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Jacoub K, Al-Eisawi Z. ABO blood group and skin cancers. Clin Hemorheol Microcirc 2021; 81:359-371. [PMID: 34974432 DOI: 10.3233/ch-211290] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
Abstract
Beside the role of ABO group in immunohaematology, there is accumulating evidence that the ABO blood group also plays a key role in various human disorders. The interest in blood groups and their association with disease stems from the awareness that blood group antigens are incredibly important components in the process of cell maturation and control. Studies have indicated a link between cancer and the ABO blood group. The appearance or disappearance of blood type antigens is now considered a hallmark of malignancy in many common cancers. Several tumour markers are in fact known blood group antigens. The aim of this review is to describe the history and possible functions of the ABO group and then summarize the association between blood groups and skin cancers.
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Affiliation(s)
- Khaldun Jacoub
- Faculty of Applied Medical Sciences, Department of Medical Laboratory Sciences, The Hashemite University, Jordan
| | - Zaynab Al-Eisawi
- Faculty of Applied Medical Sciences, Department of Medical Laboratory Sciences, The Hashemite University, Jordan
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2
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Barozet E, Valenzuela CY, Cifuentes L, Verdugo RA, Herrera L, Acuña M, Llop E, Moraga M, Berríos S, Di Genova A, Digman D, Symon A, Asenjo S, López P, Bustamante ML, Pezo-Valderrama P, Suazo J, Caba F, Villalón M, Alvarado S, Cáceres D, Salgado K, Portales P, Loira N, Maas A. The Chilean socio-ethno-genomic cline. BIODEMOGRAPHY AND SOCIAL BIOLOGY 2021; 66:156-171. [PMID: 34182852 DOI: 10.1080/19485565.2021.1879626] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/13/2023]
Abstract
Studies of the current Chilean population performed using classical genetic markers have established that the Chilean population originated primarily from the admixture of European people, particularly Spaniards, and Amerindians. A socioeconomic-ethno-genetic cline was established soon after the conquest. Spaniards born in Spain or Chile occupied the highest Socioeconomic Strata, while Amerindians belonged to the lowest. The intermediate strata consisted of people with different degrees of ethnic admixture; the larger the European admixture, the higher the Socioeconomic Level. The present study of molecular genomic markers sought to calculate the percentage of Amerindian admixture and revealed a finer distribution of this cline, as well as differences between two Amerindian groups: Aymara and Mapuche. The use of two socioeconomic classifications - Class and Socioeconomic Level - reveals important differences. Furthermore, Self-reported Ethnicity (self-assignment to an ethnic group) and Self-reported Ancestry (self-recognition of Amerindian ancestors) show variations and differing relationships between socioeconomic classifications and genomic Amerindian Admixture. These data constitute a valuable input for the formulation of public healthcare policy and show that the notions of Ethnicity, Socioeconomic Strata and Class should always be a consideration in policy development.
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Affiliation(s)
- E Barozet
- Departamento de Sociología, Facultad de Ciencias Sociales, Universidad de Chile, Centro de Estudios de Conflicto y Cohesión, Social, Santiago, Chile
| | - C Y Valenzuela
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - L Cifuentes
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - R A Verdugo
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - L Herrera
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - M Acuña
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - E Llop
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - M Moraga
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - S Berríos
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - A Di Genova
- Mathomics, Centro de Modelamiento Matemático y Centro Para la Regulación del Genoma, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile
| | - D Digman
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - A Symon
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - S Asenjo
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - P López
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - M L Bustamante
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
- Departamento de Psiquiatría y Salud Mental Norte, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - P Pezo-Valderrama
- Programa de Genética Humana del ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
| | - J Suazo
- Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago, Chile
| | - F Caba
- Escuela de Puericultura, Facultad de Ciencias Médicas, Universidad Bernardo O'Higgins, Chile
| | - M Villalón
- Instituto de Salud Poblacional "Escuela de Salud Pública", Universidad de Chile, Santiago, Chile
| | - S Alvarado
- Instituto de Salud Poblacional "Escuela de Salud Pública", Universidad de Chile, Santiago, Chile
| | - D Cáceres
- Instituto de Salud Poblacional "Escuela de Salud Pública", Universidad de Chile, Santiago, Chile
| | - K Salgado
- Escuela de Puericultura, Facultad de Ciencias Médicas, Universidad Bernardo O'Higgins, Chile
| | - P Portales
- Corporación Municipal de Desarrollo Social, Iquique, Chile
| | - N Loira
- Mathomics, Centro de Modelamiento Matemático y Centro Para la Regulación del Genoma, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile
| | - A Maas
- Mathomics, Centro de Modelamiento Matemático y Centro Para la Regulación del Genoma, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile
- Departamento de Ingeniería Matemática, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile
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Tazebew B, Munshea A, Nibret E. Prevalence and association of malaria with ABO blood group and hemoglobin level in individuals visiting Mekaneeyesus Primary Hospital, Estie District, northwest Ethiopia: a cross-sectional study. Parasitol Res 2021; 120:1821-1835. [PMID: 33655352 DOI: 10.1007/s00436-021-07093-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/24/2020] [Accepted: 02/16/2021] [Indexed: 10/22/2022]
Abstract
Malaria is a serious and sometimes fatal mosquito-borne disease caused by protozoan parasite of the genus Plasmodium. ABO blood group antigens represent polymorphic traits inherited among individuals and populations. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. This study was undertaken to determine the prevalence of malaria and its possible association with ABO blood group and hemoglobin level among individuals attending Mekaneeyesus Primary Hospital, Estie District, northwestern Ethiopia. Sociodemographic variables and relevant data were collected from 390 randomly selected individuals through structured questionnaire. Then, thick and thin smears were prepared from finger pricked blood samples, stained, and examined microscopically for detection and identification of malaria parasites. ABO blood group and hemoglobin levels of the same subjects were also determined. The data generated were analyzed for descriptive and logistic regression models. Variables with p value < 0.05 in multivariable logistic regression were considered explanatory variables. The overall prevalence of malaria was 8.5%; Plasmodium vivax (5.6%) was the most predominant, followed by P. falciparum (2.3%), and mixed infection of the two species (0.5%). In our study, being male (AOR = 3.48), under-five years of age (AOR = 72.84), rural residence (AOR = 2.64), and failing to use bed net (AOR =4.65) were significantly associated with the risk of malaria. Most (14.6%) of malaria-positive cases were among individuals with blood group "A," while the least numbers of cases were among subjects with blood group "O." Individuals with blood group "A" were about four times at risk of malaria as compared to individuals with blood group "O" (AOR= 3.74). The prevalence of anemia was 23.1% and significantly associated with malaria (p<0.05). Prevalence of malaria in this study is still higher compared to some of previous reports from Ethiopia. Thus, there is a need to intensify effort in malaria prevention among potentially at risk segments of population, including males, rural residents, and under-five children, and promotion of ITNs use in the community. Supplementation of iron-rich diet for iron-deficient anemia people is needed. Further in-depth investigation is also necessary to clearly establish the role that ABO blood group plays in malaria.
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Affiliation(s)
- Belaynesh Tazebew
- Department of Biology, College of Science, Bahir Dar University, P.O. Box-79, Bahir Dar, Ethiopia
| | - Abaineh Munshea
- Department of Biology, College of Science, Bahir Dar University, P.O. Box-79, Bahir Dar, Ethiopia. .,Biotechnology Research Institute, Bahir Dar University, P.O. Box-79, Bahir Dar, Ethiopia.
| | - Endalkachew Nibret
- Department of Biology, College of Science, Bahir Dar University, P.O. Box-79, Bahir Dar, Ethiopia.,Biotechnology Research Institute, Bahir Dar University, P.O. Box-79, Bahir Dar, Ethiopia
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Göçer M, Kurtoğlu E. Effect of the ABO blood groups on the development, clinical features and survival of multiple myeloma. MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY 2020; 14:235-240. [PMID: 33362882 PMCID: PMC7757415 DOI: 10.1007/s12254-020-00669-y] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 10/14/2020] [Accepted: 12/02/2020] [Indexed: 12/01/2022]
Abstract
Background Multiple myeloma (MM) is a cytogenetically heterogeneous and incurable plasma cell disease with unknown etiology. It is thought that the ABO blood groups may play a role in the etiology of many diseases. The purpose of this study is to determine whether there is a relationship between the ABO blood groups and the development of MM, clinical findings and overall survival. Methods In this single-center, retrospective and observational study, 198 patients with known blood types who diagnosed with MM between January 2012 and June 2020 were included. Results It was shown that individuals with blood group 0 had a significantly lower risk of MM (OR = 0.575, 95% confidence interval 0.416-0.794, P = 0.001). The incidence of extramedullary lesion was significantly higher in those with 0 blood group compared to other blood groups (P = 0.000). Overall survival was significantly shorter in patients with 0 blood group than those without 0 blood group (P = 0.007). Conclusion Individuals with 0 blood group had a lower risk of developing MM. It was determined that having 0 blood group is a predisposing factor for the development of extramedullary lesion in MM patients. However, it was shown that having a blood group of 0 was a very significant prognostic factor for MM patients and was associated with short OS.
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Affiliation(s)
- Mesut Göçer
- Department of Internal Medicine, Division of Hematology, Antalya Training and Research Hospital, 07100 Antalya, Turkey
| | - Erdal Kurtoğlu
- Department of Internal Medicine, Division of Hematology, Antalya Training and Research Hospital, 07100 Antalya, Turkey
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Zhang S, Jia M, Cai X, Yang W, Liao S, Liu Z, Wen J, Luo K, Cheng C. Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients. Front Oncol 2020; 10:586084. [PMID: 33392080 PMCID: PMC7775654 DOI: 10.3389/fonc.2020.586084] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/22/2020] [Accepted: 11/17/2020] [Indexed: 12/24/2022] Open
Abstract
Background The prognostic value of ABO blood types is not well clarified for esophageal carcinoma (EC). This study attempted to elucidate the associations between different ABO blood types and disease-free survival (DFS) and overall survival (OS) of EC. Methods This study was a retrospective review of the records of 2179 patients with EC who received surgery from December 2000 to December 2008. The prognostic impact of ABO blood group on DFS and OS were estimated using the Kaplan-Meier method and cox proportional hazard models. Results Univariate analyses found significant differences in DFS and OS among the four blood types. Multivariate analyses showed ABO blood type independently predicted DFS (P=0.001) and OS (P=0.002). Furthermore, patients with non-B blood types had a significantly shorter DFS (HR=1.22, 95%CI:1.07–1.38, P=0.002) and OS (HR=1.22, 95%CI:1.07–1.38, P=0.003) than patients with blood type B, and patients with non-O blood types had a significantly better DFS (HR=0.86, 95%CI:0.77–0.96, P=0.006) and OS (HR=0.86, 95%CI:0.77–0.96, P=0.007) than patients with blood type O. Subgroup analyses found that blood type B had a better DFS and OS than non-B in patients who were male, younger, early pathological stages and had squamous-cell carcinomas (ESCC). Blood type O had a worse DFS and OS than non-O in patients who were male, younger, and had ESCC (P<0.05). Conclusions The results demonstrate that ABO blood group is an independent prognostic factor of survival, and that type B predicts a favorable prognosis, whereas type O predicts an unfavorable prognosis for survival in patients with EC, especially those with ESCC.
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Affiliation(s)
- Shuishen Zhang
- Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
| | - Minghan Jia
- Department of Breast Cancer, Guangdong Provincial People's Hospital Cancer Center, Guangdong Academy of Medical Sciences, Guangzhou, China
| | - Xiaoli Cai
- Department of Medical Ultrasonics, First Affiliated Hospital of Jinan University, Guangzhou, China
| | - Weixiong Yang
- Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
| | - Shufen Liao
- Operating room of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
| | - Zhenguo Liu
- Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
| | - Jing Wen
- Guangdong Esophageal Cancer Institute, Guangzhou, China.,Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
| | - Kongjia Luo
- Guangdong Esophageal Cancer Institute, Guangzhou, China.,Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.,State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
| | - Chao Cheng
- Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
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Hobgood DK. ABO O gene frequency increase in the US might be causing increased maternal mortality. Med Hypotheses 2020; 144:109971. [PMID: 32540606 DOI: 10.1016/j.mehy.2020.109971] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/29/2020] [Revised: 06/02/2020] [Accepted: 06/05/2020] [Indexed: 10/24/2022]
Abstract
Maternal mortality rate has increased in the United States over the past 30 years from 16 deaths per 100,000 births to 28 deaths per 100,000 births while the rest of the world is experiencing declining rates. Increasing obesity and c-section rates in the US have been cited as contributing factors needing remediation, and because of the two to three fold difference in maternal mortality rates in non-Hispanic black women compared to white women, inequality and implicit racial bias has been targeted as well for remediation. Using an epidemiologic approach, a hypothesis here brought to bear is that US immigration policy changes over the past 50 years have brought changes in the gene pool that have caused increasing obstetric hemorrhage and other causes of maternal death. ABO gene frequencies have changed in the US during this time such that ABO O, a gene associated with hemorrhage and mortality in pregnancy, has increased in frequency in the US thus increasing population maternal mortality rate. Using mendelian randomization logic, noting the increase in ABO O gene in the US population over the past 30 years and the association of ABO O gene with both hemorrhage and lower longevity, the increase in frequency of the ABO O gene in the past 30 years in the US population might be causative of an increase in maternal mortality rate. Consequences of this hypothesis would include recognition of the role of ABO gene and thus ABO blood group in prediction of risk of obstetric hemorrhage. Thus those at risk on this basis would be under high surveillance and would have medications and treatment strategies readily available. While research on ABO gene and pregnancy has been done, much of the research is being done in countries other than the US, and given the increasing mortality in the US as well as the role that ABO gene may have in that, further research needs to be done in US populations to quantify risk for all adverse events in pregnancy related to ABO blood type including hemorrhage as well as inter-related causes including pre-eclampsia, cardiovascular disease, thromboembolic disease and infection.
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Affiliation(s)
- Donna K Hobgood
- Chattanooga Units of UT College of Medicine, Chattanooga, Tennessee 37403, 1751 Gunbarrel Road, Suite 200, Chattanooga, TN 37421, USA
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Korucu O, Bulur O. Relationship between ABO blood group and Migraine. ANKARA MEDICAL JOURNAL 2019. [DOI: 10.17098/amj.624430] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/06/2024] Open
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Association of ABO Blood Group and Body Mass Index: A Cross-Sectional Study from a Ghanaian Population. J Nutr Metab 2018; 2018:8050152. [PMID: 29780641 PMCID: PMC5892219 DOI: 10.1155/2018/8050152] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2017] [Revised: 12/21/2017] [Accepted: 02/15/2018] [Indexed: 12/28/2022] Open
Abstract
ABO blood group and body mass index (BMI) have individually been appraised as risk factors for certain diseases. From statistical perspective, it may be important to examine the relationship between the ABO blood antigen and BMI. This cross-sectional study involved 412 participants aged 18 to 46 at the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi. Weight and height of participants were measured for BMI calculation; blood group determination was done using antisera. Blood group O was the most prevalent (51.2%), while Rhesus-positive individuals constituted 90.3%. 6.3% of the participants were obese, while 18.7% were overweight. There was significant (p=0.006) higher prevalence of obesity in females (10.3%) than in males (3.4%). The study did not observe any significant difference by association of ABO blood group with gender (p=0.973), BMI (p=0.307), or Rhesus status (p=0.723). Regarding gender (p=0.400) and BMI (p=0.197), no statistically significant difference was observed between Rhesus blood groups. The prevalence of overweight, obesity, blood type O, and rhesus positive observed among students in this study is largely similar to what has been reported in published studies in Ghana and from other countries. Overweight and obesity were not associated with ABO blood groups or Rhesus in this study.
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Golassa L, Tsegaye A, Erko B, Mamo H. High rhesus (Rh(D)) negative frequency and ethnic-group based ABO blood group distribution in Ethiopia. BMC Res Notes 2017; 10:330. [PMID: 28747227 PMCID: PMC5530478 DOI: 10.1186/s13104-017-2644-3] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2017] [Accepted: 07/21/2017] [Indexed: 12/20/2022] Open
Abstract
Background Knowledge of the distribution of ABO-Rh(D) blood groups in a locality is vital for safe blood services. However, the distribution of these blood systems among Ethiopians in general is little explored. This study was, therefore, designed to determine the ABO-Rh(D) blood group distribution among patients attending Gambella hospital, southwestern Ethiopia. Methods A cross-sectional study was conducted between November and December 2013 (N = 449). The patients were grouped into two broad categories. Those who originally moved from different parts of Ethiopia and currently residing in Gambella are named ‘highlanders’ (n = 211). The other group consisted of natives (Nilotics) to the locality (n = 238). ABO-Rh(D) blood groups were typed by agglutination, open-slide test method, using commercial antisera (Biotech laboratories Ltd, Ipswich, Suffolk, UK). Results Overall, majority of the participants (41.20%) had blood type ‘O’ followed by types ‘A’ (34.96%), ‘B’ (20.48%) and ‘AB’ (3.34%). However, blood type ‘A’ was the most frequent (44.07%) blood group among the ‘highlanders’ and 50.42% of Nilotic natives had type ‘O’. The proportion of participants devoid of the Rh factor was 19.37%. Conclusions While the ABO blood group distribution is similar to previous reports, the Rh(D) frequency is much higher than what was reported so far for Ethiopia and continental Africa.
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Affiliation(s)
- Lemu Golassa
- Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia
| | | | - Berhanu Erko
- Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia
| | - Hassen Mamo
- Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
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Dali SM, Aour MA, Belmokhtar F, Belmokhtar R, Boazza F. The relationship between ABO/rhesus blood groups and type 2 diabetes mellitus in Maghnia, western Algeria. S Afr Fam Pract (2004) 2014. [DOI: 10.1080/20786204.2011.10874154] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2022] Open
Affiliation(s)
- Sahi M Dali
- Laboratoire de valorisation de l'action de l'homme pour la protection de l'environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bakr Belkaïd de Tlemcen, Algérie
| | - Metri A Aour
- Laboratoire de valorisation de l'action de l'homme pour la protection de l'environnement et application en santé publique (équipe environnement et santé), Faculté des Sciences, Université Abou Bakr Belkaïd de Tlemcen, Algérie
| | - F Belmokhtar
- Department of Ecology and Environment, Université Abou Bakr Belkaïd de Tlemcen, Algérie
| | - R Belmokhtar
- Department of Ecology and Environment, Université Abou Bakr Belkaïd de Tlemcen, Algérie
| | - F Boazza
- Laboratoire d'Anthropologie des Religions et comparaison, Faculté des Sciences Humaines et Sociales, Université Abou Bakr Belkaïd de Tlemcen, Algérie
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Allele frequency of ABO blood group antigen and the risk of esophageal cancer. BIOMED RESEARCH INTERNATIONAL 2014; 2014:286810. [PMID: 25054136 PMCID: PMC4089147 DOI: 10.1155/2014/286810] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 04/09/2014] [Revised: 06/05/2014] [Accepted: 06/07/2014] [Indexed: 11/17/2022]
Abstract
BACKGROUND ABO blood group and risk of squamous cell carcinoma of esophagus have been reported by many studies, but there is no discipline that had provided association with the genotype and gene frequency by population statics. METHODS We conducted a case-control study on 480 patients with squamous cell carcinoma of the esophagus and 480 noncancer patients. ABO blood group was determined by presence of antigen with the help of monoclonal antibody. Chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were calculated by statistical methods, and gene frequencies were calculated by Hardy-Weinberg model. RESULTS We observed significant associations between ABO genotype and squamous cell carcinoma of esophagus. OR (95% CIs) was 1.69 (1.31-2.19) for presence of B antigen allele relative to its absence (P < 0.0001); in female subgroup OR (95% CIs) observed at 1.84 (1.27-2.65) was statistically significant (P = 0.001). SCC of esophagus shows significant difference in comparison to general population; blood group B is found to be higher in incidence (P = 0.0001). Increased risk of cancer was observed with absence of Rh antigen (P = 0.0001). Relatively increased gene frequency of q[B] allele is observed more significantly in female cancer patients (P = 0.003). CONCLUSION Statistically significant association between squamous cell carcinoma of the esophagus and ABO and Rh genotype is identified by this study. Sex and anatomical site of cancer also present with statistically significant relative association. However, larger randomised trials are required to establish the hypothesis.
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A relationship between ABO blood groups and clinicopathologic characteristics of patients with gastric adenocarcinoma in China. Med Oncol 2010; 28 Suppl 1:S268-73. [PMID: 21053099 DOI: 10.1007/s12032-010-9735-5] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/17/2010] [Accepted: 10/22/2010] [Indexed: 01/30/2023]
Abstract
Little is known about the relationship between ABO blood groups and the clinicopathologic features in gastric adenocarcinoma patients of China. Whether the distribution of ABO blood groups in patients with gastric adenocarcinoma differs from that with benign diseases is also unknown. A total of 474 gastric adenocarcinoma patients and 404 with benign diseases were enrolled for the study. The relationship between patients' ABO blood groups and the clinicopathologic features was analyzed. The percentage of blood group AB was more common in men of gastric cancer than in benign diseases. The proportion of angiolymphatic invasion among patients with blood group O was significantly lower than those with other blood groups (P = 0.034). Proportion of tumors associated with estrogen receptor (ER), progestogen receptor (PR) and carcinoembryonic antigen (CEA) expression in blood type A was significantly higher than in other blood types (P = 0.002 for ER expression, 0.009 for PR expression, 0.003 for CEA expression). Proportion of tumors associated with serum CEA and CA19-9 elevation in blood type AB was significantly lower than in other blood types (P < 0.001 for serum CEA elevation, 0.005 for CA19-9 elevation). Though there was no significant difference between ABO blood groups and survival of the patients, patients with blood group B had a trend to show superiority in the survival. The significance of ABO blood group distribution might be associated with biological behavior of gastric adenocarcinoma patients. However, it was found not to be a prognosis factor for patients with gastric adenocarcinoma.
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Preece AF, Strahan KM, Devitt J, Yamamoto FI, Gustafsson K. Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement. Blood 2002; 99:2477-82. [PMID: 11895782 DOI: 10.1182/blood.v99.7.2477] [Citation(s) in RCA: 51] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/20/2022] Open
Abstract
No definitive biologic function has been associated with the human ABO histo-blood group polymorphism, or any other terminal carbohydrate differences within or between closely related species. We have experimentally addressed the question of whether viral particles can become glycosylated as determined by the glycosylation (eg, ABO) status of the producer cell and as a result be affected by human serum containing specific natural antibodies (NAbs). Measles virus was produced in cells transfected with cDNA encoding, either human A-transferase, B-transferase, an inactive "O-transferase," or a pig alpha1-3galactosyltransferase (alpha1-3GT) synthesizing the Galalpha1-3Gal structure. The viruses were shown to carry the same ABO structures as the cells; that is, A but not B if produced in A-type cells, and B but not A if produced in B-type cells. Only O was detected on the virus produced from O-type cells, whereas reduced amounts of O appeared on the A- and B-type viral particles. In addition, the Galalpha1-3Gal structure was transferred onto measles only when grown in human cells expressing this structure. When subjected to human preimmune sera, the A-type, the B-type, and the Galalpha1-3Gal viral particles were partially neutralized in a complement-dependent manner. However, the O-type or the Galalpha1-3Gal-negative viral particles were not neutralized. The neutralization appeared to be mediated by specific NAb, as judged by specific inhibition using synthetic A and Galalpha1-3Gal oligosaccharides. Such viral glycosylation may thus partly explain why the ABO antigens and other similar intraspecies as well as interspecies polymorphic carbohydrates have evolved and been maintained over long evolutionary periods.
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Affiliation(s)
- Andrew F Preece
- Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
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Su M, Lu SM, Tian DP, Zhao H, Li XY, Li DR, Zheng ZC. Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China. World J Gastroenterol 2001; 7:657-61. [PMID: 11819849 PMCID: PMC4695569 DOI: 10.3748/wjg.v7.i5.657] [Citation(s) in RCA: 50] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/31/2001] [Revised: 07/06/2001] [Accepted: 07/18/2001] [Indexed: 02/06/2023] Open
Abstract
AIM To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago. METHODS Data on age, sex, ABO blood type and X-ray or pathological diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 patients with esophageal carcinoma (EC) and 2955 patients with cardiac cancer (CC) in Chaoshan district were retrospectively assessed for their association with ABO blood groups. RESULTS The distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B O was 1.1415 (P<0.05) and 1.2696 (P<0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation. CONCLUSION ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distribution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.
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Affiliation(s)
- M Su
- Department of Pathology, Shantou University Medical College, Shantou 515031,China.
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Abstract
Recent developments in DNA-based techniques may revolutionize the study of human behavioral genetics. However, unless these methods are used with great care, many of the same mistakes which have plagued non-molecular genetic analyses of behavior will reoccur. Errors in the application of genetic approaches and in the interpretation of results have been a common feature of published studies in this field. We review studies in human behavioral genetics, focusing on those using identical twins and DNA-based linkage techniques in order to draw attention to recurrent problems in molecular and non-molecular studies. We suggest possible guidelines for future research in the area of the biological basis of human behavior.
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Affiliation(s)
- P R Billings
- Department of Medicine, Harvard Medical School, Boston, MA 02115
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Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischaemic heart disease in British men. BMJ (CLINICAL RESEARCH ED.) 1990; 300:1679-82. [PMID: 2390546 PMCID: PMC1663328 DOI: 10.1136/bmj.300.6741.1679] [Citation(s) in RCA: 82] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]
Abstract
OBJECTIVE To establish whether ABO blood group is related to ischaemic heart disease on an individual and geographic basis in Britain. DESIGN Prospective study of 7662 men with known ABO blood group selected from age-sex registers in general practices in 24 British towns. MEASUREMENTS ABO blood group, standard cardiovascular risk factors, social class, and presence or absence of ischaemic heart disease determined at entry to study. END POINTS Eight year follow up of fatal and nonfatal ischaemic heart disease events achieved for 99% of study population. RESULTS Towns with a higher prevalence of blood group O had higher incidences of ischaemic heart disease. In individual subjects, however, the incidence of ischaemic heart disease was higher in those with group A than in those with other blood groups (relative risk 1.21, 95% confidence limits 1.01 to 1.46). Total serum cholesterol concentration was slightly higher in subjects of blood group A. No other cardiovascular risk factor (including social class) was related to blood group. CONCLUSIONS Blood group A is related to the incidence of ischaemic heart disease in individual subjects. Geographic differences in the distribution of ABO blood groups do not explain geographic variation in rates of ischaemic heart disease in Britain. The findings do not support the view that ABO blood group and social class are related.
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Affiliation(s)
- P H Whincup
- Department of Public Health and Primary Care, Royal Free Hospital, School of Medicine, London
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Kelleher C, Cooper J, Sadlier D. ABO blood group and social class: a prospective study in a regional blood bank. J Epidemiol Community Health 1990; 44:59-61. [PMID: 2348151 PMCID: PMC1060599 DOI: 10.1136/jech.44.1.59] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]
Abstract
STUDY OBJECTIVE The aim of the study was to investigate an association previously reported in a retrospective study between the A phenotype and social classes I and II. DESIGN The study was a prospective survey using a cohort of blood donors. SETTING Participants were donors at a regional blood bank in southern Ireland servicing a population of approximately 380,000. PARTICIPANTS Of 2442 donors considered for inclusion in the study, 21 refused to participate, 33 provided insufficient information, and 184 were excluded because they were not wholly of Irish extraction, leaving a total of 2204 subjects, 64% of whom were male. MEASUREMENT AND RESULTS Occupation, age and birth place were obtained from a short questionnaire given to all potential donors during the study period. Social class was defined according to the United Kingdom Registrar General's criteria. No association between the ABO phenotype and social class could be found, either on the whole sample, or on currently employed persons, or on separate analysis of the sexes. CONCLUSIONS The balance of current evidence is against a variation in ABO distribution by social class designation.
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Affiliation(s)
- C Kelleher
- MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, United Kingdom
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Chalmers I. Short, Black, Baird, Himsworth, and social class differences in fetal and neonatal mortality rates. BRITISH MEDICAL JOURNAL 1985; 291:231-3. [PMID: 3926132 PMCID: PMC1416870 DOI: 10.1136/bmj.291.6490.231] [Citation(s) in RCA: 17] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/08/2023]
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Mitchell JR. What constitutes evidence on the dietary prevention of coronary heart disease? Cosy beliefs or harsh facts? Int J Cardiol 1984; 5:287-98. [PMID: 6706436 DOI: 10.1016/0167-5273(84)90106-2] [Citation(s) in RCA: 13] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/21/2023]
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Benbow CP, Benbow RM. Biological correlates of high mathematical reasoning ability. PROGRESS IN BRAIN RESEARCH 1984; 61:469-90. [PMID: 6396712 DOI: 10.1016/s0079-6123(08)64455-6] [Citation(s) in RCA: 26] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/20/2023]
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