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For: Mortensen A, Skibsted LH, Sampson J, Rice-Evans C, Everett SA. Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants. FEBS Lett 1997;418:91-7. [PMID: 9414102 DOI: 10.1016/s0014-5793(97)01355-0] [Citation(s) in RCA: 182] [Impact Index Per Article: 6.5] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/05/2023]

For:	Mortensen A, Skibsted LH, Sampson J, Rice-Evans C, Everett SA. Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants. FEBS Lett 1997;418:91-7. [PMID: 9414102 DOI: 10.1016/s0014-5793(97)01355-0] [Citation(s) in RCA: 182] [Impact Index Per Article: 6.5] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/05/2023]

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Cited by Other Article(s)

Bharadwaj VG, Mb T, Hv A, Ca A, R S, Cp P, Mv J, Eranimose B, Reddy PA. Beneficial Effects of a Lutein-Zeaxanthin Complex on Macular Pigment Optical Density Levels of Healthy Individuals With Prolonged Screen Time. Cureus 2025;17:e79481. [PMID: 40135032 PMCID: PMC11933726 DOI: 10.7759/cureus.79481] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 02/20/2025] [Indexed: 03/27/2025] Open

Abstract

Introduction Macular pigment (MP), consisting of lutein (L) and zeaxanthin (Z), is believed to provide retinal protection against photo-oxidative damage. The objective of the study was to evaluate the effect of lutein and zeaxanthin complex 5:1 (extracted from marigold flowers) supplementation on macular pigment optical density (MPOD), contrast sensitivity, and quality of sleep in healthy subjects who exposed themselves to an electronic gadget screen for a minimum of 8 hours every day. This study also aimed to assess the long-term safety of the supplement by administering it for 8 months in one of the groups. The study also assessed the retention effects of lutein and zeaxanthin on MPOD after discontinuation of supplementation. Methods The study was registered with the Clinical Trial Registry of India (CTRI/2022/12/048392). Subjects were screened as per the defined inclusion and exclusion criteria. Subjects aged 18-55 years with a screen time of at least 8 hours daily and MPOD values below 0.8 were recruited. The study, conducted at Narayana Nethralaya Super Specialty Eye Hospital, Bangalore, spanned from December 2022 to May 2024. This was a randomized, placebo-controlled, crossover study. Of the 96 volunteers screened for this study, 71 were recruited, and 60 completed the study. Subjects were divided into 3 groups, viz. A, B, and C. Group A received lutein 10mg and zeaxanthin 2mg twice daily for the first four months, had a wash-off period of 15 days, and continued with the same supplementation for the remaining four months. Group B received lutein 10mg and zeaxanthin 2mg twice daily for the first four months, had a wash-off period of 15 days, and then switched over to a placebo for the next four months. Group C received a Placebo for the first 4 months, had a wash-off period of 15 days, and then switched over to lutein 10mg and zeaxanthin 2mg for the next four months. All the subjects were given either, lutein and zeaxanthin complex-5:1 or placebo capsules as per the randomization chart prepared computationally. Subjects were analyzed for their MPOD values, contrast sensitivity scores, and quality of sleep. Intraocular pressure, retinal thickness, renal function tests, and liver function tests were conducted during visits to ensure clinical safety. Results After supplementation with the lutein-zeaxanthin complex-5:1, the average MPOD (at 1ᴏ eccentricity) increased significantly. At the first visit, the mean MPOD for Groups A, B, and C were 0.3, 0.22, and 0.29 (right eye) and 0.31, 0.27, and 0.27 (left eye), respectively. At the second visit, these values were 0.61, 0.66, and 0.21 (right eye) and 0.54, 0.53, and 0.2 (left eye). By the third visit, the mean MPOD values were 0.7, 0.65, and 0.38 (right eye) and 0.66, 0.53, and 0.36 (left eye). Supplementation significantly improved MPOD, contrast sensitivity, and the quality of sleep compared to placebo. Conclusions The supplementation with lutein and zeaxanthin resulted in higher MPOD values as compared to that of the placebo. This intervention also led to improvement in contrast sensitivity and quality of sleep. Lutein and zeaxanthin complex-5:1 may be a promising remedial measure for increasing the MPOD of people exposed to prolonged screen time.

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Hernández-Ayala LF, Guzmán-López EG, Pérez-González A, Reina M, Galano A. Molecular Insights on Coffee Components as Chemical Antioxidants. J MEX CHEM SOC 2024;68:888-969. [DOI: 10.29356/jmcs.v68i4.2238] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/03/2025]

Abstract Coffee is not only a delicious beverage but also an important dietary source of natural antioxidants. We live in a world where it is impossible to avoid pollution, stress, food additives, radiation, and other sources of oxidants that eventually lead to severe health disorders. Fortunately, there are chemicals in our diet that counteract the hazards posed by the reactive species that trigger oxidative stress. They are usually referred to as antioxidants; some of them can be versatile compounds that exert such a role in many ways. This review summarizes, from a chemical point of view, the antioxidant effects of relevant molecules found in coffee. Their mechanisms of action, trends in activity, and the influence of media and pH in aqueous solutions, are analyzed. Structure-activity relationships are discussed, and the protective roles of these compounds are examined. A particular section is devoted to derivatives of some coffee components, and another one to their bioactivity. The data used in the analysis come from theoretical and computational protocols, which have been proven to be very useful in this context. Hopefully, the information provided here will pro-mote further investigations into the amazing chemistry contained in our morning coffee cup. Resumen. El café no solo es una bebida deliciosa, sino también una importante fuente dietética de antioxidantes naturales. Vivimos en un mundo donde es imposible evitar la contaminación, el estrés, los aditivos alimentarios, la radiación y otras fuentes de oxidantes que eventualmente conducen a trastornos de salud graves. Afortunadamente, existen sustancias químicas en nuestra dieta que contrarrestan los peligros planteados por las especies reactivas que desencadenan el estrés oxidativo. Por lo general, se les denomina antioxidantes; algunos de ellos pueden ser compuestos versátiles que ejercen dicho papel de muchas maneras. Este artículo de revisión resume, desde un punto de vista químico, los efectos antioxidantes de moléculas relevantes encontradas en el café. Se analizan sus mecanismos de acción, tendencias en la actividad y la influencia del medio y el pH en soluciones acuosas. Se discuten las relaciones estructura-actividad, y se examinan los roles protectores de estos compuestos. Se dedica una sección particular a los derivados de algunos componentes del café, y otra a su bioactividad. Los datos utilizados en el análisis provienen de protocolos teóricos y computacionales, que han demostrado ser muy útiles en este contexto. Se espera que la información proporcionada aquí promueva investigaciones futuras sobre la química contenida en nuestra taza de café matutina. Collapse

Mashayekhi-Sardoo H, Rezaee R, Riahi-Zanjani B, Karimi G. Alleviation of microcystin-leucine arginine -induced hepatotoxicity: An updated overview. Toxicon 2024;243:107715. [PMID: 38636613 DOI: 10.1016/j.toxicon.2024.107715] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/15/2023] [Revised: 04/04/2024] [Accepted: 04/09/2024] [Indexed: 04/20/2024]

Obana A, Ote K, Gohto Y, Yamada H, Hashimoto F, Okazaki S, Asaoka R. Deep learning-based correction of cataract-induced influence on macular pigment optical density measurement by autofluorescence spectroscopy. PLoS One 2024;19:e0298132. [PMID: 38349916 PMCID: PMC10863874 DOI: 10.1371/journal.pone.0298132] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/02/2023] [Accepted: 01/19/2024] [Indexed: 02/15/2024] Open

Arbuscular Mycorrhizal Fungi Enhance Biomass Growth, Mineral Content, and Antioxidant Activity in Tomato Plants under Drought Stress. J FOOD QUALITY 2023. [DOI: 10.1155/2023/2581608] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/09/2023] Open

Abstract Arbuscular mycorrhizal fungi (AMF) are symbiotically associated with crops. They increase biomass production, nutritional elements, and antioxidant activities in food and vegetable crops grown in soil under stress conditions. The present study focused on the effects of AMF (Acaulospora morrowiae, Paraglomus occultum, Funneliformis mosseae, Rhizophagus clarus, and Rhizophagus intraradices) on biomass growth and yield, contents of chlorophyll and carotenoids, activities of catalase (CAT) and ascorbate peroxidase (APX), and contents of hydrogen peroxide (H2O2), malondialdehyde (MDA), and minerals (Na, K, Ca, Mg, and Fe) in Unnayan, LT896, and Minto super tomato (Solanum lycopersicum L.) varieties grown in soil under drought stress (<10% moisture). The results showed that root length and shoot mass in plants treated with R. clarus and P. occultum were significantly higher than those of the control (non-AMF) in Minto super tomato. Compared to the control, the shoot’s dry weight and yield were enhanced by 28% and 20% with AMF-treated tomatoes. The CAT activity in P. occultum-treated plants was statistically higher than that of the control in Unnayan tomatoes. H2O2 content was detected higher in the control than R. clarus-treated LT896 tomatoes. In plants treated with A. morrowiae and R. clarus, APX activity was significantly higher than that of the control in the Unnayan tomatoes. CAT and APX activity increased by 42% and 66% in AMF-treated leaves of tomatoes compared to non-AMF. Treatment with AMF reduced the content of MDA and H2O2 (ROS) in the leaves of tomato plants by 50% and 2% compared to the control, respectively. Potassium (K), calcium (Ca), magnesium (Mg), and iron (Fe) of tomato fruits increased by 2%, 13%, 24%, and 37% with AMF treatment compared to the control. These results suggested that biomass growth, yield, photosynthetic pigments, antioxidant enzyme activity, and mineral contents could be enhanced by AMF in food crops grown under drought stress. It is concluded that AMF might be used for the development of AMF-enriched biofertilizers that will improve the nutritional quality of food crops grown under stress conditions. Collapse

Wang Y, Lu J, Qu H, Cai C, Liu H, Chu J. β-Carotene extracted from Blakeslea trispora attenuates oxidative stress, inflammatory, hepatic injury and immune damage induced by copper sulfate in zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol 2022;258:109366. [PMID: 35533964 DOI: 10.1016/j.cbpc.2022.109366] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/20/2022] [Revised: 04/12/2022] [Accepted: 05/04/2022] [Indexed: 11/29/2022]

di Masi A, Sessa RL, Cerrato Y, Pastore G, Guantario B, Ambra R, Di Gioacchino M, Sodo A, Verri M, Crucitti P, Longo F, Naciu AM, Palermo A, Taffon C, Acconcia F, Bianchi F, Ascenzi P, Ricci MA, Crescenzi A. Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma. Antioxidants (Basel) 2022;11:antiox11081463. [PMID: 36009182 PMCID: PMC9405418 DOI: 10.3390/antiox11081463] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/18/2022] [Revised: 07/12/2022] [Accepted: 07/20/2022] [Indexed: 02/01/2023] Open

Abstract

Among the thyroid cancers, papillary thyroid cancer (PTC) accounts for 90% of the cases. In addition to the necessity to identify new targets for PTC treatment, early diagnosis and management are highly demanded. Previous data indicated that the multivariate statistical analysis of the Raman spectra allows the discrimination of healthy tissues from PTC ones; this is characterized by bands typical of carotenoids. Here, we dissected the molecular effects of carotenoid accumulation in PTC patients by analyzing whether they were required to provide increased retinoic acid (RA) synthesis and signaling and/or to sustain antioxidant functions. HPLC analysis revealed the lack of a significant difference in the overall content of carotenoids. For this reason, we wondered whether the carotenoid accumulation in PTC patients could be related to vitamin A derivative retinoic acid (RA) biosynthesis and, consequently, the RA-related pathway activation. The transcriptomic analysis performed using a dedicated PCR array revealed a significant downregulation of RA-related pathways in PTCs, suggesting that the carotenoid accumulation in PTC could be related to a lower metabolic conversion into RA compared to that of healthy tissues. In addition, the gene expression profile of 474 PTC cases previously published in the framework of the Cancer Genome Atlas (TGCA) project was examined by hierarchical clustering and heatmap analyses. This metanalysis study indicated that the RA-related pathways resulted in being significantly downregulated in PTCs and being associated with the follicular variant of PTC (FV-PTC). To assess whether the possible fate of the carotenoids accumulated in PTCs is associated with the oxidative stress response, the expression of enzymes involved in ROS scavenging was checked. An increased oxidative stress status and a reduced antioxidant defense response were observed in PTCs compared to matched healthy thyroids; this was possibly associated with the prooxidant effects of high levels of carotenoids. Finally, the DepMap datasets were used to profile the levels of 225 metabolites in 12 thyroid cancer cell lines. The results obtained suggested that the high carotenoid content in PTCs correlates with tryptophan metabolism. This pilot provided novel possible markers and possible therapeutic targets for PTC diagnosis and therapy. For the future, a larger study including a higher number of PTC patients will be necessary to further validate the molecular data reported here.

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Affiliation(s)

Alessandra di Masi Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.) Correspondence: ; Tel.: +39-06-57336363
Rosario Luigi Sessa Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Ylenia Cerrato Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Gianni Pastore CREA (Council for Agricultural Research and Economics), Research Centre for Food and Nutrition, 00178 Rome, Italy; (G.P.); (B.G.); (R.A.)
Barbara Guantario CREA (Council for Agricultural Research and Economics), Research Centre for Food and Nutrition, 00178 Rome, Italy; (G.P.); (B.G.); (R.A.)
Roberto Ambra CREA (Council for Agricultural Research and Economics), Research Centre for Food and Nutrition, 00178 Rome, Italy; (G.P.); (B.G.); (R.A.)
Michael Di Gioacchino Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Armida Sodo Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Martina Verri Pathology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (M.V.); (C.T.); (A.C.)
Pierfilippo Crucitti Unit of Thoracic Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (P.C.); (F.L.)
Filippo Longo Unit of Thoracic Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (P.C.); (F.L.)
Anda Mihaela Naciu Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (A.M.N.); (A.P.)
Andrea Palermo Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (A.M.N.); (A.P.)
Chiara Taffon Pathology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (M.V.); (C.T.); (A.C.)
Filippo Acconcia Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Fabrizio Bianchi Cancer Biomarkers Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, FG, Italy;
Paolo Ascenzi Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Maria Antonietta Ricci Department of Sciences, Roma Tre University, 00146 Rome, Italy; (R.L.S.); (Y.C.); (M.D.G.); (A.S.); (F.A.); (P.A.); (M.A.R.)
Anna Crescenzi Pathology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy; (M.V.); (C.T.); (A.C.)

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Patil AD, Kasabe PJ, Dandge PB. Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin. NATURAL PRODUCTS AND BIOPROSPECTING 2022;12:25. [PMID: 35794254 PMCID: PMC9259778 DOI: 10.1007/s13659-022-00347-y] [Citation(s) in RCA: 40] [Impact Index Per Article: 13.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/31/2021] [Accepted: 05/09/2022] [Indexed: 05/31/2023]

Maswanna T, Maneeruttanarungroj C. Identification of major carotenoids from green alga Tetraspora sp. CU2551: partial purification and characterization of lutein, canthaxanthin, neochrome, and β-carotene. World J Microbiol Biotechnol 2022;38:129. [PMID: 35689122 DOI: 10.1007/s11274-022-03320-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/21/2022] [Accepted: 05/22/2022] [Indexed: 10/18/2022]

Lau TY, Kwan HY. Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer. Mar Drugs 2022;20:md20060370. [PMID: 35736173 PMCID: PMC9229252 DOI: 10.3390/md20060370] [Citation(s) in RCA: 17] [Impact Index Per Article: 5.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2022] [Revised: 05/18/2022] [Accepted: 05/24/2022] [Indexed: 12/04/2022] Open

Probing the Role of Cysteine Thiyl Radicals in Biology: Eminently Dangerous, Difficult to Scavenge. Antioxidants (Basel) 2022;11:antiox11050885. [PMID: 35624747 PMCID: PMC9137623 DOI: 10.3390/antiox11050885] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2022] [Revised: 04/21/2022] [Accepted: 04/23/2022] [Indexed: 11/17/2022] Open

Wang X, Zhang T, Chen X, Xu Y, Li Z, Yang Y, Du X, Jiang Z, Ni H. Simultaneous Inhibitory Effects of All-Trans Astaxanthin on Acetylcholinesterase and Oxidative Stress. Mar Drugs 2022;20:md20040247. [PMID: 35447920 PMCID: PMC9032561 DOI: 10.3390/md20040247] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/24/2022] [Revised: 03/26/2022] [Accepted: 03/30/2022] [Indexed: 02/04/2023] Open

Affiliation(s)

Xin Wang College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.)
Tao Zhang College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.)
Xiaochen Chen College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.)
Yating Xu College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.)
Zhipeng Li College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.) Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China Research Center of Food Biotechnology, Xiamen 361021, China Key Laboratory of Systemic Utilization and In-Depth Processing of Economic Seaweed, Xiamen Southern Ocean Technology Center of China, Xiamen 361021, China Correspondence: (Z.L.); (X.D.); Tel.: +86-13696920945 (X.D.)
Yuanfan Yang College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.) Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China Research Center of Food Biotechnology, Xiamen 361021, China Key Laboratory of Systemic Utilization and In-Depth Processing of Economic Seaweed, Xiamen Southern Ocean Technology Center of China, Xiamen 361021, China
Xiping Du College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.) Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China Research Center of Food Biotechnology, Xiamen 361021, China Key Laboratory of Systemic Utilization and In-Depth Processing of Economic Seaweed, Xiamen Southern Ocean Technology Center of China, Xiamen 361021, China Correspondence: (Z.L.); (X.D.); Tel.: +86-13696920945 (X.D.)
Zedong Jiang College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.) Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China Research Center of Food Biotechnology, Xiamen 361021, China Key Laboratory of Systemic Utilization and In-Depth Processing of Economic Seaweed, Xiamen Southern Ocean Technology Center of China, Xiamen 361021, China
Hui Ni College of Food and Biological Engineering, Jimei University, Xiamen 361021, China; (X.W.); (T.Z.); (X.C.); (Y.X.); (Y.Y.); (Z.J.); (H.N.) Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China Research Center of Food Biotechnology, Xiamen 361021, China Key Laboratory of Systemic Utilization and In-Depth Processing of Economic Seaweed, Xiamen Southern Ocean Technology Center of China, Xiamen 361021, China Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China

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Composition, cultivation and potential applications of Chlorella zofingiensis – A comprehensive review. ALGAL RES 2021. [DOI: 10.1016/j.algal.2021.102508] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022]

Lutein and Zeaxanthin Distribution in the Healthy Macula and Its Association with Various Demographic Factors Examined in Pseudophakic Eyes. Antioxidants (Basel) 2021;10:antiox10121857. [PMID: 34942960 PMCID: PMC8698861 DOI: 10.3390/antiox10121857] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/01/2021] [Revised: 11/18/2021] [Accepted: 11/19/2021] [Indexed: 02/06/2023] Open

Abstract

The macular pigment consisting of lutein (L) and zeaxanthin (Z) protects photoreceptors via its antioxidative and barrier activities. This study aimed to determine L and Z distribution in the healthy macula and their association with various demographic factors. Macular pigment optical density (MPOD) was measured using fundus autofluorescence spectroscopy in 352 pseudophakic eyes with no fundus diseases. Pseudophakia was chosen to avoid the influence of cataract in the measurement of fundus autofluorescence. The mean patient age was 72.3 ± 8.6 years. MPOD was analyzed separately in three zones, i.e., A: a central area within a radius of 0.5°, mainly containing Z; B: a ring area with radii from 0.5° to 1.3°, containing Z and L; C: a ring area with radii from 1.3° to 9°, containing L. Multivariate analyses were performed with MPOD as the dependent variable and sex, supplement intake, smoking habits, glaucoma, diabetes, age, body mass index (BMI), skin carotenoid levels, retinal thickness, retinal volume, axial length as the independent variables. The mean total MPOD volume within 9° eccentricity was 20,121 ± 6293. Age was positively associated with MPOD in all zones. Supplement and BMI were positively and negatively associated with MPOD in zones B and C. Smoking was negatively associated with MPOD in zone A. This study revealed the standard MP values of aged Japanese, which resulted to be higher than the previously reported values in other races. Age was found to have a positive association with MP values. L in the outer foveola was affected by BMI and supplements, but Z in the foveola was not. The amount of Z in the Müller cell cone may not be changed easily by factors such as hunger and satiety in the context of preservation of homeostasis in the human body, but tobacco had a negative effect on Z.

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Cao C, Sun S, Li J, Song C, Meng Q, Shi B, Shan A. Lycopene modulates lipid metabolism in rats and their offspring under a high-fat diet. Food Funct 2021;12:8960-8975. [PMID: 34378595 DOI: 10.1039/d1fo01039e] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2022]

Abstract

The purpose of this study was to investigate the effects of lycopene supplementation on lipid metabolism in rats and their offspring. The experiment was conducted on 60 female rats divided into four groups: normal diet, normal diet with 200 mg kg^-1 lycopene, high-fat diet, and high-fat diet with 200 mg kg^-1 lycopene. The plasma levels of TG, LDL-C, AST and ALT in female rats fed a high-fat diet were significantly increased (P < 0.05). Lycopene supplementation reduced the plasma TG, LEP and AST levels (P < 0.05). In addition, the activity of ACC and mRNA expression of SREBP1c, FAS, PPARγ, CPT1, HMGCR, ACC, PLIN1 and FATP1 in the liver were also increased after feeding a high-fat diet (P < 0.05), whereas the expression of HSL was decreased (P < 0.05). Lycopene increased the activity of HSL and the expression of ATGL in the liver (P < 0.05), and the activity of ACC and mRNA expression of HMGCR and ACC were decreased (P < 0.05). For the offspring, maternal feeding of a high-fat diet reduced the plasma HDL-C levels (P < 0.05), but lycopene supplementation reduced the plasma TC levels (P < 0.05). Maternal high-fat diet also decreased the activity of HSL and the expression of CD36, PLIN1 and FATP1 in the liver while increasing the expression of PPARγ (P < 0.05). Maternal lycopene supplementation decreased the activities of ACC and FAS in the liver and decreased the expression of PPARγ, ACC and PLIN1 (P < 0.05). Maternal feeding of a high-fat diet increased the level of oxidative stress in the liver, the level of blood lipids in plasma and the rate of lipid production in the liver of rats and their offspring. Maternal lycopene supplementation can reduce the level of oxidative stress in rats and their offspring, reduce the level of blood lipids in plasma, and also reduce the rate of lipid production in the liver of rats and offspring.

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Obana A, Ote K, Hashimoto F, Asaoka R, Gohto Y, Okazaki S, Yamada H. Correction for the Influence of Cataract on Macular Pigment Measurement by Autofluorescence Technique Using Deep Learning. Transl Vis Sci Technol 2021;10:18. [PMID: 34003903 PMCID: PMC7884288 DOI: 10.1167/tvst.10.2.18] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022] Open

Sun S, Cao C, Li J, Meng Q, Cheng B, Shi B, Shan A. Lycopene Modulates Placental Health and Fetal Development Under High-Fat Diet During Pregnancy of Rats. Mol Nutr Food Res 2021;65:e2001148. [PMID: 34018317 DOI: 10.1002/mnfr.202001148] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/03/2020] [Revised: 04/09/2021] [Indexed: 01/07/2023]

Jiang YW, Sun ZH, Tong WW, yang K, Guo KQ, Liu G, Pan A. Dietary Intake and Circulating Concentrations of Carotenoids and Risk of Type 2 Diabetes: A Dose-Response Meta-Analysis of Prospective Observational Studies. Adv Nutr 2021;12:1723-1733. [PMID: 33979433 PMCID: PMC8483954 DOI: 10.1093/advances/nmab048] [Citation(s) in RCA: 38] [Impact Index Per Article: 9.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/20/2020] [Revised: 02/20/2021] [Accepted: 03/31/2021] [Indexed: 01/04/2023] Open

Abstract

Previous meta-analysis studies have indicated inverse associations between some carotenoids and risks of metabolic syndrome, cardiovascular disease, cancer, and all-cause mortality. However, the results for associations between carotenoids and type 2 diabetes (T2D) remain inconsistent and no systematic assessment has been done on this topic. We conducted a systematic review and meta-analysis to examine the associations of dietary intakes and circulating concentrations of carotenoids with risk of T2D. We searched PubMed and Ovid Embase from database inception to July 2020. Prospective observational studies of carotenoids and T2D risk were included. Random-effects models were used to summarize the RRs and 95% CIs. Thirteen publications were included. Dietary intake of β-carotene was inversely associated with the risk of T2D, and the pooled RR comparing the highest with the lowest categories was 0.78 (95% CI: 0.70, 0.87; I2 = 13.7%; n = 6); inverse associations were also found for total carotenoids (n = 2), α-carotene (n = 4), and lutein/zeaxanthin (n = 4), with pooled RRs ranging from 0.80 to 0.91, whereas no significant associations were observed for β-cryptoxanthin and lycopene. Circulating concentration of β-carotene was associated with a lower risk of T2D, and the pooled RR comparing extreme categories was 0.60 (95% CI: 0.46, 0.78; I2 = 56.2%; n = 7); inverse associations were also found for total carotenoids (n = 3), lycopene (n = 4), and lutein (n = 2), with pooled RRs ranging from 0.63 to 0.85, whereas no significant association was found for circulating concentrations of α-carotene and zeaxanthin when comparing extreme categories. Dose-response analysis indicated that nonlinear relations were observed for circulating concentrations of α-carotene, β-carotene, lutein, and total carotenoids (all P-nonlinearity < 0.05), but not for other carotenoids or dietary exposures. In conclusion, higher dietary intakes and circulating concentrations of total carotenoids, especially β-carotene, were associated with a lower risk of T2D. More studies are needed to confirm the causality and explore the role of foods rich in carotenoids in prevention of T2D. This systematic review was registered at www.crd.york.ac.uk/prospero as CRD42020196616.

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Antiradical Activity of Beetroot (Beta vulgaris L.) Betalains. Molecules 2021;26:molecules26092439. [PMID: 33922131 PMCID: PMC8122748 DOI: 10.3390/molecules26092439] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2021] [Revised: 04/03/2021] [Accepted: 04/20/2021] [Indexed: 11/16/2022] Open

Obana A, Gohto Y, Asaoka R. Macular pigment changes after cataract surgery with yellow-tinted intraocular lens implantation. PLoS One 2021;16:e0248506. [PMID: 33764992 PMCID: PMC7993776 DOI: 10.1371/journal.pone.0248506] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2020] [Accepted: 02/26/2021] [Indexed: 11/21/2022] Open

Lin Q, Wu D, Singh H, Ye A. Improving solubility and stability of β-carotene by microencapsulation in soluble complexes formed with whey protein and OSA-modified starch. Food Chem 2021;352:129267. [PMID: 33691207 DOI: 10.1016/j.foodchem.2021.129267] [Citation(s) in RCA: 19] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/22/2020] [Revised: 01/28/2021] [Accepted: 01/30/2021] [Indexed: 11/29/2022]

Picciotti U, Massaro A, Galiano A, Garganese F. Cheese Fortification: Review and Possible Improvements. FOOD REVIEWS INTERNATIONAL 2021. [DOI: 10.1080/87559129.2021.1874411] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/12/2023]

Antiradical Properties of trans-2-(4-substituted-styryl)-thiophene. J Fluoresc 2020;31:51-61. [PMID: 33057974 DOI: 10.1007/s10895-020-02629-5] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2020] [Accepted: 10/05/2020] [Indexed: 11/27/2022]

Oberoi DPS, Singh TP, Sogi DS. In Vivo Bioavailability of Lycopene from Watermelon (Citrullus lanatus Thunb) Coloring. Nutr Cancer 2020;73:1365-1370. [PMID: 32752891 DOI: 10.1080/01635581.2020.1801773] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]

Structures of Astaxanthin and Their Consequences for Therapeutic Application. INTERNATIONAL JOURNAL OF FOOD SCIENCE 2020;2020:2156582. [PMID: 32775406 PMCID: PMC7391096 DOI: 10.1155/2020/2156582] [Citation(s) in RCA: 78] [Impact Index Per Article: 15.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 02/03/2020] [Revised: 06/24/2020] [Accepted: 06/29/2020] [Indexed: 12/20/2022]

Effect of an antioxidant supplement containing high dose lutein and zeaxanthin on macular pigment and skin carotenoid levels. Sci Rep 2020;10:10262. [PMID: 32581313 PMCID: PMC7314813 DOI: 10.1038/s41598-020-66962-2] [Citation(s) in RCA: 23] [Impact Index Per Article: 4.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/19/2020] [Accepted: 05/27/2020] [Indexed: 12/18/2022] Open

Association between dietary carotenoid intakes and hypertension in adults: National Health and Nutrition Examination Survey 2007-2014. J Hypertens 2020;37:2371-2379. [PMID: 31356404 DOI: 10.1097/hjh.0000000000002200] [Citation(s) in RCA: 34] [Impact Index Per Article: 6.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/20/2022]

Abstract

OBJECTIVE

Few epidemiological studies concentrated on dietary carotenoids and hypertension since new hypertension guideline released in 2017. Thus, this study was aimed to evaluate their association.

METHODS

Data from National Health and Nutrition Examination Survey (NHANES) 2007-2014 were used in this cross-sectional study. Dietary carotenoids data were obtained from 24-h dietary recall interviews. Hypertension was defined as SBP at least 130 mmHg or DBP at least 80 mmHg, taking antihypertensive medicine or self-report. Logistic regression models and restricted cubic spline models were applied to explore the associations between α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin, and total carotenoids from diet and supplements and hypertension. Total carotenoids showed significant reductive risk of hypertension at 100 μg/kg per day and over.

RESULTS

A total of 17 398 adults aged 20 years and over were identified. High dose of β-carotene, lycopene, lutein with zeaxanthin, and total carotenoids were significantly associated with decreased risk of hypertension in crude results. After multivariate-adjustment in model 2, the odds ratios (OR) with 95% confidence intervals (CI) of β-cryptoxanthin, lycopene, lutein with zeaxanthin and total carotenoids for hypertension were 0.79 (0.67-0.93), 0.85 (0.73-0.98), 0.69 (0.58-0.83), 0.73 (0.62-0.86) for the highest versus lowest quartile intakes, respectively. Dose-response analyses showed that all of the carotenoids were inversely associated with hypertension in a linear manner. Total carotenoids showed significant effect of lower risk of hypertension at 100 μg/kg per day.

CONCLUSION

Intakes of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin, and total carotenoids were inversely associated with hypertension in US adults. The intake of total carotenoids was suggested at least 100 μg/kg per day for general adult population.

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Abuzaytoun R, Budge S, Hansen LT, MacKinnon S. Modification of the Ferrous Oxidation‐Xylenol Orange Method for Determination of Peroxide Value in Highly Pigmented Sea Cucumber Viscera Lipid. J AM OIL CHEM SOC 2020. [DOI: 10.1002/aocs.12344] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/06/2022]

Faraone I, Sinisgalli C, Ostuni A, Armentano MF, Carmosino M, Milella L, Russo D, Labanca F, Khan H. Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review. Pharmacol Res 2020;155:104689. [PMID: 32057895 DOI: 10.1016/j.phrs.2020.104689] [Citation(s) in RCA: 92] [Impact Index Per Article: 18.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/28/2019] [Revised: 02/04/2020] [Accepted: 02/10/2020] [Indexed: 02/07/2023]

Singh AK, Patel PK, Choudhary K, Joshi J, Yadav D, Jin JO. Quercetin and Coumarin Inhibit Dipeptidyl Peptidase-IV and Exhibits Antioxidant Properties: In Silico, In Vitro, Ex Vivo. Biomolecules 2020;10:biom10020207. [PMID: 32023875 PMCID: PMC7072504 DOI: 10.3390/biom10020207] [Citation(s) in RCA: 39] [Impact Index Per Article: 7.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2019] [Revised: 01/28/2020] [Accepted: 01/29/2020] [Indexed: 02/02/2023] Open

Ba C, Fu Y, Niu F, Wang M, Jin B, Li Z, Chen G, Zhang H, Li X. Effects of environmental stresses on physiochemical stability of β-carotene in zein-carboxymethyl chitosan-tea polyphenols ternary delivery system. Food Chem 2019;311:125878. [PMID: 31771910 DOI: 10.1016/j.foodchem.2019.125878] [Citation(s) in RCA: 37] [Impact Index Per Article: 6.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/26/2019] [Revised: 11/03/2019] [Accepted: 11/07/2019] [Indexed: 11/26/2022]

Turkovic V, Prete M, Bregnhøj M, Inasaridze L, Volyniuk D, Obrezkov FA, Grazulevicius JV, Engmann S, Rubahn HG, Troshin PA, Ogilby PR, Madsen M. Biomimetic Approach to Inhibition of Photooxidation in Organic Solar Cells Using Beta-Carotene as an Additive. ACS APPLIED MATERIALS & INTERFACES 2019;11:41570-41579. [PMID: 31609582 PMCID: PMC7899186 DOI: 10.1021/acsami.9b13085] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/10/2023]

Liang X, Ma C, Yan X, Liu X, Liu F. Advances in research on bioactivity, metabolism, stability and delivery systems of lycopene. Trends Food Sci Technol 2019. [DOI: 10.1016/j.tifs.2019.08.019] [Citation(s) in RCA: 37] [Impact Index Per Article: 6.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/15/2022]

Mazumdar N, Novis PM, Visnovsky G, Gostomski P. Effect of culturing parameters on the vegetative growth of Haematococcus alpinus (strain lcr-cc-261f) and modeling of its growth kinetics. JOURNAL OF PHYCOLOGY 2019;55:1071-1081. [PMID: 31166612 DOI: 10.1111/jpy.12889] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/27/2018] [Accepted: 05/19/2019] [Indexed: 06/09/2023]

The antioxidant properties of canthaxanthin and its potential effects in the poultry eggs and on embryonic development of the chick. Part 1. WORLD POULTRY SCI J 2019. [DOI: 10.1017/s0043933912000578] [Citation(s) in RCA: 31] [Impact Index Per Article: 5.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/08/2022]

Elia AC, Prearo M, Dörr AJM, Pacini N, Magara G, Brizio P, Gasco L, Abete MC. Effects of astaxanthin and canthaxanthin on oxidative stress biomarkers in rainbow trout. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A 2019;82:760-768. [PMID: 31370749 DOI: 10.1080/15287394.2019.1648346] [Citation(s) in RCA: 22] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/29/2023]

Obana A, Gohto Y, Sasano H, Gellermann W, Sharifzadeh M, Seto T, Bernstein PS. Grade of Cataract and Its Influence on Measurement of Macular Pigment Optical Density Using Autofluorescence Imaging. Invest Ophthalmol Vis Sci 2019;59:3011-3019. [PMID: 30025122 PMCID: PMC5995481 DOI: 10.1167/iovs.17-23699] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/21/2023] Open

Kim D, Shi G, Kim Y, Koo S. Fast Assembly and High-Throughput Screening of Structure and Antioxidant Relationship of Carotenoids. Org Lett 2019;21:714-718. [PMID: 30648872 DOI: 10.1021/acs.orglett.8b03915] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]

Wang C, Qiao A, Fang X, Sun L, Gao P, Davis AR, Liu S, Luan F. Fine Mapping of Lycopene Content and Flesh Color Related Gene and Development of Molecular Marker-Assisted Selection for Flesh Color in Watermelon (Citrullus lanatus). FRONTIERS IN PLANT SCIENCE 2019;10:1240. [PMID: 31649702 PMCID: PMC6791925 DOI: 10.3389/fpls.2019.01240] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/14/2019] [Accepted: 09/05/2019] [Indexed: 05/06/2023]

Abstract

Lycopene content and flesh color are important traits determined by a network of carotenoid metabolic pathways in watermelon. Based on our previous study of genetic inheritance and initial mapping using F₂ populations of LSW-177 (red flesh) × cream of Saskatchewan (pale yellow flesh), red flesh color was controlled by one recessive gene regulating red and pale yellow pigmentation, and a candidate region related to lycopene content was detected spanning a 392,077-bp region on chromosome 4. To obtain a more precise result for further study, three genetic populations and a natural panel of 81 watermelon accessions with different flesh colors were used in this research. Herein, we narrowed the preliminary mapping region to 41,233 bp with the linkage map generated from F₂ populations of LSW-177 (red flesh) × cream of Saskatchewan (pale yellow flesh) with 1,202 individuals. Two candidate genes, Cla005011 and Cla005012, were found in the fine mapping region; therein Cla005011 was a key locus annotated as a lycopene β-cyclase gene. Phylogenetic tree analysis showed that Cla005011 was the closest relative gene in gourd. LSW-177 × PI 186490 (white flesh) and another BC₁ population derived from garden female (red flesh) × PI 186490 were generated to verify the accuracy of the red flesh candidate gene region. By analyzing the expression levels of candidate genes in different developmental stages of different color watermelon varieties, Cla005011 for the expression differences was not the main reason for the flesh color variation between COS and LSW-177. This indicated that the LCYB gene might regulate fruit color changes at the protein level. A new marker-assisted selection system to identify red and yellow flesh colors in watermelon was developed with flesh color-specific CAPS markers and tested in 81 watermelon accessions.

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Affiliation(s)

Chaonan Wang Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China
Aohan Qiao Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China
Xufeng Fang Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China
Lei Sun Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China
Peng Gao Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China
Angela R. Davis Woodland Research Station, Sakata Seed America, Inc.Woodland, CA, United States
Shi Liu Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China *Correspondence: Shi Liu, ; Feishi Luan,
Feishi Luan Key Laboratory of Biology and Genetic Improvement of Horticulture Crops (Northeast Region), Ministry of Agriculture, Northeast Agricultural University, Harbin, China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, China *Correspondence: Shi Liu, ; Feishi Luan,

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Imokawa G. The Xanthophyll Carotenoid Astaxanthin has Distinct Biological Effects to Prevent the Photoaging of the Skin Even by its Postirradiation Treatment. Photochem Photobiol 2018;95:490-500. [DOI: 10.1111/php.13039] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2018] [Accepted: 10/02/2018] [Indexed: 11/29/2022]

Li YC, Zhong G, Meng FB, Yu H, Liu DY, Peng LX. Konjac glucomannan octenyl succinate (KGOS) as an emulsifier for lipophilic bioactive nutrient encapsulation. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 2018;98:5742-5749. [PMID: 29766500 DOI: 10.1002/jsfa.9122] [Citation(s) in RCA: 15] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/19/2018] [Revised: 05/03/2018] [Accepted: 05/04/2018] [Indexed: 06/08/2023]

Selig MJ, Mehrad B, Zamani H, Kierulf A, Licker J, Abbaspourrad A. Distribution of oil solubilized β-carotene in stabilized locust bean gum powders for the delivery of orange colorant to food products. Food Hydrocoll 2018. [DOI: 10.1016/j.foodhyd.2018.05.027] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/18/2023]

Bergantin C, Maietti A, Tedeschi P, Font G, Manyes L, Marchetti N. HPLC-UV/Vis-APCI-MS/MS Determination of Major Carotenoids and Their Bioaccessibility from "Delica" (Cucurbita maxima) and "Violina" (Cucurbita moschata) Pumpkins as Food Traceability Markers. Molecules 2018;23:E2791. [PMID: 30373266 PMCID: PMC6278257 DOI: 10.3390/molecules23112791] [Citation(s) in RCA: 27] [Impact Index Per Article: 3.9] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/09/2018] [Revised: 10/23/2018] [Accepted: 10/24/2018] [Indexed: 11/16/2022] Open

Abstract

Carotenoids are a widespread group of fat-soluble pigments, and their major nutritional importance comes from their pro-vitamin A activity and their antioxidant capacity. In this study, two different pumpkin cultivars (Cucurbita maxima, also named `Delica' and Cucurbita moschata, also known as `Violina') from the southern Po Delta area were investigated in terms of carotenoid content and the influence of food processing on compositional changes and carotenoid bioaccessibility. Quali- and quantitative determination of carotenoids in sample extracts were performed on a C30 column by means of an online coupled HPLC-UV/Vis-APCI-MS/MS technique. The identification of separated compounds was tentatively achieved by merging (i) chromatographic data, (ii) UV-Vis spectra, and (iii) MS/MS fragmentation spectra. The chromatographic profiles for the two cultivars showed qualitative differences. Two major carotenoids were considered for quantification purposes and further investigations: lutein and β -carotene. Quantification of target carotenoids was performed with external calibration through analytical standards. The concentration of lutein and β -carotene was higher in C. maxima than in the other variety, C. moschata. Carotenoids are susceptible to degradation (isomerization and oxidation) during food processing (i.e., cooking), and the concentration of lutein and β -carotene were monitored in oven-cooked and steam-cooked pumpkins. The steam-cooking process was superior in terms of limiting carotenoid loss. A complete functional profile of pumpkins as a source of carotenoids was gained with the evaluation of their in vitro bioaccessibility and their bioavailability after intake during human digestion. Bioaccessibility of lutein and β -carotene were estimated by an in vitro static digestion model that involved salivary, gastric, and duodenal phases. Bioaccessibility values progressively increased from the salivary to the duodenal phase for both pumpkin varieties and cooking methods. Bioaccessibility of lutein was always lower than β -carotene for both cultivars and for both cooking methods. Bioaccessibility values for lutein and β -carotene changed from 1.93% to 2.34% vs. 4.94% and 8.83% in the salivary phase, from 2.7% to 4.63% vs. 7.83% and 15.60% in the gastric phase, and from 10.04% to 13.42% vs. 25.81% and 35.32% in the duodenal phase. For both target compounds, bioaccessibility in the duodenal phase was more than twice the gastric values, and it underlined that the type of cooking did not influence release from the initial matrix.

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Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity. Molecules 2018;23:molecules23102601. [PMID: 30314284 PMCID: PMC6222411 DOI: 10.3390/molecules23102601] [Citation(s) in RCA: 46] [Impact Index Per Article: 6.6] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2018] [Revised: 10/08/2018] [Accepted: 10/10/2018] [Indexed: 11/20/2022] Open

Marchetti N, Bonetti G, Brandolini V, Cavazzini A, Maietti A, Meca G, Mañes J. Stinging nettle (Urtica dioica L.) as a functional food additive in egg pasta: Enrichment and bioaccessibility of Lutein and β-carotene. J Funct Foods 2018. [DOI: 10.1016/j.jff.2018.05.062] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/19/2022] Open

Lu P, Gao X, Dong H, Liu Z, Secundo F, Xue C, Mao X. Identification of a Novel Esterase from Marine Environmental Genomic DNA Libraries and Its Application in Production of Free All- trans-Astaxanthin. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018;66:2812-2821. [PMID: 29468878 DOI: 10.1021/acs.jafc.7b06062] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/14/2023]

Obana A, Gellermann W, Gohto Y, Seto T, Sasano H, Tanito M, Okazaki S. Reliability of a two-wavelength autofluorescence technique by Heidelberg Spectralis to measure macular pigment optical density in Asian subjects. Exp Eye Res 2018;168:100-106. [DOI: 10.1016/j.exer.2017.12.015] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2017] [Revised: 11/09/2017] [Accepted: 12/28/2017] [Indexed: 01/28/2023]

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017;2017:1956104. [PMID: 29104724 PMCID: PMC5637851 DOI: 10.1155/2017/1956104] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/02/2017] [Revised: 06/14/2017] [Accepted: 07/25/2017] [Indexed: 12/19/2022]

Sellimi S, Ksouda G, Benslima A, Nasri R, Rinaudo M, Nasri M, Hajji M. Enhancing colour and oxidative stabilities of reduced-nitrite turkey meat sausages during refrigerated storage using fucoxanthin purified from the Tunisian seaweed Cystoseira barbata. Food Chem Toxicol 2017;107:620-629. [PMID: 28389351 DOI: 10.1016/j.fct.2017.04.001] [Citation(s) in RCA: 30] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/04/2017] [Revised: 03/31/2017] [Accepted: 04/02/2017] [Indexed: 01/31/2023]

Mukai K, Yoshimoto M, Ishikura M, Nagaoka SI. Kinetic Study of the Aroxyl-Radical-Scavenging Activity of Five Fatty Acid Esters and Six Carotenoids in Toluene Solution: Structure-Activity Relationship for the Hydrogen Abstraction Reaction. J Phys Chem B 2017;121:7593-7601. [PMID: 28737395 DOI: 10.1021/acs.jpcb.7b04570] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]