The aim was to assess the diagnostic accuracy of four different nutrition screening and evaluation instruments in nasopharyngeal carcinoma patients, benchmarked against Global Leadership Initiative on Malnutrition (GLIM) criteria.

An observational, single-institution study was conducted between June 2022 and May 2023. Nutrition status was assessed using Nutritional Risk Screening 2002 (NRS-2002), Malnutrition Universal Screening Tool (MUST), Malnutrition Screening Tool (MST), Patient-Generated Subjective Global Assessment (PG-SGA), and GLIM criteria at two time points: postadmission and predischarge. Metrics such as sensitivity, specificity, concordance, and Kappa coefficient were computed.

For the trial, 140 participants were enrolled. Based on GLIM criteria, the rate of undernutrition was 22.9% before radiation and 73.6% after it ended. NRS-2002 (k = 0.721) demonstrated substantial concordance with GLIM criteria at admission, followed by MUST (k = 0.604) and MST (k = 0.378). Kappa coefficients were reduced at discharge (NRS-2002: k = 0.696; MUST: k = 0.690; MST: k = 0.496). GLIM criteria were moderately consistent with PG-SGA at admission (k = 0.453) and slightly consistent at discharge (k = 0.136).

NRS-2002 demonstrated greater concordance with GLIM criteria than MUST and MST. Therefore, NRS-2002 could be a more appropriate choice for initial nutrition screening in the diagnostic framework of GLIM for individuals afflicted with nasopharyngeal cancer, both before and after radiotherapy. The alignment of GLIM criteria with PG-SGA in identifying undernourished patients varied from slight to moderate.

The prevalence of undernutrition in hospitalized patients and its impact on their length of stay (LOS) varies considerably depending on the population studied, the diagnosis criteria or the screening tools used. Previous reports using controlled data have been done on small populations while large cohorts have been studied on unverified declarative data. This study aims at determining the prevalence of undernutrition in a large population using verified anthropometric data and assessing its impact on the LOS.

- For 10 years (2007-2017), a specialized nutritional assessment unit screened inpatients in a tertiary hospital for undernutrition, with the exception of those in emergency and intensive care, orthopedics, pediatrics and maternity wards. Within each unit, screening was carried out every two to three weeks. The diagnosis of undernutrition in adult inpatients was made using body mass index (BMI) (<18.5 kg/m2 for age <70 or < 21 kg/m2 for age ≥70) or weight loss (weight loss >5 % over a month or >10 % over 6 months). We retrospectively analyzed this database, looking at all adults (>18 years) hospitalized for at least one day. The analysis of the prevalence of undernutrition and its consequence on the LOS was performed on the entire population as well as by sex, age groups and diagnosis-related groups (DRGs). Statistics were performed using the chi-square test, T-test, ANOVA and mixed linear analysis. Age and gender were added as potential confounders, while DRG was included as a random effect.

The analysis included data from 65,226 stays. Mean age 65 years (min 18, max 113), 58.2 % male patients. The overall prevalence of undernutrition was 29.77 %, lower in the 40 to 70-year-old group than in the younger and older population. Undernutrition was present in all of the 53 surveyed DRGs, with a prevalence ranging from 12 % to 57.89 %. In the overall population, undernourished patients had a longer LOS than well-nourished patients, with a median increase of 5 days. In 42 of the 53 DRGs, representing 97.57 % of the total population, undernutrition significantly increased the LOS.

This large study of the prevalence of undernutrition diagnosed from verified anthropometric data in hospitalized adults does not confirm recent findings obtained from unverified data in hospital databases.

Many survivors of critical illness experience long-term functional, cognitive, and psychological impairments known as post-intensive care syndrome (PICS). Yet, the nutritional recovery experiences of intensive care unit (ICU) survivors after hospital discharge remain underrecognized and poorly understood. The objective of this review was to characterize nutritional indices and nutrition-related outcomes in survivors of critical illness, and to understand the nutritional recovery experience after hospital discharge.

Searches were conducted for eligible quantitative and qualitative studies between June and August 2024 using PubMed, CINAHL Complete, and Scopus electronic databases. Abstracts and full texts were screened against predetermined inclusion and exclusion criteria. Primary research analyzing anthropometric, nutritional, and/or experiential data of adult survivors of critical illness after hospital discharge were included in this review.

21 quantitative (n = 3054) and 7 qualitative (n = 162) studies were included. After hospital discharge, ICU survivors seldom returned to their baseline weight with many having small to modest weight gains in the first months of recovery. Average calorie (18-33.5 calories/kilogram/day) and protein (0.96-1.6 g/kg/day) intakes largely did not meet requirements needed to facilitate recovery, resulting in high rates of malnutrition, ranging from 16.8 to 63 % 3 months after discharge. A multitude of barriers to nutritional recovery were faced in the post-discharge period resulting from persistent physical and functional limitations due to critical illness. Ongoing individualized nutrition monitoring and follow-up from dietetic professionals knowledgeable in post-ICU care has the potential to improve nutrition-related outcomes for survivors yet remains underutilized. Improving the availability and affordability of such services is a key facilitator to improve the nutritional recovery experience for ICU survivors.

After hospital discharge, many survivors of critical illness face numerous barriers to nutritional recovery resulting in long-term nutritional complications. Future research efforts should target nutritional characterization, associations between nutritional variables and PICS, and the identification and development of effective nutrition interventions to improve long-term outcomes for survivors of critical illness after hospital discharge.

Malnutrition remains a major problem in the world's hospitals, and although nutrition screening (such as by Nutrition Risk Screening NRS-2002) improves detection and management, it has proved difficult to ensure that this is routinely performed. There is a case for automated approaches that are independent of staff time. As common laboratory tests such as serum albumin are not considered markers of malnutrition, they are not included in screening tools, but it is possible that combinations of tests would predict malnutrition, and probable that high risk patients would be identified.

We studied 300 unselected consenting internal medicine patients recently admitted to a university hospital. We determined NRS-2002, Malnutrition Universal Screening Tool (MUST) and Subjective Global Assessment (SGA). No additional interventions were performed. The laboratory database was searched for investigations already performed. The dataset was split randomly into 200 for training and 100 for validation. The primary endpoint was an algorithm to predict SGA (Towards Interdisciplinary Automated MAlnutrition screening Tool - TIAMAT). Blood results for which there were data from at least 60 % of patients were selected; dimensionality was checked with factor analysis, and a multivariate logistic model using stepwise regression was formed. The predictions of SGA from NRS-2002 and MUST were compared with those from the newly created score.

Simple haematological and biochemical tests had been performed in all patients. To predict SGA (none vs moderately/severely malnourished) the training set yielded a score with an optimal sensitivity of 71 % (95 % CI 58-81 %), specificity 81 % (70-89), positive predictive value (PPV) 79 % (66-88) negative predictive value (NPV) 73 % (62-83) and AUC 0.81 (0.74-0.88). In the validation cohort - in which missing data were imputed with the relevant median - TIAMAT had sensitivity of 60 % (44-75) specificity of 75 % (62-86), PPV 65 % (48-79), NPV 72 % (59-83) and AUC 0.77 (0.69-0.82) compared with MUST ≥2 for which sensitivity was 63 % (47-77), specificity 91 % (81-97), PPV 84 % (67-95), NPV 76 % (65-86) and AUC 0.80 (0.72-0.89), and NRS-2002 for which sensitivity was 93 % (81-99), specificity 91 % (81-97), PPV 89 % (76-96), NPV 95 % (85-99) and AUC 0.92 (0.86-0.97).

Composites of standard laboratory data form a potential alternative to current screening methods, the results of which could be displayed to all data viewers without any human intervention. This could facilitate and thus improve the efficacy of screening by extending it to the entire hospital population.

Malnutrition is related to increased mortality and poor outcome. Therefore, early diagnosis and intervention of malnutrition are recommended. However, the optimal nutrition screening tool for diagnosing malnutrition remains undetermined. This study aimed to verify the discrimination and difficulty of nutrition screening items through item response theory (IRT) analysis and develop a simpler malnutrition screening tool.

This study enrolled 10,375 patients aged ≥18 years who were admitted at Tokushima University Hospital. Patients who were pregnant had short-term hospitalization (≤3 days), were hospitalized only in the weekend, could not hear clearly, and were hospitalized merely for examination were excluded. A skilled dietitian performed the Subjective Global Assessment, rating a good nutritional status as A, moderate malnutrition as B, and severe malnutrition as C.

According to Subjective Global Assessment, we classified 7119 patients as A, 2892 as B, and 364 as C. Between these classes, the total number of application items was significantly lower in class A but significantly higher in class C. In the discrimination of each item calculated by IRT analysis, the highest discrimination item was "Has your food intake been less than usual?", followed by "Have you had anorexia?", "Have you had vomiting?", "Have you had nausea?", "Have you had dehydration?", and "Have you lost weight?".

Human Key Tool of Nutrition, which is based on the IRT analysis results, is a new simple nutrition screening tool developed by us. Human Key Tool of Nutrition can contribute to the widespread use of nutrition screening.

Body mass index (BMI) is an inexpensive, easy-to-calculate, and noninvasive marker of malnutrition. Few studies have examined the longitudinal effects of BMI on the incidence of unfavorable physical health outcomes (UPHOs) among older adults receiving homecare nursing. Therefore, this prospective cohort study examined the longitudinal effects of low BMI on the occurrence of UPHOs at multiple time points (i.e., 1-, 3-, and 6-months) among older adults (≥ 75 years) receiving homecare nursing across Japan. Using an online questionnaire, homecare nurses reported clients' height and weight, as well as socio-demographic characteristics (e.g., age and gender) and health conditions (e.g., diagnosis and dependency level). The occurrence of seven UPHOs (urinary tract infection, respiratory infection, pressure ulcer or skin tear, dehydration, poor dyspnea control, poor pain control, and traumatic fall) was also reported. The longitudinal effects of low BMI on the total number of UPHOs at 1-, 3-, and 6-months follow-ups were examined using a Restricted Moment Model (RMM) with a log link function. Among 660 participants included in the analysis, 42.12% were males, 36.96% had dementia, and 44.09% had low BMI. Adjusting for client's characteristics and the number of UPHOs at the baseline, low BMI at the baseline could increase the incidence of UPHOs at 1-, 3- and 6-month follow-ups (incidence rate ratio [95% confidence interval]:1.59 [1.21, 2.07], 1.57 [1.18, 2.07], 1.35 [1.02, 1.79], respectively). Adequate management of low BMI among older adults receiving homecare nursing would have a favorable effect on reducing the occurrence of UPHOs, thereby reducing the deterioration of overall physical conditions.

Frailty, nutrition, and comorbid conditions are all challenges that contribute to significant morbidity in patients undergoing lower extremity arterial bypass (LEAB). Evidence supports that enhanced recovery pathways (ERP) can improve perioperative outcomes. However, few studies have demonstrated successful implementation of an ERP for LEAB. The goal of this study was to demonstrate successful implementation of an ERP in a complex patient population undergoing LEAB, including elective, urgent, or emergent procedures with the goal of reducing length of stay and morbidity for patients undergoing these procedures at our institution.

Multi-stakeholder meetings with representatives from all vascular surgery practice sites in the Northwestern Medicine system were conducted to review current evidence-based practices and finalize an ERP for patients undergoing LEAB. Pathway elements included standardized patient education, minimal perioperative fasting with preoperative carbohydrate loading, opioid-sparing analgesia, and early postoperative diet and mobilization. The ERP was initiated in February 2022 as a pilot at a single institution. At 20 months, patient data and process and outcome measures were abstracted from the medical record and validated by four independent reviewers for univariate analysis.

Over the 20-month study period, 112 patients underwent LEAB. Process measures were tracked to determine compliance with the ERP. Patients had to receive >70% of the pathway elements to be considered part of the ERP (n=60). If patients missed more than 30% of the elements, they were analyzed as traditional pathway (TP) (n=52). There were no significant differences in patient demographics, BMI, or hemoglobin A1c. ERP patients were more likely to be elective (76.7% vs. 48.1%, p=0.0004) and for CLTI (76.7% vs. 48.1%, p=0.001) and less likely to be urgent or emergent. No significant difference was observed in frequency of infrageniculate bypass target or operative duration. Compliance with 10 perioperative process measures ranged from 28-98% in the ERP group. Compliance was most successful with preoperative education (81.6%), chlorhexidine wash (80.0%), postoperative mobilization (90.0%), early solid diet (98.3%), and postoperative opioid sparing strategies (98.3%). Challenges included preoperative acetaminophen (28.3%), carbohydrate load (33.8%), and postoperative protein supplementation (28.3%). Notably, ERP patients demonstrated significantly reduced total length of stay (7.8 vs. 13.6 days, p=0.014), postoperative length of stay (6.0 vs. 11.0 days, p=0.0058), and unplanned reoperations (10.0% vs. 28.9%, p=0.015) when compared to TP patients. ERP patients trended towards fewer unplanned readmissions (13.3% vs. 26.9%, p=0.095).

Our findings suggest that an ERP for LEAB is feasible in both elective and non-elective settings although compliance with the ERP individual elements was more challenging for patients undergoing procedures for emergent or urgent indications. Patients undergoing ERP had improved compliance with process measures, reduced length of stay and unplanned reoperation. Our results highlight the benefits of ERP for LEAB and the complex vascular surgery population and some of the potential barriers worth considering in this patient population.

The relationship between subclinical carotid artery atherosclerosis and sarcopenia has not been clarified in many respects. In this study, the possible relationship between composite clinical sarcopenia indices and various levels of subclinical atherosclerosis parameters was revisited. The Ishii score (Ishii-max and Ishii-average) was used to determine sarcopenia in 257 prospectively recruited healthy controls and patients with neurological diseases (age: 65 ± 10 years, 50% female). Carotid artery distensibility indices (stress, strain, modulus, stiffness, and distensibility), intima-media thickness (IMT-max and IMT-mean), and 10 Kate plaque burden score were obtained for ultrasonographic subclinical atherosclerosis evaluation, together with detailed clinical and anthropometric, quality of life, and nutritional assessments. Sarcopenic subjects (n = 75) were older, slimmer, and at higher risk of malnutrition (Malnutrition Universal Screening Tool score > 0) than nonsarcopenic subjects (n = 182). IMT-mean and IMT-max were significantly higher in sarcopenic cases (mean difference: 45 microns and 60 microns, respectively, P < .05). Carotid plaque burden score was significantly higher in sarcopenic patients (average score: 2.2 vs 0.8 in sarcopenic and nonsarcopenic ones, P < .001). There was no difference in terms of carotid artery distensibility parameters. In various regression models, the Ishii score was always determined as an independent predictor of IMT-max and IMT-mean in the models (standardized beta, from 0.132-0.168; partial-r, from 0.156-0.201; p, from 0.019-0.001). Structural indices of subclinical atherosclerosis (carotid IMT and plaque burden), but not functional ones (carotid artery modulus and distensibility), are significantly abnormal in sarcopenic subjects. If future research validates these findings, employing ultrasonographic atherosclerosis indices as surrogate markers in sarcopenia treatments could address a crucial unmet need.

Objectives: Critically ill COVID-19 patients are at high risk of malnutrition; however, no study has directly compared the prognostic accuracy of different nutritional assessment tools. This study aimed to determine the optimal cutoff values for the Modified Nutrition Risk in the Critically Ill (mNUTRIC) score, Nutritional Risk Screening 2002 (NRS 2002), and Malnutrition Universal Screening Tool (MUST) and to evaluate their predictive value for ICU mortality. Method: A retrospective analysis was conducted on patients with laboratory-confirmed COVID-19 admitted to our ICU between 20 March 2020 and 15 June 2021. Clinical and laboratory data, as well as patient outcomes, were retrieved from electronic medical records and patient charts. The mNUTRIC, NRS 2002, and MUST scores were calculated at ICU admission. Results: The study included 397 patients, with 273 survivors and 124 non-survivors. The median age was 65 (55-76) years, and the median BMI was 26.1 (24.0-29.4). Non-survivors had significantly higher median scores in all three nutritional assessment tools compared to survivors (mNUTRIC: 5 vs. 3, NRS 2002: 4 vs. 3, MUST: 2 vs. 2; p < 0.01). At the optimal cutoff values, mNUTRIC ≥ 4 demonstrated the highest prognostic accuracy (sensitivity: 0.77, specificity: 0.74; AUC = 0.75, CI = 0.70-0.81), followed by NRS 2002 ≥ 4 (sensitivity: 0.63, specificity: 0.60; AUC = 0.62, CI = 0.56-0.67) and MUST ≥ 3 (sensitivity: 0.21, specificity: 0.91; AUC = 0.56, CI = 0.50-0.68). Higher scores were associated with increased disease severity, poorer patient performance, prolonged hospital stays, and elevated ICU, 28-day, and overall hospital mortality rates. Among the three assessment tools, only an mNUTRIC score of ≥ 4 was independently associated with ICU mortality (OR = 1.54, CI = 1.21-1.96, p < 0.01). Conclusions: At ICU admission, mNUTRIC ≥ 4, NRS 2002 ≥ 4, and MUST ≥ 3 were identified as the most accurate predictors of mortality in critically ill COVID-19 patients. However, only the mNUTRIC score was an independent predictor of ICU mortality.

Objectives: This study aimed to analyze the effect of a multimodal prehabilitation program for colorectal cancer patients in body composition, physical and cardiorespiratory fitness as well as its ability to reduce postoperative complications. Methods: A longitudinal observational study evaluated the efficacy of a prehabilitation intervention based on four components: (a) health education and self-care, (b) nutritional counseling, (c) psychological support, and (d) supervised physical exercise. Body composition was determined through bioelectrical impedance analysis; physical fitness variables such as strength was measured by a handgrip dynamometer for upper limbs, and a squat-jump test, countermovement jump test using a contact platform, and a chair-stand test for lower limbs. Flexibility was assessed with the sit-and-reach test. Cardiorespiratory fitness was assessed with the 6 min walking test (6MWT). Moreover, we measured lifestyles related to the amount of physical exercise by accelerometry. Results: The final cohort included 30 patients. Patients completed an average of 9.90 ± 5.26 exercise sessions. Statistically significant changes with varying effect sizes were observed in the following outcomes: SJ values in cm and W for both sexes (p = 0.021/d = 0.14 and p = 0.043/d = 0.10, respectively), SJ in W for women (p = 0.023/d = 0.21), all chair-stand test values (p = 0.021/d = 0.65 for men, p = 0.004/d = 2.08 for women, and p = 0.000/d = 0.84 for both sexes), and sit-and-reach for both sexes (p = 0.005/d = 0.12) and for men (p = 0.044/d = 0.08). All 6MWT values had statistically significant changes (p = 0.001/0.46). Women reduced the weekly minutes spent in sedentary behavior (p = 0.037/d = 0.65) and increased the minutes spent performing light physical activity (p = 0.037/d = 0.63). With regard to surgical outcomes, there was a tendency towards a decrease in postoperative complications and hospitalization days, as well as minutes in postoperative REA (p = 0.009/d = 0.69) in relation to the control group. Conclusions: Participation in a multimodal prehabilitation program improves several aspects of physical condition and lifestyles related to the amount of physical exercise and reduces both days of hospitalization and several complications post-surgery.

there is a need for a kidney-specific nutritional screening tool for patients with renal failure. It was planned to perform the validity and reliability of the Renal Inpatient Nutrition Screening Tool screening tool developed for renal patients in Turkey.

the validity and reliability of the Renal Inpatient Nutrition Screening Tool were investigated by comparing it with the Malnutrition Universal Screening Tool and the Subjective Global Assessment for assessing malnutrition in 153 adult patients newly admitted to the nephrology unit. Nutritional status was assessed using anthropometric measurements and nurse opinion was assessed using a questionnaire.

the Renal Inpatient Nutrition Screening Tool was found to be more sensitive than the Malnutrition Universal Screening Tool in identifying increased malnutrition risks and providing dietary guidance. Cramer V coefficient was 0.238 between the Malnutrition Universal Screening Tool and the Renal Inpatient Nutrition Screening Tool, and 0.137 between the Subjective Global Assessment and the Renal Inpatient Nutrition Screening Tool, indicating the compatibility of the Renal Inpatient Nutrition Screening Tool with the variables in the Malnutrition Universal Screening Tool screening tool. A significant positive moderate correlation was observed between the total number of red boxes in the Renal Inpatient Nutrition Screening Tool and the total score of Malnutrition Universal Screening Tool (p < 0.05; r = 0.404).

the Renal Inpatient Nutrition Screening Tool is a valid and reliable tool for assessing malnutrition risks in renal patients in Turkey, particularly when used by experienced specialist nurses in nephrology units.

Nutrition status evaluation is essential for patients undergoing cardiac surgery. The Nutrition Risk in the Critically Ill (NUTRIC) and modified NUTRIC (mNUTRIC) scores are nutrition risk assessment tools specifically for patients in the intensive care unit (ICU). The objective of this study was to validate and compare the accuracy of these two nutrition scores in predicting hospital mortality in patients undergoing cardiac surgery.

This retrospective study screened adult patients undergoing cardiopulmonary bypass cardiac surgery in the ICU from June 2020 to August 2022. Patients were grouped according to NUTRIC score and mNUTRIC score within 24 h of ICU admission. Logistic regression was used to analyze the risk factors affecting the prognosis of these patients. The area under the receiver operating characteristic curve (AUC-ROC) was used to compare the predictive performance of these two nutrition scores for hospital mortality.

Data from 252 eligible patients (55.6% of whom were male) were analyzed. It was found that Acute Physiological and Chronic Health Evaluation Ⅱ score, aortic surgery, serum albumin level, NUTRIC score, and mNUTRIC score were independent influencing factors of hospital mortality. The AUC-ROC of the NUTRIC score and the mNUTRIC score for predicting hospital mortality were 0.830 (95% confidence interval [CI]: 0.778-0.874) and 0.824 (95% CI: 0.771-0.869), respectively. There was no significant difference in ROC curves between the two scores (P = 0.492).

Both the NUTRIC and mNUTRIC scores showed good predictive performance for hospital mortality in patients undergoing cardiac surgery, and the mNUTRIC score might be a more convenient and cost-effective tool for nutrition risk assessment.

To translate, cross-culturally adapt, and validate the Malnutrition Awareness Scale (MAS) among Chinese community-dwelling older adults.

This study consists of two parts. First, we developed the Chinese version of the MAS (C-MAS) through direct translation, back translation, cross-cultural adaptation, and pilot testing. Then, we selected 380 community-dwelling older adults from two community healthcare centers in Zhengzhou from May to July 2024 for a questionnaire survey to assess the scale's reliability and validity, including internal reliability, test-retest reliability, split-half reliability, content validity, and construct validity.

The C-MAS included 4 dimensions and 23 items. At the scale level, the content validity index (S-CVI) was 0.91; at the item level, the content validity ranged from 0.86 to 1.00. The exploratory factor analysis (EFA) extracted four common factors with factor loads of 0.646 to 0.893 for each item, and the cumulative variance contribution rate was 71.418%. The confirmatory factor analysis (CFA) indicated a satisfactory fit for each indicator. The Cronbach's alpha coefficient for this scale was 0.908, with test-retest reliability of 0.952 and split-half reliability of 0.738.

The reliability and validity of C-MAS are up to standard and can be used to assess malnutrition awareness among Chinese community-dwelling older adults.

Quality of life (QOL) has been reported to be associated with sociodemographic characteristics and geriatric syndromes in older adults, but the impact of interactions among multiple geriatric syndromes on QOL remains unexplored. We aimed to apply a machine learning method to evaluate the effects of interactions among multiple geriatric syndromes on QOL in older adults.

We recruited adults aged ≥ 65 years admitted to a tertiary medical center from June 2018 to September 2018. The main outcome was the three-level five-dimensional Euro-Quality of Life tool (EQ-5D-3 L) utility value. The random forest algorithm was used to identify and rank the strongest predictors of geriatric syndromes. The relation between predictors and outcomes was visualized with accumulated local effects plots and interaction effects. Model performance was evaluated by 5-fold cross-validation with metrics of R-square, the mean square error of estimation and the mean absolute error of estimation.

The study included 160 older adults with a mean age of 79 years. The top ten features that significantly influenced the utility prediction were activities of daily living (ADL), frailty, pain, the number of medications used, age, depression, the Charlson Comorbidity Index (CCI), body mass index (BMI), peptic ulcer, and emotional loneliness. The two-way interactions between ADL, frailty, and pain significantly interacted with other predictors.

ADL, frailty, and pain are important factors to be considered when assessing QOL in older adults. It is important for clinicians to consider them together in clinical decision-making.

Introduction: the NOA project analyses the nutritional care of cancer patients in different centres in Andalusia, establishes areas for improvement (phases 1 and 2) and evaluates its implementation during a period of 6 months (phase 3). The results of the different phases have been previously published. Objectives: to evaluate the degree of implementation of the different measures in clinical practice 6 months after the end of the project (12 months after the start of the project) in the Hospital Puerta del Mar (Cádiz). Methods: prospective evaluation of the percentage of patients with nutritional screening, during hospitalisation and in outpatient clinics of Medical Oncology and Radiation Oncology, of the participation of members of the Nutrition Unit in oncology committees and of the assessment of the patients presented at these sessions. Results: during the duration of the project we observed a progressive increase in the percentage of patients with nutritional screening (both in hospitalised patients and in outpatients), a regular incorporation of members of the Nutrition Unit in tumour committees and an increase in the number of patients undergoing nutritional assessment and intervention. These results have been maintained after the end of the project. Conclusions: the implementation of these measures has resulted in a change in the usual clinical practice in the nutritional care of cancer patients and an increase in the detection of patients in need of nutritional intervention.

The Global Leadership Initiative on Malnutrition (GLIM) criteria for diagnosing malnutrition were established to provide a standardized approach for diagnosing malnutrition in clinical practice using a nutrition screening tool (NST) as the first step for this process. This study aimed to compare the complementarity of NSTs with the GLIM criteria for malnutrition diagnosis in patients with cancer.

Hospitalized patients with different cancer types were evaluated in a prospective cohort study in which they were initially screened using the Patient-Generated Subjective Global Assessment (PG-SGA), Protocol for Nutritional Risk in Oncology (PRONTO), Malnutrition Universal Screening Tool, Nutritional Risk Screening 2002, Malnutrition Screening Tool, and NutriScore for nutrition risk. Malnutrition diagnosis involved phenotypic and etiological criteria as proposed by the GLIM. Complementarity of NST to GLIM criteria was evaluated by calculating accuracy metrics and investigating association with 12-month mortality.

Nutrition risk ranged from 14.8% (NutriScore) to 82.8% (PRONTO) and frequency of malnutrition from 13.8% (with NutriScore) to 88.9% (with PG-SGA). NutriScore presented the lowest negative predictive value (25.1%) whereas PG-SGA presented the highest (58.32%). Regardless of the NST applied, the risk of malnutrition and diagnosis of malnutrition according to the GLIM criteria, combined or isolated, increased the risk of 12-month mortality.

All NSTs presented low negative predictive value when their complementarity to GLIM criteria for malnutrition diagnosis was tested. Indeed, patients "at risk" presented similar increased risk of 12-month after discharge mortality in comparison with those at risk and malnourished by the GLIM criteria when all NSTs were applied.

Appendiceal neoplasms are rare entities prone to direct peritoneal spread. As these neoplasms occur in few patients, research regarding their management is largely retrospective, limiting its utility. Classification of these neoplasms continues to evolve and is largely based on histopathology. Thorough workup of patients with appendiceal mucinous neoplasms is essential for appropriate management and decision making. The cornerstone of treatment of low-grade and high-grade appendiceal mucinous neoplasms with peritoneal spread is cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), with limited use of systemic chemotherapy. For those patients who experience recurrence, it may be managed using CRS/HIPEC and possibly systemic chemotherapy.

Head and neck cancer (HNC) involves several tumor locations, the most common of which are the oropharynx and oral cavity. Patients with HNC are at high risk of developing malnutrition. Together with treatment, the tumor location contributes to difficulties in eating and swallowing, which can lead to a negative energy balance and weight loss. This study aimed to examine malnutrition via the Global Leadership Initiative on Malnutrition (GLIM) criteria, explore the different combinations of the GLIM criteria, study changes in body composition and body energy content and evaluate health-related quality of life (HRQoL) in patients with locally advanced HNC.

Malnutrition was diagnosed via the GLIM criteria. Body weight, muscle mass, body fat, C-reactive protein (CRP) levels, energy intake, use of enteral feeding tubes or parenteral nutrition were assessed, and HRQoL scales from the European Organization for Research and Treatment of Cancer (EORTC), including the Quality of Life Questionnaire-Core 30 (QLQ-C30) and the Quality of Life Questionnaire-Head and Neck 35 (QLQ-HN35), and the M.D. Anderson Dysphagia Inventory (MDADI) were completed at baseline, 6 weeks and at 3, 6 and 12 months after the start of treatment. Body composition was measured via dual-energy X-ray absorptiometry, and body energy content was calculated.

Eighty patients were included. The prevalence of malnutrition varied over time and peaked at the end of treatment at 71 %, and at this time, the most common combination of the GLIM criteria was weight loss + reduced food intake + inflammation (31 %), followed by weight loss + reduced muscle mass + reduced food intake + inflammation (20 %). At the end of treatment patients were in a negative energy balance, and compared to baseline, body weight, body fat, and muscle mass had decreased with 6.0 % (p<0.0001), 5.9 % (p<0.0001), and 8.0 % (p<0.0001) respectively. At the 3-month follow-up, the reduction in muscle mass had ceased, despite a negative energy balance, and patients started to regain muscle mass. At 12 months body weight had decreased with 7.4 % (p<0.0001), body fat with 18.9 % (p<0.0001), and muscle mass with 2.4 % (p<0.0001) compared to baseline. Patients with malnutrition reported significantly worse HRQoL on a majority of the 16 quality of life scales at all time points, except at the end of treatment, when no significant differences were found between malnourished and nonmalnourished patients.

Patients with advanced HNC receiving combined treatment experience major nutritional problems, and malnutrition is common at the end of treatment. Inflammation-driven muscle depletion during treatment is challenging, but it seems possible to recover muscle mass after treatment. Patients with malnutrition reported worse HRQoL at all time points, except at the end of treatment, when all patients' quality of life was very negatively affected.

The increasingly complex health care systems, the large and diverse population to whom nutritional therapy is addressed, and the need of specialized health care professionals implies an organizational strategy to be defined. The organization of nutritional care is a fundamental strategy to promote an optimal, quality and safety nutritional therapy. This is why, the organization of nutritional care should be based on 4 principles, including: Nutritional care should be considered as a process, a multidisciplinary approach is essential to a good nutritional care, the economic approach and the patient centered approach are essential to the organization of nutritional care. In this paper we will address the organization of nutritional care and its 4 principles.

Wernicke's encephalopathy (WE) is an acute or subacute neuropsychiatric condition associated with thiamine deficiency that is more often seen in cases of alcohol abuse. The current study presents a rare case of primary cervical cancer complicated by WE. A 44-year-old woman who underwent a laparoscopic radical hysterectomy with endoscopic pelvic lymphadenectomy for primary cervical adenocarcinoma in 2014 developed multiple metastases in the pelvic and abdominal cavities, right iliopsoas muscle and iliac wing 2 years post-surgery. The patient was hospitalized due to the rupture of a mass in the right lower abdomen in August 2019. A computed tomography scan demonstrated the spreading of primary cervical cancer to the right lower abdomen, which broke through the skin. In this terminal stage of cervical cancer accompanied with malnutrition, the patient suddenly presented with cognitive impairment, particularly in recent and immediate memory, as well as bilateral sustained nystagmus during hospitalization. Brain magnetic resonance imaging showed hyperintensity in the periaqueductal midbrain on T2 fluid-attenuated inversion recovery imaging. Based on these findings, a diagnosis of WE was made, and thiamine (100 mg) was immediately administered intramuscularly three times a day. After a week, the patient's eye movement disorder and recent memory improved gradually. The present case report with literature review aims to demonstrate the significant comorbidity between cancer and WE, raising awareness about the importance of recognizing the risk of thiamine deficiency in advanced cancer to prevent the development of WE.

To explore the prevalence of vitamin C deficiency, 'undetectable' vitamin C status, and scurvy features, in adult hospitalised patients with protein-energy malnutrition diagnosed using validated malnutrition screening and assessment tools commonly used in clinical practice.

This study included adult inpatients from four acute hospitals within a single Australian tertiary health service, over a 3.5-year period. A medical file review activity retrospectively determined malnutrition risk and diagnosis, via Malnutrition Screening Tool, Malnutrition Universal Screening Tool, Subjective Global Assessment and Global Leadership Initiative on Malnutrition criteria. Prevalence of vitamin C deficiency and scurvy features was examined in adult patients with plasma vitamin C levels <11.4 μmol/L and <5 μmol/L ('undetectable'), respectively.

In the final cohort (n = 364), prevalence of vitamin C deficiency was 30.2%. Malnutrition was present in 76.1% and 79.8% of patients via Subjective Global Assessment (n = 310) and Global Leadership Initiative on Malnutrition criteria (n = 342) respectively. Patients with high nutrition risk and those diagnosed with severe malnutrition had the highest prevalence of vitamin C deficiency, reported as 32.8% for malnutrition detected via Malnutrition Screening Tool (n = 244), 32.9% via Malnutrition Universal Screening Tool (n = 222), 35.8% via Subjective Global Assessment (n = 106), and 34.2% via Global Leadership Initiative on Malnutrition (n = 152). Scurvy features were associated with severe malnutrition in patients with 'undetectable' vitamin C status.

Severely malnourished adult hospital patients have a high prevalence of vitamin C deficiency, and scurvy features in those with 'undetectable' vitamin C status. Leveraging existing malnutrition screening and assessment practices may support early identification of patients with vitamin C deficiency during hospitalisation.

Although spine surgery has been shown to be an effective treatment for many spinal disorders, perioperative complications can increase patient morbidity and lead to poorer surgical outcomes. Nutritional status is a modifiable factor that affects spine surgery results. Malnutrition can negatively influence inflammatory pathways and can change circulating stress hormones. Perioperative nutrition status can be evaluated by both clinical and laboratory parameters, with nutritional indices allowing for determination of perioperative risk. Perioperative nutritional optimization has been attempted and has been associated with improved outcomes, for patients undergoing spine surgery. Additional investigation is needed to determine effective perioperative nutritional protocols.

This study aimed to compare the performance of six different screening tools with the GLIM criteria in identifying malnutrition risk among older adults with cardiovascular diseases.

In this diagnostic accuracy study, data from 669 patients aged 65 and older, hospitalized at Bandırma Training and Research Hospital diagnosed with cardiovascular disease, were evaluated. The data were obtained using a questionnaire that included a Demographic Information Form, Global Leadership Initiative on Malnutrition (GLIM) Criteria, Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool (MUST), Short Nutritional Assessment Questionnaire (SNAQ), Mini Nutritional Assessment-Short Form (MNA-SF), Nutritional Risk Screening-2002 (NRS-2002), and Graz Malnutrition Screening (GMS) tool. GLIM criteria were used as gold standard and six screening tools were used as index tests. Receiver Operating Characteristic (ROC) curve analysis was conducted to calculate the Area Under the Curve (AUC), and the sensitivity, specificity, accuracy, and Cohen's Kappa (κ) coefficient of the index tests were assessed.

The mean age of the patients was 75.5 ± 7.7 years, 55.2% were female. According to the GLIM criteria, the prevalence of malnutrition was calculated as 22.0%. The AUC calculated by ROC indicated that MST (AUC: 0.905) had excellent predictive value, while MUST (AUC: 0.874), SNAQ (AUC: 0.851), MNA-SF (AUC: 0.842), and GMS (AUC: 0.820) demonstrated good predictive value. Among the screening tools, GMS had the highest sensitivity (92.5%), whereas MNA-SF exhibited the highest specificity (91.6%). MNA-SF also demonstrated the highest agreement with the GLIM criteria (Cohen's κ: 66.8) and the highest accuracy (88.3%).

This study found that the MNA-SF tool outperformed other comprehensive screening tools when evaluating malnutrition risk in light of the GLIM criteria.

The purpose was to explore the independent risk factors for esophagogastric anastomotic leakage (EGAL) and establish a nomogram.

Patients who underwent esophagectomy were enrolled and randomly divided into a training cohort and a validation cohort at a ratio of 7:3. The differences between the two groups of factors were analyzed by difference analysis, and multivariate regression analysis was subsequently performed. A nomogram was established, and the feasibility of the nomogram was verified by analyzing the discrimination, calibration, and decision curves.

A total of 775 patients were enrolled, including 532 in the training cohort and 223 in the validation cohort. Multivariate regression analysis revealed that age, smoking history, drinking history, nutritional indicators, and anastomotic location were independent risk factors. In terms of discrimination, in the training group, the area under the curve was 0.757 (P = 0.025). In the calibration curve, the curves and fitting lines before and after correction in the training group and the validation group were basically the same. The results of the Hosmer-Lemeshow test showed that the chi-square value of the training cohort was 5.48 (P = 0.791). In the decision curve analysis of the training set, when the threshold probability was in the range of 5-63%, the net benefit of patients was greater than that of the two extreme curves.

Preoperative malnutrition is an independent risk factor for EGAL. A diagnostic model, developed on age, anastomotic location, smoking status, and drinking history, was a reliable noninvasive tool to timely predict the occurrence of AL.

Despite the high prevalence of malnutrition in Systemic Sclerosis (SSc), it often remains overlooked in daily routine. The study aimed to assess the nutritional status of SSc patients using two different tools, concerning their clinical presentation and laboratory results. This retrospective study included 44 SSc patients. We assessed malnutrition with the Malnutrition Universal Screening Tool (MUST) and the Controlling Nutritional Status (CONUT) score. Systemic involvement and laboratory parameters were analysed. Statistical analysis was performed using ANOVA Kruscal-Wallis with post-hoc tests for continuous variables and Chi2 tests for dichotomous variables. The CONUT revealed a substantial proportion of malnourished patients (n = 27; 61,4%), which was higher compared to the assessment with MUST (n = 14; 34,1%). CONUT-undernourished patients had higher C-reactive-protein (28,84 ± 31,72 versus 2,91 ± 2,18, p = 0,0126), higher red-cell-distribution-width (moderate-16,46 ± 2,52 versus normal-13,90 ± 1,03, p = 0,0150), lower hemoglobin (moderate-11,45 ± 2,28 versus normal-13,49 ± 1,28, p = 0,0426), higher N-terminal pro-B-type-natriuretic-peptide (moderate-3790,53 ± 6810,00 versus normal-193,87 ± 265,16, p = 0,0406). However, these observations were not confirmed for MUST-assessed malnutrition. The prevalence of malnutrition in our study was similar to other described cohorts. The CONUT score appeared to be a more sensitive screening tool for malnutrition, however, in patients with cardiological involvement, it may give false-positive results. This study is the first to evaluate SSc patients with the CONUT score, highlighting the need for further research to assess its effectiveness thoroughly.

Background: Patients undergoing cardiovascular surgery often experience postoperative complications and Activities of Daily Living (ADL) decline, even in the absence of preoperative malnutrition. Since postoperative ADL decline is particularly serious in elderly patients, this study aimed to identify a nutritional assessment tool that is effective in predicting postoperative ADL decline. Methods: Patients undergoing open-heart surgery with cardiopulmonary bypass were assessed using eight nutritional assessment tools, including the Malnutrition Universal Screening Tool (MUST), the Global Leadership Initiative on Malnutrition (GLIM) criteria, the Nutritional Risk Screening 2002 (NRS-2002), the Subjective Global Assessment (SGA), the Controlling Nutritional Status (CONUT) score, the Prognostic Nutritional Index (PNI), the Geriatric Nutritional Risk Index (GNRI), and the Mini Nutritional Assessment-Short Form (MNA-SF). Results: A total of 197 patients were enrolled in this study, with a mean age of 70.4 ± 11.6 years old; 31.0% were female. Depending on the nutritional assessment tool, 17.8% to 78.2% of patients were identified as at risk of malnutrition. Among the various assessment tools, the MUST was the most effective in predicting postoperative ADL decline (OR 4.75, 95% CI 1.37-16.5, p = 0.014) and was also associated with severe complications and length of hospital stay (OR 3.08, 95% CI 0.20-0.76, p = 0.009). On the other hand, nutritional risk detected by assessment tools other than MUST, including MNA-SF and GLIM, could predict postoperative complications but showed no relationship to ADL decline. Conclusions: We concluded that MUST was the most useful preoperative nutritional assessment tool for predicting outcomes, particularly for assessing the risk of postoperative ADL decline in patients undergoing cardiovascular surgery.

There is increasing evidence supporting the use of morphofunctional assessment (MFA) as a tool for clinical characterization and decision-making in malnourished patients. MFA enables the diagnosis of malnutrition, sarcopenia, obesity, and cachexia, leading to a novel phenotype-based classification of nutritional disorders. Bioelectrical impedance analysis (BIVA), nutritional ultrasound® (NU) and computed tomography (CT) are included, along with functional tests like the Timed Up and Go test (TUG). Myoesteatosis, detectable via CT, can occur independently from nutritional phenotypes and has been identified as a significant mortality predictor in idiophatic pulmonary fibrosis (IPF). Our aim is to analyze the prevalence and overlap of nutritional phenotypes in IPF and evaluate the prognostic value of myoesteatosis. Our bicenter cross-sectional study included 82 IPF patients (84.1% male and with a medium age of 71.1 ± 7.35 years). MFA was performed using BIVA, NU, CT at the T12 level (CT-T12), the handgrip strength (HGS) test, and the TUG. CT-T12 BC parameters were analyzed using FocusedON® software, while statistical analyses were conducted with JAMOVI version 2.3.22. All four major nutritional phenotypes were represented in our cohort, with significant overlap. A total of 80.5% met the GLIM criteria for malnutrition, 14.6% had cachexia, 17% were sarcopenic, and 28% were obese. Of the obese patients, 70% were also malnourished, while 100% of sarcopenic obese patients (5.9% of total) had malnutrition. A total of 55% of sarcopenic patients with available CT also had myosteatosis, suggesting muscle quality deterioration as a potential driver of functional impairment. The presence of myosteatosis > 15% in T12-CT was an independent predictor of 12-month mortality (HR = 3.13; 95% CI: 1.01-9.70; p = 0.049), with survival rates of 78.1% vs. 96.6% in patients with vs. without myosteatosis, respectively. To conclude, this study underscores the relevance of MFA in the nutritional characterization of patients with IPF, demonstrating its potential to identify specific phenotypes associated with malnutrition, functional impairment, and the presence of myoesteatosis, thereby providing a valuable tool for clinical decision-making.

Intrinsic capacity is a crucial indicator of adverse outcomes and has predictive value for diseases and mortality. The objective of this study is to assess the association between nighttime sleep duration and intrinsic capacity in older Chinese adults.

Data were collected from the China Health and Retirement Longitudinal Study (CHARLS) spanning the years 2008-2020. Minimally sufficient adjustment was made for confounding factors identified through a Directed Acyclic Graphs (DAGs), and multivariate logistic regression analysis was conducted to determine the relationship between nighttime sleep duration and intrinsic capacity. Restricted cubic splines (RCS) were used to assess the nonlinear relationship between nighttime sleep duration and intrinsic capacity in this population. Finally, subgroup analysis and interaction effect analysis were performed.

Among the 4994 older adults, 3118 (62.4%) experienced a decline in intrinsic capacity. After adjusting for confounding factors, nighttime sleep duration was associated with an increased risk of intrinsic capacity decline (P < 0.001), exhibiting a nonlinear J-shaped pattern.

For Chinese older adults, increased nighttime sleep duration shows a nonlinear, J-shaped dose-response relationship with the risk of intrinsic capacity decline. Our study provides important insights into the intrinsic capacity and health self-management of older adults.

To quantify the frequency and impact of malnutrition in systemic sclerosis (SSc), as diagnosed by the Global Leadership Initiative on Malnutrition (GLIM) criteria, based on weight loss, BMI and muscle atrophy.

Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for SSc with ≥1 concurrent weight and height measurement were included. The chi-squared test, two-sample t-test or Wilcoxon's rank-sum test was used for between-group comparison as appropriate. Multivariable logistic regression models were used to establish the determinants of malnutrition diagnosis. Kaplan-Meier and Cox proportional hazard models were used for survival analyses, based on malnutrition diagnosis, and individual GLIM criteria (percentage weight loss, BMI thresholds and presence of muscle atrophy).

In this study of 1903 participants, 43% were diagnosed with malnutrition according to GLIM criteria, of whom 33% had severe malnutrition. Participants diagnosed with malnutrition were older, and more likely to have diffuse cutaneous SSc (dcSSc), higher SSc severity scores and RNA polymerase-3 positivity. Gastrointestinal (GI) involvement, multimorbidity, cardiopulmonary disease, raised inflammatory markers, hypoalbuminaemia and anaemia were more common in malnourished participants (P < 0.01). Multimorbidity (odds ratio [OR] 1.6; 95% CI: 1.2, 2.0; P < 0.01), pulmonary arterial hypertension (OR 2.1; 95% CI: 1.4, 2.0; P < 0.01) and upper GI symptoms (OR 1.6; 95% CI: 1.3, 2.0; P < 0.01) were all associated with malnutrition. Health-related quality-of-life (HRQoL) and physical function were poorer in malnourished participants. Survival was worse in those with malnutrition after adjusting for age, sex and dcSSc (hazard ratio 1.4; 95% CI: 1.1, 1.7; P < 0.01).

Malnutrition is common in SSc and confers poorer survival, HRQoL and physical function.

To provide a snapshot of the current use of oral nutritional supplements, its association with inpatient characteristics, and with a focus on the role of nursing monitoring of food intake and implementing nutritional interventions for patients with low intake.

Retrospective cohort study.

The study collected data from a hospital database regarding oral nutritional supplement initiation and variables of patients hospitalised in internal medicine departments, who did not receive enteral or parenteral nutrition.

Of the 5155 admissions, 1087 fulfilled the inclusion criteria (47% female; mean age, 72.4 ± 14.6 years; mean length of stay, 14.6 ± 11.4 days). Sufficient food intake reporting was noted in 74.6% of the patients; of these 17% had decreased intake. Oral nutritional supplements and non-oral nutritional supplements groups did not differ in terms of sex, age, length of stay, Charlson Comorbidity Index, proportion of nursing reports, and absence of intake monitoring. Oral nutritional supplements were initiated in 31.9% of patients with a Malnutrition Universal Screening Tool score ≥2 and in 34.6% with decreased food intake. On multivariable analysis, hypoalbuminemia (adjusted odds ratio, 3.70), decreased food intake (adjusted odds ratio, 3.38), Malnutrition Universal Screening Tool score ≥2 (adjusted odds ratio, 2.10), and age <70 years (adjusted odds ratio, 1.56) were significantly associated with oral nutritional supplements use.

The prevalence of oral nutritional intervention was suboptimal in patients at risk of malnutrition during acute hospitalisation, although decreased food intake and Malnutrition Universal Screening Tool score ≥2 independently increased the probability of oral nutritional supplements initiation.

Understanding the clinical practice and nursing impact of care management in relation to nutritional intervention can assist in reviewing and improving patient care. IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE IMPACT (ADDRESSING): This study informs clinical management and influences nursing practice standards related to assessing, monitoring, and managing malnutrition risk.

The study impacts the quality of care for patients at risk of malnutrition.

We adhered to the STROBE Checklist for cohort studies.

No Patient or Public Contribution.

Depressive mood is prevalent in geriatric patients who undergo rehabilitation. Malnutrition, which frequently coexists in this demographic group, likely affects mental health status significantly. This study examined the association between malnutrition and depressive mood at discharge in geriatric patients who were undergoing rehabilitation and identified the mediating roles of specific malnutrition components in this association.

This prospective cohort study comprised 189 geriatric rehabilitation patients. Malnutrition was determined using the Global Leadership Initiative on Malnutrition (GLIM) criteria, and depressive mood was assessed using the Geriatric Depression Scale-15 (GDS-15). The potential mediation of the GLIM components in the relationship between malnutrition and depressive mood was evaluated using causal mediation analysis.

Malnutrition was positively associated with increased GDS-15 scores at both admission (p = 0.007) and discharge (p < 0.001). The severity of malnutrition corresponded with increased odds of depressive mood at discharge (moderate malnutrition: odds ratio [OR] 3.84, 95% confidence interval [CI] 1.48-9.94, p = 0.005; severe malnutrition: OR 5.11, 95% CI 1.52-15.17, p = 0.003). Notably, both muscle mass reduction (OR 1.51, 95% CI 1.01-2.27, p = 0.042) and disease burden (OR 1.37, 95% CI 1.00-1.89, p = 0.047) were identified as mediators in the association between malnutrition and depressive mood at discharge.

Nutritional status significantly influenced the mental health of geriatric rehabilitation patients, with muscle mass reduction and disease burden mediating this relationship. These findings emphasize the importance of a multidimensional geriatric rehabilitation approach that includes nutritional interventions.

Bariatric surgery (BS) is an effective treatment for severe obesity and its related comorbidities, such as type 2 diabetes and hypertension. However, the anatomical and physiological changes associated with these procedures significantly increase the risk of preoperative and postoperative micronutrient deficiencies, which can lead to severe complications such as anemia, osteoporosis, and neurological disorders. This narrative review examines the prevalence and clinical implications of micronutrient deficiencies in BS patients, as well as evidence-based strategies for their prevention and management. The most common deficiencies include iron, vitamin B12, folate, calcium, vitamin D, and fat-soluble vitamins (A, E, and K). Procedures with a hypoabsorptive component, such as Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion with duodenal switch (BPD/DS), pose higher risks of deficiencies compared to restrictive procedures like sleeve gastrectomy (SG). Effective strategies involve the preoperative correction of deficiencies, continuous monitoring, and tailored supplementation. However, long-term adherence to supplementation tends to decrease over time, influenced by behavioral and socioeconomic factors. Hence, preventing and managing micronutrient deficiencies are crucial for the long-term success of BS. While current guidelines provide valuable recommendations, many are based on low-certainty evidence, underscoring the need for more robust studies. A multidisciplinary approach, combined with innovative strategies, such as telemedicine, can enhance adherence and achieve sustainable clinical outcomes.

Bariatric surgery has become the preferred treatment for individuals with morbid obesity. Nutrition is key in optimizing surgical outcomes by reducing risks and enhancing recovery. Preoperative strategies, such as reducing body fat, decreasing liver size, and improving metabolic profiles, have been shown to facilitate safer surgical procedures with fewer complications. This narrative review aims to provide an analysis of the fundamental role of preoperative nutritional management in improving bariatric surgery outcomes, emphasizing the importance of addressing specific nutritional challenges to enhance surgical safety, recovery, and overall health. Preoperative nutritional interventions focus on correcting comorbidities and nutritional deficiencies, particularly hypovitaminosis and micronutrient imbalances, through a multidisciplinary approach involving nutritionists and other healthcare professionals. These interventions not only prepare patients for the physiological demands of surgery but also initiate a period of adaptation to new dietary habits, aiming to improve long-term compliance and mitigate risks such as postoperative weight regain and dumping syndrome. Adopting dietary changes, such as very low-calorie or ketogenic diets 6-12 weeks before surgery, enhances adherence to postoperative restrictions and overall surgical success. Future research should focus on developing comprehensive guidelines for preoperative nutritional care to improve patient outcomes globally.

Evidence of poor nutrition status in a patient present on admission to the intensive care unit is associated with worse clinical outcomes than that for a well-nourished patient who becomes critically ill. Diagnosing malnutrition in this setting is fraught with difficulty, though, because elements of nutrition history are hard to obtain, the interpretation of anthropometric parameters is influenced by the disease process and interventions of critical care and the subjectivity of traditional assessment tools lacks precision. Determining the severity of disease drives the initial management and sets priorities in the derivation of the nutrition plan, focusing on strategies that promote survival. Its design should provide safe and effective nutrition support, avoiding aggressive feeding to make up for deficits in the acute phase of critical illness. In time, with resuscitation and stabilization, addressing pre-existing or developing malnutrition will change management and alter the design of the nutrition therapy.

Many nutrition risk screening tools include low body mass index (BMI). It remains uncertain whether it affects the validity of these tools in patients with overweight or obesity. We aimed to determine the frequency of malnutrition risk and evaluate its association with hospital length of stay in hospitalized adults according to BMI classification.

Secondary analysis involving inpatients with BMI ≥ 18.5 kg/m2. Malnutrition risk was assessed using the Nutritional Risk Screening 2002 (NRS-2002), Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool, Short Nutritional Assessment Questionnaire, and Nutritional Risk in Emergency-2017. Length of hospital stay, in-hospital mortality, readmission, and mortality within 6 months postdischarge were considered as outcomes.

Among the 582 patients analyzed, the malnutrition risk ranged from 34.5% to 49.7% in patients with normal weight (n = 171), 20.8% to 33.9% in patients with overweight (n = 221), and 5.3% to 22.1% in patients with obesity (n = 190). Malnutrition risk by the NRS-2002 was associated with prolonged hospital stay, regardless of BMI category, and with 6-month hospital readmission in normal weight and those with obesity. The MST was associated with prolonged hospital stay, mortality, and hospital readmission in 6 months in normal-weight patients and with the first two outcomes in patients with overweight. No tool was associated with in-hospital death.

The prognostic value of nutrition risk screening tools varies according to BMI: the MST appears to be more appropriate for normal-weight and overweight patients, whereas the NRS-2002 may be more suitable for patients with obesity.

Laparoscopic spleen-preserving distal pancreatectomy (LSPDP) is a widely adopted surgical approach for benign and low-grade malignant neoplasms of the distal pancreas. The Kimura and Warshaw techniques represent two principal strategies, yet it still needs to be determined which one is superior. Our investigation aimed to evaluate the clinical outcomes associated with each technique.

This single-center, parallel-group, patient-blinded randomized controlled trial was conducted at the West China Hospital of Sichuan University. Stratified block randomization was utilized to enroll 114 patients starting in March 2022, with an interim analysis of short-term outcomes scheduled after 45-50% of participant enrollment. Patients were randomized to receive LSPDP via either the Kimura or Warshaw technique. The primary endpoint was intraoperative blood loss, while secondary endpoints included a range of outcomes from composite outcome to quality of life, as quantified by the EQ-5D-5L.

From March 2022 to November 2023, 53 patients were randomly allocated to the Kimura ( n =25) or Warshaw ( n =28) groups for LSPDP. Baseline characteristics and postoperative outcomes were similar between the groups, such as pancreatic fistula incidence, EQ-5D-5L index scores, and delayed gastric emptying rates. Per-protocol (PP) analysis revealed that the Kimura group experienced significantly less blood loss (52.5±51.6 ml vs. 91.7±113.5 ml, P =0.007) and a reduced rate of composite outcome (23.8 vs. 56.7%, P =0.019), but incurred higher costs in the Warshaw group (¥56 227.4±¥7027.0 vs. ¥63 513.8±¥12 944.5, P =0.013). Splenic infarction rates were higher in the Warshaw group, though not statistically significant (ITT: 39.3 vs. 12.5%, P =0.058; PP: 36.7 vs. 14.3%, P =0.113), without necessitating intervention. Neither group experienced postpancreatectomy hemorrhage, 90-day mortality, or ICU admissions, and all postoperative complications were mild (Clavien-Dindo Grade

CONCLUSIONS

The 90-day interim analysis postoperatively indicates that both Kimura and Warshaw techniques for LSPDP are safe and viable. The Kimura technique, however, confers superior in terms of reduced intraoperative blood loss and fewer complications, alongside lower costs.

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Various explicit screening tools, developed mostly in central Europe and the USA, assist clinicians in optimizing medication use for older adults. The Turkish Inappropriate Medication use in oldEr adults (TIME) criteria set, primarily based on the STOPP/START criteria set, is a current explicit tool originally developed for Eastern Europe and subsequently validated for broader use in Central European settings. Reviewed every three months to align with the latest scientific literature, it is one of the most up-to-date tools available. The tool is accessible via a free mobile app and website platforms, ensuring convenience for clinicians and timely integration of updates as needed. Healthcare providers often prefer to use their native language in medical practice, highlighting the need for prescribing tools to be translated and adapted into multiple languages to promote optimal medication practices.

To describe the protocol for cross-cultural and language validation of the TIME criteria in various commonly used languages and to outline its protocol for clinical validation across different healthcare settings.

The TIME International Study Group comprised 24 geriatric pharmacotherapy experts from 12 countries. In selecting the framework for the study, we reviewed the steps and outcomes from previous research on cross-cultural adaptations and clinical validations of explicit tools. Assessment tools were selected based on both their validity in accurately addressing the relevant issues and their feasibility for practical implementation. The drafted methodology paper was circulated among the study group members for feedback and revisions leading to a final consensus.

The research methodology consists of two phases. Cross-cultural adaptation/language validation phase follows the 8-step approach recommended by World Health Organization. This phase allows regions or countries to make modifications to existing criteria or introduce new adjustments based on local prescribing practices and available medications, as long as these adjustments are supported by current scientific evidence. The second phase involves the clinical validation, where participants will be randomized into two groups. The control group will receive standard care, while the intervention group will have their treatment evaluated by clinicians who will review the TIME criteria and consider its recommendations. A variety of patient outcomes (i.e., number of hospital admissions, quality of life, number of regular medications [including over the counter medications], geriatric syndromes and mortality) in different healthcare settings will be investigated.

The outputs of this methodological report are expected to promote broader adoption of the TIME criteria. Studies building on this work are anticipated to enhance the identification and management of inappropriate medication use and contribute to improved patient outcomes.

To explore the predictive value of the geriatric nutritional risk index (GNRI) for postoperative complications and their severity in older adults with pancreatic cancer undergoing pancreaticoduodenectomy (PD).

This study conducted a retrospective analysis of 109 older adults with pancreatic cancer undergoing PD at the Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Quzhou Medical University, between May 2019 and May 2022. Statistical analysis of clinical data was performed to assess the predictive value of the GNRI for postoperative complications and their severity in older adults with pancreatic cancer undergoing PD.

Among the 109 individuals in this study, a total of 41 older adults undergoing PD experienced postoperative complications. The outcomes of the regression analysis showed that preoperative GNRI (OR = 0.184, 95 % CI = 0.023-0.457, P < 0.001), albumin levels (OR = 0.897, 95 % CI = 0.812-0.912, P < 0.001) and haemoglobin levels (OR = 1.231, 95 % CI = 1.043-1.451, P = 0.034) significantly influence the incidence of postoperative complications in older adults with pancreatic cancer. The prognostic value of the GNRI in predicting overall postoperative complications boasts a sensitivity of 83.2 %, specificity of 71.2 %, positive predictive value of 81.1 %, negative predictive value of 65.9 %, accuracy rate of 73.1 %, area under the curve (AUC) of 0.756 (P < 0.001) and a discriminative threshold of 97.0. Furthermore, the predictive efficacy of the GNRI in gauging the severity of postoperative complications demonstrates a sensitivity of 85.32 % and specificity of 79.54 %.

The GNRI can offer a faster, simpler and more effective method for evaluating nutritional risk in individuals with pancreatic tumours. Moreover, for older adults undergoing PD, it can serve as a convenient and efficient nutritional predictive indicator for postoperative complications and their severity.

Background and aims: nutritional screening tools assess factors like weight loss, BMI, food intake, and disease severity to determine a patient's nutritional risk and needed care. Plasma transthyretin is a practical measurement used to assess nutritional evolution due to its rapid response to food intake. This study examines the relationship between nutritional scores, transthyretin protein levels, and the possibility of death. Methods: the sample consisted of 302 patients hospitalized in the wards or intensive care unit of a public teaching hospital, using parenteral nutrition as the primary source of nutrition. Five nutritional screening tools were applied, and patient charts were verified for transthyretin levels. Results: from the sample, 260 were adults, and 42 were children, with a mean age of 48.3 years. When evaluating the patient's outcome in relation to the scores, the Malnutrition Universal Screening Tool proved to be better at predicting death (p-value = 0.02). None of the scores were related to transthyretin levels, showing that lower transthyretin values did not influence nutritional risk. Conclusion: we believe early identification of nutritional risk through nutritional scores is necessary for better nutritional monitoring to minimize unfavorable outcomes. This study corroborates the more recent concept that transthyretin is not useful for determining unfavorable outcomes in hospitalized patients with a severe inflammatory process. In clinical practice, identifying a patient at nutritional risk according to the Malnutrition Universal Screening Tool and promoting adequate nutritional monitoring may reduce mortality.