Center and Karolinska University Hospital, Stockholm 17164, Sweden.
| | - Stavroula Droufakou
- 5th Department of Medical Oncology, Iaso General Clinic, Athens 15123, Greece.
| | | | - Konstantinos Tsilidis
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W12 0BZ, UK.
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Papadopoulou A, Litkowski EM, Graff M, Wang Z, Smit RAJ, Chittoor G, Dinsmore I, Josyula NS, Lin M, Shortt J, Zhu W, Vedantam SL, Yengo L, Wood AR, Berndt SI, Holm IA, Mentch FD, Hakonarson H, Kiryluk K, Weng C, Jarvik GP, Crosslin D, Carrell D, Kullo IJ, Dikilitas O, Hayes MG, Wei WQ, Edwards DRV, Assimes TL, Hirschhorn JN, Below JE, Gignoux CR, Justice AE, Loos RJF, Sun YV, Raghavan S, Deloukas P, North KE, Marouli E. Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height. NPJ Genom Med 2025; 10:14. [PMID: 40016231 PMCID: PMC11868580 DOI: 10.1038/s41525-025-00464-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/14/2023] [Accepted: 01/20/2025] [Indexed: 03/01/2025] Open
Abstract
We performed ancestry and sex specific Phenome Wide Association Studies (PheWAS) to explore disease related outcomes associated with genetically predicted height. This is the largest PheWAS on genetically predicted height involving up to 840,000 individuals of diverse ancestry. We explored European, African, East Asian ancestries and Hispanic population groups. Increased genetically predicted height is associated with hyperpotassemia and autism in the male cross-ancestry analysis. We report male-only European ancestry associations with anxiety disorders, post-traumatic stress and substance addiction and disorders. We identify a signal with benign neoplasm of other parts of digestive system in females. We report associations with a series of disorders, several with no prior evidence of association with height, involving mental disorders and the endocrine system. Our study suggests that increased genetically predicted height is associated with higher prevalence of many clinically relevant traits which has important implications for epidemiological and clinical disease surveillance and risk stratification.
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Affiliation(s)
- A Papadopoulou
- William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK
| | - E M Litkowski
- VA Eastern Colorado Health Care System, Aurora, CO, USA
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
| | - M Graff
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
| | - Z Wang
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
| | - R A J Smit
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Department of Clinical Epidemiology, Leiden University Medical Center Leiden, Leiden, NL, The Netherlands
- The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA
| | - G Chittoor
- Department of Population Health Sciences, Geisinger, Danville, PA, USA
| | - I Dinsmore
- Department of Genomic Health, Geisinger, Danville, PA, USA
| | - N S Josyula
- Department of Population Health Sciences, Geisinger, Danville, PA, USA
| | - M Lin
- Colorado Center for Personalized Medicine, Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, USA
| | - J Shortt
- Colorado Center for Personalized Medicine, Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, USA
| | - W Zhu
- Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
| | - S L Vedantam
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
- Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA
| | - L Yengo
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
| | - A R Wood
- Department of Biomedical Science, Centre of Membrane Interactions and Dynamics, University of Sheffield, Western Bank, Sheffield, UK
| | - S I Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
| | - I A Holm
- Division of Genetics and Genomics and Manton Center for Orphan Diseases Research, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA
| | - F D Mentch
- The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA
| | - H Hakonarson
- The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA
| | - K Kiryluk
- Department of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
| | - C Weng
- Department of Biomedical Informatics, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA
| | - G P Jarvik
- Department of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA, USA
| | - D Crosslin
- Division of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, Tulane University, School of Medicine, New Orleans, LA, USA
| | - D Carrell
- Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
| | - I J Kullo
- Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA
| | - O Dikilitas
- Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA
| | - M G Hayes
- Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
| | - W -Q Wei
- Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
| | - D R V Edwards
- Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA
| | - T L Assimes
- VA Palo Alto Health Care System, Palo Alto, CA, USA
| | - J N Hirschhorn
- Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA
- Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA
- Departments of Genetics and Pediatrics Harvard Medical School, Boston, MA, USA
| | - J E Below
- Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
| | - C R Gignoux
- Colorado Center for Personalized Medicine, Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, USA
| | - A E Justice
- Department of Population Health Sciences, Geisinger, Danville, PA, USA
| | - R J F Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
| | - Y V Sun
- Atlanta VA Health Care System, Decatur, GA, USA
- Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA
| | - S Raghavan
- VA Eastern Colorado Health Care System, Aurora, CO, USA
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
| | - P Deloukas
- William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK
| | - K E North
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
| | - E Marouli
- William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
- Digital Environment Research Institute, Queen Mary University of London, London, UK.
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Gonçalves E, Fontes F, Rodrigues JR, Antunes L, Bento MJ, Lunet N, Morais S. Temporal trends in the incidence of second primary cancers in Northern Portugal: a population-based study. Eur J Cancer Prev 2025:00008469-990000000-00212. [PMID: 40019750 DOI: 10.1097/cej.0000000000000962] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/01/2025]
Abstract
The growing number of cancer survivors has led to an increase in the frequency of multiple primary cancers. This study aimed to describe the temporal trends in the incidence rates and standardized incidence ratios (SIRs) of second primary cancers (SPCs) among patients diagnosed with a first primary cancer (FPC) in 2000-03, 2004-07 and 2008-11 in Northern Portugal. Population-based samples of patients diagnosed with an FPC (excluding skin non-melanoma) in 3 periods of 4 years, between 1 January 2000 and 31 December 2011, and registered in the Portuguese North Region Cancer Registry were followed for the diagnosis of an SPC or death until 31 December 2013. Incidence rates and SIRs were estimated for each period by sex, and considering the time between FPC and SPC diagnosis (synchronous and metachronous). During follow-up, 10 119 (7.4%) SPCs were identified among patients diagnosed with an FPC in 2000-11 (n = 136 382). The incidence rate of SPCs was over 10-fold higher in the first few months, remaining stable over the follow-up. Higher rates were observed in 2004-07 and 2008-11. Overall, a greater proportion of SPCs was diagnosed among males than females. The proportion of SPCs diagnosed increased with age. Increases in SIRs of SPCs were observed from 2000-03 to 2008-11, ranging from 1.16 to 1.77 and from 1.54 to 2.33, among males and females, respectively. This was particularly evident for FPCs and SPCs of the lip, oral cavity, pharynx, oesophagus and larynx among males, and colon and rectum, lung, ovary and cervix among females. Survivors of cancer in Northern Portugal had higher incidence rates of cancer than the general population, which have increased over time. Our findings highlight the need for enhanced surveillance and tailored strategies for survivors of cancer, emphasizing the challenges of their heightened cancer risk, patient expectations, and associated economic burden.
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Affiliation(s)
- Elisabete Gonçalves
- EPIUnit - Instituto de Saúde Pública, Universidade do Porto
- Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR)
| | - Filipa Fontes
- Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto
- Grupo de Abordagem de Lesões Pré-Cancerosas e Cancro Precoce
| | - Jéssica Rocha Rodrigues
- Grupo de Investigação em Epidemiologia, Resultados, Economia e Gestão em Oncologia - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde)
- Serviço de Epidemiologia, Instituto Português de Oncologia do Porto FG, EPE (IPO-Porto)
| | - Luis Antunes
- Grupo de Investigação em Epidemiologia, Resultados, Economia e Gestão em Oncologia - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde)
| | - Maria José Bento
- Grupo de Investigação em Epidemiologia, Resultados, Economia e Gestão em Oncologia - Centro de Investigação (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investigação em Saúde)
- Serviço de Epidemiologia, Instituto Português de Oncologia do Porto FG, EPE (IPO-Porto)
- Departamento de Estudos de Populações, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
| | - Nuno Lunet
- EPIUnit - Instituto de Saúde Pública, Universidade do Porto
- Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR)
- Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto
| | - Samantha Morais
- EPIUnit - Instituto de Saúde Pública, Universidade do Porto
- Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR)
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