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Bai Y, Zhang D, Wang K, Li F, Chen N, Zhou Z, Ye J. Analysis of Heavy Metal Characteristics and Health Risk Assessment of Dried Fish Marketed in Guangzhou, China. Biol Trace Elem Res 2025; 203:2041-2057. [PMID: 38954322 DOI: 10.1007/s12011-024-04291-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/12/2024] [Accepted: 06/24/2024] [Indexed: 07/04/2024]
Abstract
This study investigated heavy metal contamination in dried fish sold in Guangzhou, China, and evaluated the resultant non-carcinogenic and carcinogenic health risks. Dried fish samples were purchased from Baiyun, Tianhe, Panyu, and Yuexiu districts in Guangzhou, where the population is substantial. They were randomly acquired in bustling supermarkets and farmers' markets, targeting the most popular dried fish in these areas. Sixty samples from five dried fish types (Stolephorus chinensis, Thamnaconus modestus, Nemipterus-virgatus, river fish, Ctenopharyngodon idella) were analyzed for chromium (Cr), arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) content. Quantification of the heavy metals were carried out by inductively coupled plasma mass spectrometry (ICP-MS) for Cr, As, Cd, and Pb, and an automatic mercury analyzer for Hg. The median concentration of these heavy metals in dried fish were 0.358 mg/kg, 2.653 mg/kg, 0.032 mg/kg, 0.083 mg/kg, and 0.042 mg/kg, respectively. Pollution severity was ranked as dried Nemipterus-virgatus > dried Stolephorus chinensis > dried Thamnaconus modestus > dried river fish > dried Ctenopharyngodon idella, with As being the most predominant pollutant. All fish types showed severe As pollution. Non-carcinogenic risks were identified in the consumption of dried Nemipterus-virgatus and dried Stolephorus chinensis for both genders, while potential carcinogenic risks were associated with four of the fish types. Women faced higher health risks than men from dried fish consumption. Consequently, we advise consumers to minimize their intake of dried fish and regulatory agencies conduct regular monitoring of heavy metal levels in commercially available dried fish to avert potential health risks.
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Affiliation(s)
- Yifei Bai
- Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, China
| | - Dimei Zhang
- Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, China
| | - Kang Wang
- Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, China
| | - Fangfei Li
- Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, China
| | - Nachuan Chen
- Department of Preventive Medicine, School of Public Health, Southern Medical University, Guangzhou, China
| | - Zhifeng Zhou
- Department of Hygiene Inspection and Quarantine Science, Center for Hygiene Testing and Analysis, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, 510515, Guangdong, China.
| | - Jufeng Ye
- Experimental Teaching Center of Preventive Medicine, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), National Preventive Medicine Experimental Teaching Demonstration Center, Guangzhou, 510515, Guangdong, China.
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Majumdar A, Upadhyay MK, Ojha M, Biswas R, Dey S, Sarkar S, Moulick D, Niazi NK, Rinklebe J, Huang JH, Roychowdhury T. A critical review on the organo-metal(loid)s pollution in the environment: Distribution, remediation and risk assessment. THE SCIENCE OF THE TOTAL ENVIRONMENT 2024; 951:175531. [PMID: 39147056 DOI: 10.1016/j.scitotenv.2024.175531] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/16/2024] [Revised: 08/07/2024] [Accepted: 08/12/2024] [Indexed: 08/17/2024]
Abstract
Toxic metal(loid)s, e.g., mercury, arsenic, lead, and cadmium are known for several environmental disturbances creating toxicity to humans if accumulated in high quantities. Although not discussed critically, the organo-forms of these inorganic metal(loid)s are considered a greater risk to humans than their elemental forms possibly due to physico-chemical modulation triggering redox alterations or by the involvement of biological metabolism. This extensive review describes the chemical and physical causes of organometals and organometal(loid)s distribution in the environment with ecotoxicity assessment and potential remediation strategies. Organo forms of various metal(loid)s, such as mercury (Hg), arsenic (As), lead (Pb), tin (Sn), antimony (Sb), selenium (Se), and cadmium (Cd) have been discussed in the context of their ecotoxicity. In addition, we elaborated on the transformation, speciation and transformation pathways of these toxic metal(loid)s in soil-water-plant-microbial systems. The present review has pointed out the status of toxic organometal(loid)s, which is required to make the scientific community aware of this pressing condition of organometal(loid)s distribution in the environment. The gradual disposal and piling of organometal(loid)s in the environment demand a thorough revision of the past-present status with possible remediation strategies prescribed as reflected in this review.
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Affiliation(s)
- Arnab Majumdar
- Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom; School of Environmental Studies, Jadavpur University, Kolkata 700032, India.
| | - Munish Kumar Upadhyay
- Centre for Environmental Science & Engineering, Department of Civil Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India
| | - Megha Ojha
- Department of Biology, Indian Institute of Science Education and Research (IISER) Pune, Pashan, Maharashtra 411008, India
| | - Rakesh Biswas
- Department of Chemistry, University of Ulsan, 93 Daehak-ro, Nam-gu, Ulsan, South Korea
| | - Saikat Dey
- Division of Agronomy, School of Agriculture and Rural Development, Ramakrishna Mission Vivekananda Educational and Research Institute, Narendrapur, Kolkata 700103, India
| | - Sukamal Sarkar
- Division of Agronomy, School of Agriculture and Rural Development, Ramakrishna Mission Vivekananda Educational and Research Institute, Narendrapur, Kolkata 700103, India
| | - Debojyoti Moulick
- Department of Environmental Science, University of Kalyani, Nadia, West Bengal 741235, India
| | - Nabeel Khan Niazi
- Institute of Soil and Environmental Sciences, University of Agriculture Faisalabad, Faisalabad 38040, Pakistan
| | - Jörg Rinklebe
- University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water- and Waste-Management, Laboratory of Soil- and Groundwater-Management, Pauluskirchstraße 7, 42285 Wuppertal, Germany
| | - Jen-How Huang
- State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China
| | - Tarit Roychowdhury
- School of Environmental Studies, Jadavpur University, Kolkata 700032, India
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Lin Y, Liu J, Sun Y, Chen S, Chen J, Fu F. Bio-accessibility and bio-availability evaluation of each arsenic species existing in various edible seaweeds in vitro and in vivo for arsenic risk assessment. THE SCIENCE OF THE TOTAL ENVIRONMENT 2024; 946:174247. [PMID: 38936725 DOI: 10.1016/j.scitotenv.2024.174247] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/23/2024] [Revised: 06/18/2024] [Accepted: 06/21/2024] [Indexed: 06/29/2024]
Abstract
Seaweeds consumption is one of main internal exposure sources of arsenic for human. However, the absence of representative bio-availabilities of arsenic species makes the accurate assessment of arsenic health risk originating from seaweeds consumption impossible. Herein, the arsenic species in various seaweeds collected from Fujian of China were investigated, and the bio-accessibilities/bio-availabilities of arsenic species existing in seaweeds were evaluated in vitro and in vivo. Results revealed that in vitro bio-availabilities of arsenic species presenting in seaweeds, which obtained with Caco-2 cells, were lower than those of pure arsenic standards, and varied with order of inorganic arsenic (iAs) > dimethylarsinic acid (DMA) ≈ arsenobetaine (AsB) > arsenosugars. During gastrointestinal digestion of mice, As5+ was partly methylated into monomethylarsonic acid (MMA) and DMA, which makes the in vivo bioavailability of iAs (⁓31.8 %) obtained with mouse metabolic experiment is much higher than its in vitro bio-availability (⁓10.3 %). The in vivo bio-availabilities of DMA and total arsenic (tAs) are similar to their in vitro bio-availabilities. As the dominant arsenic species in most seaweeds, arsenosugars have an ⁓0.0 % of in vivo bioavailability and only a ⁓3.7 % of in vitro bioavailability. The simulated calculation of target hazard quotient (THQ) and target cancer risk (TR) revealed that the arsenic risk originating from seaweeds was greatly degraded by taking into consideration of arsenic species and bio-availabilities, and all seaweeds collected from Fujian are safety for consumption. The simulated calculation also revealed that arsenic risk of seaweeds can be also more accurately assessed based on tAs together with bioavailability, which provides a simple but accurate and protective method for the risk assessment of arsenic originating from seaweeds. Our work provides the possible representative bio-availabilities of arsenic species presenting in seaweeds for accurately assessing arsenic risk of seaweeds, and novel insights into the bio-availabilities of arsenic in animal.
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Affiliation(s)
- Yue Lin
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Junfeng Liu
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Ying Sun
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Shilong Chen
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Jianlang Chen
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - FengFu Fu
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
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Ra WJ, Yoo HJ, Kim YH, Yun T, Soh B, Cho SY, Joo Y, Lee KW. Heavy metal concentration according to shrimp species and organ specificity: Monitoring and human risk assessment. MARINE POLLUTION BULLETIN 2023; 197:115761. [PMID: 37952375 DOI: 10.1016/j.marpolbul.2023.115761] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/18/2023] [Revised: 10/24/2023] [Accepted: 11/06/2023] [Indexed: 11/14/2023]
Abstract
This study assessed heavy metal levels (lead (Pb), cadmium (Cd), total arsenic (tAs), arsenite (As (III)), arsenate (As (V)), monomethyl arsenic acid (MMA), dimethylarsinic acid (DMA), total mercury (tHg), and methylmercury (MeHg)) in six organs (total portion, head, body, shell, muscle, and intestine) of 11 shrimp species distributed in Korea. Shrimp exhibited significant variability in heavy metal accumulation, with Alaskan pink and dried shrimp (Lesser glass, Southern rough, and Chinese ditch prawn) showing the highest metal concentrations. Notably, the intestine having the highest overall metal content, while Cd was most prominent in the head, tHg was highest in the muscle. The Hazard Quotient values of 11 shrimp species in South Korea were below the European Food Safety Authority's allowable limits for heavy metals. This study illuminates the heavy metal profiles of distributed shrimp in Korea and emphasizes the ongoing need for monitoring heavy metals on seafood to ensure consumer safety.
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Affiliation(s)
- Wook-Jin Ra
- Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Republic of Korea
| | - Hee Joon Yoo
- Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Republic of Korea
| | - Yeon-Hee Kim
- Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Republic of Korea
| | - Taehyun Yun
- Department of Statistics, College of Natural Science, Dongguk University, Seoul 04620, Republic of Korea
| | - Bokyung Soh
- Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Republic of Korea
| | - Su Yeob Cho
- Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Republic of Korea
| | - Yongsung Joo
- Department of Statistics, College of Natural Science, Dongguk University, Seoul 04620, Republic of Korea
| | - Kwang-Won Lee
- Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Republic of Korea.
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Khatun M, Siddique AE, Wahed AS, Haque N, Tony SR, Islam J, Alam S, Sarker MK, Kabir I, Hossain S, Sumi D, Saud ZA, Barchowsky A, Himeno S, Hossain K. Association between serum periostin levels and the severity of arsenic-induced skin lesions. PLoS One 2023; 18:e0279893. [PMID: 36598904 PMCID: PMC9812306 DOI: 10.1371/journal.pone.0279893] [Citation(s) in RCA: 8] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/01/2022] [Accepted: 12/18/2022] [Indexed: 01/05/2023] Open
Abstract
Arsenic is a potent environmental toxicant and human carcinogen. Skin lesions are the most common manifestations of chronic exposure to arsenic. Advanced-stage skin lesions, particularly hyperkeratosis have been recognized as precancerous diseases. However, the underlying mechanism of arsenic-induced skin lesions remains unknown. Periostin, a matricellular protein, is implicated in the pathogenesis of many forms of skin lesions. The objective of this study was to examine whether periostin is associated with arsenic-induced skin lesions. A total of 442 individuals from low- (n = 123) and high-arsenic exposure areas (n = 319) in rural Bangladesh were evaluated for the presence of arsenic-induced skin lesions (Yes/No). Participants with skin lesions were further categorized into two groups: early-stage skin lesions (melanosis and keratosis) and advanced-stage skin lesions (hyperkeratosis). Drinking water, hair, and nail arsenic concentrations were considered as the participants' exposure levels. The higher levels of arsenic and serum periostin were significantly associated with skin lesions. Causal mediation analysis revealed the significant effect of arsenic on skin lesions through the mediator, periostin, suggesting that periostin contributes to the development of skin lesions. When skin lesion was used as a three-category outcome (none, early-stage, and advanced-stage skin lesions), higher serum periostin levels were significantly associated with both early-stage and advanced-stage skin lesions. Median (IQR) periostin levels were progressively increased with the increasing severity of skin lesions. Furthermore, there were general trends in increasing serum type 2 cytokines (IL-4, IL-5, IL-13, and eotaxin) and immunoglobulin E (IgE) levels with the progression of the disease. The median (IQR) of IL-4, IL-5, IL-13, eotaxin, and IgE levels were significantly higher in the early-and advanced-stage skin lesions compared to the group of participants without skin lesions. The results of this study suggest that periostin is implicated in the pathogenesis and progression of arsenic-induced skin lesions through the dysregulation of type 2 immune response.
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Affiliation(s)
- Moriom Khatun
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
| | - Abu Eabrahim Siddique
- Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America
| | - Abdus S. Wahed
- Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
| | - Nazmul Haque
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
| | - Selim Reza Tony
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
| | - Jahidul Islam
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
| | - Shahnur Alam
- Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
| | | | | | - Shakhawoat Hossain
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
| | - Daigo Sumi
- Laboratory of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
| | - Zahangir Alam Saud
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
| | - Aaron Barchowsky
- Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
| | - Seiichiro Himeno
- Laboratory of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
- Division of Health Chemistry, School of Pharmacy, Showa University, Tokyo, Japan
| | - Khaled Hossain
- Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
- * E-mail:
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Alshana U, Altun B, Ertaş N, Çakmak G, Kadioglu E, Hisarlı D, Aşık E, Atabey E, Çelebi CR, Bilir N, Serçe H, Tuncer AM, Burgaz S. Evaluation of low-to-moderate arsenic exposure, metabolism and skin lesions in a Turkish rural population exposed through drinking water. CHEMOSPHERE 2022; 304:135277. [PMID: 35688195 DOI: 10.1016/j.chemosphere.2022.135277] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/22/2022] [Revised: 06/03/2022] [Accepted: 06/05/2022] [Indexed: 06/15/2023]
Abstract
BACKGROUND There is no human data regarding the exposure, metabolism and potential health effects of arsenic (As) contamination in drinking water in the Central Anatolian region of Turkey. METHODS Residents in ten villages with drinking water of total As (T-As) level >50 μg L-1 and 10-50 μg L-1 were selected as an exposed group (n = 420) and <10 μg L-1 as an unexposed group (n = 185). Time-weighted average-As (TWA-As) intake was calculated from T-As analysis of drinking water samples. Concentrations of T-As in urine and hair samples, urinary As species [i.e., As(III), As(V), MMA(V) and DMA(V], and some micronutrients in serum samples of residents of the study area were determined. Primary and secondary methylation indices (PMI and SMI, respectively) were assessed from urinary As species concentrations and the presence of skin lesion was examined. RESULTS TWA-As intake was found as 75 μg L-1 in the exposed group. Urinary and hair T-As and urinary As species concentrations were significantly higher in the exposed group (P < 0.05). The PMI and SMI values revealed that methylation capacities of the residents were efficient and that there was no saturation in As metabolism. No significant increase was observed in the frequency of skin lesions (hyperpigmentation, hypopigmentation, keratosis) of the exposed group (P > 0.05). Only frequency of keratosis either at the hand or foot was higher in individuals with hair As concentration >1 μg g-1 (P < 0.05). CONCLUSIONS Individuals living in the study area were chronically exposed to low-to-moderate As due to geological contamination in drinking water. No significant increase was observed in the frequency of skin lesions. Because of the controversy surrounding the health risks of low-to-moderate As exposure, it is critical to initiate long-term follow-up studies on health effects in this region.
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Affiliation(s)
- Usama Alshana
- Gazi University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey
| | - Beril Altun
- Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
| | - Nusret Ertaş
- Gazi University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkey
| | - Gonca Çakmak
- Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
| | - Ela Kadioglu
- Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
| | - Deniz Hisarlı
- Middle East Technical University, Department of Biochemistry, Ankara, Turkey
| | - Elif Aşık
- Middle East Technical University, Department of Biotechnology, Ankara, Turkey
| | - Eşref Atabey
- General Directorate of Mineral Research and Exploration, Ankara, Turkey
| | | | - Nazmi Bilir
- Hacettepe University, Faculty of Medicine, Department of Public Health, Ankara, Turkey
| | - Hakan Serçe
- Ürgüp State Hospital, Turkish Ministry of Health, Nevşehir, Turkey
| | - A Murat Tuncer
- Turkish Ministry of Health, Cancer Control Department, Ankara, Turkey
| | - Sema Burgaz
- Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey.
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Tong S, Yang L, Gong H, Wang L, Li H, Yu J, Li Y, Deji Y, Nima C, Zhao S, Gesang Z, Kong C, Wang X, Men Z. Association of selenium, arsenic, and other trace elements in drinking water and urine in residents of the plateau region in China. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL 2022; 29:26498-26512. [PMID: 34855178 DOI: 10.1007/s11356-021-17418-1] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/25/2021] [Accepted: 11/04/2021] [Indexed: 05/27/2023]
Abstract
Drinking water is considered to be an important exposure pathway for humans to ingest trace elements; human urine samples are widely accepted as biometric substrates that can reflect human exposure to trace elements. The current study aimed at investigating the concentrations of trace elements including selenium (Se), arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in drinking water and human urine in plateau region of China, determining the association among trace elements in drinking water and urine, and analyzing their associations with age and gender. The results showed that the majority of trace element concentrations were in the range of the World Health Organization (WHO 2011) guideline values, in both urine samples of male and female, and the median values were descending in the order: Zn > Cu > As > Se > Cr > Ni > Mn > Pb > Cd > Co. Selenium contributed to the excretion of As, Cr, Cu, Cd, and Zn in human body, group of 31-40 years appeared to present the greatest excretion ability in most of the trace elements. Weak positive correlations were observed between age and Mn in female urine samples, and negative correlations were observed between age and Se, As, Co, and Cu in male urine samples and between age and Co in female urine samples, respectively. Significant positive correlation was observed in As between drinking water and the whole human urine. In the same family, female seemed to show higher proportions of urinary As levels than male. This study will provide elementary information regarding trace element levels in drinking water and human urine in residents in plateau region of China and is helpful to provide reference for dietary nutrient trace element intake and effective control for local resident.
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Affiliation(s)
- Shuangmei Tong
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
- College of Tourism and Historical Culture, Liupanshui Normal University, Liupanshui, 553004, China
| | - Linsheng Yang
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
| | - Hongqiang Gong
- Tibet Center of Disease Control and Prevention, Lhasa, 850030, People's Republic of China
| | - Li Wang
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
| | - Hairong Li
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
| | - Jiangping Yu
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
| | - Yonghua Li
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
| | - Yangzong Deji
- Tibet Center of Disease Control and Prevention, Lhasa, 850030, People's Republic of China
| | - Cangjue Nima
- Tibet Center of Disease Control and Prevention, Lhasa, 850030, People's Republic of China
| | - Shengcheng Zhao
- Tibet Center of Disease Control and Prevention, Lhasa, 850030, People's Republic of China
| | - Zongji Gesang
- Tibet Center of Disease Control and Prevention, Lhasa, 850030, People's Republic of China
| | - Chang Kong
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
| | - Xiaoya Wang
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
| | - Zhuming Men
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
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Lin C, Ping M, Zhang X, Wang X, Chen L, Wu Y, Fu F. In vitro bio-accessibility and distribution characteristic of each arsenic species in different fishes and shellfishes/shrimps collected from Fujian of China. JOURNAL OF HAZARDOUS MATERIALS 2021; 420:126660. [PMID: 34329088 DOI: 10.1016/j.jhazmat.2021.126660] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/03/2021] [Revised: 07/14/2021] [Accepted: 07/14/2021] [Indexed: 06/13/2023]
Abstract
It is very important to consider the bio-accessibilities and concentrations of each arsenic species, not total arsenic, in seafood in order to accurately assess internal exposure level and health risk of arsenic from seafood. Herein, the concentrations and in vitro bio-accessibilities of each arsenic species in various fishes and shellfishes/shrimps were extensively investigated. Experimental results showed that arsenic species and contents in shellfishes/fishes remarkably varied with the difference of fish/shellfish species or individuals and sampling area, and arsenobetaine (AsB) is dominant arsenic species for fishes and shellfishes/shrimps. Different arsenic species in the same fish/shellfish have quite different bio-accessibilities, and the bio-accessibilities of each arsenic species also varied with fish/shellfish species or individuals. As3+ in fishes/shellfishes was partly oxidized to form As5+ during gastrointestinal digestion, and thus it is more reasonable and practicable to evaluate the bio-accessibilities of inorganic arsenic (iAs, total As3+ and As5+), not individual As3+ and As5+. Fishes and shellfishes/shrimps have similar bio-accessibilities of iAs, AsB and total arsenic, whereas have different bio-accessibilities of MMA (monomethylarsonic acid), DMA (dimethylarsinic acid), and two un-identified arsenic (Ui-As1 and Ui-As2). The results of this study provided a valuable knowledge for accurately assessing the health risk of arsenic in seafood.
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Affiliation(s)
- Chen Lin
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Meiling Ping
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Xu Zhang
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Xusheng Wang
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Lian Chen
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
| | - Yongning Wu
- NHC Key Lab of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of China Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China
| | - FengFu Fu
- Key Laboratory for Analytical Science of Food Safety and Biology of MOE, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
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Sanyal T, Paul M, Bhattacharjee S, Bhattacharjee P. Epigenetic alteration of mitochondrial biogenesis regulatory genes in arsenic exposed individuals (with and without skin lesions) and in skin cancer tissues: A case control study. CHEMOSPHERE 2020; 258:127305. [PMID: 32563914 DOI: 10.1016/j.chemosphere.2020.127305] [Citation(s) in RCA: 25] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/27/2020] [Revised: 05/28/2020] [Accepted: 06/01/2020] [Indexed: 05/22/2023]
Abstract
Chronic arsenic toxicity has become a global concern due to its adverse pathophysiological outcome and carcinogenic potential. It is already established that arsenic induced reactive oxygen species alters mitochondrial functionality. Major regulatory genes for mitochondrial biogenesis, i.e., PGC1α, Tfam, NRF1and NRF2 are located in the nucleus. As a result, mitochondria-nucleus crosstalk is crucial for proper mitochondrial function. This previous hypothesis led us to investigateinvolvement of epigenetic alteration behindenhanced mitochondrial biogenesis in chronic arsenic exposure. An extensive case-control study was conducted with 390 study participants (unexposed, exposed without skin lesion, exposed with skin lesion and exposed skin tumour) from highly arsenic exposed areas ofWest Bengal, India. Methylation specific PCRrevealed significant promoter hypomethylation oftwo key biogenesis regulatory genes, PGC1αandTfam in arsenic exposed individuals and also in skin tumour tissues. Linear regression analysis indicated significant negative correlation between urinary arsenic concentration and promoter methylation status. Increased expression of biogenesis regulatory genes wasobtained by quantitative real-time PCR analysis. Moreover, altered mitochondrial fusion-fission regulatory gene expression was also observed in skin tumour tissues. miR663, having tumour suppressor gene like function was known to be epigenetically regulated through mitochondrial retrograde signal. Promoter hypermethylation with significantly decreased expression of miR663 was found in skin cancer tissues compared to non-cancerous control tissue. In conclusion, results indicated crucial role of epigenetic alteration in arsenic induced mitochondrial biogenesis and arsenical skin carcinogenesis for the first time. However, further mechanistic studies are necessary for detailed understanding of mitochondria-nucleus crosstalk in arsenic perturbation.
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Affiliation(s)
- Tamalika Sanyal
- Department of Zoology, University of Calcutta, Kolkata, 700019, India; Department of Environmental Science, University of Calcutta, Kolkata, 700019, India
| | - Manabi Paul
- Department of Environmental Science, University of Calcutta, Kolkata, 700019, India
| | | | - Pritha Bhattacharjee
- Department of Environmental Science, University of Calcutta, Kolkata, 700019, India.
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Sanyal T, Bhattacharjee P, Paul S, Bhattacharjee P. Recent Advances in Arsenic Research: Significance of Differential Susceptibility and Sustainable Strategies for Mitigation. Front Public Health 2020; 8:464. [PMID: 33134234 PMCID: PMC7578365 DOI: 10.3389/fpubh.2020.00464] [Citation(s) in RCA: 28] [Impact Index Per Article: 5.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/20/2020] [Accepted: 07/23/2020] [Indexed: 12/16/2022] Open
Abstract
Arsenic contamination in drinking water and associated adverse outcomes are one of the major health issues in more than 50 countries worldwide. The scenario is getting even more detrimental with increasing number of affected people and newer sites reported from all over the world. Apart from drinking water, the presence of arsenic has been found in various other dietary sources. Chronic arsenic toxicity affects multiple physiological systems and may cause malignancies leading to death. Exposed individuals, residing in the same area, developed differential dermatological lesion phenotypes and varied susceptibility toward various other arsenic-induced disease risk, even after consuming equivalent amount of arsenic from the similar source, over the same duration of time. Researches so far indicate that differential susceptibility plays an important role in arsenic-induced disease manifestation. In this comprehensive review, we have identified major population-based studies of the last 20 years, indicating possible causes of differential susceptibility emphasizing arsenic methylation capacity, variation in host genome (single nucleotide polymorphism), and individual epigenetic pattern (DNA methylation, histone modification, and miRNA expression). Holistic multidisciplinary strategies need to be implemented with few sustainable yet cost-effective solutions like alternative water source, treatment of arsenic-contaminated water, new adaptations in irrigation system, simple modifications in cooking strategy, and dietary supplementations to combat this menace. Our review focuses on the present perspectives of arsenic research with special emphasis on the probable causes of differential susceptibility toward chronic arsenic toxicity and sustainable remediation strategies.
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Affiliation(s)
- Tamalika Sanyal
- Department of Zoology, University of Calcutta, Kolkata, India.,Department of Environmental Science, University of Calcutta, Kolkata, India
| | - Pritha Bhattacharjee
- Department of Zoology, University of Calcutta, Kolkata, India.,Department of Environmental Science, University of Calcutta, Kolkata, India
| | - Somnath Paul
- Department of Epigenetics and Molecular Carcinogenesis, U.T. MD Anderson Cancer Center, Smithville, TX, United States
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11
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Sanyal T, Bhattacharjee P, Paul S, Bhattacharjee P. Recent Advances in Arsenic Research: Significance of Differential Susceptibility and Sustainable Strategies for Mitigation. Front Public Health 2020. [PMID: 33134234 DOI: 10.3389/fpubh/2020.00464] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/23/2023] Open
Abstract
Arsenic contamination in drinking water and associated adverse outcomes are one of the major health issues in more than 50 countries worldwide. The scenario is getting even more detrimental with increasing number of affected people and newer sites reported from all over the world. Apart from drinking water, the presence of arsenic has been found in various other dietary sources. Chronic arsenic toxicity affects multiple physiological systems and may cause malignancies leading to death. Exposed individuals, residing in the same area, developed differential dermatological lesion phenotypes and varied susceptibility toward various other arsenic-induced disease risk, even after consuming equivalent amount of arsenic from the similar source, over the same duration of time. Researches so far indicate that differential susceptibility plays an important role in arsenic-induced disease manifestation. In this comprehensive review, we have identified major population-based studies of the last 20 years, indicating possible causes of differential susceptibility emphasizing arsenic methylation capacity, variation in host genome (single nucleotide polymorphism), and individual epigenetic pattern (DNA methylation, histone modification, and miRNA expression). Holistic multidisciplinary strategies need to be implemented with few sustainable yet cost-effective solutions like alternative water source, treatment of arsenic-contaminated water, new adaptations in irrigation system, simple modifications in cooking strategy, and dietary supplementations to combat this menace. Our review focuses on the present perspectives of arsenic research with special emphasis on the probable causes of differential susceptibility toward chronic arsenic toxicity and sustainable remediation strategies.
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Affiliation(s)
- Tamalika Sanyal
- Department of Zoology, University of Calcutta, Kolkata, India
- Department of Environmental Science, University of Calcutta, Kolkata, India
| | - Pritha Bhattacharjee
- Department of Zoology, University of Calcutta, Kolkata, India
- Department of Environmental Science, University of Calcutta, Kolkata, India
| | - Somnath Paul
- Department of Epigenetics and Molecular Carcinogenesis, U.T. MD Anderson Cancer Center, Smithville, TX, United States
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Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BIOMED RESEARCH INTERNATIONAL 2019; 2019:4978018. [PMID: 31737665 PMCID: PMC6815581 DOI: 10.1155/2019/4978018] [Citation(s) in RCA: 24] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/29/2019] [Revised: 07/17/2019] [Accepted: 08/20/2019] [Indexed: 12/26/2022]
Abstract
Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm). Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes. Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls. Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen's disease, and kidney, liver, bladder, and lung cancer).
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Spratlen MJ, Grau-Perez M, Umans JG, Yracheta J, Best LG, Francesconi K, Goessler W, Bottiglieri T, Gamble MV, Cole SA, Zhao J, Navas-Acien A. Targeted metabolomics to understand the association between arsenic metabolism and diabetes-related outcomes: Preliminary evidence from the Strong Heart Family Study. ENVIRONMENTAL RESEARCH 2019; 168:146-157. [PMID: 30316100 PMCID: PMC6298442 DOI: 10.1016/j.envres.2018.09.034] [Citation(s) in RCA: 18] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/06/2018] [Revised: 09/02/2018] [Accepted: 09/25/2018] [Indexed: 05/03/2023]
Abstract
BACKGROUND Inorganic arsenic exposure is ubiquitous and both exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes. This profile, however, has also been associated with increased risk for diabetes-related outcomes. OBJECTIVES The mechanism behind these conflicting associations is unclear; we hypothesized the one-carbon metabolism (OCM) pathway may play a role. METHODS We evaluated the influence of OCM on the relationship between arsenic metabolism and diabetes-related outcomes (HOMA2-IR, waist circumference, fasting plasma glucose) using metabolomic data from an OCM-specific and P180 metabolite panel measured in plasma, arsenic metabolism measured in urine, and HOMA2-IR and FPG measured in fasting plasma. Samples were drawn from baseline visits (2001-2003) in 59 participants from the Strong Heart Family Study, a family-based cohort study of American Indians aged ≥14 years from Arizona, Oklahoma, and North/South Dakota. RESULTS In unadjusted analyses, a 5% increase in DMA% was associated with higher HOMA2-IR (geometric mean ratio (GMR)= 1.13 (95% CI: 1.03, 1.25)) and waist circumference (mean difference=3.66 (0.95, 6.38). MMA% was significantly associated with lower HOMA2-IR and waist circumference. After adjustment for OCM-related metabolites (SAM, SAH, cysteine, glutamate, lysophosphatidylcholine 18.2, and three phosphatidlycholines), associations were attenuated and no longer significant. CONCLUSIONS These preliminary results indicate that the association of lower MMA% and higher DMA% with diabetes-related outcomes may be influenced by OCM status, either through confounding, reverse causality, or mediation.
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Affiliation(s)
- Miranda J Spratlen
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
| | - Maria Grau-Perez
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Fundación Investigación Clínico de Valencia-INCLIVA, Area of Cardiometabolic and Renal Risk, Valencia, Valencia, Spain; University of Valencia, Department of Statistics and Operational Research, Valencia, Valencia, Spain
| | - Jason G Umans
- MedStar Health Research Institute, Hyattsville, MD, USA; Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA
| | - Joseph Yracheta
- Missouri Breaks Industries Research, Inc., Eagle Butte, SD, USA
| | - Lyle G Best
- Missouri Breaks Industries Research, Inc., Eagle Butte, SD, USA
| | - Kevin Francesconi
- Institute of Chemistry - Analytical Chemistry, University of Graz, Austria
| | - Walter Goessler
- Institute of Chemistry - Analytical Chemistry, University of Graz, Austria
| | | | - Mary V Gamble
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA
| | - Shelley A Cole
- Texas Biomedical Research Institute, San Antonio, TX, USA
| | - Jinying Zhao
- College of Public Health and Health Professions and the College of Medicine at the University of Florida, Gainesville, FL, USA
| | - Ana Navas-Acien
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA; Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
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Spratlen MJ, Grau-Perez M, Umans JG, Yracheta J, Best LG, Francesconi K, Goessler W, Balakrishnan P, Cole SA, Gamble MV, Howard BV, Navas-Acien A. Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. ENVIRONMENT INTERNATIONAL 2018; 121:728-740. [PMID: 30321848 PMCID: PMC6221918 DOI: 10.1016/j.envint.2018.09.048] [Citation(s) in RCA: 29] [Impact Index Per Article: 4.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/23/2018] [Revised: 09/25/2018] [Accepted: 09/26/2018] [Indexed: 05/02/2023]
Abstract
BACKGROUND Inorganic arsenic exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes; however, this profile has also been associated with increased risk for diabetes-related outcomes. The mechanism behind these contrasting associations is equivocal; we hypothesized one carbon metabolism (OCM) may play a role. METHODS We evaluated the association between OCM-related variables (nutrient intake and genetic variants) and both arsenic metabolism biomarkers (iAs%, MMA% and DMA%) and diabetes-related outcomes (metabolic syndrome, diabetes, HOMA2-IR and waist circumference) in 935 participants free of prevalent diabetes and metabolic syndrome from the Strong Heart Family Study, a family-based prospective cohort comprised of American Indian tribal members aged 14+ years. RESULTS Of the 935 participants free of both diabetes and metabolic syndrome at baseline, 279 (29.8%) developed metabolic syndrome over a median of 5.3 years of follow-up and of the 1458 participants free of diabetes at baseline, 167 (11.3%) developed diabetes over follow-up. OCM nutrients were not associated with arsenic metabolism, however, higher vitamin B6 was associated with diabetes-related outcomes (higher HOMA2-IR and increased risk for diabetes and metabolic syndrome). A polymorphism in an OCM-related gene, methionine synthase (MTR), was associated with both higher MMA% (β = 2.57, 95% CI: 0.22, 4.92) and lower HOMA2-IR (GMR = 0.79, 95% CI = 0.66, 0.93 per 5 years of follow-up). Adjustment for OCM variables did not affect previously reported associations between arsenic metabolism and diabetes-related outcomes; however, the association between the MTR variant and diabetes-related outcomes were attenuated after adjustment for arsenic metabolism. CONCLUSIONS Our findings suggest MMA% may be a partial mediator in the association between OCM and diabetes-related outcomes. Additional mediation analyses with longer follow-up period are needed to confirm this finding. Further research is needed to determine whether excess B vitamin intake is associated with increased risk for diabetes-related outcomes.
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Affiliation(s)
- Miranda J Spratlen
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, NY, New York, United States of America; Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
| | - Maria Grau-Perez
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, NY, New York, United States of America; Fundación Investigación Clínico de Valencia-INCLIVA, Area of Cardiometabolic and Renal Risk, Valencia, Spain; Department of Statistics and Operational Research, University of Valencia, Valencia, Spain
| | - Jason G Umans
- MedStar Health Research Institute, Hyattsville, MD, United States of America; Department of Medicine, Georgetown University School of Medicine, Washington, DC, United States of America
| | - Joseph Yracheta
- Missouri Breaks Industries Research, Inc., Eagle Butte, SD, United States of America
| | - Lyle G Best
- Missouri Breaks Industries Research, Inc., Eagle Butte, SD, United States of America
| | - Kevin Francesconi
- Institute of Chemistry - Analytical Chemistry, University of Graz, Austria
| | - Walter Goessler
- Institute of Chemistry - Analytical Chemistry, University of Graz, Austria
| | - Poojitha Balakrishnan
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, NY, New York, United States of America
| | - Shelley A Cole
- Texas Biomedical Research Institute, San Antonio, TX, United States of America
| | - Mary V Gamble
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, NY, New York, United States of America
| | - Barbara V Howard
- MedStar Health Research Institute, Hyattsville, MD, United States of America; Department of Medicine, Georgetown University School of Medicine, Washington, DC, United States of America
| | - Ana Navas-Acien
- Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, NY, New York, United States of America; Department of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America
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Wei B, Yu J, Kong C, Li H, Yang L, Xia Y, Wu K. A follow-up study of the development of skin lesions associated with arsenic exposure duration. ENVIRONMENTAL GEOCHEMISTRY AND HEALTH 2018; 40:2729-2738. [PMID: 29948538 DOI: 10.1007/s10653-018-0136-6] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/28/2017] [Accepted: 06/08/2018] [Indexed: 06/08/2023]
Abstract
Little information about the development of skin lesions in relation to arsenic exposure duration is available. Therefore, skin lesions in a cohort from the Bameng region of China were diagnosed in 2012 and 2017. The results indicated that the prevalence of hyperkeratosis, pigmentation and depigmentation in 2017 was 64.67, 6.67 and 12.67%. There were 42 and 34% of male subjects and female subjects suffered from skin lesions in 2012. Their morbidity rates were 10.43 and 8.98 per 1000 person-years. In 2017, the values were significantly increased. The prevalence and morbidity rate of skin lesions were positively correlated with age and arsenic levels in drinking water. Males had higher prevalence of skin lesions compared with female. However, the ≤ 40 years female group had higher prevalence of skin lesions. In addition, the increased rate of skin lesions prevalence was negatively correlated with arsenic levels in drinking water. The odds ratios (ORs) showed that the risks of skin lesions were positively associated with the proportion of inorganic arsenic (%iAs) and monomethylarsonic acid (%MMA) in urine, and negatively correlated with arsenic methylation capacity in both 2012 and 2017. It can be concluded that females immigrated from other areas were more susceptible to developing skin lesions. A certain cumulative arsenic exposure dose, which may be existing, significantly increased the prevalence of skin lesions. Longer arsenic exposure duration might elevate the toxicity of iAs to skin lesions and reduce the positive effects of arsenic methylation capacity on skin lesions.
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Affiliation(s)
- Binggan Wei
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, People's Republic of China
| | - Jiangping Yu
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, People's Republic of China
| | - Chang Kong
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, People's Republic of China
- Collage of Resources and Environment, University of Chinese Academy of Sciences, Beijing, People's Republic of China
| | - Hairong Li
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, People's Republic of China.
- Collage of Resources and Environment, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
| | - Linsheng Yang
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, Beijing, 100101, People's Republic of China.
- Collage of Resources and Environment, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
| | - Yajuan Xia
- Inner Mongolia Center for Comprehensive Disease Control and Prevention, Hohhot, Inner Mongolia, People's Republic of China
| | - Kegong Wu
- Inner Mongolia Center for Comprehensive Disease Control and Prevention, Hohhot, Inner Mongolia, People's Republic of China
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Chi H, Zhang Y, Williams PN, Lin S, Hou Y, Cai C. In Vitro Model To Assess Arsenic Bioaccessibility and Speciation in Cooked Shrimp. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2018; 66:4710-4715. [PMID: 29633616 DOI: 10.1021/acs.jafc.7b06149] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/08/2023]
Abstract
Shrimp, a popular and readily consumed seafood, contains high concentrations of arsenic. However, few studies have focused on whether arsenic in the shrimp could be transformed during the cooking process and gastrointestinal digestion. In this study, a combined in vitro model [Unified Bioaccessibility Research Group of Europe (BARGE) Method-Simulator of Human Intestinal Microbial Ecosystem (UBM-SHIME)] was used to investigate arsenic bioaccessibility and its speciation in raw and cooked shrimps. The results showed that the cooking practices had little effect on the arsenic content and speciation. Bioaccessibility of arsenic in raw shrimp was at a high level, averaging 76.9 ± 4.28 and 86.7 ± 3.74% in gastric and small intestinal phases, respectively. Arsenic speciation was stable in all of the shrimp digestions, with nontoxic arsenobetaine (AsB) being the dominated speciation. The cooking practice significantly increased the bioaccessibility of arsenate ( p < 0.05) in shrimp digests, indicating the increase of the potential health risks.
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Affiliation(s)
- Haifeng Chi
- Department of Environmental Science and Engineering , Huaqiao University , Xiamen , Fujian 361021 , People's Republic of China
- State Key Laboratory of Urban Environment and Health, Institute of Urban Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's Republic of China
| | - Youchi Zhang
- State Key Laboratory of Urban Environment and Health, Institute of Urban Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's Republic of China
| | - Paul N Williams
- Institute for Global Food Security, School of Biological Sciences , Queen's University Belfast , Belfast BT9 7BL , United Kingdom
| | - Shanna Lin
- Department of Environmental Science and Engineering , Huaqiao University , Xiamen , Fujian 361021 , People's Republic of China
- State Key Laboratory of Urban Environment and Health, Institute of Urban Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's Republic of China
| | - Yanwei Hou
- Department of Environmental Science and Engineering , Huaqiao University , Xiamen , Fujian 361021 , People's Republic of China
| | - Chao Cai
- State Key Laboratory of Urban Environment and Health, Institute of Urban Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's Republic of China
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17
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Liu T, Guo H, Xiu W, Wei C, Li X, Di Z, Song W. Biomarkers of arsenic exposure in arsenic-affected areas of the Hetao Basin, Inner Mongolia. THE SCIENCE OF THE TOTAL ENVIRONMENT 2017; 609:524-534. [PMID: 28763649 DOI: 10.1016/j.scitotenv.2017.07.120] [Citation(s) in RCA: 22] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/20/2017] [Revised: 07/07/2017] [Accepted: 07/13/2017] [Indexed: 05/12/2023]
Abstract
Seventy saliva samples, seventy urine samples, seventy nail samples, seventy hair samples, eight drinking water samples and ninety-three crop samples were collected from four villages of the Hetao Basin in Inner Mongolia to determine arsenic (As) exposure biomarkers and evaluate relationship between As uptake and human health risk. Trivalent As (As(III)), pentavalent As (As(V)), dimethylarsinic acid (DMA), arsenobetaine (AsB) and monomethylarsonic acid (MMA) were found in all urine samples. Only As(III) and As(V) were detected in saliva samples. In nail and hair samples, DMA, MMA, As(III) and As(V) were observed. Based on total As contents in crops and drinking water, the local residents' daily intake of total arsenic (TDIAs), the hazard quotient (HQ), and the cancer risk (R) were assessed. Male, older and cases of skin lesion participants generally had higher As contents in saliva, urine, nail and hair samples in relative to others. Salivary, urinary, nail and hair As were not significantly affected by body mass index (BMI) and smoking. Good correlations were observed between TDIAs and salivary, urinary, nail and hair As, showing that saliva, urine, nail and hair samples can be used as biomarkers of As exposure. Individually, levels of arsenicosis were positively correlated with TDIAs. The relationship between TDIAs and prevalence of arsenicosis concluded that, although As levels in crops and drinking water did not exceed national standards, they still pose a potential threat to human health. It was suggested that the maximum permissible levels of crop As and drinking water As should be re-evaluated for protecting human health.
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Affiliation(s)
- Ting Liu
- State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences (Beijing), Beijing 100083, PR China
| | - Huaming Guo
- State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences (Beijing), Beijing 100083, PR China; School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing 100083, PR China.
| | - Wei Xiu
- State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences (Beijing), Beijing 100083, PR China
| | - Chao Wei
- The National Institute of Metrology, Beijing 100013, PR China
| | - Xiaomeng Li
- School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing 100083, PR China
| | - Zhen Di
- Hangjinhouqi Center of Diseases Prevention and Control, Shanba 015400, PR China
| | - Wei Song
- Hangjinhouqi Center of Diseases Prevention and Control, Shanba 015400, PR China
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18
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Wei B, Yu J, Kong C, Li H, Yang L, Guo Z, Cui N, Xia Y, Wu K. An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL 2017; 24:25947-25954. [PMID: 28940151 DOI: 10.1007/s11356-017-0203-z] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/15/2017] [Accepted: 09/12/2017] [Indexed: 06/07/2023]
Abstract
Few studies have been conducted to compare arsenic exposure, metabolism, and methylation in populations exposed to arsenic in drinking water and from coal combustion. Therefore, arsenic concentrations in the environment and arsenic speciation in the urine of subjects exposed to arsenic as a consequence of coal combustion in a rural area in Shaanxi province (CCA) and in drinking water in a rural area in Inner Mongolia (DWA) were investigated. The mean arsenic concentrations in drinking water, indoor air, and soil in CCA were 4.52 μg/L, 0.03 mg/m3, and 14.93 mg/kg, respectively. The mean arsenic concentrations in drinking water and soil in DWA were 144.71 μg/L and 10.19 mg/kg, respectively, while the level in indoor air was lower than the limit of detection. The total daily intakes of arsenic in DWA and CCA were 4.47 and 3.13 μg/day·kg, respectively. The mean urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsenic acid (DMA), and total arsenic (TAs) for subjects with skin lesions in DWA were 50.41, 47.01, 202.66, and 300.08 μg/L. The concentrations for subjects without skin lesions were 49.76, 44.20, 195.60, and 289.56 μg/L, respectively. The %iAs, %MMA, and %DMA in the TAs in the urine of subjects from CCA were 12.24, 14.73, and 73.03%, while the corresponding values from DWA were 17.54, 15.57, and 66.89%, respectively. The subjects in DWA typically had a higher %iAs and %MMA, and a lower %DMA, and primary and secondary methylation index (PMI and SMI) than the subjects in CCA. It was concluded that the arsenic methylation efficiency of subjects in DWA and CCA was significantly influenced by chronic exposure to high levels of arsenic in the environment. The lower PMI and SMI values in DWA revealed lower arsenic methylation capacity due to ingestion of arsenic in drinking water. However, it remained unclear if the differences in arsenic metabolism between the two groups were due to differences in exposure levels or in exposure route.
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Affiliation(s)
- Binggan Wei
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, 100101, Beijing, People's Republic of China
| | - Jiangping Yu
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, 100101, Beijing, People's Republic of China
| | - Chang Kong
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, 100101, Beijing, People's Republic of China
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China
| | - Hairong Li
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, 100101, Beijing, People's Republic of China.
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China.
| | - Linsheng Yang
- Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 11 A Datun Road, 100101, Beijing, People's Republic of China.
- College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China.
| | - Zhiwei Guo
- Inner Mongolia Center for Disease Control and Research, Hohhot, China
| | - Na Cui
- Inner Mongolia Center for Disease Control and Research, Hohhot, China
| | - Yajuan Xia
- Inner Mongolia Center for Disease Control and Research, Hohhot, China
| | - Kegong Wu
- Inner Mongolia Center for Disease Control and Research, Hohhot, China
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