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Maiolini TCS, Nicácio KDJ, Rosa W, Miranda DDO, Santos MFC, Bueno PCP, Lago JHG, Sartorelli P, Dias DF, Chagas de Paula DA, Soares MG. Potential anti-inflammatory biomarkers from Myrtaceae essential oils revealed by untargeted metabolomics. Nat Prod Res 2025; 39:985-992. [PMID: 38006221 DOI: 10.1080/14786419.2023.2283758] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/03/2023] [Revised: 10/21/2023] [Accepted: 11/06/2023] [Indexed: 11/26/2023]
Abstract
Many species from Myrtaceae have traditionally been used in traditional medicine as anti-inflammatory, antimicrobial, antidiarrheal, antioxidant and antirheumatic, besides in blood cholesterol reduction. In the present work, the anti-inflammatory activity of essential oils from eighteen Myrtaceae spp. were evaluated according to their ex-vivo anti-inflammatory activity in human blood, and the corresponding biomarkers were determined using untargeted metabolomics data and multivariate data analysis. From these studied species, six displayed anti-inflammatory activity with percentage rates of inhibition of PGE2 release above 70%. Caryophyllene oxide (1), humulene epoxide II (2), β-selinene (3), α-amorphene (4), α-selinene (5), germacrene A (6), β-bisabolene (7), α-muurolene (8), α-humulene (9), β-gurjunene (10), myrcene (11), β-elemene (12), α-cadinol (13), α-copaene (14), E-nerolidol (15) and ledol (16) were annotated as potential anti-inflammatory biomarkers. The results obtained in this study point to essential oils from species of the Myrtaceae family as a rich source of anti-inflammatory agents.
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Affiliation(s)
| | | | - Welton Rosa
- Chemistry Institute, Federal University of Alfenas, Alfenas, Brazil
| | | | - Mario Ferreira Conceição Santos
- Department of Chemistry and Physics, Center for Exact, Natural and Health Sciences, Federal University of Espírito Santo, Alegre, Brazil
| | - Paula Carolina Pires Bueno
- Leibniz Institute of Vegetable and Ornamental Crops, Department of Plant Biotic Interactions, Grossbeeren, Germany
| | | | - Patricia Sartorelli
- Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, Brazil
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Sereno AB, Pinto CD, Gibbert L, de Andrade MTP, da Silva MAB, Etgeton SAP, Miguel OG, Dias JDFG, Krüger CCH, de Messias Reason IJ. Cytotoxic and Phytotoxic Activities of Native Brazilian Forest Gabiroba ( Campomanesia xanthocarpa Berg.), Fruits, and Flour against Shrimp ( Artemia salina L.) and Lettuce ( Lactuca sativa L.). Foods 2023; 13:123. [PMID: 38201151 PMCID: PMC10779049 DOI: 10.3390/foods13010123] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/25/2023] [Revised: 12/15/2023] [Accepted: 12/21/2023] [Indexed: 01/12/2024] Open
Abstract
Gabiroba, a native fruit in Brazil's Atlantic Forest region, has significant nutritional and therapeutic properties. However, due to its seasonality, consumption by the population is limited. Thus, the development of gabiroba byproducts would add significant value to the food and therapeutic industries. Therefore, it is essential to study and support the lack of toxicity of gabiroba fruit extracts. In the present study, physicochemical analyses of fresh fruits (GF) and dehydrated whole gabiroba flour (WGF) and preliminary toxicity analyses of WGF were performed. The toxicity results showed a microcrustacean LC50 of >1000 mg/mL when exposed to WGF extracts at various concentrations (10-1000 μg/mL; p = 0.062) using the Artemia salina method, with no evidence observed of proliferative activity or toxic metabolic compounds in the WGF extract. The phytotoxicity of WGF using Lactuca sativa L. allowed germination and root growth at various concentrations of WGF extract, with the lowest (100 μg/mL) and highest (1000 μg/mL) concentrations exhibiting 98.3% and 100% seed germination, respectively. In conclusion, these results indicate that the WGF preparation preserved the nutritional and antioxidant potential of gabiroba fruits and that WGF is safe for use as a raw material in the food industry and for therapeutic purposes.
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Affiliation(s)
- Aiane Benevide Sereno
- Graduate Program in Internal Medicine, and Health Sciences, Federal University of Paraná (UFPR), R. Padre Camargo, 280, Curitiba 80.069-900, Paraná, Brazil; (C.D.P.); (M.A.B.d.S.); (I.J.d.M.R.)
| | - Carla Dayane Pinto
- Graduate Program in Internal Medicine, and Health Sciences, Federal University of Paraná (UFPR), R. Padre Camargo, 280, Curitiba 80.069-900, Paraná, Brazil; (C.D.P.); (M.A.B.d.S.); (I.J.d.M.R.)
| | - Luciana Gibbert
- Graduate Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Av. Lothário Meissner, 632, Curitiba 80.210-170, Paraná, Brazil; (L.G.); (M.T.P.d.A.); (O.G.M.)
| | - Marina Talamini Piltz de Andrade
- Graduate Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Av. Lothário Meissner, 632, Curitiba 80.210-170, Paraná, Brazil; (L.G.); (M.T.P.d.A.); (O.G.M.)
| | - Michelli Aparecida Bertolazo da Silva
- Graduate Program in Internal Medicine, and Health Sciences, Federal University of Paraná (UFPR), R. Padre Camargo, 280, Curitiba 80.069-900, Paraná, Brazil; (C.D.P.); (M.A.B.d.S.); (I.J.d.M.R.)
| | - Schaina Andriela Pontarollo Etgeton
- Graduate Program in Food, and Nutrition, Federal University of Paraná (UFPR), Av. Lothário Meissner, 632, Curitiba 80.210-170, Paraná, Brazil;
| | - Obdulio Gomes Miguel
- Graduate Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Av. Lothário Meissner, 632, Curitiba 80.210-170, Paraná, Brazil; (L.G.); (M.T.P.d.A.); (O.G.M.)
| | - Josiane de Fátima Gaspari Dias
- Graduate Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Av. Lothário Meissner, 632, Curitiba 80.210-170, Paraná, Brazil; (L.G.); (M.T.P.d.A.); (O.G.M.)
| | - Claudia Carneiro Hecke Krüger
- Department of Nutrition, Federal University of Paraná (UFPR), Av. Lothário Meissner, 632, Curitiba 80.210-170, Paraná, Brazil
| | - Iara José de Messias Reason
- Graduate Program in Internal Medicine, and Health Sciences, Federal University of Paraná (UFPR), R. Padre Camargo, 280, Curitiba 80.069-900, Paraná, Brazil; (C.D.P.); (M.A.B.d.S.); (I.J.d.M.R.)
- Department of Medical Pathology, Clinical Hospital, Federal University of Paraná (UFPR), R. Padre Camargo, 280, Curitiba 80.069-900, Paraná, Brazil
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Park RY, Lee H, Park K. Total synthesis of 2′,4′,6′‐trimethoxy‐3′,5′‐dimethylchalcone derivatives. B KOREAN CHEM SOC 2022. [DOI: 10.1002/bkcs.12515] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022]
Affiliation(s)
- Rae Yeon Park
- School of Chemical Engineering and Material Science Chung‐Ang University Seoul Republic of Korea
| | - Hana Lee
- School of Chemical Engineering and Material Science Chung‐Ang University Seoul Republic of Korea
| | - Kwangyong Park
- School of Chemical Engineering and Material Science Chung‐Ang University Seoul Republic of Korea
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Regginato A, Cunico L, Bertoncello K, Schindler MSZ, Chitolina R, Marins K, Zanatta AP, Calisto JF, Oliveira JV, Magro JD, Zanatta L. Antidiabetic and hypolipidemic potential of Campomanesia xanthocarpa seed extract obtained by supercritical CO2. BRAZ J BIOL 2021; 81:621-631. [DOI: 10.1590/1519-6984.227388] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/13/2019] [Accepted: 02/18/2020] [Indexed: 12/18/2022] Open
Abstract
Abstract Campomanesia xanthocarpa, a plant belonging to the Myrtaceae family, is popularly known as gabiroba. Leaves of gabiroba has been popularly used to treat various diseases, including inflammatory, renal, and digestive, among others. Additionally, studies have shown an effect to reduce blood cholesterol levels. The aim of this study was to evaluate the antihyperglycemic and hypolipidemic effects of Campomanesia xanthocarpa seed extract in hyperglycemic rats. The results showed that 400 mg/kg of seed extract was able to decrease blood glucose levels and to increase the muscular and hepatic glycogen content as well as to inhibit the sucrase and maltase activity. At doses of 200 mg/kg and 800 mg/kg, the activity of these enzymes was also reduced. In the lipid profile 400 mg/kg produced a decrease in total and LDL cholesterol serum levels; and with 200 mg/kg there was an increase in HDL cholesterol levels. The extract did not present hepatic and renal toxic effects at the different doses tested. The results suggest that the treatment with Campomanesia xanthocarpa seeds extract is useful in reducing glycemia, total cholesterol and LDL levels with potential adjuvant therapeutic in the treatment of diabetes and hypercholesterolemia, however, additional pharmacological and toxicological studies are still required.
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Affiliation(s)
- A. Regginato
- Universidade Comunitária da Região de Chapecó, Brasil
| | - L. Cunico
- Universidade Comunitária da Região de Chapecó, Brasil
| | | | | | - R. Chitolina
- Universidade Comunitária da Região de Chapecó, Brasil
| | - K. Marins
- Universidade Comunitária da Região de Chapecó, Brasil
| | - A. P. Zanatta
- Universidade Comunitária da Região de Chapecó, Brasil
| | - J. F. Calisto
- Universidade Comunitária da Região de Chapecó, Brasil
| | - J. V. Oliveira
- Universidade Comunitária da Região de Chapecó, Brasil; Universidade Federal de Santa Catarina, Brasil
| | - J. D. Magro
- Universidade Comunitária da Região de Chapecó, Brasil
| | - L. Zanatta
- Universidade Comunitária da Região de Chapecó, Brasil; Universidade Comunitária da Região de Chapecó, Brasil; Universidade do Estado de Santa Catarina, Brasil
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Sabrina Anzollin G, Zaki L, Perin TM, Finger B, Perin LT, Petry F, Sebulsqui Saraiva T, Lima da Costa Lopes ML, Betti AH, Scapinello J, Oliveira JV, Magro JD, Müller LG. Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system. J Tradit Complement Med 2021; 12:309-317. [PMID: 35747347 PMCID: PMC9209823 DOI: 10.1016/j.jtcme.2021.08.013] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/11/2020] [Revised: 08/19/2020] [Accepted: 08/29/2021] [Indexed: 11/07/2022] Open
Abstract
Background and aim Campomanesia xanthocarpa Berg. (Myrtaceae) present several pharmacological actions, but there are no reports on its antidepressant-like potential. This study investigated the antidepressant-like effect and mechanism of action of Campomanesia xanthocarpa seeds extract obtained from supercritical CO2 (40 °C, 250 bar). Experimental procedure Mice were orally treated with the extract 1 h before the TST. To investigate the involvement of the monoaminergic system in the antidepressant-like activity of the extract, pharmacological antagonists were administered prior to the acute oral administration of the extract (60 mg/kg). Also, the interaction of the extract with antidepressants was assessed in the tail suspension test (TST). The in vitro inhibitory potential of C. xanthocarpa seeds extract towards MAO A and MAO B enzymes was tested in vitro. Results and conclusion Animals treated with Campomanesia xanthocarpa seeds extract showed a significant reduction in the immobility time in the TST. Mice pretreatment with SCH23390, sulpiride, prazosin, yohimbine, and p-chlorophenylalanine prevented the anti-immobility effect of the extract in the TST. The combined administration of sub-effective doses of the extract with imipramine, bupropion and fluoxetine significantly reduced mice immobility time in the TST. The extract showed MAO A inhibitory activity (IC50 = 151.10 ± 5.75 μg/mL), which was greater than that toward MAO B (IC50 > 400 μg/mL). The extract of Campomanesia xanthocarpa seeds obtained by supercritical CO2 shows antidepressant-like activity, which relies on the activation of the monoaminergic neurotransmission (serotoninergic, dopaminergic and noradrenergic), suggesting that this species might represent a resource for developing new antidepressants.
C. xanthocarpa show antidepressant-like effect in mice tail suspension test. C. xanthocarpa potentiates the effect of antidepressants in tail suspension test. C. xanthocarpa mode of action involves the monoaminergic system.
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de Oliveira Raphaelli C, Pereira EDS, Camargo TM, Ribeiro JA, Pereira MC, Vinholes J, Dalmazo GO, Vizzotto M, Nora L. Biological activity and chemical composition of fruits, seeds and leaves of guabirobeira (Campomanesia xanthocarpa O. Berg – Myrtaceae): A review. FOOD BIOSCI 2021. [DOI: 10.1016/j.fbio.2021.100899] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]
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Anti-Inflammatory Effects of Campomanesia xanthocarpa Seed Extract Obtained from Supercritical CO 2. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021; 2021:6670544. [PMID: 33727941 PMCID: PMC7935572 DOI: 10.1155/2021/6670544] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 10/23/2020] [Revised: 02/04/2021] [Accepted: 02/11/2021] [Indexed: 11/17/2022]
Abstract
Campomanesia xanthocarpa is a plant species traditionally used in the treatment of diabetes, fever, hypercholesterolemia, obesity, and urinary tract diseases. The anti-inflammatory effects of C. xanthocarpa leaves in mice were already known. Nevertheless, studies on the anti-inflammatory activity of its seeds are still lacking. The aim of this study was to investigate the anti-inflammatory activity and acute toxicity of C. xanthocarpa seed extract, obtained from supercritical CO2 extraction (SCCO2) at 40°C and 250 bar, in mice. GC/MS analysis revealed that β-caryophyllene is the major compound present in the C. xanthocarpa SCCO2 extract. The extract (60 mg/kg, p.o.) significantly reduced the nociceptive behavior in the second phase of the formalin test and prevented the paw oedema induced by carrageenan up to 6 h after carrageenan injection. The extract (0.1–1 μg/mL) inhibited neutrophils migration induced by LPS from E. coli in vitro. This antichemostatic effect was comparable to the effect of indomethacin. Acute administration (2000 mg/kg, p.o.) of C. xanthocarpa SCCO2 extract caused no mice mortality, demonstrating that the extract is devoid of acute toxicity. These data suggest that C. xanthocarpa seeds present anti-inflammatory activity and represent a source of anti-inflammatory compounds.
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Lee H, Park RY, Park K. Total Syntheses of 4′,6′‐Dimethoxy‐2'‐Hydroxy‐3′,5′‐Dimethylchalcone Derivatives. B KOREAN CHEM SOC 2020. [DOI: 10.1002/bkcs.12156] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/19/2022]
Affiliation(s)
- Hana Lee
- School of Chemical Engineering and Material Science Chung‐Ang University 84 Heukseok‐ro, Dongjak‐gu, Seoul 06974 Republic of Korea
| | - Rae Yeon Park
- School of Chemical Engineering and Material Science Chung‐Ang University 84 Heukseok‐ro, Dongjak‐gu, Seoul 06974 Republic of Korea
| | - Kwangyong Park
- School of Chemical Engineering and Material Science Chung‐Ang University 84 Heukseok‐ro, Dongjak‐gu, Seoul 06974 Republic of Korea
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Inada AC, Silva GT, da Silva LPR, Alves FM, Filiú WFDO, Asato MA, Junior WHK, Corsino J, Figueiredo PDO, Garcez FR, Garcez WS, da Silva RDNO, dos Santos-Eichler RA, Guimarães RDCA, Freitas KDC, Hiane PA. Therapeutic Effects of Morinda citrifolia Linn. (Noni) Aqueous Fruit Extract on the Glucose and Lipid Metabolism in High-Fat/High-Fructose-Fed Swiss Mice. Nutrients 2020; 12:nu12113439. [PMID: 33182564 PMCID: PMC7696076 DOI: 10.3390/nu12113439] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/16/2020] [Revised: 10/13/2020] [Accepted: 10/20/2020] [Indexed: 12/28/2022] Open
Abstract
The aim of this study was to evaluate the therapeutic effects of two different doses (250 and 500 mg/kg) of Morinda citrifolia fruit aqueous extract (AE) in high-fat/high-fructose-fed Swiss mice. The food intake, body weight, serum biochemical, oral glucose tolerance test (OGTT), and enzyme-linked immunosorbent assay (ELISA), as well as histological analyses of the liver, pancreatic, and epididymal adipose tissue, were used to determine the biochemical and histological parameters. The chemical profile of the extract was determined by ultra-fast liquid chromatography–diode array detector–tandem mass spectrometry (UFLC–DAD–MS), and quantitative real-time PCR (qRT-PCR) was used to evaluate the gene expressions involved in the lipid and glucose metabolism, such as peroxisome proliferative-activated receptors-γ (PPAR-γ), -α (PPAR-α), fatty acid synthase (FAS), glucose-6-phosphatase (G6P), sterol regulatory binding protein-1c (SREBP-1c), carbohydrate-responsive element-binding protein (ChREBP), and fetuin-A. Seventeen compounds were tentatively identified, including iridoids, noniosides, and the flavonoid rutin. The higher dose of AE (AE 500 mg/kg) was demonstrated to improve the glucose tolerance; however, both doses did not have effects on the other metabolic and histological parameters. AE at 500 mg/kg downregulated the PPAR-γ, SREBP-1c, and fetuin-A mRNA in the liver and upregulated the PPAR-α mRNA in white adipose tissue, suggesting that the hypoglycemic effects could be associated with the expression of genes involved in de novo lipogenesis.
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Affiliation(s)
- Aline Carla Inada
- Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil; (G.T.S.); (L.P.R.d.S.); (R.d.C.A.G.); (K.d.C.F.); (P.A.H.)
- Correspondence: ; Tel.: +55-(67)-3345-7410
| | - Gabriela Torres Silva
- Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil; (G.T.S.); (L.P.R.d.S.); (R.d.C.A.G.); (K.d.C.F.); (P.A.H.)
| | - Laleska Pâmela Rodrigues da Silva
- Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil; (G.T.S.); (L.P.R.d.S.); (R.d.C.A.G.); (K.d.C.F.); (P.A.H.)
| | - Flávio Macedo Alves
- Institute of Biosciences, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil;
| | - Wander Fernando de Oliveira Filiú
- Faculty of Pharmaceutical Science, Food and Nutrition, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil;
| | - Marcel Arakaki Asato
- Faculty of Medicine, Federal University of Mato Grosso do Sul—UFMS, Campo Grande, MS 79070-900, Brazil;
| | - Wilson Hino Kato Junior
- Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil; (W.H.K.J.); (J.C.); (P.d.O.F.); (F.R.G.); (W.S.G.)
| | - Joaquim Corsino
- Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil; (W.H.K.J.); (J.C.); (P.d.O.F.); (F.R.G.); (W.S.G.)
| | - Patrícia de Oliveira Figueiredo
- Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil; (W.H.K.J.); (J.C.); (P.d.O.F.); (F.R.G.); (W.S.G.)
| | - Fernanda Rodrigues Garcez
- Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil; (W.H.K.J.); (J.C.); (P.d.O.F.); (F.R.G.); (W.S.G.)
| | - Walmir Silva Garcez
- Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, MS 79070-900, Brazil; (W.H.K.J.); (J.C.); (P.d.O.F.); (F.R.G.); (W.S.G.)
| | - Renée de Nazaré Oliveira da Silva
- Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, São Paulo, SP 05508-900, Brazil; (R.d.N.O.d.S.); (R.A.d.S.-E.)
| | | | - Rita de Cássia Avellaneda Guimarães
- Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil; (G.T.S.); (L.P.R.d.S.); (R.d.C.A.G.); (K.d.C.F.); (P.A.H.)
| | - Karine de Cássia Freitas
- Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil; (G.T.S.); (L.P.R.d.S.); (R.d.C.A.G.); (K.d.C.F.); (P.A.H.)
| | - Priscila Aiko Hiane
- Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil; (G.T.S.); (L.P.R.d.S.); (R.d.C.A.G.); (K.d.C.F.); (P.A.H.)
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Bernstein N, Akram M, Yaniv-Bachrach Z, Daniyal M. Is it safe to consume traditional medicinal plants during pregnancy? Phytother Res 2020; 35:1908-1924. [PMID: 33164294 DOI: 10.1002/ptr.6935] [Citation(s) in RCA: 40] [Impact Index Per Article: 8.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/11/2020] [Revised: 10/04/2020] [Accepted: 10/18/2020] [Indexed: 12/24/2022]
Abstract
The popularity of natural medicine is growing worldwide. Unlike conventional licensed medicines, herbal medicine practices are usually not supported by effectiveness, efficacy, or safety studies, which raise concerns about potential risks involved in their usage, particularly in high-risk patients such as pregnant women where teratogenicity is a concern. Despite a lack of science-based evidence, the use of herbal products for the management of pregnancy-associated challenges is common, due to the common notion that they are free of toxic effects and adverse reactions because they are "natural." The lack of concern about utilizing herbal remedies during pregnancy is strengthened by the lack of regulation in most countries for their marketing. However, plant-based remedies are not free of adverse reactions. Medicinal plants and herbal remedies contain substances that can be toxic to the human body and the fetus. Potential effects of indiscriminate use of medicinal plants are embryotoxicity, teratogenic, and abortifacient effects. Some plant constituents can cross the placenta and reach the fetus. Phytochemicals and their metabolites are known to induce stimulation of uterine contraction and hormone imbalance that could result in abortion. The alterations to the hormonal profile can affect conception, induce teratogenic activity, and halt the pregnancy or produce a congenital malformation. Due to the wide range of modes of action of phytochemicals, some medicinal plants may be safe to use during certain trimesters of pregnancy and harmful at other stages. This manuscript reviews available scientific information concerning potential health hazards associated with the consumption of herbal medicines during pregnancy, highlighting those herbs that should be avoided due to their potential abortifacient and/or teratogenic activity. We focused on plants that were tested by preclinical studies, and studies of these plants are summarized. Common therapeutic use of these herbs, estimated effects, toxicological effects, and animal studies of these plants is summarized. The literature reviewed suggests that consumption of the following medicinal plants should be avoided during pregnancy: Abrus precatorius, Achyranthes aspera, Ailanthus excelsa, Aloe vera, Aristolochia indica, Areca catechu, Bambusa vulgaris, Cassia occidentalis, Cicer arietinum, Cimicifuga racemose, Dolichandrone falcate, Ginkgo biloba, Hydrastis canadensis, Indigofera trifoliate, Lavandula latifolia, Maytenus ilicifolia, Momordica cymbalaria, Moringa oleifera, Musa rosacea, Oxalis corniculate, Phytolacca dodecandra, Plumeria rubra, Ricinus communis, Ruta graveolens, Stachys lavandulifolia, Senna alata, Trigonella foenum-graecum, Vitus agnus-castus, and Valeriana officinalis.
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Affiliation(s)
- Nirit Bernstein
- Institute of Soil, Water and Environmental Sciences, Volcani Center, Rishon LeZion, Israel
| | - Muhammad Akram
- Department of Eastern Medicine, Government College University Faisalabad, Faisalabad, Pakistan
| | | | - Muhammad Daniyal
- TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.,College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, China
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Ferreira FBP, Herculano Ramos-Milaré ÁCF, Gonçalves JE, Lazarin-Bidóia D, Nakamura CV, Sugauara RR, Fernandez CMM, Gazim ZC, Demarchi IG, Silveira TGV, Lonardoni MVC. Campomanesia xanthocarpa (Mart.) O. Berg essential oil induces antileishmanial activity and remodeling of the cytoplasm organelles. Nat Prod Res 2020; 35:6112-6116. [PMID: 32998582 DOI: 10.1080/14786419.2020.1827401] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/06/2023]
Abstract
Leishmaniasis is a neglected disease that affects millions of people worldwide. This study aimed to analyze antileishmanial activity of Campomanesia xanthocarpa leaf essential oil (EO) on promastigote and amastigote forms of Leishmania amazonensis, cytotoxicity in murine macrophages and sheep erythrocytes. The essential oil (EO) was analyzed by gas chromatography/mass spectrophotometry. The main and most abundant compounds were sesquiterpene hydrocarbons (71.22%) such as trans-caryophyllene (7.87%), bicyclogermacrene (11.28%), and δ-cadinene (8.34%). The IC50 for promastigote and amastigote forms of L. amazonensis was 70 µg mL-1 and 6 µg mL-1, respectively. C. xanthocarpa EO was not cytotoxic for murine macrophages (CC50 1860 µg mL-1) and sheep erythrocytes (1.5%), presenting high selectivity index for protozoan (310). C. xanthocarpa EO induced effects on the morphology and ultrastructure of this parasite. The high activity for intracellular amastigote forms, low toxicity to murine macrophages, and erythrocytes, suggest that C. xanthocarpa EO is promising for the treatment of leishmaniasis.
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Affiliation(s)
| | | | - José Eduardo Gonçalves
- Posgraduate in Clean Technologies, UniCesumar, Maringá, Paraná State, Brazil.,Cesumar Instituto de Ciências, Tecnologia e Inovação - ICETI, Maringá, Paraná State, Brazil
| | - Danielle Lazarin-Bidóia
- Laboratory of Innovation in Development of Medicines and Cosmetics, Department of Health Sciences, Universidade Estadual de Maringá, Maringá, Paraná State, Brazil
| | - Celso Vataru Nakamura
- Laboratory of Innovation in Development of Medicines and Cosmetics, Department of Health Sciences, Universidade Estadual de Maringá, Maringá, Paraná State, Brazil
| | - Rosangela Rumi Sugauara
- Posgraduate in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama, Paraná State, Brazil
| | | | - Zilda Cristiani Gazim
- Posgraduate in Biotechnology Applied to Agriculture, Universidade Paranaense, Umuarama, Paraná State, Brazil
| | | | - Thaís Gomes Verzignassi Silveira
- Posgraduate Program in Health Sciences, Universidade Estadual de Maringá, Maringá, Paraná State, Brazil.,Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Paraná State, Brazil
| | - Maria Valdrinez Campana Lonardoni
- Posgraduate Program in Health Sciences, Universidade Estadual de Maringá, Maringá, Paraná State, Brazil.,Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Paraná State, Brazil
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Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet. Molecules 2020; 25:molecules25112693. [PMID: 32531999 PMCID: PMC7321075 DOI: 10.3390/molecules25112693] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2020] [Revised: 04/19/2020] [Accepted: 04/20/2020] [Indexed: 01/10/2023] Open
Abstract
There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. Campomanesia xanthocarpa, found in the Brazilian Cerrado, demonstrated beneficial effects in metabolic disorders associated with obesity. We investigated the effects of Campomanesia xanthocarpa hydroethanolic extract and two isolated substances from the extract (S1 and S2) in a diet-induced obesity (DIO) model. Male Swiss mice were divided into five groups: (1) American Institute of Nutrition (AIN-93M) diet, (2) high-fat diet (HF), (3) HF supplemented with C. xanthocarpa hydroethanolic leaf extract at 100 mg/kg (HFE), (4) HF supplemented with S1 at 1 mg/kg (HFS1) and (5) HF supplemented with S2 at 1 mg/kg (HFS2). The HFS1, HFS2 and HFE groups did not present decreasing body weight or visceral adiposity gain. No differences in glycemic and lipid parameters, or in the expression of protein content in two cytokines, interleukin-6 (IL-6) and anti-inflammatory (IL-10), were observed. Only the HFS1 group displayed decreased food intake. Even though substantial effects such as an improvement in obesity features or the metabolic and histological parameters promoted by S1, S2 and the extract were not observed, further investigations are necessary to evaluate the principal genes and protein expressions involved in regulating food behavior promoted by S1.
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Psychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity. Inflammation 2020; 42:1561-1574. [PMID: 31102122 DOI: 10.1007/s10753-019-01018-w] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]
Abstract
Species from Psychotria are used in folk medicine against inflammatory diseases, respiratory disturbances, and anti-hallucinogenic. In the present study, the compound vincosamide (PL-1) was identified for the first time in methanolic extract of the Psychotria leiocarpa (ME-PL) leaves, as well as the anti-inflammatory and anticholinesteric effects in rodents and molecular docking simulations. The fractionation of the chloroform fraction (CF-PL) through chromatographic methods afforded the known compound PL-1. The anti-inflammatory activity of the ME-PL (30, 100, and 300 mg/kg) and PL-1 (3, 30, and 100 mg/kg) was analyzed using experimental models: paw edema, pleurisy, and mechanical and thermal hyperalgesia induced by carrageenan. The anticholinesterase activity of the ME-PL (30 and 100 mg/kg) and PL-1 (30 mg/kg) was showed by acetylcholinesterase (AChE) inhibitory in brain structures. The molecular docking simulations were performed using Molegro Virtual Docker v6.0. Overall, the results indicated that ME-PL and PL-1 demonstrated an anti-edematogenic effect in Cg-induced paw edema, leukocyte migration in the pleurisy model, and significantly reduced mechanical hyperalgesia, cold response to acetone in mice. The samples exhibited maximal inhibition of enzyme acetylcholinesterase (AChE) in the frontal cortex. The molecular coupling of PL-1 with the AChE showed significant interactions with the catalytic and peripheral site, corroborating the activity presented in the inhibition assay. The acute administration of ME-PL did not cause signs of toxicity in the treated animals. The results showed that P. leiocarpa inhibited AChE and anti-inflammatory activity, and alkaloid vincosamide could be responsible, at least in part, for the observed effects, supporting the popular use of this genus.
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de Paulo Farias D, Neri-Numa IA, de Araújo FF, Pastore GM. A critical review of some fruit trees from the Myrtaceae family as promising sources for food applications with functional claims. Food Chem 2020; 306:125630. [DOI: 10.1016/j.foodchem.2019.125630] [Citation(s) in RCA: 26] [Impact Index Per Article: 5.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/15/2019] [Revised: 09/26/2019] [Accepted: 09/30/2019] [Indexed: 12/19/2022]
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Catelan TBS, Gaiola L, Duarte BF, Cardoso CAL. Evaluation of the in vitro photoprotective potential of ethanolic extracts of four species of the genus Campomanesia. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2019; 197:111500. [DOI: 10.1016/j.jphotobiol.2019.04.009] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/12/2018] [Revised: 04/22/2019] [Accepted: 04/24/2019] [Indexed: 10/27/2022]
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Sasso S, Sampaio E Souza PC, Santana LF, Cardoso CAL, Alves FM, Portugal LC, de Faria BB, da Silva AF, Motta-Castro ARC, Soares LS, Bandeira LM, Guimarães RDCA, Freitas KDC. Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. Nutrients 2019; 11:nu11071509. [PMID: 31269728 PMCID: PMC6682994 DOI: 10.3390/nu11071509] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/04/2019] [Revised: 06/06/2019] [Accepted: 06/30/2019] [Indexed: 12/27/2022] Open
Abstract
Annona muricata Linn, commonly known as graviola, is one of the most popular plants used in Brazil for weight loss. The aim of this study is to evaluate the therapeutic effects of three different doses (50 mg/kg, 100 mg/kg, and 150 mg/kg) of aqueous graviola leaf extract (AGE) supplemented by oral gavage, on obese C57BL/6 mice. Food intake, body weight, an oral glucose tolerance test (OGTT), an insulin sensitivity test, quantification of adipose tissue cytokines, weight of fat pads, and serum biochemical and histological analyses of the liver, pancreas, and epididymal adipose tissue were measured. AGE had an anti-inflammatory effect by increasing IL-10 at doses of 50 and 100 mg/kg. Regarding the cholesterol profile, there was a significant decrease in LDL-cholesterol levels in the AGE 150 group, and VLDL-cholesterol and triglycerides in the AGE 100 and 150 groups. There was an increase in HDL cholesterol in the AGE 150 group. The extract was able to reduce the adipocyte area of the epididymal adipose tissue in the AGE 100 and 150 groups. According to the histological analysis of the liver and pancreas, no significant difference was found among the groups. There were no significant effects of AGE on OGTT and serum fasting glucose concentration. However, the extract was effective in improving glucose tolerance in the AGE 150 group.
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Affiliation(s)
- Sandramara Sasso
- Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Priscilla Cristovam Sampaio E Souza
- Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Lidiani Figueiredo Santana
- Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | | | - Flávio Macedo Alves
- Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Luciane Candeloro Portugal
- Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | | | - Anderson Fernandes da Silva
- Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Ana Rita Coimbra Motta-Castro
- Laboratory of Clinical Immunology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
- Oswaldo Cruz Foundation, Campo Grande, 79074-460 Mato Grosso do Sul, Brazil
| | - Luana Silva Soares
- Laboratory of Clinical Immunology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Larissa Melo Bandeira
- Laboratory of Clinical Immunology, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Rita de Cássia Avellaneda Guimarães
- Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil
| | - Karine de Cássia Freitas
- Posgraduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900 Mato Grosso do Sul, Brazil.
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Teixeira N, Melo JC, Batista LF, Paula-Souza J, Fronza P, Brandão MG. Edible fruits from Brazilian biodiversity: A review on their sensorial characteristics versus bioactivity as tool to select research. Food Res Int 2019; 119:325-348. [DOI: 10.1016/j.foodres.2019.01.058] [Citation(s) in RCA: 43] [Impact Index Per Article: 7.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/21/2018] [Revised: 01/21/2019] [Accepted: 01/23/2019] [Indexed: 12/24/2022]
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De Sousa JA, Prado LDS, Alderete BL, Boaretto FBM, Allgayer MC, Miguel FM, De Sousa JT, Marroni NP, Lemes MLB, Corrêa DS, Ferraz ADBF, Picada JN. Toxicological aspects of Campomanesia xanthocarpa Berg. associated with its phytochemical profile. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A 2019; 82:62-74. [PMID: 30741125 DOI: 10.1080/15287394.2018.1562392] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/09/2023]
Abstract
Campomanesia xanthocarpa leaves are used as tea to treat diarrhea, inflammation, and hypercholesterolemia. Some pharmacological studies noted its beneficial uses of C. xanthocarpa; however, few investigations examined the toxicological profile of this plant. The aim of this study was to determine the chemical composition, genotoxic, and mutagenic potential of an aqueous extract of C. xanthocarpa leaves (CxAE), and potential protective effects against oxidative damage. Phytochemical constituents were determined using HPLC, and antioxidant effect in vitro was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. Genotoxic effects and chromosomic mutations were assessed using comet assay and micronucleus (MN) test in Wistar rats treated with CxAE at 250, 500 or 1000 mg/kg for 7 consecutive days. Lipid peroxidation and antioxidant enzyme activities were measured in several tissues. CxAE induced mutations in TA98, TA97a, and TA102 strains. However, in the presence of metabolic activation, data were negative for all strains tested. Lack of mutagenicity was also observed in the MN test. This extract did not induce DNA damage, except when the highest concentration was used. DNA oxidative damage induced by hydrogen peroxide (H2O2) decreased in blood after treatment with CxAE. Lipid peroxidation levels were reduced while superoxide dismutase (SOD) activity increased in kidneys. The inhibitory concentration of CxAE required to lower DPPH levels to 50% was 38.47 ± 2.06 μg/ml. In conclusion, frameshift and oxidative mutations were observed only in the absence of metabolic activation which may be attributed to the presence of flavonoids such as quercetin. It is of interest that CxAE also showed protective effects against DNA oxidative damage associated with presence of ellagic acid, a phenolic acid with antioxidant activities. CxAE did not induce in vivo mutagenicity, suggesting that this extract poses a low toxic hazard over the short term.
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Affiliation(s)
- Joubert Aires De Sousa
- a Laboratory of Toxicological Genetics , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Lismare da Silva Prado
- a Laboratory of Toxicological Genetics , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Bárbara Lopes Alderete
- a Laboratory of Toxicological Genetics , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | | | - Mariangela C Allgayer
- b Laboratory of Clinical Pathology, Veterinary Hospital , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Fabiano Moraes Miguel
- c Laboratory of Oxidative Stress and Antioxidants , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Jayne Torres De Sousa
- c Laboratory of Oxidative Stress and Antioxidants , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Norma Possa Marroni
- c Laboratory of Oxidative Stress and Antioxidants , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Maria Luísa Brodt Lemes
- d Laboratory of Pharmacognosis and Phytochemistry , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
| | - Dione Silva Corrêa
- e Center for Research in Product and Development (CEPPED) , Lutheran University of Brazil (ULBRA) , Canoas , RS , Brazil
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Catelan TBS, Santos Radai JA, Leitão MM, Branquinho LS, Vasconcelos PCDP, Heredia-Vieira SC, Kassuya CAL, Cardoso CAL. Evaluation of the toxicity and anti-inflammatory activities of the infusion of leaves of Campomanesia guazumifolia (Cambess.) O. Berg. JOURNAL OF ETHNOPHARMACOLOGY 2018; 226:132-142. [PMID: 30114515 DOI: 10.1016/j.jep.2018.08.015] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/14/2018] [Revised: 06/26/2018] [Accepted: 08/12/2018] [Indexed: 06/08/2023]
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE Some species of Campomanesia are used in the folk medicine due to anti-inflammatory, anti-diarrheal, anti-diabetes and hypercholesterolemic. However studies with Campomanesia guazumifolia (Cambess.) O. Berg. are scarce. AIM OF THE STUDY This study investigated the anti-inflammatory activity and toxicological profile of infusion obtained from leaves of Campomanesia guazumifolia in mice. MATERIALS AND METHODS Leaves infusion of C. guazumifolia was obtained in the proportion of 20 g/L (leaves/water) at 95-100 °C for 10 min in an enclosed container. The acute toxicity of the leaves infusion of C. guazumifolia lyophilized (ICG) was assessed by oral administration to female mice at doses of 500, 1000, 2000, and 5000 mg/kg, and the general behavior and toxic symptoms were observed for 14 days. In the subacute toxicity model, female mice were treated orally with the ICG (250, 500, and 1000 mg/kg) during 28 days, and biochemical, toxic signs and the estrous cycle were evaluated. The anti-inflammatory activity of the ICG (70, 300 and 700 mg/kg) was analyzed using carrageenan-induced pleurisy and inflammatory paw (mechanical and thermal hyperalgesia). RESULTS Three flavonoids glycosylated and a cyclohexanecarboxylic acid were identified in the ICG: quercetin pentose, quercetin deoxyhexoside, myricetin deoxyhexoside and quinic acid. No clinical signs of acute toxicity were observed, suggesting that the LD50 (Lethal Dose) is above 5000 mg/kg. Subacute exposure of mice to the ICG did not change significantly the hematological and biochemical parameters as well as histology of organs. The ICG increased the duration of estrous cycle in all phases, showing anti-inflammatory potential by decreasing leukocyte migration, extravasation protein in the pleural cavity and antiedematogenic activity. The ICG treatment at a dose of 700 mg/kg decreased the mechanical hyperalgesia, while at doses of 300 mg/kg and 700 mg/kg, decreased the sensitivity to the cold. CONCLUSION The results evidenced the anti-inflammatory potential with low toxicity of infusion of the leaves of C. guazumifolia, supporting the popular use of this species.
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Affiliation(s)
- Taline Baganha Stefanello Catelan
- Programa de Pós-Graduação em Recursos Naturais - Centro de Estudos de Recursos Naturais (CERNA), UEMS, 79804-970 Dourados, MS, Brazil; Curso de Farmácia - Centro Universitário de Grande Dourados - UNIGRAN, Jd. Universidade, 79.824-900 Dourados, MS, Brazil.
| | | | - Maicon Matos Leitão
- Pós-graduação em Ciências da Saúde, UFGD, Cidade Universitária,79804-970 Dourados, MS, Brazil
| | | | | | - Silvia Cristina Heredia-Vieira
- Programa de Pós-Graduação em Recursos Naturais - Centro de Estudos de Recursos Naturais (CERNA), UEMS, 79804-970 Dourados, MS, Brazil
| | | | - Claudia Andrea Lima Cardoso
- Programa de Pós-Graduação em Recursos Naturais - Centro de Estudos de Recursos Naturais (CERNA), UEMS, 79804-970 Dourados, MS, Brazil.
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Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions. Molecules 2018; 23:molecules23092336. [PMID: 30216974 PMCID: PMC6225494 DOI: 10.3390/molecules23092336] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2018] [Revised: 09/03/2018] [Accepted: 09/04/2018] [Indexed: 12/25/2022] Open
Abstract
Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects. Though there are different varieties of guavira, the principal Brazilian Cerrado guaviras demonstrated hypoglycemic, anti-inflammatory, and hypocholesterolemic actions. There is also a potential antiplatelet agent in C. xanthocarpa, while C. adamantium displayed hypocholesterolemic actions in animal models and human clinical trials. On the other hand, even with a lack of studies related to C. pubescens, it demonstrated anti-inflammatory effects and an antioxidant capacity in in vitro studies. Despite the fact that most of the studies were not performed to evaluate pathological conditions specific to obese animal models or obese subjects, guavira demonstrated effects in metabolic disorders that are commonly related to the obesity context, such as cardiovascular disturbances and hyperglycemia status. This suggests that guavira is a potential therapeutic approach to obesity-induced metabolic syndrome.
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